Usual source and better quality of primary care are associated with lower loneliness scores: a cross-sectional study

Background Loneliness is a global issue, and primary care physicians play an important role in assessing and intervening with loneliness. This study aimed to examine the association between having a usual source of care (USC) or a good quality of primary care, and loneliness.

Impact of the COVID-19 Pandemic on Cancer Treatment: Nationwide Japanese Registration Until 2021

We read with great interest a recent research article by Mallouh and colleagues1 demonstrating that the COVID-19 pandemic did not precipitate stage migration at presentation of breast and lung cancer in Massachusetts. We would like to show the data from Japan.

Panitumumab vs Bevacizumab Added to Standard First-line Chemotherapy and Overall Survival Among Patients With RAS Wild-type, Left-sided Metastatic Colorectal Cancer A Randomized Clinical Trial

Question : Among patients with RAS wild-type, left-sided metastatic colorectal cancer, does adding panitumumab (an anti–epidermal growth factor receptor monoclonal antibody) vs bevacizumab (an anti–vascular endothelial growth factor monoclonal antibody) to standard first-line chemotherapy improve overall survival?

Genome-wide identification of tandem repeats associated with splicing variation across 49 tissues in humans

Tandem repeats (TRs) are one of the largest sources of polymorphism, and their length is associated with gene regulation. Although previous studies reported several tandem repeats regulating gene splicing in cis (spl-TRs), no large-scale study has been conducted. In this study, we established a genome-wide catalog of 9537 spl-TRs with a total of 58,290 significant TR–splicing associations across 49 tissues (false discovery rate 5%) by using Genotype-Tissue expression (GTex) Project data.