Research Archives - Page 43 of 72 - Yokohama City University

2022-03-10

De novo creation of a naked eye–detectable fluorescent molecule based on quantum chemical computation and machine learning

Designing fluorescent molecules requires considering multiple interrelated molecular properties, as opposed to properties that straightforwardly correlated with molecular structure, such as light absorption of molecules.

2022-03-03

Deficiency of the kidney tubular angiotensin II type1 receptor-binding molecule ATRAP exacerbates streptozotocin-induced diabetic glomerular injury via reducing protective macrophage polarisation

Although activation of the renin-angiotensin system and of its glomerular components is implicated in the pathogenesis of diabetic nephropathy, the functional roles of the tubular renin-angiotensin system with AT1 receptor signaling in diabetic nephropathy are unclear.

2022-03-02

Impact of the COVID-19 pandemic on cancer diagnosis and resection in a COVID-19 low-burden country: nationwide registration study in Japan

I read a recent article written by Dr. Toes-Zoutendijk et al. that described how the coronavirus disease (COVID)-19 pandemic affected colorectal cancer screening and its incidence in the Netherlands.

2022-02-17

Genome-wide DNA Methylation Analysis in Pediatric Acute Myeloid Leukemia

We investigated genome-wide DNA methylation patterns in 64 pediatric patients with acute myeloid leukemia (AML). Based on unsupervised clustering with the 567 most variably methylated cytosine guanine dinucleotide (CpG) sites, patients were categorized into 4 clusters associated with genetic alterations.