YCU PR Office, Author at Yokohama City University

2022-09-13

Improved immune response to the third COVID-19 mRNA vaccine dose in hemodialysis patients

Introduction A third dose of SARS-CoV-2 mRNA vaccine has been administered in several countries.1,2 Patients with end-stage kidney disease have a weak immune response to 2-sessional doses of the mRNA vaccine.3, 4, 5, 6, 7 Because patients undergoing hemodialysis (HD) are at a high risk for COVID-19 severity and death, they have been prioritized in vaccination programs worldwide.8,9

2022-09-08

Association between fruit/vegetable intake and mortality risk: results of the Japan Public Health Center-based Prospective Study (JPHC Study)

Key points in the announcement ・In a Japanese cohort, the association between fruit and vegetable intake and the risk of all-cause and specific-cause mortality was evaluated.

2022-09-08

Inverse Association between Fruit and Vegetable Intake and All-Cause Mortality: Japan Public Health Center-Based Prospective Study

Background A dose–response and nonlinear association between fruit and vegetable intake and mortality has been reported in Europe and the United States, but little is known about this association in Asia.

2022-09-01

Heme Oxygenase-1 as an Important Predictor of the Severity of COVID-19

Background and objective A cytokine storm is caused by inflammatory cells, including pro-inflammatory macrophage phenotype (M1), and play a critical role in the pathogenesis of COVID-19, in which diffuse alveolar damage occurs in the lungs due to oxidative stress exposure. Heme oxygenase (HO)-1 is a stress-induced protein produced by the anti-inflammatory / anti-oxidative macrophage phenotype (M2), which also produces soluble CD163 (sCD163). In our study, we investigated and determined that serum HO-1 can be a predictive biomarker for assessing both the severity and the outcome of COVID-19 patients.