Research Archives - Page 63 of 72 - Yokohama City University

2020-06-08

Environmental Maintenance with Effective and Useful Zoning for Severe COVID‐19 due to Protect to and from Patients and Medical Staffs

We repurposed a general ward into an acute care unit for severe COVID‐19 patients taking into consideration airflow, the direction of movement of medical staff, and prevention of the spread of infection to medical staff and other patients. We checked the daily condition and body temperature of all medical staff for 60 days.

2020-06-05

Astellas, City of Yokohama, and Yokohama City University Developed Science-Based Exercise Programs through Industry-Government-Academia Collaboration

Astellas Pharma Inc. developed science-based exercise programs in cooperation with the City of Yokohama, Kanagawa Prefecture and Yokohama City University.

2020-06-03

Serine 298 Phosphorylation in Linker 2 of UHRF1 Regulates Ligand-Binding Property of Its Tandem Tudor Domain

Ubiquitin-like with PHD and RING finger domains 1 (UHRF1) is an essential factor for the maintenance of mammalian DNA methylation and harbors several reader modules for recognizing epigenetic marks. The tandem Tudor domain (TTD) of UHRF1 has a peptide-binding groove that functions as a binding platform for intra- or intermolecular interactions. Besides the groove interacting with unphosphorylated linker 2 and spacer of UHRF1, it also interacts with di/tri-methylated histone H3 at Lys9 and DNA ligase 1 (LIG1) at Lys126. Here we focus on the phosphorylation of Ser298 in linker 2, which was implied to regulate the ligand-binding property of the TTD.

2020-05-28

Pushing property limits in materials discovery via boundless objective-free exploration

Materials chemists develop chemical compounds to meet often conflicting demands of industrial applications. This process may not be properly modeled by black-box optimization because the target property is not well defined in some cases. Herein, we propose a new algorithm for automated materials discovery called BoundLess Objective-free eXploration (BLOX) that uses a novel criterion based on kernel-based Stein discrepancy in the property space.