幹細胞とaPKC-PAR系
幹細胞とaPKC-PAR系
細胞極性タンパク質の遺伝子操作マウスを武器として、個体レベルでの解析を進めています。
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Yuki Sugiyama, Alan R. Prescott, Frederique M.D. Tholozana, Shigeo Ohno, Roy A. Quinlan, Expression and localisation of apical junctional complex proteins in lens epithelial cells., Experimental Eye Research, in press.
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Yuki Sugiyama, Asuka Nishimura and Shigeo Ohno, Symmetrically dividing cell specific division axes alteration observed in proteasome depleted C. elegans embryo. Mechanisms of Development, in press.
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Imai F, Hirai S-I, Akimoto K, Koyama H, Miyata T, Ogawa M, Noguchi S, Sasaoka T, Noda T and Ohno S : Inactivation of aPKCλ results in a loss of adherens junctions inneuroepithelial cells without affecting neurogenesis in mouse neocortex. Development, 133(9), 1735-1744, 2006.(PubMed)
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Hirose T, Karasawa M, Sugitani Y, Fujisawa M, Akimoto K, Ohno S and Noda T : PAR3 is essential for cyst-mediated epicardial development by establishing apical cortical domains. Development, 133(7), 1389-1398, 2006.(PubMed)
紹介記事, IN THIS ISSUE, Knockout insights into mammalian PAR3. Development 133: 705, 2006.
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Manabe N, Hirai S, Imai F, Nakanishi H, Takai Y, Ohno S. Association of ASIP/mPAR-3 with adherens junctions of mouse neuroepithelial cells. Dev Dyn. Sep;225(1):61-69, 2002. ( PubMed)
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Nakaya, M., Fukui, A., Izumi, Y., Akimoto, K., Asashima, M., and Ohno, S.: Meiotic Maturation Induces Animal-Vegetal Asymmetric Distribution of aPKC and ASIP/PAR-3 in Xenopus oocytes., Development, 127, 5021-5031, 2000. ( PubMed)
大野茂男 (ohnos@med.yokohama-cu.ac.jp)
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