Genome-Wide Association Study in Asians Identifies Novel Loci for High Myopia and Highlights a Nervous System Role in Its Pathogenesis

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Genome-Wide Association Study in Asians Identifies Novel Loci for High Myopia and Highlights a Nervous System Role in Its Pathogenesis

Date: 16 May 2020

We identified 9 loci with genome-wide significance (P < 5.0 × 10–8). Three loci were previously reported myopia-related loci (ZC3H11B on 1q41, GJD2 on 15q14, and RASGRF1 on 15q25.1), and the other 6 were novel (HIVEP3 on 1p34.2, NFASC/CNTN2 on 1q32.1, CNTN4/CNTN6 on 3p26.3, FRMD4B on 3p14.1, LINC02418 on 12q24.33, and AKAP13 on 15q25.3). The GO analysis revealed a significant role of the nervous system related to synaptic signaling, neuronal development, and Ras/Rho signaling in the pathogenesis of high myopia.

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Akira MEGURO

Project Associate Professor
Department of Ophthalmology and Visual Science, Department of Advanced Medicine for Ocular Diseases,
Yokohama City University Graduate School of Medicine

Fukuura 3-9, Kanazawa-ku, Yokohama, 236-0004 JAPAN
akmeguro@yokohama-cu.ac.jp

Nobuhisa MIZUKI

Professor
Department of Ophthalmology and Visual Science,
Yokohama City University Graduate School of Medicine

Fukuura 3-9, Kanazawa-ku, Yokohama, 236-0004 JAPAN
mizunobu@yokohama-cu.ac.jp