Ca2+-mediated higher-order assembly of heterodimers in amino acid transport system b0,+ biogenesis and cystinuria
2022-05-17Impact of renin-angiotensin-aldosterone system inhibitors on COVID-19
2022-05-18
Date: 18 May 2022
A research group that included Yokohama City University Graduate School of Nanobioscience third-year doctoral program student Marina Abe, Assistant Professor Ryo Suzuki, Professor Masaru Tachibana, and Professor Emeritus Kenichi Kojima; High Energy Accelerator Research Organization (KEK) Associate Professor Keiichi Hirano; and Hiroshima University Graduate School of Integrated Sciences for Life Associate Professor Haruhiko Koizumi achieved the world’s first observation of slight twisting in protein crystals*.
The findings of the research were published in the Proceedings of the National Academy of Sciences of the United States of America (PNAS). (May 17, 2022, Japan time)
Key points in the findings
- The study marked the world’s first observation of slight twisting in protein crystals
- The study elucidated the correlation between degree of twisting and quality of protein crystals
- Further elucidation of the principle behind twisting in crystals is expected
- Improvement of the quality of protein crystals is also expected through control of twisting
* Protein crystal: A crystal in which protein molecules are arranged regularly. The three-dimensional structure of the protein molecules can be discerned by analyzing the intensity of X-ray diffraction in the protein crystal.