2023-11-10

Structural basis for ligand recognition and signaling of hydroxy- carboxylic acid receptor 2

Hydroxycarboxylic acid receptors (HCAR1, HCAR2, and HCAR3) transduce Gi/o signaling upon biding to molecules such as lactic acid, butyric acid and 3-hydroxyoctanoic acid, which are associated with lipolytic and atherogenic activity, and neuroinflammation.
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2023-11-06

Changes in the Number of Gastrointestinal Cancers and Stage at Diagnosis with COVID-19 Pandemic in Japan: A Multicenter Cohort Study Cancers

The number of gastrointestinal cancer patients declined during the COVID-19 pandemic. In Japan, the number of early-stage gastric and colorectal cancer patients decreased significantly.
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2023-11-02

Structural bases for the Charcot-Marie-Tooth disease induced by single amino acid substitutions of myelin protein zero

Myelin protein zero (MPZ or P0) is a transmembrane protein which functions to glue membranes in peripheral myelin. Inter-membrane adhesion is mediated by homophilic interactions between the extracellular domains (ECDs) of MPZ.
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2023-10-26

Simplifying the Estimation of Volatile Organic Compounds Emitted From Wildfires

Researchers find that information on combustion temperatures can help in estimating the emission of volatile organic compounds from wildfires
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