We appreciate the commendable work by Wang et al.1 in evaluating the incidence and case fatality rate (CFR) of SARS-CoV-2 Delta and Omicron variants. Two and a half years have passed since the outbreak of the coronavirus disease 19 (COVID-19) pandemic. The CFR from hospitalized COVID-19 patients was estimated to be 20% or more during the early phase of the pandemic.2, 3 Over the course of 2.5 years, the mortality rate has drastically decreased. While some believe that COVID-19 is now similar to the common cold or seasonal influenza, others still think of COVID-19 as a highly fatal disease. As the authors stated, the Omicron variant led to a lower CFR around the world. To our knowledge, a chronological study of COVID-19 CFR spanning 2.5 years has not been reported.