Research at Yokohama City University

Yokohama City University strives to contribute to the development of arts and sciences, conduct research activities that contribute to advanced technology, and announce research results to the world with high expertise and from a global point of view. We pride ourselves on research that contributes to state-of-the-art technology through specialization and a global outlook. Aiming to contribute to the advancement of science and the global community, we provide support for an array of global standard research programs.

Research Highlights


Intraoperative Integrated Diagnostic System for Malignant Central Nervous System Tumors

Purpose: The 2021 World Health Organization (WHO) classification of central nervous system (CNS) tumors uses an integrated approach involving histopathology and molecular profiling. Because majority of adult malignant brain tumors are gliomas and primary CNS lymphomas (PCNSL), rapid differentiation of these diseases is required for therapeutic decisions. In addition, diffuse gliomas require molecular information on single-nucleotide variants (SNV), such as IDH1/2. Here, we report an intraoperative integrated diagnostic (i-ID) system to classify CNS malignant tumors, which updates legacy frozen-section (FS) diagnosis through incorporation of a qPCR-based genotyping assay.

Influence on the accuracy in ChatGPT: Differences in the amount of information per medical field

Objectives Although ChatGPT was not developed for medical use, there is growing interest in its use in medical fields. Understanding its capabilities and precautions for its use in the medical field is an urgent matter. We hypothesized that differences in the amounts of information published in different medical fields would be proportionate to the amounts of training ChatGPT receives in those fields, and hence its accuracy in providing answers.

Structural basis for ligand recognition and signaling of hydroxy- carboxylic acid receptor 2

Hydroxycarboxylic acid receptors (HCAR1, HCAR2, and HCAR3) transduce Gi/o signaling upon biding to molecules such as lactic acid, butyric acid and 3-hydroxyoctanoic acid, which are associated with lipolytic and atherogenic activity, and neuroinflammation.

Researcher Database

A strong research culture is fostered across all disciplines and all departments in Yokohama City University. To learn more about our faculty and their research, click on the link below.