Dynamics of AMPA receptors regulate epileptogenesis in patients with epilepsy

The excitatory glutamate α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors (AMPARs) contribute to epileptogenesis. Thirty patients with epilepsy and 31 healthy controls are scanned using positron emission tomography with our recently developed radiotracer for AMPARs, [11C]K-2, which measures the density of cell-surface AMPARs.

A leaf-emanated signal orchestrates grain size and number in response to maternal resources

In plants, variations in seed size and number are outcomes of different reproductive strategies. Both traits are often environmentally influenced, suggesting that a mechanism exists to coordinate these phenotypes in response to available maternal resources.

Usual source and better quality of primary care are associated with lower loneliness scores: a cross-sectional study

Background Loneliness is a global issue, and primary care physicians play an important role in assessing and intervening with loneliness. This study aimed to examine the association between having a usual source of care (USC) or a good quality of primary care, and loneliness.

Impact of the COVID-19 Pandemic on Cancer Treatment: Nationwide Japanese Registration Until 2021

We read with great interest a recent research article by Mallouh and colleagues1 demonstrating that the COVID-19 pandemic did not precipitate stage migration at presentation of breast and lung cancer in Massachusetts. We would like to show the data from Japan.