Reduced replication efficacy of SARS-CoV-2 Omicron variant in “mini-gut” organoids.

Over 480 million infections and 6 million deaths have been recorded since the novel coronavirus disease 2019 pandemic began over 2 years ago. Coronavirus disease 2019 is principally a respiratory illness caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which infects the cells of the airway and can also replicate in the gastrointestinal tract. Notably, over half of those with SARS-CoV-2 infections shed SARS-CoV-2 genomes in their stool,1 and infectious viruses can be isolated from their fecal samples,2 suggesting that the virus also infects and replicates in the intestinal tract.

Development and validation of a Japanese version of the Person-Centered Primary Care Measure

Background Although primary care (PC) is an indispensable part of the health system, measuring its quality is challenging. A recent measure of PC, Person-Centered Primary Care Measure (PCPCM), covers 11 important domains of PC and has been translated into 28 languages. This study aimed to develop a Japanese version of the PCPCM and assess its reliability and validity.

Large-scale discovery of novel neurodevelopmental disorder-related genes through a unified analysis of single-nucleotide and copy number variants

Background Previous large-scale studies of de novo variants identified a number of genes associated with neurodevelopmental disorders (NDDs); however, it was also predicted that many NDD-associated genes await discovery. Such genes can be discovered by integrating copy number variants (CNVs), which have not been fully considered in previous studies, and increasing the sample size.

Ecology of medical care for 90+ individuals: An exhaustive cross-sectional survey in an ageing city

Aim Urbanization and ageing are worldwide issues for healthcare providers. In particular, older adults aged 90 years and older have increased cognitive impairment and lower daily functioning than younger adults. However, the healthcare use of the oldest old remains unclear. This study aimed to describe the healthcare use of the oldest old compared with younger older adults in a city using the ecology of medical care model.