YCU PR Office

Histone lysine acylation, including acetylation and crotonylation, plays a pivotal role in gene transcription in health and diseases. However, our understanding of histone lysine acylation has been limited to gene transcriptional activation. Here, we report that histone H3 lysine 27 crotonylation (H3K27cr) directs gene transcriptional repression rather than activation.

Multicellular organisms rely on intercellular communication systems to organize their cellular functions. In studies focusing on intercellular communication, the key experimental techniques include the generation of chimeric tissue using transgenic DNA recombination systems represented by the CRE/loxP system.

This study analyzes the potential for energy savings by identifying inefficiencies in electricity use and their determinants in the Japanese industrial sector. Specifically, we used stochastic frontier analysis to estimate inefficiencies in electricity consumption based on data obtained from electric power companies. We identified significant determinants of electricity consumption efficiency and that changes in national energy policy following the Great East Japan Earthquake changed electricity consumption behavior. The contribution of this study is that its findings can be used to improve the cost-effectiveness of policies aimed at improving energy efficiency.