HSP90 inhibition overcomes resistance to molecular targeted therapy in BRAFV600E mutant high-grade glioma

Purpose: Molecular targeted therapy using BRAF and/or MEK inhibitors has been applied to BRAFV600E-mutant high-grade gliomas (HGG); however, the therapeutic effect is limited by the emergence of drug resistance.

Trends in suicide in Japan following the 2019 Coronavirus Pandemic.

During the coronavirus disease 2019 (COVID-19) pandemic, there were concerns that suicides would increase due to changes in lifestyle that restricted human contact in schooling, employment, and social activities.

Evasion of vaccine-induced humoral immunity by emerging sub-variants of SARS-CoV-2

Background: Emergence of vaccine-escaping SARS-CoV-2 variants is a serious problem for global public health. The currently rampant Omicron has been shown to possess remarkable vaccine escape; however, the selection pressure exerted by vaccines might pave the way for other escape mutants in the near future.

Naming-related spectral responses predict neuropsychological outcome after epilepsy surger

This prospective study determined the use of intracranially recorded spectral responses during naming tasks in predicting neuropsychological performance following epilepsy surgery.