2022-05-18

Impact of renin-angiotensin-aldosterone system inhibitors on COVID-19

Since the onset of the coronavirus disease 2019 (COVID-19) pandemic, the possible roles of renin–angiotensin system (RAS) inhibitors in COVID-19 have been debated as favorable, harmful, or neutral.
2022-05-17

Ca2+-mediated higher-order assembly of heterodimers in amino acid transport system b0,+ biogenesis and cystinuria

Cystinuria is a genetic disorder characterized by overexcretion of dibasic amino acids and cystine
2022-05-12

Reduced replication efficacy of SARS-CoV-2 Omicron variant in “mini-gut” organoids.

Over 480 million infections and 6 million deaths have been recorded since the novel coronavirus disease 2019 pandemic began over 2 years ago. Coronavirus disease 2019 is principally a respiratory illness caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which infects the cells of the airway and can also replicate in the gastrointestinal tract. Notably, over half of those with SARS-CoV-2 infections shed SARS-CoV-2 genomes in their stool,1 and infectious viruses can be isolated from their fecal samples,2 suggesting that the virus also infects and replicates in the intestinal tract.
2022-05-11

Development and validation of a Japanese version of the Person-Centered Primary Care Measure

Background Although primary care (PC) is an indispensable part of the health system, measuring its quality is challenging. A recent measure of PC, Person-Centered Primary Care Measure (PCPCM), covers 11 important domains of PC and has been translated into 28 languages. This study aimed to develop a Japanese version of the PCPCM and assess its reliability and validity.