Research Archives - Page 61 of 71 - Yokohama City University

2020-06-14

Multisystem Inflammatory Syndrome in Children (MIS-C) with COVID-19: Insights from simultaneous familial Kawasaki Disease cases

Recently, an increasing number of SARS-CoV-2 patients with COVID-19 syndrome, which overlaps with Kawasaki Disease (KD), have been reported, supporting the suggestion that infection is one of the triggers of KD.

2020-06-11

A YCU alumnus, Prof. Dr. S. M. Abe Kawsar, University of Chittagong, published two academic books from a German publisher.

Prof. Dr. Kawsar is an honorable alumnus at Yokohama City University (YCU) who was promoted to a professor position after the completion of the Ph.D. program (2005-2009). In 2014, he was promoted to professor at the University of Chittagong, Bangladesh. Prof. Dr. Kawsar returned to YCU the next year as a visiting professor at the Japan Society for the Promotion of Science. He researched on clinical and diagnostical applications of marine invertebrate lectins and provided special lectures at YCU as visiting professor.

2020-06-09

Adaptive reduction of male gamete number in the selfing plant Arabidopsis thaliana

Ubiquitin-like with PHD and RING finger domains 1 (UHRF1) is an essential factor for the maintenance of mammalian DNA methylation and harbors several reader modules for recognizing epigenetic marks. The tandem Tudor domain (TTD) of UHRF1 has a peptide-binding groove that functions as a binding platform for intra- or intermolecular interactions. Besides the groove interacting with unphosphorylated linker 2 and spacer of UHRF1, it also interacts with di/tri-methylated histone H3 at Lys9 and DNA ligase 1 (LIG1) at Lys126. Here we focus on the phosphorylation of Ser298 in linker 2, which was implied to regulate the ligand-binding property of the TTD.

2020-06-09

The protective effect of Bifidobacterium bifidum G9-1 against mucus degradation by Akkermansia muciniphila following small intestine injury caused by a proton pump inhibitor and aspirin

Proton pump inhibitors (PPIs) can alleviate upper gastrointestinal injury but paradoxically exacerbate aspirin (ASA)-induced small intestine injury. In this study, our goal was to simulate this exacerbation by developing an appropriate animal model, which may help in establishing treatments. Methods: Male mice were fed a 60% fructose diet for 9 weeks, then administered 200 mg/kg ASA 3 h before sacrifice. The PPI omeprazole was administered intraperitoneally once daily for 9 weeks.