Sentanken Archives - Page 2 of 35 - Yokohama City University

2023-11-10

Structural basis for ligand recognition and signaling of hydroxy- carboxylic acid receptor 2

Hydroxycarboxylic acid receptors (HCAR1, HCAR2, and HCAR3) transduce Gi/o signaling upon biding to molecules such as lactic acid, butyric acid and 3-hydroxyoctanoic acid, which are associated with lipolytic and atherogenic activity, and neuroinflammation.

2023-11-06

Changes in the Number of Gastrointestinal Cancers and Stage at Diagnosis with COVID-19 Pandemic in Japan: A Multicenter Cohort Study Cancers

The number of gastrointestinal cancer patients declined during the COVID-19 pandemic. In Japan, the number of early-stage gastric and colorectal cancer patients decreased significantly.

2023-11-02

Structural bases for the Charcot-Marie-Tooth disease induced by single amino acid substitutions of myelin protein zero

Myelin protein zero (MPZ or P0) is a transmembrane protein which functions to glue membranes in peripheral myelin. Inter-membrane adhesion is mediated by homophilic interactions between the extracellular domains (ECDs) of MPZ.

2023-10-16

Abnormal lactate metabolism is linked to albuminuria and kidney injury in diabetic nephropathy

Diabetic nephropathy (DN) is characterized by abnormal kidney energy metabolism, but its causes and contributions to DN pathogenesis are not clear. To examine this issue, we carried out targeted metabolomics profiling in a mouse model of DN that develops kidney disease resembling the human disorder.