2022-05-26

The 3′ Pol II pausing at replication-dependent histone genes is regulated by Mediator through Cajal bodies’ association with histone locus bodies

The 3' Pol II pausing at replication-dependent histone genes is regulated by Mediator through Cajal bodies’ association with histone locus bodies
2022-05-19

Auxin Distribution in Lateral Root Primordium Development Affects the Size and Lateral Root Diameter of Rice

Lateral roots (LRs) occupy a large part of the root system and play a central role in plant water and nutrient uptake. Monocot plants, such as rice, produce two types of LRs: the S-type (short and thin) and the L-type (long, thick, and capable of further branching).
2022-05-18

Existence of twisting in dislocation-free protein single crystals

Significance Growing high-quality protein crystals is a prerequisite for the structure analysis of proteins by X-ray diffraction. However, dislocation-free perfect protein crystals such as silicon and diamond are limited to two kinds of protein crystals. We wonder whether other high-quality or dislocation-free protein crystals still exhibit some imperfection. Here, we explore the existence of twisting as a cause of imperfection in high-quality protein crystals by X-ray topography with synchrotron radiation. The magnitude of twisting is quite small and cannot be detected by conventional techniques as optical and electron microscopy. The formation of twisting may be related to the geometric frustration mechanism proposed as a primary mechanism of twisting. This finding provides insights on high-quality protein crystals with the ubiquity of twisting.
2022-05-18

Structural insights into the HBV receptor and bile acid transporter NTCP

Around 250 million people are infected with hepatitis B virus (HBV) worldwide1, and 15 million may also carry the satellite virus hepatitis D virus (HDV), which confers even greater risk of severe liver disease2.