Research Archives - Page 27 of 63 - Yokohama City University

2022-06-28

SARS-CoV-2 spike protein antibody titers 6 months after SARS-CoV-2 mRNA vaccination among patients undergoing hemodialysis in Japan

Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination is shown to prevent severe illness and death in hemodialysis (HD) patients, but the immune response to vaccines is reduced in this population. This study compared SARS-CoV-2 spike protein antibody titers between HD patients and healthy controls in Japan for up to 6 months following vaccination.

2022-06-21

Volume-Based Radiofrequency Thermocoagulation for Pediatric Insulo-Opercular Epilepsy: A Feasibility Study

BACKGROUND: Stereotactic ablation surgeries including radiofrequency thermocoagulation (RFTC) and laser interstitial thermal therapy are recent less invasive treatment methods for insular epilepsy. Volume-based RFTC after stereoelectroencephalography was first proposed by a French group as a more effective method for seizure relief in insular epilepsy patients than stereoelectroencephalography-guided RFTC.

2022-06-14

Chronic Kidney Disease and Clinical Outcomes in Patients with COVID-19 in Japan

Background Identifying predictive factors for coronavirus disease 2019 (COVID-19) is crucial for risk stratification and intervention. Kidney dysfunction contributes to the severity of various infectious diseases. However, the association between on-admission kidney dysfunction and the clinical outcome in COVID-19 patients is unclear.

2022-06-14

Indole-3-pyruvic acid regulates TAA1 activity, which plays a key role in coordinating the two steps of auxin biosynthesis

Significance The plant hormone auxin (indole-3-acetic acid [IAA]) plays a central role in regulating plant growth and development, but the regulation of IAA biosynthesis is poorly understood. Here, we identified a key push and pull feedback mechanism, which governs auxin biosynthesis through the tryptophan aminotransferase TAA1. We demonstrate that novel inhibitors of TAA1 function in both monocots and eudicots and present a catalytic mechanism that explains both its substrate specificity and its inhibition.