Histone H3 lysine 27 crotonylation mediates gene transcriptional repression in chromatin

Histone lysine acylation, including acetylation and crotonylation, plays a pivotal role in gene transcription in health and diseases. However, our understanding of histone lysine acylation has been limited to gene transcriptional activation. Here, we report that histone H3 lysine 27 crotonylation (H3K27cr) directs gene transcriptional repression rather than activation.

Targeted single-cell gene induction by optimizing the dually regulated CRE/loxP system by a newly defined heat- shock promoter and the steroid hormone in Arabidopsis thaliana

Multicellular organisms rely on intercellular communication systems to organize their cellular functions. In studies focusing on intercellular communication, the key experimental techniques include the generation of chimeric tissue using transgenic DNA recombination systems represented by the CRE/loxP system.

Sez6l2 autoimmunity in a large cohort study

There are many causes of cerebellar ataxia (CA) including neurodegeneration and autoimmunity. We detected antiseizure-related 6 homolog-like 2 (Sez6l2) antibody from the serum of a patient with subacute CA.1 In this study, we conducted an 11-year follow-up of a previously reported female (case 1)1 and reported two new cases (case 2 and case 3) of Sez6l2 antibody-positive CA in Japan (online supplemental table 1).

Industrial electricity consumption efficiency and energy policy in Japan

This study analyzes the potential for energy savings by identifying inefficiencies in electricity use and their determinants in the Japanese industrial sector. Specifically, we used stochastic frontier analysis to estimate inefficiencies in electricity consumption based on data obtained from electric power companies. We identified significant determinants of electricity consumption efficiency and that changes in national energy policy following the Great East Japan Earthquake changed electricity consumption behavior. The contribution of this study is that its findings can be used to improve the cost-effectiveness of policies aimed at improving energy efficiency.