Research

Advanced Medical Research Center

Advanced Medical Research Center(SENTANKEN)conducts basic studies aimed at overcoming cancer and lifestyle diseases and translational researches which applies the scientific finding to clinical medicine. It has three omics centers – genomics, proteomics, cellomics –and a biobank, collaborates within YCU and with other research institutions, and promote translational researches. AMRC is also involved in a number of R&D, working with the industry. Our goal is to make our research findings available to the society without delay.

Outline, Structure & Function of the Advanced Medical Research Center >
RESEARCH > ADVANCED MEDICAL RESEARCH CENTER

Message from the Director

The Advanced Medical Research Center (SENTANKEN) of Yokohama City University(YCU) was established in 2006. The assignment of SENTANKEN is to facilitate advanced medical research associated with diseases such as cancer and lifestyle-related diseases. SENTANKEN is focused on basic researches in the field of genomics, proteomics and cellomics, as well as translational researches, which can fill the gap between basic and clinical researches, and promotes not only intramural collaboration but also between government, industry and academia.

Our goal is to make an attractive YCU that can contribute to the community by delivering the research outcomes of our basic and clinical researches promptly to the citizens of Yokohama and by connecting these activities for the revitalization of industries in Yokohama.

Research News

2021-05-17

Maintenance DNA methylation in pre-meiotic germ cells regulates meiotic prophase by facilitating homologous chromosome pairing

Heterochromatin-related epigenetic mechanisms, such as DNA methylation, facilitate pairing of homologous chromosomes during the meiotic prophase of mammalian spermatogenesis. In pro-spermatogonia, de novo DNA methylation plays a key role in completing meiotic prophase and initiating meiotic division. However, the role of maintenance DNA methylation in the regulation of meiosis, especially in the adult, is not well understood. Here, we reveal that NP95 (also known as UHRF1) and DNMT1 – two essential proteins for maintenance DNA methylation – are co-expressed in spermatogonia and are necessary for meiosis in male germ cells.
2021-05-14

Refinement of the clinical variant interpretation framework by statistical evidence and machine learning

Although the American College of Medical Geneticsand Genomics/Association for Molecular Pathology (ACMG/AMP)guidelines for variant interpretation are used widely in clinical ge-netics, there is room for improvement of these knowledge-basedguidelines.
2021-05-07

Sustained Neutralizing Antibodies 6 Months Following Infection in 376 Japanese COVID-19 Survivors

There is scarce evidence regarding the long-term persistence of neutralizing antibodies among coronavirus disease 2019 (COVID-19) survivors. This study determined neutralizing antibody titers (NT50) and antibodies against spike protein (SP) or nucleocapsid protein (NP) antigens approximately 6 months after the diagnosis of COVID-19.
 
Contact info

E-mail
sentan@yokohama-cu.ac.jp
Our location

3-9 Fukuura, Kanazawa-ku, Yokohama, Kanagawa 236-0004 Japan

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