PAR-aPKC系と細胞分化、個体発生-分子細胞生物学大野研究室

PAR-aPKC系と細胞分化、個体発生

TOP ＞研究の概要＞ PAR-aPKC系と細胞分化、個体発生

細胞極性タンパク質の遺伝子操作マウスを武器として、個体レベルでの解析を進めています。

Yuki Sugiyama, Alan R. Prescott, Frederique M.D. Tholozana, Shigeo Ohno, Roy A. Quinlan, Expression and localisation of apical junctional complex proteins in lens epithelial cells., Experimental Eye Research, in press.
Yuki Sugiyama, Asuka Nishimura and Shigeo Ohno, Symmetrically dividing cell specific division axes alteration observed in proteasome depleted C. elegans embryo. Mechanisms of Development, in press.
Imai F, Hirai S-I, Akimoto K, Koyama H, Miyata T, Ogawa M, Noguchi S, Sasaoka T, Noda T and Ohno S : Inactivation of aPKCλ results in a loss of adherens junctions inneuroepithelial cells without affecting neurogenesis in mouse neocortex. Development, 133(9), 1735-1744, 2006.(PubMed)
Hirose T, Karasawa M, Sugitani Y, Fujisawa M, Akimoto K, Ohno S and Noda T : PAR3 is essential for cyst-mediated epicardial development by establishing apical cortical domains. Development, 133(7), 1389-1398, 2006.(PubMed)
紹介記事, IN THIS ISSUE, Knockout insights into mammalian PAR3. Development 133: 705, 2006.
Manabe N, Hirai S, Imai F, Nakanishi H, Takai Y, Ohno S. Association of ASIP/mPAR-3 with adherens junctions of mouse neuroepithelial cells. Dev Dyn. Sep;225(1):61-69, 2002. ( PubMed)
Nakaya, M., Fukui, A., Izumi, Y., Akimoto, K., Asashima, M., and Ohno, S.: Meiotic Maturation Induces Animal-Vegetal Asymmetric Distribution of aPKC and ASIP/PAR-3 in Xenopus oocytes., Development, 127, 5021-5031, 2000. ( PubMed)