Research at Yokohama City University

Yokohama City University strives to contribute to the development of arts and sciences, conduct research activities that contribute to advanced technology, and announce research results to the world with high expertise and from a global point of view. We pride ourselves on research that contributes to state-of-the-art technology through specialization and a global outlook. Aiming to contribute to the advancement of science and the global community, we provide support for an array of global standard research programs.

Research Highlights


Polygenic architecture informs potential vulnerability to drug-induced liver injury

Drug-induced liver injury (DILI) is a leading cause of termination in drug development programs and removal of drugs from the market; this is partially due to the inability to identify patients who are at risk. In this study, we developed a polygenic risk score (PRS) for DILI by aggregating effects of numerous genome-wide loci identified from previous large-scale genome-wide association studies.

Rapid quantitative screening assay for SARS-CoV-2 neutralizing antibodies using HiBiT-tagged virus-like particles

SARS-CoV-2 neutralizing antibodies confer protective immunity against reinfection. We have developed a rapid test for screening SARS-CoV-2 neutralization antibodies using genome-free virus-like particles incorporated with a small luciferase peptide, HiBiT. Their entry into LgBiT-expressing target cells reconstitutes NanoLuc luciferase readily detected by a luminometer.

A pipeline for complete characterization of complex germline rearrangements from long DNA reads

Many genetic/genomic disorders are caused by genomic rearrangements. Standard methods can often characterize these variations only partly, e.g., copy number changes or breakpoints. It is important to fully understand the order and orientation of rearranged fragments, with precise breakpoints, to know the pathogenicity of the rearrangements.

Researcher Database

A strong research culture is fostered across all disciplines and all departments in Yokohama City University. To learn more about our faculty and their research, click on the link below.