Research Archives - Page 15 of 72 - Yokohama City University

2023-10-11

Strain-level detection of Fusobacterium nucleatum in colorectal cancer specimens by targeting the CRISPR–Cas region.

Fusobacterium nucleatum is associated with colorectal cancer (CRC), and identical F. nucleatum strains seemed to be detected in 75% of patients who exhibited the presence of F. nucleatum in both CRC and saliva samples in our previous study; however,

2023-09-29

Combination of Sacubitril/Valsartan and Blockade of the PI3K Pathway Enhanced Kidney Protection in a Mouse Model of Cardiorenal Syndrome

Aims Angiotensin receptor-neprilysin inhibitor (ARNI) is an established treatment for heart failure. However, whether ARNI has renoprotective effects beyond renin-angiotensin system inhibitors alone in cardiorenal syndrome (CRS) has not been fully elucidated. Here, we examined the effects of ARNI on the heart and kidneys of CRS model mice with overt albuminuria and identified the mechanisms underlying ARNI-induced kidney protection.

2023-09-22

Seasonal pigment fluctuation in diploid and polyploid Arabidopsis revealed by machine learning-based phenotyping method PlantServation

Long-term field monitoring of leaf pigment content is informative for understanding plant responses to environments distinct from regulated chambers but is impractical by conventional destructive measurements. We developed PlantServation, a method incorporating robust image-acquisition hardware and deep learning-based software that extracts leaf color by detecting plant individuals automatically.

2023-09-15

Flexible Thin-Film Neural Electrodes with Improved Conformability for ECoG Measurements and Electrical Stimulation

Neural electrodes for electrocorticography (ECoG) recording and electrical stimulation are used for diagnosis and treatment of epilepsy, which are temporarily attached to the surface of cerebral cortex within the subdural space. However, conventional electrodes have a mechanical mismatch with the surface curvature of the brain cortex.