News - Page 64 of 69 - Yokohama City University

2019-04-24

PIM kinases facilitate lentiviral evasion from SAMHD1 restriction via Vpx phosphorylation

Lentiviruses have evolved to acquire an auxiliary protein Vpx to counteract the intrinsic host restriction factor SAMHD1. Although Vpx is phosphorylated, it remains unclear whether such phosphorylation indeed regulates its activity toward SAMHD1. Here we identify the PIM family of serine/threonine protein kinases as the factors responsible for the phosphorylation of Vpx and the promotion of Vpx-mediated SAMHD1 counteraction.

2019-04-15

PI3K/AKT/mTOR pathway alterations promote malignant progression and xenograft formation in oligodendroglial tumors

Oligodendroglioma (OD) has a relatively favorable prognosis, however, often undergoes malignant progression. We hypothesized that preclinical models of OD could facilitate identification of therapeutic targets in progressive OD. We established multiple OD xenografts to determine if PI3K/AKT/mTOR signaling pathway drives tumor progression.

2019-01-02

A stigmatic gene confers interspecies incompatibility in the Brassicaceae

Pre-zygotic interspecies incompatibility in angiosperms is a male–female relationship that inhibits the formation of hybrids between two species. Here, we report on the identification of STIGMATIC PRIVACY 1 (SPRI1), an interspecies barrier gene in Arabidopsis thaliana. We show that the rejection activity of this stigma-specific plasma membrane protein is effective against distantly related Brassicaceae pollen tubes and is independent of self-incompatibility.

2018-09-12

Event Report: The 9th IACSC International Symposium/General Assembly

The 10th International Academic Consortium for Sustainable Cities (IACSC) International Symposium/General Assembly was held on August 26th and 27th, 2019, at Hasanuddin University in Indonesia.