Research

2022-11-24

Structural basis for activation of DNMT1

DNMT1 is an essential enzyme that maintains genomic DNA methylation, and its function is regulated by mechanisms that are not yet fully understood.

2022-11-22

A global analysis of matches and mismatches between human genetic and linguistic histories

Significance There has been considerable debate about the extent to which our biological and linguistic histories match to each other, supported by examples of both matches and mismatches. We introduce a genomic database (GeLaTo, or Genes and Languages Together) to quantify matches and mismatches worldwide.

2022-11-10

Angiotensin II type‑1 receptor‑associated protein interacts with transferrin receptor‑1 and promotes its internalization

Kidney fibrosis is a common pathway that leads to chronic kidney disease. Angiotensin II type-1 receptor (AT1R)-associated protein (ATRAP) was originally identified as an AT1R-binding protein. Previously, we reported that systemic knockout of ATRAP exacerbates kidney fibrosis in aged mice.

2022-11-08

Multifunctional chemical inhibitors of the florigen activation complex discovered by structure-based high-throughput screening

Structure-based high-throughput screening of chemical compounds that target protein–protein interactions (PPIs) is a promising technology for gaining insight into how plant development is regulated, leading to many potential agricultural applications.