発表論文-分子細胞生物学大野研究室

発表論文

TOP ＞発表論文　

2016

Metz P. J, Lopez J, Kim S. H, Akimoto K, Ohno S, Chang J. T: Regulation of Asymmetric Division by Atypical Protein Kinase C Influences Early Specification of CD8(+) T Lymphocyte Fates. Sci Rep, 6: 19182, 2016.(PubMed)
Mizushima T, Asai-Sato M, Akimoto K, Nagashima Y, Taguri M, Sasaki K, Nakaya M. A, Asano R, Tokinaga A, Kiyono T, Hirahara F, Ohno S, Miyagi E: Aberrant Expression of the Cell Polarity Regulator aPKClambda/iota is Associated With Disease Progression in Cervical Intraepithelial Neoplasia (CIN): A Possible Marker for Predicting CIN Prognosis. Int J Gynecol Pathol, 35(2): 106-117, 2016.(PubMed)

2015

Miyake N, Tsukaguchi H, Koshimizu E, Shono A, Matsunaga S, Shiina M, Mimura Y, Imamura S, Hirose T, Okudela K, Nozu K, Akioka Y, Hattori M, Yoshikawa N, Kitamura A, Cheong H. I, Kagami S, Yamashita M, Fujita A, Miyatake S, Tsurusaki Y, Nakashima M, Saitsu H, Ohashi K, Imamoto N, Ryo A, Ogata K, Iijima K, Matsumoto N: Biallelic Mutations in Nuclear Pore Complex Subunit NUP107 Cause Early-Childhood-Onset Steroid-Resistant Nephrotic Syndrome. Am J Hum Genet, 97(4): 555-566, 2015.(PubMed)
Osada S, Minematsu N, Oda F, Akimoto K, Kawana S, Ohno S: Atypical Protein Kinase C Isoform, aPKClambda, Is Essential for Maintaining Hair Follicle Stem Cell Quiescence. J Invest Dermatol, 135(11): 2584-2592, 2015.(PubMed)
Sasaki K, Kakuwa T, Akimoto K, Koga H, Ohno S: Regulation of epithelial cell polarity by PAR-3 depends on Girdin transcription and Girdin-Galphai3 signaling. J Cell Sci: 128(13):2244-58, 2015.(PubMed)
- 紹介記事,IN THIS ISSUE,PAR-3 regulates polarity through Girdin. Journal of Cell Science,128 (13), July 1, 2015.
Yamashita K, Ide M, Furukawa K. T, Suzuki A, Hirano H, Ohno S: Tumor suppressor protein Lgl mediates G1 cell cycle arrest at high cell density by forming an Lgl-VprBP-DDB1 complex. Mol Biol Cell: 26(13):2426-38, 2015.(PubMed)
Horikoshi Y, Kitatani K, Toriumi K, Fukunishi N, Itoh Y, Nakamura N, Ohno S, Matsura T, Takekoshi S: Aberrant activation of atypical protein kinase C in carbon tetrachloride-induced oxidative stress provokes a disturbance of cell polarity and sealing of bile canalicular lumen. Am J Pathol, 185(4): 958-968, 2015.(PubMed)
Metz P. J, Arsenio J, Kakaradov B, Kim S. H, Remedios K. A, Oakley K, Akimoto K, Ohno S, Yeo G. W, Chang J. T: Regulation of Asymmetric Division and CD8+ T Lymphocyte Fate Specification by Protein Kinase Czeta and Protein Kinase Clambda/iota. J Immunol, 194(5): 2249-2259, 2015.(PubMed)

2014

Sato Y, Hayashi K, Amano Y, Takahashi M, Yonemura S, Hayashi I, Hirose H, Ohno S, Suzuki A: MTCL1 crosslinks and stabilizes non-centrosomal microtubules on the Golgi membrane. Nat Commun, 5: 5266, 2014.(PubMed)
Ichikawa Y, Nagashima Y, Morioka K, Akimoto K, Kojima Y, Ishikawa T, Goto A, Kobayashi N, Watanabe K, Ota M, Fujii S, Kawamata M, Takagawa R, Kunizaki C, Takahashi H, Nakajima A, Maeda S, Shimada H, Inayama Y, Ohno S, Endo I: Colorectal laterally spreading tumors show characteristic expression of cell polarity factors, including atypical protein kinase C lambda/iota, E-cadherin, beta-catenin and basement membrane component. Oncol Lett, 8(3): 977-984, 2014.(PubMed)
Nicholson P, Josi C, Kurosawa H, Yamashita A, Muhlemann O: A novel phosphorylation-independent interaction between SMG6 and UPF1 is essential for human NMD. Nucleic Acids Res, 42(14): 9217-9235, 2014.(PubMed )
Melero R, Uchiyama A, Castano R, Kataoka N, Kurosawa H, Ohno S, Yamashita A, Llorca O: Structures of SMG1-UPFs complexes: SMG1 contributes to regulate UPF2-dependent activation of UPF1 in NMD. Structure, 22(8): 1105-1119, 2014.(PubMed )
Satoh D, Hirose T, Harita Y, Daimon C, Harada T, Kurihara H, Yamashita A, Ohno S: aPKClambda maintains the integrity of the glomerular slit diaphragm through trafficking of nephrin to the cell surface. J Biochem: 156(2):115-28, 2014.(PubMed)
Imagawa E, Osaka H, Yamashita A, Shiina M, Takahashi E, Sugie H, Nakashima M, Tsurusaki Y, Saitsu H, Ogata K, Matsumoto N, Miyake N: A hemizygous GYG2 mutation and Leigh syndrome: a possible link? Hum Genet, 133(2): 225-234, 2014.(PubMed)
Kudoh A, Takahama S, Sawasaki T, Ode H, Yokoyama M, Okayama A, Ishikawa A, Miyakawa K, Matsunaga S, Kimura H, Sugiura W, Sato H, Hirano H, Ohno S, Yamamoto N, Ryo A: The phosphorylation of HIV-1 Gag by atypical protein kinase C facilitates viral infectivity by promoting Vpr incorporation into virions. Retrovirology, 11: 9, 2014.(PubMed)

2013

Yamanaka T, Tosaki A, Kurosawa M, Akimoto K, Hirose T, Ohno S, Hattori N, Nukina N: Loss of aPKClambda in differentiated neurons disrupts the polarity complex but does not induce obvious neuronal loss or disorientation in mouse brains. PLoS One, 8(12): e84036, 2013.(PubMed)
Wakui H, Dejima T, Tamura K, Uneda K, Azuma K, Maeda A, Ohsawa M, Kanaoka T, Azushima K, Kobayashi R, Matsuda M, Yamashita A, Umemura S: Activation of angiotensin II type 1 receptor-associated protein exerts an inhibitory effect on vascular hypertrophy and oxidative stress in angiotensin II-mediated hypertension. Cardiovasc Res, 100(3): 511-519, 2013.(PubMed)
Azushima K, Tamura K, Wakui H, Maeda A, Ohsawa M, Uneda K, Kobayashi R, Kanaoka T, Dejima T, Fujikawa T, Yamashita A, Toya Y, Umemura S: Bofu-tsu-shosan, an oriental herbal medicine, exerts a combinatorial favorable metabolic modulation including antihypertensive effect on a mouse model of human metabolic disorders with visceral obesity. PLoS One, 8(10): e75560, 2013.(PubMed)
Sato Y, Akitsu M, Amano Y, Yamashita K, Ide M, Shimada K, Yamashita A, Hirano H, Arakawa N, Maki T, Hayashi I, Ohno S, Suzuki A: The novel PAR-1-binding protein MTCL1 has crucial roles in organizing microtubules in polarizing epithelial cells. J Cell Sci, 126(Pt 20): 4671-4683, 2013.(PubMed)
Usuki F, Yamashita A, Shiraishi T, Shiga A, Onodera O, Higuchi I, Ohno S: Inhibition of SMG-8, a subunit of SMG-1 kinase, ameliorates nonsense-mediated mRNA decay-exacerbated mutant phenotypes without cytotoxicity. Proc Natl Acad Sci U S A, 110(37): 15037-15042, 2013.(PubMed)
Shirakawa T, Yaman-Deveci R, Tomizawa S, Kamizato Y, Nakajima K, Sone H, Sato Y, Sharif J, Yamashita A, Takada-Horisawa Y, Yoshida S, Ura K, Muto M, Koseki H, Suda T, Ohbo K: An epigenetic switch is crucial for spermatogonia to exit the undifferentiated state toward a Kit-positive identity. Development, 140(17): 3565-3576, 2013.(PubMed)
Usuki F, Yamashita A, Shiraishi T, Shiga A, Onodera O, Higuchi I, Ohno S: Inhibition of SMG-8, a subunit of SMG-1 kinase, ameliorates nonsense-mediated mRNA decay-exacerbated mutant phenotypes without cytotoxicity. Proc Natl Acad Sci U S A, 110(37): 15037-15042, 2013.(PubMed)
Maeda A, Tamura K, Wakui H, Dejima T, Ohsawa M, Azushima K, Kanaoka T, Uneda K, Matsuda M, Yamashita A, Miyazaki N, Yatsu K, Hirawa N, Toya Y, Umemura S: Angiotensin receptor-binding protein ATRAP/Agtrap inhibits metabolic dysfunction with visceral obesity. J Am Heart Assoc, 2(4): e000312, 2013.(PubMed)
Kimura J, Ono H. A, Kosaka T, Nagashima Y, Hirai S, Ohno S, Aoki K, Julia D, Yamamoto M, Kunisaki C, Endo I: Conditionally replicative adenoviral vectors for imaging the effect of chemotherapy on pancreatic cancer cells. Cancer Sci, 104(8): 1083-1090, 2013.(PubMed)
Kato S, Akimoto K, Nagashima Y, Ishiguro H, Kubota K, Kobayashi N, Hosono K, Watanabe S, Sekino Y, Sato T, Sasaki K, Nakaigawa N, Kubota Y, Inayama Y, Endo I, Ohno S, Maeda S, Nakajima A: aPKClambda/iota is a beneficial prognostic marker for pancreatic neoplasms. Pancreatology, 13(4): 360-368, 2013.(PubMed)
Hirate Y, Hirahara S, Inoue K, Suzuki A, Alarcon V. B, Akimoto K, Hirai T, Hara T, Adachi M, Chida K, Ohno S, Marikawa Y, Nakao K, Shimono A, Sasaki H: Polarity-dependent distribution of angiomotin localizes Hippo signaling in preimplantation embryos. Curr Biol, 23(13): 1181-1194, 2013.(PubMed)
Satake T, Otsuki K, Banba Y, Suenaga J, Hirano H, Yamanaka Y, Ohno S, Hirai S: The interaction of Kinesin-1 with its adaptor protein JIP1 can be regulated via proteins binding to the JIP1-PTB domain. BMC Cell Biol, 14 12, 2013.(PubMed)
Nakayama M, Nakayama A, van Lessen M, Yamamoto H, Hoffmann S, Drexler H. C, Itoh N, Hirose T, Breier G, Vestweber D, Cooper J. A, Ohno S, Kaibuchi K, Adams R. H: Spatial regulation of VEGF receptor endocytosis in angiogenesis. Nat Cell Biol, 15(3): 249-260, 2013.(PubMed)
Yoshihama Y, Izumisawa Y, Akimoto K, Satoh Y, Mizushima T, Satoh K, Chida K, Takagawa R, Akiyama H, Ichikawa Y, Kunisaki C, Inayama Y, Endo I, Nagashima Y, Ohno S: High expression of KIBRA in low atypical protein kinase C-expressing gastric cancer correlates with lymphatic invasion and poor prognosis. Cancer Sci, 104(2): 259-265, 2013.(PubMed)
Yamashita A: Role of SMG-1-mediated Upf1 phosphorylation in mammalian nonsense-mediated mRNA decay. Genes Cells, 18(3): 161-175, 2013.(PubMed)
Matsuda M, Tamura K, Wakui H, Maeda A, Ohsawa M, Kanaoka T, Azushima K, Uneda K, Haku S, Tsurumi-Ikeya Y, Toya Y, Maeshima Y, Yamashita A, Umemura S: Upstream stimulatory factors 1 and 2 mediate the transcription of angiotensin II binding and inhibitory protein. J Biol Chem, 288(26): 19238-19249, 2013.(PubMed)
Wakui H, Tamura K, Masuda S, Tsurumi-Ikeya Y, Fujita M, Maeda A, Ohsawa M, Azushima K, Uneda K, Matsuda M, Kitamura K, Uchida S, Toya Y, Kobori H, Nagahama K, Yamashita A, Umemura S: Enhanced angiotensin receptor-associated protein in renal tubule suppresses angiotensin-dependent hypertension. Hypertension, 61(6): 1203-1210, 2013.(PubMed)
Schweingruber C, Rufener S. C, Zund D, Yamashita A, Muhlemann O: Nonsense-mediated mRNA decay - mechanisms of substrate mRNA recognition and degradation in mammalian cells. Biochim Biophys Acta, 1829(6-7): 612-623, 2013.(PubMed)

2012

Abe K, Ishigami T, Shyu A. B, Ohno S, Umemura S, Yamashita A: Analysis of interferon-beta mRNA stability control after poly(I:C) stimulation using RNA metabolic labeling by ethynyluridine. Biochem Biophys Res Commun, 428(1): 44-49, 2012.(PubMed)
Iden S, van Riel W. E, Schafer R, Song J. Y, Hirose T, Ohno S, Collard J. G: Tumor type-dependent function of the par3 polarity protein in skin tumorigenesis. Cancer Cell, 22(3): 389-403, 2012.(PubMed)
Zhao Y, Koebis M, Suo S, Ohno S, Ishiura S: Regulation of the alternative splicing of sarcoplasmic reticulum Ca(2)(+)-ATPase1 (SERCA1) by phorbol 12-myristate 13-acetate (PMA) via a PKC pathway. Biochem Biophys Res Commun, 423(2): 212-217, 2012.(PubMed)
Yoshihama Y, Chida K, Ohno S: The KIBRA-aPKC Connection: A Potential Regulator of Membrane Trafficking and Cell Polarity, Communicative & Integrative Biology, 5(2): 1-6, 2012.(PubMed)
Hayashi K, Suzuki A, Ohno, S: "PAR-1/MARK: a kinase essential for maintaining the dynamic state of microtubules." Cell Struct Funct 37(1): 21-25, 2012.(PubMed)
Okada-Katsuhata Y, Yamashita A, Kutsuzawa K, Izumi N, Hirahara F, Ohno S: N- and C-terminal Upf1 phosphorylations create binding platforms for SMG-6 and SMG-5:SMG-7 during NMD. Nucleic Acids Res. 40(3):1251-66, 2012. Epub 2011 Sep 29. (PubMed)
Izumi N, Yamashita A, Hirano H, Ohno S: Hsp90 regulates PIKK family proteins together with the RUVBL1/2 and Tel2-containing co-factor complex. Cancer Sci. 03(1):50-7, 2012. Epub 2011 Oct 24. (PubMed)
Izumi N, Yamashita A, Ohno S. Integrated regulation of PIKK-mediated stress responses by AAA+ proteins RUVBL1 and RUVBL2, Nucleus, 3(1), 2012. Jan 1 (PubMed)

2011

Brown JA, Roberts TL, Richards R, Woods R, Birrell G, Lim YC, Ohno S, Yamashita A, Abraham RT, Gueven N, Lavin MF: A novel role for hSMG-1 in stress granule formation. Mol Cell Biol, 31(22): 4417-4429, 2011.(PubMed)
Hayashi K, Suzuki A, Hirai S, Kurihara Y, Hoogenraad CC, Ohno S: Maintenance of dendritic spine morphology by partitioning-defective 1b through regulation of microtubule growth. J Neurosci, 31(34):12094-12103, 2011. (PubMed)
Ishiguro H, Akimoto K, Nagashima Y, Kagawa E, Sasaki T, Sano J, Takagawa R, Fujinami K, Sasaki K, Aoki I, Ohno S, Kubota Y, Uemura H: The co-expression of aPKCλ/ι and IL-6 in prostate cancer tissue correlates with biochemical recurrence. Cancer Science, 102(8):1576-1581 2011. (PubMed)
Horikoshi Y, Hamada S, Ohno S, Suetsugu S: Phosphoinositide binding by par-3 involved in par-3 localization. Cell Structure and Function, 36(1): 97-102, 2011.(PubMed)
Yoshihama Y, Sasaki K, Horikoshi Y, Suzuki A, Ohtsuka T, Hakuno F, Takahashi S-I, Ohno S, Chida K: KIBRA Suppresses Apical Exocytosis through Inhibition of aPKC Kinase Activity in Epithelial Cells. Current Biol, 21, 705-711, 2011.(PubMed)
Hirai S, Banba Y, Satake T, Ohno: Axon Formation in Neocortical Neurons Depends on Stage-Specific Regulation of Microtubule Stability by the Dual Leucine Zipper Kinase-c-Jun N-terminal Kinase Pathway. J Neuroscience, 31(17), 6468-6480, 2011.(PubMed)
Arias-Palomo E, Yamashita A, Fernández IS, Núñez-Ramírez R, Bamba Y, Izumi N, Ohno S, Llorca O: The nonsense-mediated mRNA decay SMG-1 kinase is regulated by large-scale conformational changes controlled by SMG-8. Genes Dev, 25(2):153-64, 2011.(PubMed)
Fernández IS, Yamashita A, Arias-Palomo E, Bamba Y, Bartolomé RA, Canales MA, Teixidó J, Ohno S, Llorca O: Characterization of SMG-9, an essential component of the nonsense-mediated mRNA decay SMG1C complex. Nucleic Acids Res, 39(1):347-358, 2011. (Epub 2010 Sep 3) (PubMed)

2010

Cong W, Hirose T, Harita Y, Yamashita A, Mizuno K, Hirano H, Ohno S: ASPP2 regulates epithelial cell polarity through the PAR complex. Curr Biol, 20(15): 1408-1414, 2010.(PubMed)
- 紹介記事, Research Highlight, Nature Reviews Cancer 10, 528 (August 2010) .
  The tumour suppressor ASPP2 is involved in the regulation of cell polarity.
Wakui H, Tamura K, Matsuda M, Bai Y, Dejima T, Shigenaga A, Masuda S, Azuma K, Maeda A, Hirose T, Ishigami T, Toya Y, Yabana M, Minamisawa S, Umemura S: Intrarenal suppression of angiotensin II type 1 receptor binding molecule in angiotensin II-infused mice. Am J Physiol Renal Physiol, 299(5):F991-F1003, 2010.(PubMed)
Masuda S, Tamura K, Wakui H, Maeda A, Dejima T, Hirose T, Toyoda M, Azuma K, Ohsawa M, Kanaoka T, Yanagi M, Yoshida S, Mitsuhashi H, Matsuda M, Ishigami T, Toya Y, Suzuki D, Nagashima Y, Umemura S: Expression of angiotensin II type 1 receptor-interacting molecule in normal human kidney and IgA nephropathy. Am J Physiol Renal Physiol, 299(4):F720-31, 2010.(PubMed)
Kan Y, Ohmura M, Suzuki A, Theeraladanon C, Oka T, Nakagami Y, Suzuki A, Nagashima Y, Inoue T: Proliferation of human lung cancer in an orthotopic transplantation mouse model . Experimental and Therapeutic Medicine, 1(3): 471-475, 2010.
Izumi N, Yamashita A, Iwamatsu A , Kurata R, Nakamura H, Saari B, Hirano H, Anderson P, Ohno S: AAA+ Proteins RUVBL1 and RUVBL2 Coordinate PIKK Activity and Function in Nonsense-Mediated mRNA Decay. Science Signaling, 3(116): ra27, 2010. (Reprint)
- 紹介記事, Editor's Summary　Masters of Integrity
Machida H, Ito S, Hirose T, Takeshita F, Oshiro H, Nakamura T, Mori M, Inayama Y, Yan K, Kobayashi N, Yokota S: Expression of Toll-like receptor 9 in renal podocytes in childhood-onset active and inactive lupus nephritis. Nephrol Dial Transplant, 25(8): 2530-2537, 2010.(PubMed)
Yamashita A, Ohno S: Analysis of Nonsense-Mediated mRNA Decay by Monitoring mRNA Half-Lives in Mammalian Cells. Cold Spring Harbor Protocols, (2): pdb.prot5386, 2010.(PubMed)
Yamashita K, Suzuki A, Satoh Y, Ide M, Amano Y, Masuda-Hirata M, Hayashi Y. K, Hamada K, Ogata K, Ohno S: The 8th and 9th tandem spectrin-like repeats of utrophin cooperatively form a functional unit to interact with polarity-regulating kinase PAR-1b. Biochem Biophys Res Commun, 391(1): 812-817, 2010. (PubMed)
Jin J, Suzuki H, Hirai S-I, Mikoshiba K, Ohima T: JNK phosphorylates Ser332 of doublecortin and regulates its function in neurite extension and neuronal migration. Dev Neurobiol. 70(14): 929-942, 2010. (PubMed)
Takagawa R, Akimoto K, Ichikawa Y, Akiyama H, Kojima Y, Ishiguro H, Inayama Y, Aoki I, Kunisaki C, Endo I, Nagashima Y, Ohno S: High expression of atypical protein kinase C lambda/iota in gastric cancer as a prognostic factor for recurrence. Ann Surg Oncol, 17(1): 81-88, 2010. (Epub 2009 Sep 23)(PubMed)

2009

Sugiyama Y, Akimoto K, Robinson M. L, Ohno S, Quinlan R. A: A cell polarity protein aPKClambda is required for eye lens formation and growth. Dev Biol, 336(2): 246-256, 2009.(PubMed)
Ishiguro H, Akimoto K, Nagashima Y, Kojima Y, Sasaki T, Ishiguro-Imagawa Y, Nakaigawa N, Ohno S, Kubota Y, Uemura H: aPKClambda/iota promotes growth of prostate cancer cells in an autocrine manner through transcriptional activation of interleukin-6. Proc Natl Acad Sci U S A, 106(38): 16369-16374, 2009. (PubMed)
Mori D, Yamada M, Mimori-Kiyosue Y, Shirai Y, Suzuki A, Ohno S, Saya H, Wynshaw-Boris A, Hirotsune S: An essential role of the aPKC-Aurora A-NDEL1 pathway in neurite elongation by modulation of microtubule dynamics. Nat Cell Biol, 11(9): 1057-1068, 2009.(PubMed)
Masuda-Hirata M, Suzuki A, Amano Y, Yamashita K, Ide M, Yamanaka T, Sakai M, Imamura M, Ohno S: Intracellular polarity protein PAR-1 regulates extracellular laminin assembly by regulating the dystroglycan complex. Genes Cells, 14(7): 835 - 850, 2009.(PubMed)
Horikoshi Y, Suzuki A, Yamanaka T , Sasaki K, Mizuno K, Sawada H, Yonemura S, Ohno S: Interaction between PAR-3 and the aPKC-PAR-6 complex is indispensable for apical domain development of epithelial cells. Journal of Cell Science, 122(10): 1595-1606, 2009.(PubMed)
- 紹介記事, IN THIS ISSUE, Going apical with PAR-3. J Cell Science, Volume 122, Issue 10, e1003, May 15 2009.
Yamashita A, Izumi N, Kashima I, Ohnishi T, Saari B, Katsuhata Y, Muramatsu R, Morita T, Iwamatsu A, Hachiya T, Kurata R, Hirano H, Anderson P, Ohno S: SMG-8 and SMG-9, two novel subunits of the SMG-1 complex, regulate remodeling of the mRNA surveillance complex during nonsense-mediated mRNA decay. Genes Dev, 23(9): 1091-1105, 2009.(PubMed)
Hirose T, Satoh D, Kurihara H, Kusaka C, Hirose H, Akimoto K, Matsusaka T, Ichikawa I, Noda T, Ohno S: An essential role of the universal polarity protein, aPKClambda, on the maintenance of podocyte slit diaphragms. PLoS ONE, 4(1): e4194, 2009.(PubMed)
- 紹介記事, IN THIS ISSUE, Lawrence B. H, Puneet G: Initial Insight on the Determinants of Podocyte Polarity. JASN,20: 683-685,

2008

Kishikawa, M., Suzuki A, Ohno S: aPKC enables development of zonula adherens by antagonizing centripetal contraction of the circumferential actomyosin cables. J Cell Sci, 121: 2481-2492, 2008.(PubMed)
Sugiyama Y, Nishimura A Ohno S: Symmetrically dividing cell specific division axes alteration observed in proteasome depleted C. elegans embryo. Mechanisms of Development, 125(8): 743-755, 2008. (PubMed)
Sugiyama Y, Prescott A. R, Tholozana F M D, Ohno S, Quinlan R A: Expression and localisation of apical junctional complex proteins in lens epithelial cells. Experimental Eye Research, 87(1): 64-70, 2008. (PubMed)
Kojima Y, Akimoto K, Nagashima Y, Ishiguro H, Shirai S, Chishima T, Ichikawa Y, Ishikawa T, Sasaki T, Kubota Y, Inayama Y, Aoki I, Ohno S, Shimada H: The overexpression and altered localization of the atypical Protein Kinase Clambda/iota in breast cancer correlates with the pathological type of these tumors. Human Pathology, 39(6): 824-831, 2008. (PubMed)
Saitsu H, Kato M, Mizuguchi T, Hamada K, Osaka H, Tohyama J, Uruno K, Kumada S, Nishiyama K, Nishimura A, Okada I, Yoshimura Y, Hirai S, Kumada T, Hayasaka K, Fukuda A, Ogata K, Matsumoto N: De novo mutations in the gene encoding STXBP1 (MUNC18-1) cause early infantile epileptic encephalopathy. Nat Genet, 40(6): 782-788, 2008. (PubMed)
Yamanaka T, Ohno S: Role of Lgl/Dlg/Scribble in the regulation of epithelial junction, polarity and growth. Frontiers in Bioscience, 13: 6693-6707, 2008.(PubMed)
Ebnet K, Iden S, Gerke V, Suzuki A: Regulation of epithelial and endothelial junctions by PAR proteins. Front Biosci., 13: 6520-6536, 2008.(PubMed)
Matsuda C, Kameyama K, Suzuki A, Mishima W, Yamaji S, Okamoto H, Nishino I, Hayashi Y. K: Affixin activates Rac1 via betaPIX in C2C12 myoblast. FEBS Lett, 582(8): 1189-1196, 2008.(PubMed)
Takahama S, Hirose T, Ohno S: aPKC restricts the basolateral determinant PtdIns(3,4,5)P3 to the basal region. Biochem Biophys Res Commun. 368(2): 249-255, 2008. (2008 Apr 4)(PubMed)
Nakayama M, Goto TM, Sugimoto M, Nishimura T, Shinagawa T, Ohno S, Amano M, Kaibuchi K : Rho-kinase phosphorylates PAR-3 and disrupts PAR complex formation. Dev Cell, 14(2): 205-215. 2008 Feb.(PubMed)

2007

Fujita E, Tanabe Y, Hirose T, Aurrand-Lions M, Kasahara T, Imhof B. A, Ohno S, Momoi T: Loss of partitioning-defective-3/isotype-specific interacting protein (par-3/ASIP) in the elongating spermatid of RA175 (IGSF4A/SynCAM)-deficient mice. Am J Pathol, 171(6): 1800-1810, 2007. (PubMed)
Terabayashi T, Itoh T J, Yamaguchi H, Yoshimura Y, Funato Y, Ohno S, Miki H: Polarity-regulating kinase Par1b/MARK2 negatively regulates development of dendrites on hippocampal neurons. J. Neuroscience, 27(48): 13098-13107, 2007.(PubMed)
Ezzeddine N, Chang T. C, Zhu W, Yamashita A, Chen C. Y, Zhong Z, Yamashita Y, Zheng D, Shyu A. B: Human TOB, an antiproliferative transcription factor, is a poly(A)-binding protein-dependent positive regulator of cytoplasmic mRNA deadenylation. Mol Cell Biol, 27(22): 7791-801, 2007.(PubMed)
Chen C. Y, Yamashita Y, Chang T. C, Yamashita A, Zhu W, Zhong Z, Shyu A. B: Versatile applications of transcriptional pulsing to study mRNA turnover in mammalian cells. RNA, 13(10): 1775-1786, 2007.(PubMed)
Ohno S: Extrinsic Wnt signalling controls the polarity component aPKC. Nat Cell Biol., 9(7): 738-740, 2007. ( Jul,2007)(PubMed)
Akita Y, Kawasaki H, Imajoh-Ohmi S, Fukuda H, Ohno S, Hirano H, Ono Y, Yonekawa H: Protein kinase C epsilonphosphorylates keratin 8 at Ser8 and Ser23 in GH(4)C(1) cells stimulated by thyrotropin-releasing hormone. FEBS J., 274(13): 3270-3285, 2007.(PubMed)
Saadat I, Higashi H, Obuse C, Umeda M, Murata-Kamiya N, Saito Y, Lu H, Ohnishi N, Azuma T, Suzuki A, Ohno S,Hatakeyama M: Helicobacter pylori CagA targets PAR1/MARK kinase to disrupt epithelial cell polarity. Nature, 447(7142): 330-333, 2007.(PubMed)
Morita T, Yamashita A, Kashima I, Ogata K, Ishiura S, Ohno S: Distant N- and C-terminal domains are required for intrinsic kinase activity of SMG-1, a critical component of nonsense-mediated mRNA decay. J. Biol., Chem., 282(11): 7799-7808, 2007.(PubMed)
Zhao W, Hirose T, Ishikawa M, Oshima Y, Hirai S, Ohno S, Taniguchi H : Neonatal pancreatic cells redifferentiate into both neural and pancreatic lineages. Biochem. Biophys. Res. Commun., 352(1): 84-90, 2007.(PubMed)

2006

Iden S, Rehder D, August B, Suzuki A, Wolburg-Buchholz K, Woburg H, Ohno S, Behrens J, Vestweber D and Klaus E: A distinct PAR complex associates physically with VE-cadherin in vertebrate endothelial cells. EMBO Rep., 7(12): 1239-1246, 2006. (RI)(PubMed)
Hirai S-I, Cui1 DF, Miyata T, Ogawa M, Kiyonari H, Suda Y, Aizawa S, Banba Y, and Ohno S: JNK activator DLK regulates axon growth and neuronal migration in the developing cerebral cortex. Journal of Neuroscience, 15;26(46): 11992-2002, 2006. (PubMed)
Liu XF, Ohno S and Miki T: Nucleotide exchange factor ECT2 regulates epithelial cell polarity. Cell Signal, 18(10): 1604-1615, 2006.(PubMed)
Usuki F, Yamashita A, Kashima I, Higuchi I, Osame M, Ohno S: Specific inhibition of nonsense-mediated mRNA decay components, SMG-1 or Upf1, rescues the phenotype of Ullrich disease fibroblasts. Mol Ther, 14(3): 351-360, 2006.(PubMed)
Suenaga J, Cui de F, Yamamoto I, Ohno S, Hirai S: Developmental changes in the expression pattern of the JNK activator kinase MUK/DLK/ZPK and active JNK in the mouse cerebellum. Cell Tissue Res., 325(1): 189-195, 2006.(PubMed)
Yamanaka T, Horikoshi Y, Izumi N, Suzuki A, Mizuno K, Ohno S: Lgl mediates apical domain disassembly by suppressing the PAR-3-aPKC-PAR-6 complex to orient apical membrane polarity. J Cell Sci, 119(Pt 10): 2107-2118, 2006.(PubMed)
- 紹介記事, IN THIS ISSUE, Lgl polarizes the (t)issue. J Cell Sci 2006 119: e1004. First published online on May 10, 2006
Hirose T, Karasawa M, Sugitani Y, Fujisawa M, Akimoto K, Ohno S and Noda T: PAR3 is essential for cyst-mediated epicardial development by establishing apical cortical domains. Development, 133(7): 1389-1398, 2006.(PubMed)
- 紹介記事, IN THIS ISSUE , Knockout insights into mammalian PAR3. Development 133: 705, 2006.(First published online on March 9, 2006)
Yoshimi R, Yamaji S, Suzuki A, Mishima W, Okamura M, Obana T, Matsuda C, Miwa Y, Ohno S and Ishigatsubo Y: The {gamma}-Parvin-Integrin-Linked Kinase complex is critically involved in leukocyte-substrate interaction. J. Immunology, 176(6): 3611-3624, 2006.(PubMed)
Suzuki A and Ohno S: The PAR-aPKC system: lessons in polarity. J. Cell Science, 119: 979-987, 2006.(PubMed)
Imai F, Hirai S, Akimoto K, Koyama H, Miyata T, Ogawa M, Noguchi S, Sasaoka T, Noda T, Ohno S: Inactivation of aPKClambda results in the loss of adherens junctions in neuroepithelial cells without affecting neurogenesis in mouse neocortex. Development, 133(9): 1735-1744, 2006.(PubMed)
Kashima I, Yamashita A, Izumi N, Kataoka N, Morishita R, Hoshino S, Ohno M, Dreyfuss G and Ohno S: Binding of a novel SMG-1-Upf1-eRF1-eRF3 complex (SURF) to the exon junction complex triggersUpf1phosphorylation and nonsense-mediated mRNA decay. Genes Dev., 20(3): 355-367, 2006. (PubMed)
Yamashita A, Kashima I and Ohno S: The role of SMG-1-mediated phosphorylation of UPF1 in NMD. in Nonsense-Mediated mRNA decay. Maquat, Landes Bioscience, (ISBN No. 1-58706-296-8): 85-95, 2006．

2005

Yamashita A, Kashima I, ; Ohno S: The role of SMG-1 on nonsense-mediated mRNA decay. Biochem Biophys. Acta ; (Proteins and Proteomics), Inhibitors of Protein Kinases, .2005 Dec 30;1754(1-2):305-315. Epub 2005 Oct 25.(PubMed)
Ogawa T, Nagashima Y, Wada H, Akimoto K, Chiba Y, Nagatani T, Inayama Y, Yao M, Aoki I, Ikezawa Z: Extramammary Paget's disease: analysis of growth signal pathway from the human epidermal growth factor receptor 2 protein. Hum Pathol, 36(12): 1273-1280, 2005.(PubMed)
Koike C, Nishida A, Akimoto K, Nakaya MA, Noda T, Ohno S, Furukawa T. Function of aPKClambda in differentiating photoreceptors is required for proper lamination of mouse retina, J Neurosci. 2005 Nov 2;25(44):10290-10298.(PubMed)
Satohisa S, Chiba H, Osanai M, Ohno S, Kojima T, Saito T, Sawada N. Behavior of tight-junction, adherens-junction and cell polarity proteins during HNF-4alpha-induced epithelial polarization.　Exp Cell Res. 2005 Oct 15;310(1):66-78. (PubMed)
Vinot S, Le T, Ohno S, Pawson T, Maro B, Louvet-Vallee S. ; ; ; Asymmetric distribution of PAR proteins in the mouse embryo begins at the 8-cell stage during compaction. Dev Biol. 2005 Jun 15;282(2):307-319. (PubMed)
Hirai S, Kawaguchi A, Suenaga J, Ono M, Cui de F, Ohno S. Expression of MUK/DLK/ZPK, an activator of the JNK pathway, in the nervous systems of the developing mouse embryo. Gene Expr Patterns. 2005 Apr;5(4):517-523.(PubMed)
Yoshii T, Mizuno K, Hirose T, Nakajima A, Sekihara H, Ohno S. sPAR-3, a splicing variant of PAR-3, shows cellular localization and expression pattern different from that of PAR-3 during enterocyte polarization. Am J Physiol Gastrointest Liver Physiol. 2004 Sep 9.(PubMed)
Nishimura T, Yamaguchi T, Kato K, Yoshizawa M, Nabeshima Y, Ohno S, Hoshino M, Kaibuchi K. PAR-6-PAR-3 mediates Cdc42-induced Rac activation through the Rac GEFs STEF/Tiam1. Nat Cell Biol. 2005 Mar;7(3):270-277. Epub 2005 Feb 20 (PubMed)
Yasumi M, Sakisaka T, Hoshino T, Kimura T, Sakamoto Y, Yamanaka T, Ohno S, Takai Y. Direct binding of Lgl2 to LGN during mitosis and its requirement for normal cell division. J Biol Chem. 2005 Feb 25;280(8):6761-6765. Epub 2005 Jan 4.(PubMed)
Hashimoto N, Kido Y, Uchida T, Matsuda T, Suzuki K, Inoue H, Matsumoto M, Ogawa W, Maeda S, Fujihara H, Ueta Y, Uchiyama Y, Akimoto K, Ohno S, Noda T, Kasuga M: PKClambda regulates glucose-induced insulin secretion through modulation of gene expression in pancreatic beta cells. J Clin Invest, 115(1): 138-145, 2005.(PubMed)

2004

Suzuki A, HirataM, Kamimura K, Maniwa R, Yamanaka T, Mizuno K, Kishikawa M, Hirose H, Amano Y, Izumi N, Miwa Y, Ohno, S. aPKC acts upstream of PAR-1b both in the establishment and maintenance of mammalian epithelial polarity. Current Biology, Aug 24;14(16):1425-1435, 2004. (PubMed)
Yamaji S, Suzuki A, Kanamori H, Mishima W, Yoshimi R, Takasaki H, Takabayashi M, Fujimaki K, Fujisawa S, Ohno S, Ishigatsubo Y. Affixin interacts with alpha-actinin and mediates integrin signaling for reorganization of F-actin induced by initial cell-substrate interaction. J Cell Biol, 165(4), 539-551, 2004. (PubMed)
Usuki F, Yamashita A, Higuchi I, Ohnishi T, Shiraishi T, Osame M, Ohno S. Inhibition of nonsense-mediated mRNA decay rescues the phenotype in Ullrich's disease. Ann Neurol, 55(5), 740-744, 2004. (PubMed)
Nishimura T, Kato K, Yamaguchi T, Fukata Y, Ohno S, Kaibuchi K. Role of the PAR-3-KIF3 complex in the establishment of neuronal polarity. Nat Cell Biol, 6(4), 328-334, 2004. (PubMed)
Mishima W, Suzuki A, Yamaji S, Yoshimi R, Ueda A, Kaneko T, Tanaka J, Miwa Y, Ohno S, Ishigatsubo Y. The first CH domain of affixin activates Cdc42 and Rac1 through alphaPIX, a Cdc42/Rac1-specific guanine nucleotide exchanging factor. Genes Cells, 9(3), 193-204, 2004. (PubMed)
Ebnet K, Suzuki A, Ohno S, Vestweber D. Junctional adhesion molecules (JAMs): more molecules with dual functions? J Cell Sci, 117(Pt 1), 19-29, 2004. (PubMed)

2003

Ohnishi, T., Yamashita, A., Kashima, I., Schell, T., Anders, K. R., Grimson, A., Hachiya, T., Matthias W. Hentze, M. W., Anderson, P., and Ohno, S. : Phosphorylation of hUPF1 Induces Formation of mRNA Surveillance Complexes Containing hSMG-5 and hSMG-7. Molecular Cell, 12 (5), 1187-1200, 2003. (PubMed)
Ebnet K, Aurrand-Lions M, Kuhn A, Kiefer F, Butz S, Zander K, Meyer zu Brickwedde M. K, Suzuki A, Imhof B. A, Vestweber D: The junctional adhesion molecule (JAM) family members JAM-2 and JAM-3 associate with the cell polarity protein PAR-3: a possible role for JAMs in endothelial cell polarity. J Cell Sci, 116(Pt 19): 3879-3891, 2003.
Matsumoto, M., Ogawa, W., Akimoto, K., Inoue, H., Miyake, K., Furukawa, K., Hayashi, Y., Iguchi, H., Matsuki, Y., Hiramatsu, R., Shimamoto, H., Yamada, N., Ohno, S., Kasuga, M. and Noda, T. : Protein kinase Clambda in liver mediates insulin-induced SREBP-1c expression and determines both hepatic lipid content and overall insulin sensitivity. J. Clinical Investigation, 112(6),935-944, 2003.(PubMed)
Keiko Mizuno, Atsushi Suzuki, Tomonori Hirose, Koichi Kitamura, Yoshikazu Kutsuzawa, Masaaki Futaki, Yoshiko Amano, and Shigeo Ohno. Self-association of PAR-3 mediated by the conserved N-terminal domain contributes to the development of epithelial tight junctions. J. Biol. Chem, 10.1074/jbc.M303593200 (PubMed)
Yoshida M, Heike Y, Ohno S, Ikekawa T, Wakasugi H: Involvement of PKC betaII in anti-proliferating action of a new antitumor compound gnidimacrin. Int J Cancer, 105(5): 601-606, 2003.(PubMed)
Koide, Y., Tamura, K., Suzuki, A., Kitamura, K., Yokoyama, K., Hashimoto, T., Hirawa, N., Kihara, M., Ohno, S. and Umemura, S. : Differential induction of protein kinase C isoforms at the cardiac hypertrophy stage and congestive heart failure stage in dahl salt-sensitive rats. Hypertens Res. 26, 421-426, 2003.(PubMed)
Masaya Baba, Syu-ichi Hirai, Hisafumi Yamada-Okabe, Kenji Hamada, Hisahiro Tabuchi, Kazuki Kobayashi, Keiichi Kondo, Minoru Yoshida, Akio Yamashita, Takeshi Kishida, Noboru Nakaigawa, Youji Nagashima, Yoshinobu Kubota, Masahiro Yao and Shigeo Ohno. Loss of von Hippel-Lindau protein causes cell density-dependent deregulation of CyclinD1 expression through Hypoxia-inducible factor. Oncogene, May 8; 22(18):2728-2738, 2003 . ( PubMed)
Tomoyuki Yamanaka, Yosuke Horikoshi, Yuki Sugiyama, Chikako Ishiyama, Atsushi Suzuki, Tomonori Hirose, Akihiro IwamatsuÝ, Azusa Shinohara and Shigeo Ohno. Mammalian Lgl forms a protein complex with PAR-6 and aPKC independently of PAR-3 to regulate epithelial cell polarity. Current Biology, Apr 29;13(9):734-743, 2003 .( PubMed)
Koichi Kitamura, Keiko Mizuno, Akiko Etoh, Yoshiko Akita, Akitomo Miyamoto, Kei-Ichi Nakayama, and Shigeo Ohno The second phase activation of protein kinase Cd at late G1 is required for DNA synthesis in serum-induced cell cycle progression. Genes to Cells, 8, 311-324, 2003.( PubMed)
(Review) Suzuki A, Alomoto K, Ohno S. Protein kinase C l/I (PKC l/I): aPKC isotype essential for the development of multicellular organism. J Biochem (Tokyo) 133 (1), 9-16, 2003. (PubMed)
（雑誌記事）Ohno s: Destroying Symmetry. J Cell Biology, 160(4), 2003.

2002

Y. Nagai-Tamai, K. Mizuno, T. Hirose, A. Suzuki, and S. Ohno. Regulated protein-protein interaction between aPKC and PAR-3 plays an essential role in the polarization of epithelial cells. Genes to Cells, Nov;7(11):1161-1171, 2002. ( PubMed)
Yamaji S, Suzuki A, Kanamori H, Mishima W, Takabayashi M, Fujimaki K, Tomita N, Fujisawa S, Ohno S, Ishigatsubo Y.ILK-affixin complex is involved in integrin-cytoskeleton linkage in platelets. Biochem Biophys Res Commun, Oct 11;297(5):1324, 2002 . ( PubMed)
(Review) Ohno S, Nishizuka Y. Protein kinase C isotypes and their specific functions: prologue. J Biochem (Tokyo) Oct; 132(4): 509-511, 2002 . ( PubMed)
Hirai S-I, Kawaguchi A, Hirasawa R, Baba M, Ohnishi T and Ohno S. MAPK-upstream protein kinase (MUK) regulates the radial migration of immature neurons in telencephalon of mouse embryo. Development , 129: 4483-4495, 2002.( PubMed)
Suzuki, A, Ishiyama, C, Hashiba, K, Shimizu, M, Ebnet, K, Takai, Y, Ohno, S.: aPKC kinase activity is required for the asymmetric differentiation of the premature junctional complex during epithelial cell polarizatioin. J Cell Science, Sep 15;115(Pt 18):3565-3573 , 2002. ( PubMed)
Manabe N, Hirai S, Imai F, Nakanishi H, Takai Y, Ohno S. Association of ASIP/mPAR-3 with adherens junctions of mouse neuroepithelial cells. Dev Dyn. Sep;225(1):61-69, 2002. ( PubMed)
Tsuru M, Katagiri H, Asano T, Yamada T, Ohno S, Ogihara T, Oka Y. Role of PKC isoforms in glucose transport in 3T3-L1 adipocytes: insignificance of atypical PKC. Am J Physiol Endocrinol Metab 2002 Aug;283(2):E338-345.( PubMed)
Mishima A, Suzuki A, Enaka M, Hirose T, Mizuno K, Ohnishi T, Mohri H, Ishigatsubo Y, Ohno S. Over-expression of PAR-3 suppresses contact-mediated inhibition of cell migration in MDCK cells. Genes to Cells. 2002 Jun;7(6):581-596.( PubMed)
Hirose T, Izumi Y, Nagashima Y, Tamai-Nagai Y, Kurihara H, Sakai T, Suzuki Y, Yamanaka T, Suzuki A, Mizuno K, Ohno S. Involvement of ASIP/PAR-3 in the promotion of epithelial tight junction formation. J Cell Science. 2002 Jun 15;115(Pt 12):2485-2495. ( PubMed)
Miyamoto A, Nakayama K, Imaki H, Hirose S, Jiang Y, Abe M, Tsukiyama T, Nagahama H, Ohno S, Hatakeyama S, Nakayama KI. Increased proliferation of B cells and auto-immunity in mice lacking protein kinase Cdelta. Nature. 2002 Apr 25;416(6883):865-869. ( PubMed)
Hiwasa T, Nakata M, Nakata M, Ohno S, Maki M, Suzuki K, Takiguchi M. Regulation of Transformed State by Calpastatin via PKCepsilon in NIH3T3 Mouse Fibroblasts. Biochem Biophys Res Commun 2002 Jan 11;290(1):510-517. ( PubMed)

2001

Harbers, M, Nomura, T, Ohno, S and Ishii, S.: Intracellular localization of the ret finger protein depends on a functional nuclear export signal and protein kinase C activation, J Biol Chem, 276: 48596-48607, 2001. ( PubMed)
Hideho Uchiyama, Teruaki Kobayashi, Akio Yamashita, Shigeo Ohno, and Shigeharu Yabe. Cloning and characterization ; of a T-box gene tbx6 in Xenopus laevis. DGD, Dec;43(6):657-669, 2001. ( PubMed) ;
Geng WD, Boskovic G, Fultz ME, Li C, Niles RM, Ohno S, Wright GL.: Regulation of expression and activity of four PKC isozymes in confluent and mechanically stimulated UMR-108 osteoblastic cells. J Cell Physiol. 2001 Nov;189(2):216-228. ( PubMed)
Okuda, H, Saitoh, K, Hirai Si, S, Iwai, K, Takaki, Y, Baba, M, Minato, N, Ohno, S and Shuin, T.: The Von Hippel-Lindau (VHL) tumor suppressor protein mediates ubiquitination of activated atypical protein kinase C, J Biol Chem, Vol. 276, Issue 47, 43611-43617, November 23, 2001. ( PubMed)

Li C, Fultz ME, Geng W, Ohno S, Norton M, Wright GL. : Concentration-dependent phorbol stimulation of PKCalpha localization at the nucleus or subplasmalemma in A7r5 cells. Pflugers Arch. 2001 Oct;443(1):38-47. ( PubMed)
(Review) Ohno S. Intercellular junctions and cellular polarity: the PAR-aPKC complex, a conserved core cassette playing fundamental roles in cell polarity. ; Current Opinion in Cell Biology 2001, 13, 641-648., 2001.( PubMed)
Zhao, X, Murata, T, Ohno, S, Day, N, Song, J, Nomura, N, Nakahara, T and Yokoyama, K K.: Protein kinase Ca plays a critical role in mannosylerythritol lipid-induced differentiation of melanoma B16 cells, J Biol Chem, Oct 26;276(43):39903-39910, 2001.( PubMed)
Shuji Matsuda, Takashi Yasukawa, Yasuko Hommma, Yuko Ito, Takako Niikura, ; Takako Hiraki, Shuishi Hirai, Shigeo Ohno,Yoshiko Kita, Masaoki Kawasumi, ; Keisuke Kouyama, Tokuo Yamamoto, John M. Kyriakis, and Ikuo Nishimoto. ; ; c-Jun N-terminal kinase (JNK)-interacting protein-1b/islet-brain-1 ; scaffolds ; Alzheimer's amyloid precursor protein with JNK. ; The Journal of Neuroscience , 21, 6597-6607., 2001. ( PubMed)
;Akio Yamashita, Tetsuo Ohnishi, Isao Kashima, Yo-ichi Taya, and Shigeo Ohno, Human SMG-1 encodes a ; novel phosphatidylinositol 3-kinase-related protein kinase involved in nonsense-mediated ; mRNA decay. Genes & Development, 15, 2215-2228., 2001. ( PubMed)
Takaki, Y., ; Hirai, S., ; Manabe, N., ; Izumi, Y., ; Hirose, T., ; Nakaya, M., ; Suzuki, A., ; Mizuno, K., ; Akimoto, K., ; Shuin, T., and ; Ohno, S. Dynamic changes in protein components of the tight junction during liver regeneration. Cell & Tissue Research , 305, 399-409., 2001. ( PubMed)
Tomoyuki Yamanaka, Yosuke Horikoshi, Atsushi Suzuki, Yuki Sugiyama, Koichi Kitamura, Rika Maniwa, Yoko Nagai, Akio Yamashita, Tomonori Hirose, Hiroko Ishikawa, and Shigeo Ohno. PAR-6 regulates aPKC activity in a novel way and mediates cell-cell contact-induced formation of the epithelial junctional complex. Genes to Cells, 6, 721-731., 2001. ( PubMed)
Klaus Ebnet, Atsushi Suzuki, Yosuke Horikoshi, Tomonori Hirose, Maria-Katharina Meyer zu Brickwedde, Shigeo Ohno, and Dietmar Vestweber. The cell polarity protein ASIP/PAR-3 directly associates with Junctional Adhesion Molecule (JAM) EMBO J, 20, 3738-3748., 2001. ( PubMed)
Satoshi Yamaji, Atsushi Suzuki,Y Yuki Sugiyama,Y Michihiko Yoshida, Heiwa Kanamori, Hiroshi Mouri, Shigeo Ohno, Yoshiaki Ishigatsubo. A novel ILK binding protein, Affixin, is involved in the early stage of cell-substrate interaction. J. Cell Biol.,153(6):1251-1264, 2001 (Jun 11) ( PubMed)
Baba, M., Hirai, S., Kawakami, S., Kishida, T., Sakai, N., Kaneko, S., Yao, M., Shuin, T., Hosaka, M., and Ohno, S.: Tumor suppressor protein VHL is induced at high cell density and mediates contact inhibition of cell growth. Oncogene ;20(22):2727-2736, 2001 May 17 ( PubMed)
Suzuki, A., Yamanaka, T., Hashiba, K., Hirose, T., Izumi, Y., Ohnishi, T., ; and Ohno, S. : Atypical PKC is involved in the establishment of epithelial polarity in mammalian cells. J. Cell Biol. , 152, 1183-1196, 2001.( PubMed)
Noda, Y., Takeya, R., Ohno, S., Naito, S., Ito, T., and Sumimoto, H. : Human homologues ofo the Caenorhabditis elegans cell polarity protein PAR6 as an adaptor that links the small GTPases Rac and Cdc42 to atypical protein kinase C. Genes to Cells, 6, 107-119, 2001. ( PubMed)

2000

Nakaya, M., ; Fukui, A., ; Izumi, Y., Akimoto, K., Asashima, M., ; and Ohno, S.: Meiotic Maturation Induces Animal-Vegetal Asymmetric Distribution of aPKC and ASIP/PAR-3 in Xenopus oocytes., Development, 127, 5021-5031, 2000. ( PubMed)
Kotani K, Ogawa W, Hashiramoto M, Onishi T, Ohno S, Kasuga M. Inhibition of insulin-induced glucose uptake by atypical protein kinase C isotype-specific interacting protein in 3T3-L1 adipocytes. J Biol Chem 2000 Aug 25;275(34):26390-5. ( PubMed)
Kuroki T, Ikuta T, Kashiwagi M, Kawabe S, Ohba M, Huh N, Mizuno K, Ohno S, Yamada E, Chida K. Cholesterol sulfate, an activator of protein kinase C mediating squamous cell differentiation: a review. Mutat Res. 2000 Apr;462(2-3):189-195. ( PubMed)
Fukuyama K, Yoshida M, Yamashita A, Deyama T, Baba M, Suzuki A, Mohri H, Ikezawa Z, Nakajima H, Hirai S, Ohno S. MAPK upstream kinase (MUK)-binding inhibitory protein, a negative regulator of MUK/dual leucine zipper-bearing kinase/leucine zipper protein kinase. J Biol Chem. 2000 Jul 14;275(28):21247-21254. ( PubMed)
Sugiyama, Y., Suzuki, A., Kishikawa, M., Akutsu, R., Hirose, T., Waye, M.M.Y., Tsui, S.K.W., Yoshida, S., adn Ohno, S. (2000). Muscle develops a specific form of small heat shock protein complex composed of MKBP/HSPB2 and HSPB3 during myogenic differentiation. J Biol Chem 275, 1095-1104. ( PubMed)
Akita Y, Kawasaki H, Ohno S, Suzuki K, Kawashima S. ; Involvement of protein kinase C epsilon in thyrotropin-releasing hormone-stimulated phosphorylation of the myristoylated alanine-rich C kinase substrate in rat pituitary clonal cells. Electrophoresis. 2000 Jan;21(2):452-459. ( PubMed)
Zhuang S, Hirai SI, Ohno S. ; Hyperosmolality induces activation of cPKC and nPKC, a requirement for ERK1/2 activation in NIH/3T3 cells. Am J Physiol Cell Physiol. 2000 Jan;278(1):C102-109. ; ( PubMed)

1999

Yoshida, K., Aki, T., Harada, K., Shama, K. M., Kamoda, Y., Suzuki, A., and Ohno, S. (1999). Translocation of HSP27 and MKBP in ischemic heart. Cell Struct Funct 24,181-185. ( PubMed)
Okuda, H., Hirai, Si., Takaki, Y., Kamada, M., Baba, M., Sakai, N., Kishida, T., Kaneko, S., Yao, M., Ohno, S., and Shuin, T. (1999). Direct Interaction of the beta-Domain of VHL Tumor Suppressor Protein with the Regulatory Domain of Atypical PKC Isotypes. Biochem Biophys Res Commun 263, 491-497. ( PubMed)
Koike H, Tomioka S, Sorimachi H, Saido TC, Maruyama K, Okuyama A, Fujisawa-Sehara A, Ohno S, Suzuki K, Ishiura S. ; Membrane-anchored metalloprotease MDC9 has an alpha-secretase activity responsible for processing the amyloid precursor protein. Biochem J. 1999 Oct 15;343 Pt 2:371-375. ( PubMed)
Imafuku, I., Masaki, T., Waragai, M., Takeuchi, S., Kawabata, M., Hirai, S., Ohno, S., Nee, L. E., Lippa, C. F., Kanazawa, I., Imagawa, M., and Okazawa, H. (1999). Presenilin 1 suppresses the function of c-Jun homodimers via interaction with QM/Jif-1. J Cell Biol 147, 121-134. ( PubMed)
Desai, D. S., Hirai, S., Karnes, W. E., Jr., Niles, R. M., and Ohno, S. (1999). Cloning and characterization of the murine PKC alpha promoter: identification of a retinoic acid response element. Biochem Biophys Res Commun 263,28-34. ( PubMed)
Miranti CK, Ohno S, Brugge JS. Protein kinase C regulates integrin-induced activation of the extracellular regulated kinase pathway upstream of Shc. J Biol Chem. 1999 Apr 9;274(15):10571-10581, UI: 99214627 ( PubMed)
Yamazaki M, Zhang Y, Watanabe H, Yokozeki T, Ohno S, Kaibuchi K, Shibata H, Mukai H, Ono Y, Frohman MA, Kanaho Y. ; Interaction of the small G protein RhoA with the C terminus of human phospholipase D1. J Biol Chem. 1999 Mar 5;274(10):6035-6038. ; PMID: 10037681; UI: 99156871
Kikuchi, R., Uemura, T., Gorai, I., Ohno, S. and Minaguchi, H. : Early and late postmenopausal bone loss is associated with Bsm1 vitamin D receptor gene polymorphism in Japanese women. Calcified Tissue Int., 64, 102-106, 1999.
Shama, K.M., Suzuki, A., Harada, K., Fujitani, N., Kimura, H., Ohno, S., and Yoshida, K. (1999). Transient up-regulation of myotonic dystrophy protein kinase-binding protein, MKBP, and HSP27 in the neonatal myocardium. Cell Struct Funct 24, 1-4. ( PubMed)
Kim, S., Yu, SS., Lee, IS., Ohno, S., Yim, J., Kim, S. and Kang, HS. : Human cytomegalovirus IE1 protein activates AP-1 through a cellular protein kinase. J. Gen. Virol., 80, 961-969, 1999.

1998

Izumi, Y., Hirata, M., Hasuwa, H., Iwamoto, R., Umata, T., Miyado, K., Tamai, Y., Kurisaki, T., Sehara-Fujisawa, A., Ohno, S., and Mekada, E. (1998). A metalloprotease-disintegrin, MDC9/meltrin-gamma/ADAM9 and PKCdelta are involved in TPA-induced ectodomain shedding of membrane-anchored heparin-binding EGF-like growth factor. EMBO J 17,7260-7272. ( PubMed)
Kotani, K., Ogawa, W., Matsumoto, M., Kitamura, T., Sakaue, H., Hino, Y., Miyake, K., Sano, W., Akimoto, K., Ohno. S., and Kasuga M (1998). Requirement of atypical protein kinase clambda for insulin stimulation of glucose uptake but not for akt activation in 3T3-L1 adipocytes. Mol Cell Biol, 18, 6971-6982. ( PubMed)
Izumi, Y., Hirose, T., Tamai, Y., Hirai, S., Nagashima, Y., Fujimoto, T., Tabuse, Y., Kemphues, K. J., and Ohno, S. (1998). An atypical PKC directly associates and colocalizes at the epithelial tight junciton with ASIP, a mammalian homologue of Caenorhabditis eleganspolarity protein PAR-3. J Cell Biol 143,95-106. ( PubMed)
Akimoto, K., Nakaya, M., Yamanaka, T., Tanaka, J., Matsuda, S., Weng, Q. P., Avruch, J., and Ohno, S. (1998). Atypical protein kinase Clambda binds and regulates p70 S6 kinase. Biochem J 335,417-424. ( PubMed)
Tabuse, Y., Izumi, Y., Piano, F., Kemphues, K. J., Miwa, J., and Ohno, S. (1998). Atypical protein kinase C cooperates with PAR-3 to establish embryonic polarity in Caenorhabditis elegans. Development 125, 3607-3614. ( PubMed)
Yuasa, T., Ohno, S., Kehrl, J. H., and Kyriakis, J. M. (1998). Tumor necrosis factor signaling to stress-activated protein kinase (SAPK)/Jun NH2-terminal kinase (JNK) and p38. Germinal center kinase couples TRAF2 to mitogen-activated protein kinase/ERK kinase kinase 1 and SAPK while receptor interacting protein associates with a mitogen-activated protein kinase kinase kinase upstream of MKK6 and p38. J Biol Chem 273, 22681-22692. ( PubMed)
Yokozeki, T., Homma, K., Kuroda, S., Kikkawa, U., Ohno, S., Takahashi, M., Imahori, K., and Kanaho, Y. (1998). Phosphatidic acid-dependent phosphorylation of a 29-kDa protein by protein kinase Calpha in bovine brain cytosol. J Neurochem 71,410-417. ( PubMed)
Nyui, N., Tamura, K., Mizuno, K., Ishigami, T., Kihara, M., Ochiai, H., Kimura, K., Umemura, S., Ohno, S., Taga, T., and Ishii, M. (1998). gp130 is involved in stretch-induced MAP kinase activation in cardiac myocytes. Biochem Biophys Res Commun 245, 928-932. ( PubMed)
Hirai, S., Noda, K., Moriguchi, T., Nishida, E., Yamashita, A., Deyama, T., Fukuyama, K., and Ohno, S. (1998). Differential activation of two JNK activators, MKK7 and SEK1, by MKN28-derived nonreceptor serine/threonine kinase/mixed lineage kinase 2. J Biol Chem 273,7406-7412. ( PubMed)

Suzuki, A., Sugiyama, Y., Hayashi, Y., Nyu-i, N., Yoshida, M., Nonaka, I., Ishiura, S., Arahata, K., and Ohno, S. (1998). MKBP, a novel member of the small heat shock protein family, binds and activates the myotonic dystrophy protein kinase. J Cell Biol 140,1113-1124. ( PubMed)

1997

Zhuang, S., Hirai, S., Mizuno, K., Suzuki, A., Akimoto, K., Izumi, Y., Yamashita, A., and Ohno, S. (1997). Involvement of protein kinase C in the activation of extracellular signal-regulated kinase 1/2 by UVC irradiation. Biochem Biophys Res Commun 240,273-278. ( PubMed)
Ichimura, T., Ito, M., Itagaki, C., Takahashi, M., Horigome, T., Omata, S., Ohno, S., and Isobe, T. (1997). The 14-3-3 protein binds its target proteins with a common site located towards the C-terminus. FEBS Lett 413,273-276. ( PubMed)
Oka, N., Yamamoto, M., Schwencke, C., Kawabe, J., Ebina, T., Ohno, S., Couet, J., Lisanti, M. P., and Ishikawa, Y. (1997). Caveolin interaction with protein kinase C. Isoenzyme-dependent regulation of kinase activity by the caveolin scaffolding domain peptide. J Biol Chem 272, 33416-33421. ( PubMed)
Mizuno, K., Noda, K., Araki, T., Imaoka, T., Kobayashi, Y., Akita, Y., Shimonaka, M., Kishi, S., and Ohno, S. (1997). The proteolytic cleavage of protein kinase C isotypes, which generates kinase and regulatory fragments, correlates with Fas-mediated and 12-O-tetradecanoyl-phorbol-13-acetate-induced apoptosis. Eur J Biochem 250,7-18. ( PubMed)
Nyui, N., Tamura, K., Mizuno, K., Ishigami, T., Hibi, K., Yabana, M., Kihara, M., Fukamizu, A., Ochiai, H., Umemura, S., Murakami, K., Ohno, S., and Ishii, M. (1997). Stretch-induced MAP kinase activation in cardiomyocytes of angiotensinogen-deficient mice. Biochem Biophys Res Commun 235, 36-41. ( PubMed)
Osada, S., Izawa, M., Saito, R., Mizuno, K., Suzuki, A., Hirai, S., and Ohno, S. (1997). YSK1, a novel mammalian protein kinase structurally related to Ste20 and SPS1, but is not involved in the known MAPK pathways. Oncogene 14,2047-2057. ( PubMed)
Kitamura, Y., Kitamura, T., Sakaue, H., Maeda, T., Ueno, H., Nishio, S., Ohno, S., Osada, S., Sakaue, M., Ogawa, W., and Kasuga, M. (1997). Interaction of Nck-associated protein 1 with activated GTP-binding protein Rac. Biochem J 322,873-878. ( PubMed)
Ebina, T., Kawabe, J., Katada, T., Ohno, S., Homcy, C. J., and Ishikawa, Y. (1997). Conformation-dependent activation of type II adenylyl cyclase by protein kinase C. J Cell Biochem 64,492-498. ( PubMed)
Lu, Z., Hornia, A., Jiang, Y. W., Zang, Q., Ohno, S., and Foster, D. A. (1997). Tumor promotion by depleting cells of protein kinase C delta. Mol Cell Biol 17,3418-3428. ( PubMed)
Fukumoto, S., Nishizawa, Y., Hosoi, M., Koyama, H., Yamakawa, K., Ohno, S., and Morii, H. (1997). Protein kinase C delta inhibits the proliferation of vascular smooth muscle cells by suppressing G1 cyclin expression. J Biol Chem 272,13816-13822. ( PubMed)
Hirai, S., Katoh, M., Terada, M., Kyriakis, J. M., Zon, L. I., Rana, A., Avruch, J., and Ohno, S. (1997). MST/MLK2, a member of the mixed lineage kinase family, directly phosphorylates and activates SEK1, an activator of c-Jun N-terminal kinase/stress-activated protein kinase. J Biol Chem 272,15167-15173. ( PubMed)
Izumi, Y., Hirai, S., Tamai, Y., Fujise-Matsuoka, A., Nishimura, Y., and Ohno, S. (1997). A protein kinase Cdelta-binding protein SRBC whose expression is induced by serum starvation. J Biol Chem 272, 7381-7389. ( PubMed)
Osada, S., Izawa, M., Koyama, T., Hirai, S., and Ohno, S. (1997). A domain containing the Cdc42/Rac interactive binding (CRIB) region of p65PAK inhibits transcriptional activation and cell transformation mediated by the Ras-Rac pathway. FEBS Lett 404,227-233. ( PubMed)
Ohno, S.: The distinct biological potential of PKC isotypes. in Protein Kinase C, pp75-93 (eds. Parker, P. J. and Dekker, L. V., R.G. Lands Company, Springer), 1997.

1996

Zappelli, F., Willems, D., Osada, S., Ohno, S., Wetsel, W. C., Molinaro, M., Cossu, G., and Bouche, M. (1996). The inhibition of differentiation caused by TGFbeta in fetal myoblasts is dependent upon selective expression of PKC theta: a possible molecular basis for myoblast diversification during limb histogenesis. Dev Biol 180,156-164. ( PubMed)
Takayanagi, J., Kimura, K., Nishioka, N., Akimoto, K., Moriya, S., Ohno, S., and Fukui, Y. (1996). Dominant negative effect of the truncated p110 subunit of phosphatidylinositol-3 kinase. Biochem Mol Biol Int 39,721-728. ( PubMed)
Chalfant, C. E., Ohno, S., Konno, Y., Fisher, A. A., Bisnauth, L. D., Watson, J. E., and Cooper, D. R. (1996). A carboxy-terminal deletion mutant of protein kinase C beta II inhibits insulin-stimulated 2-deoxyglucose uptake in L6 rat skeletal muscle cells. Mol Endocrinol 10,1273-1281. ( PubMed)
Ueda, Y., Hirai, S., Osada, S., Suzuki, A., Mizuno, K., and Ohno, S. (1996). Protein kinase C activates the MEK-ERK pathway in a manner independent of Ras and dependent on Raf. J Biol Chem 271,23512-23519. ( PubMed)
Rana, A., Gallo, K., Godowski, P., Hirai, S., Ohno, S., Zon, L., Kyriakis, J. M., and Avruch, J. (1996). The mixed lineage kinase SPRK phosphorylates and activates the stress-activated protein kinase activator, SEK-1. J Biol Chem 271,19025-19028. ( PubMed)
Sauma, S., Yan, Z., Ohno, S., and Friedman, E. (1996). Protein kinase C beta 1 and protein kinase C beta 2 activate p57 mitogen-activated protein kinase and block differentiation in colon carcinoma cells. Cell Growth Differ 7,587-594. ( PubMed)
Nakaigawa, N., Hirai, S., Mizuno, K., Shuin, T., Hosaka, M., and Ohno, S. (1996). Differential effects of overexpression of PKC alpha and PKC delta/epsilon on cellular E2F activity in late G1 phase. Biochem Biophys Res Commun 222,95-100. ( PubMed)
Hirano, M., Osada, S., Aoki, T., Hirai, S., Hosaka, M., Inoue, J., and Ohno, S. (1996). MEK kinase is involved in tumor necrosis factor alpha-induced NF-kappaB activation and degradation of IkappaB-alpha. J Biol Chem 271,13234-13238. ( PubMed)
Ueda, E., Ohno, S., Kuroki, T., Livneh, E., Yamada, K., Yamanishi, K., and Yasuno, H. (1996). The eta isoform of protein kinase C mediates transcriptional activation of the human transglutaminase 1 gene. J Biol Chem 271,9790-9794. ( PubMed)
Akimoto, K., Takahashi, R., Moriya, S., Nishioka, N., Takayanagi, J., Kimura, K., Fukui, Y., Osada, S., Mizuno, K., Hirai, S., Kazlauskas, A., and Ohno, S. (1996). EGF or PDGF receptors activate atypical PKC lambda through phosphatidylinositol 3-kinase. EMBO J 15,788-798. ( PubMed)
Hirai, S., Izawa, M., Osada, S., Spyrou, G., and Ohno, S. (1996). Activation of the JNK pathway by distantly related protein kinases, MEKK and MUK. Oncogene 12,641-650. ( PubMed)
Moriya, S., Kazlauskas, A., Akimoto, K., Hirai, S., Mizuno, K., Takenawa, T., Fukui, Y., Watanabe, Y., Ozaki, S., and Ohno, S. (1996). Platelet-derived growth factor activates protein kinase C epsilon through redundant and independent signaling pathways involving phospholipase C gamma or phosphatidylinositol 3-kinase. Proc Natl Acad Sci U S A 93,151-155. ( PubMed)

1995

Suzuki, K., Sorimachi, H., Ishiura, S. and Ohno, S. : Two family members of calpain : ubiquitous and tissue specific calpains. Editors : Ouali, A., Demeyer, D. I. and Smulders, J. M. Expression of tissue proteinases and regulation of protein degradation as related to meat quality., ECCEAMST, The Netherlands, 5-15, 1995.
Nishioka, N., Hirai, S., Mizuno, K., Osada, S., Suzuki, A., Kosaka, K., and Ohno, S. (1995). Wortmannin inhibits the activation of MAP kinase following vasopressin V1 receptor stimulation. FEBS Lett 377, 393-398. ( PubMed)
Nishioka, N., Akimoto, K., Moriya, S., Takayanagi, J., Fukui, Y., Hirai, S., Mizuno, K., Kosaka, K., and Ohno, S. (1995). Phosphatidylinositol 3-kinase is involved in TRE-dependent gene expression in response to arginine vasopressin. Biochem Biophys Res Commun 215,1037-1042. ( PubMed)
Morishita, R., Nakayama, H., Isobe, T., Matsuda, T., Hashimoto, Y., Okano, T., Fukada, Y., Mizuno, K., Ohno, S., Kozawa, O., and et al. (1995). Primary structure of a gamma subunit of G protein, gamma 12, and its phosphorylation by protein kinase C. J Biol Chem 270,29469-29475. ( PubMed)
Ogawara, M., Inagaki, N., Tsujimura, K., Takai, Y., Sekimata, M., Ha, M. H., Imajoh-Ohmi, S., Hirai, S., Ohno, S., Sugiura, H., and et al. (1995). Differential targeting of protein kinase C and CaM kinase II signalings to vimentin. J Cell Biol 131,1055-1066. ( PubMed)
Wang, F., Naik, U. P., Ehrlich, Y. H., Osada, S., Ohno, S., and Kornecki, E. (1995). Stimulatory antibody-induced activation and selective translocation of protein kinase C isoenzymes in human platelets. Biochem J 311, 401-406. ( PubMed)
Kinouchi, T., Sorimachi, H., Maruyama, K., Mizuno, K., Ohno, S., Ishiura, S., and Suzuki, K. (1995). Conventional protein kinase C (PKC)-alpha and novel PKC epsilon, but not -delta, increase the secretion of an N-terminal fragment of Alzheimer's disease amyloid precursor protein from PKC cDNA transfected 3Y1 fibroblasts. FEBS Lett 364,203-206. ( PubMed)
Ichikawa, S., Hatanaka, H., Takeuchi, Y., Ohno, S., and Inagaki, F. (1995). Solution structure of cysteine-rich domain of protein kinase C alpha. J Biochem (Tokyo) 117,566-574. ( PubMed)
Mizuno, K., Noda, K., Ueda, Y., Hanaki, H., Saido, T. C., Ikuta, T., Kuroki, T., Tamaoki, T., Hirai, S., Osada, S., and et al. (1995). UCN-01, an anti-tumor drug, is a selective inhibitor of the conventional PKC subfamily. FEBS Lett 359,259-261. ( PubMed)
Hirano, M., Hirai, S., Mizuno, K., Osada, S., Hosaka, M., and Ohno, S. (1995). A protein kinase C isozyme, nPKC epsilon, is involved in the activation of NF-kappa B by 12-O-tetradecanoylphorbol-13-acetate (TPA) in rat 3Y1 fibroblasts. Biochem Biophys Res Commun 206,429-436. ( PubMed)
Ohno, S. and Suzuki, K. : YKR2 PK (S. cerevisiae). The protein kinase factbook, Academic Press Limited., 80-88, 1995.
Ohno, S. and Suzuki, K. : Protein kinase C (vertebrates) Ca2+ - & phospholipid-dependent protein kinase. The protein kinase factbook, Academic Press Limited., pp107, 1995.
Suzuki, A., Yoshida, M. and Ozawa, E. : Mammalian alphal and betal-syntrophin bind to the alternative splice-prone region of the dystrophin C-terminus. J., Cell. Biol., 128, 373-381, 1995.
Ozawa, E., Yoshida, M., Suzuki, A., Mizuno, Y., Hagiwara, Y. and Noguchi, S. : Dystrophin-associated proteins in muscular dystrophy. Hum, Mol. Genet., 4, 1711-1716, 1995.

1994

Kim, H. M., Hirota, S., Chung, H. T., Ohno, S., Osada, S., Shin, T., Ko, K. I., Kim, J. B., Kitamura, Y., Nomura, S., and et al. (1994). Differential expression of protein kinase C genes in cultured mast cells derived from normal and mast-cell-deficient mice and mast cell lines. Int Arch Allergy Immunol 105,258-263. ( PubMed)
Ikuta, T., Chida, K., Tajima, O., Matsuura, Y., Iwamori, M., Ueda, Y., Mizuno, K., Ohno, S., and Kuroki, T. (1994). Cholesterol sulfate, a novel activator for the eta isoform of protein kinase C. Cell Growth Differ 5,943-947. ( PubMed)
Fujise, A., Mizuno, K., Ueda, Y., Osada, S., Hirai, S., Takayanagi, A., Shimizu, N., Owada, M. K., Nakajima, H., and Ohno, S. (1994). Specificity of the high affinity interaction of protein kinase C with a physiological substrate, myristoylated alanine-rich protein kinase C substrate. J Biol Chem 269,31642-1648. ( PubMed)
Kindregan, H. C., Rosenbaum, S. E., Ohno, S., and Niles, R. M. (1994). Characterization of conventional protein kinase C (PKC) isotype expression during F9 teratocarcinoma differentiation. Overexpression of PKC alpha alters the expression of some differentiation-dependent genes. J Biol Chem 269,27756-27761. ( PubMed)
Canzian, F., Gariboldi, M., Manenti, G., Gregorio, L., Osada, S., Ohno, S., Dragani, T-A. and Pierotti, M-A. : Expression in lung tumors and genetic mapping of the novel murine protein kinase Cη. Molecular Carcinogenesis, 9, 111-113, 1994.
Kawabe, J., Iwami, G., Ebina, T., Ohno, S., Katada, T., Ueda, Y., Homcy, C. J., and Ishikawa, Y. (1994). Differential activation of adenylyl cyclase by protein kinase C isoenzymes [published erratum appears in J Biol Chem 1994 Sep 9;269(36):22912]. J Biol Chem 269,16554-16558. ( PubMed)
Ohno, S., Mizuno, K., Adachi, Y., Hata, A., Akita, Y., Akimoto, K., Osada, S., Hirai, S., and Suzuki, K. (1994). Activation of novel protein kinases C delta and C epsilon upon mitogenic stimulation of quiescent rat 3Y1 fibroblasts. J Biol Chem 269,17495-17501. ( PubMed)
Mishima, K., Ohno, S., Shitara, N., Yamaoka, K., and Suzuki, K. (1994). Opposite effects of the overexpression of protein kinase C gamma and delta on the growth properties of human glioma cell line U251 MG. Biochem Biophys Res Commun 201,363-372. ( PubMed)
Hirai, S., Izumi, Y., Higa, K., Kaibuchi, K., Mizuno, K., Osada, S., Suzuki, K., and Ohno, S. (1994). Ras-dependent signal transduction is indispensable but not sufficient for the activation of AP1/Jun by PKC delta. EMBO J 13,2331-2340. ( PubMed)
Akimoto, K., Mizuno, K., Osada, S., Hirai, S., Tanuma, S., Suzuki, K., and Ohno, S. (1994). A new member of the third class in the protein kinase C family, PKC lambda, expressed dominantly in an undifferentiated mouse embryonal carcinoma cell line and also in many tissues and cells. J Biol Chem 269,12677-12683. ( PubMed)
Chida, K., Sagara, H., Suzuki, Y., Murakami, A., Osada, S., Ohno, S., Hirosawa, K., and Kuroki, T. (1994). The eta isoform of protein kinase C is localized on rough endoplasmic reticulum. Mol Cell Biol 14, 3782-3790. ( PubMed)
Koyama, H., Inaba, M., Nishizawa, Y., Ohno, S., and Morii, H. (1994). Protein kinase C is involved in 24-hydroxylase gene expression induced by 1,25(OH)2D3 in rat intestinal epithelial cells. J Cell Biochem 55,230-240. ( PubMed)
Suzuki, K., Akita, Y. and Ohno, S. : Structural and functional diversities of protein kinase C family members. Wei, Y. -H., Chen, C.-S. and Su, J.-C., (eds.) Recent Advances in Molecular and Biochemical Research on proteins, World Scientific Pub. Co., 157-166, 1994.
Akita, Y., Ohno, S., Yajima, Y., Konno, Y., Saido, T. C., Mizuno, K., Chida, K., Osada, S., Kuroki, T., Kawashima, S., and et al. (1994). Overproduction of a Ca(2+)-independent protein kinase C isozyme, nPKC epsilon, increases the secretion of prolactin from thyrotropin-releasing hormone-stimulated rat pituitary GH4C1 cells. J Biol Chem 269,4653-4660. ( PubMed)

1993

Kim, H. M., Hirota, S., Chung, H. T., Onoue, H., Ito, A., Morii, E., Hirata, T., Ohno, S., Osada, S., Kitamura, Y., and et al. (1993). PKC gamma gene expression is delayed in postnatal central nervous system of mi/mi mice. J Mol Neurosci 4,245-253. ( PubMed)
Yamaoka, K., Ohno, S., Kawasaki, H. and Suzuki, K. : Mammalian lectin as transforming growth factor. Lectius and Glycobiology, 492-499, 1993
Ohno, S., Mizuno, K., Hirai, S-I., Osada, S. and Hata, A. : Selective activation of novel protein kinase C members upon serum stimulation of quiescent rat 3Y1 fibroblasts. J. Cellular Biochem., 17A, 273, 1993.
Cutler, R. E., Jr., Maizels, E. T., Brooks, E. J., Mizuno, K., Ohno, S., and Hunzicker-Dunn, M. (1993). Regulation of delta protein kinase C during rat ovarian differentiation. Biochim Biophys Acta 1179, 260-270. ( PubMed)
Ohno, S., Akita, Y., Hata, A., Osada, S., Kubo, K., Konno, Y., Akimoto, K., Mizuno, K., Saido, T. C., Kuroki, T. and Suzuki, K. : Structural and functional diversities of a family of signal transducing protein kinases; protein kinase C family. Yokohama Med. Bull., 43, 139-140, 1993.
Ohno, S. : Diversity and specificity of multiple protein kinase C. Progress in Endocrinology, Parthenon Press, 63-66, 1993.
Koizumi, H., Kohno, Y., Osada, S., Ohno, S., Ohkawara, A., and Kuroki, T. (1993). Differentiation-associated localization of nPKC eta, a Ca(++)-independent protein kinase C, in normal human skin and skin diseases. J Invest Dermatol 101,858-863. ( PubMed)
Mischak, H., Goodnight, J., Henderson, D. W., Osada, S., Ohno, S., and Mushinski, J. F. (1993). Unique expression pattern of protein kinase C-theta: high mRNA levels in normal mouse testes and in T-lymphocytic cells and neoplasms. FEBS Lett 326,51-55. ( PubMed)
Sublette, E., Naik, M. U., Jiang, X., Osten, P., Valsamis, H., Osada, S., Ohno, S., and Sacktor, T. C. (1993). Evidence for a new, high-molecular weight isoform of protein kinase C in rat hippocampus. Neurosci Lett 159,175-178. ( PubMed)
Mizuno, K., Saido, T. C., Ohno, S., Tamaoki, T., and Suzuki, K. (1993). Staurosporine-related compounds, K252a and UCN-01, inhibit both cPKC and nPKC. FEBS Lett330,114-116. ( PubMed)
Park, H. Y., Russakovsky, V., Ohno, S., and Gilchrest, B. A. (1993). The beta isoform of protein kinase C stimulates human melanogenesis by activating tyrosinase in pigment cells. J Biol Chem 268,11742-11749. ( PubMed)
Hata, A., Akita, Y., Suzuki, K., and Ohno, S. (1993). Functional divergence of protein kinase C (PKC) family members. PKC gamma differs from PKC alpha and -beta II and nPKC epsilon in its competence to mediate-12-O-tetradecanoyl phorbol 13-acetate (TPA)-responsive transcriptional activation through a TPA-response element. J Biol Chem 268,9122-9129. ( PubMed)
Osada, S., Hashimoto, Y., Nomura, S., Kohno, Y., Chida, K., Tajima, O., Kubo, K., Akimoto, K., Koizumi, H., Kitamura, Y., and et al. (1993). Predominant expression of nPKC eta, a Ca(2+)-independent isoform of protein kinase C in epithelial tissues, in association with epithelial differentiation. Cell Growth Differ 4,167-175. ( PubMed)
Wang, F., Naik, U. P., Ehrlich, Y. H., Freyberg, Z., Osada, S., Ohno, S., Kuroki, T., Suzuki, K., and Kornecki, E. (1993). A new protein kinase C, nPKC eta', and nPKC theta are expressed in human platelets: involvement of nPKC eta' and nPKC theta in signal transduction stimulated by PAF. Biochem Biophys Res Commun 191,240-246. ( PubMed)

1992

Hashimoto, Y., Osada, S., Ohno, S., and Kuroki, T. (1992). A Ca(2+)-independent protein kinase C, nPKC eta: its structure, distribution and possible function. Tohoku J Exp Med 168,275-278. ( PubMed)
Kuroki, T., Hashimoto, Y., Osada, S., Chida, K., Nomura, S. and Ohno, S. : Protein kinase C in skin : Its activation, downregulation, substrate proteins and family members. The biology of the epidermis, 173-179, 1992.
Kim, H. M., Hirota, S., Onoue, H., Hirata, T., Suzuki, K., Ohno, S., Kuroki, T., Kitamura, Y., and Nomura, S. (1992). Localization and developmental expression of a novel protein kinase C delta gene. Brain Res Dev Brain Res 70,239-244. ( PubMed)
Osada, S., Mizuno, K., Saido, T. C., Suzuki, K., Kuroki, T., and Ohno, S. (1992). A new member of the protein kinase C family, nPKC theta, predominantly expressed in skeletal muscle. Mol Cell Biol 12, 3930-3938. ( PubMed)
Maizels, E. T., Miller, J. B., Cutler, R. E., Jr., Jackiw, V., Carney, E. M., Mizuno, K., Ohno, S., and Hunzicker-Dunn, M. (1992). Estrogen modulates Ca(2+)-independent lipid-stimulated kinase in the rabbit corpus luteum of pseudopregnancy. Identification of luteal estrogen-modulated lipid-stimulated kinase as protein kinase C delta. J Biol Chem 267,17061-17068. ( PubMed)
Gruber, J. R., Ohno, S., and Niles, R. M. (1992). Increased expression of protein kinase C alpha plays a key role in retinoic acid-induced melanoma differentiation. J Biol Chem 267,13356-13360. ( PubMed)
Hata, A., Ohno, S. and Suzuki, K. : Transcriptional activation of the gene for the large subunit of human m-calpain by 12-0-tetradecanoyl-phorbol-13-acetate. FEBS Lett., 304, 241-244, 1992.
Niino, Y. S., Ohno, S., and Suzuki, K. (1992). Positive and negative regulation of the transcription of the human protein kinase C beta gene. J Biol Chem 267,6158-6163. ( PubMed)
Saido, T. C., Mizuno, K., Konno, Y., Osada, S., Ohno, S., and Suzuki, K. (1992). Purification and characterization of protein kinase C epsilon from rabbit brain. Biochemistry 31,482-490. ( PubMed)
Ahmad, S., Trepel, J. B., Ohno, S., Suzuki, K., Tsuruo, T., and Glazer, R. I. (1992). Role of protein kinase C in the modulation of multidrug resistance: expression of the atypical gamma isoform of protein kinase C does not confer increased resistance to doxorubicin. Mol Pharmacol 42, 1004-1009. ( PubMed)
Suzuki, K., Saido, T. C. and Hirai, S-I. : Modulation of cellular signals by calpain. Ann. New York Acad. Sci., 674, 218-227, 1992.

1991

(Review) Ohno, S., Akita, Y., Hata, A., Osada, S., Kubo, K., Konno, Y., Akimoto, K., Mizuno, K., Saido, T., Kuroki, T., and et al. (1991). Structural and functional diversities of a family of signal transducing protein kinases, protein kinase C family; two distinct classes of PKC, conventional cPKC and novel nPKC. Adv Enzyme Regul 31,287-303. ( PubMed)
Yamaoka, K., Ohno, S., Kawasaki, H. and Suzuki, K. : Overexpression of a β - Garactoside binding protein causes transformation of BALB3T3 fibroblast cells. Biochem. Biophys. Res. Commun., 179, 272-279, 1991.
Mizuno, K., Kubo, K., Saido, T. C., Akita, Y., Osada, S., Kuroki, T., Ohno, S., and Suzuki, K. (1991). Structure and properties of a ubiquitously expressed protein kinase C, nPKC delta. Eur J Biochem 202,931-940. ( PubMed)
Yu, G., Ahmad, S., Aquino, A., Fairchild, C. R., Trepel, J. B., Ohno, S., Suzuki, K., Tsuruo, T., Cowan, K. H., and Glazer, R. I. (1991). Transfection with protein kinase C alpha confers increased multidrug resistance to MCF-7 cells expressing P-glycoprotein. Cancer Commun 3,181-189. ( PubMed)
Konno, Y., Natsumeda, Y., Nagai, M., Yamaji, Y., Ohno, S., Suzuki, K. and Weber, G. : Expression of human IMP dehydrogenase types I and II in escherichia coli and distribution in human normal lymphocytes and leukemic cell lines. J. Biol. Chem., 266, 506-509, 1991.

1990

Sorimachi, H., Ohmi, S., Emori, Y., Kawasaki, H., Saido, T. C., Ohno, S., Minami, Y. and Suzuki, K : A novel member of the calcium-dependent cysteine protease family. J. Biol., Chem., 371, 171-176, 1990.
Suzuki, K., Sorimachi, H., Hata, A., Ohno, S., Emori, Y., Kawasaki, H., Saido, T. C., Imajoh-Ohmi, S. and Akita, Y. : Neurotoxicity of exitary amino acids, Calcium depemdemtprotease; a novel molecular species, regulation of gene expression and activation at the cell membrane. Ravan press, New York, 1990.
Suzuki, K. and Ohno, S. : Calcium activated neutral protease-Structure-function relationship and functional implications. Cell Structure and Function, 15, 1-6, 1990.
Radmark, O., Funk, C., Fu, J. Y., Matsumoto, T., Jornvall, H., Samuelsson, B., Minami, M., Ohno, S., Kawasaki, H., Seyama, Y., Suzuki, K., Shimizu, T. : Cloning of leukotriene A4 hydrolase cDNA. Methods in Enymology, 187, 486-491, 1990.
Osada, S., Mizuno, K., Saido, T. C., Akita, Y., Suzuki, K., Kuroki, T., and Ohno, S. (1990). A phorbol ester receptor/protein kinase, nPKC eta, a new member of the protein kinase C family predominantly expressed in lung and skin. J Biol Chem 265,22434-22440. ( PubMed)
Akita, Y., Ohno, S., Yajima, Y., and Suzuki, K. (1990). Possible role of Ca2(+)-independent protein kinase C isozyme, nPKC epsilon, in thyrotropin-releasing hormone-stimulated signal transduction: differential down-regulation of nPKC epsilon in GH4C1 cells. Biochem Biophys Res Commun 172,184-189. ( PubMed)
Ohno, S., Konno, Y., Akita, Y., Yano, A., and Suzuki, K. (1990). A point mutation at the putative ATP-binding site of protein kinase C alpha abolishes the kinase activity and renders it down-regulation-insensitive. A molecular link between autophosphorylation and down-regulation. J Biol Chem 265,6296-6300. ( PubMed)
Natsumeda, Y., Ohno, S., Kawasaki, H., Konno, Y., Weber, J. and Suzuki, K. : Two distinct cDNAs for human IMP dehydrogenase. J. Biol. Chem., 265, 5292-5295, 1990.
Akita, Y., Ohno, S., Konno, Y., Yano, A., and Suzuki, K. (1990). Expression and properties of two distinct classes of the phorbol ester receptor family, four conventional protein kinase C types, and a novel protein kinase C. J Biol Chem 265,354-362. ( PubMed)

1989

Minami, Y., Ohno, S., Suzuki, K., Ohnishi, N., Shimizu, T. and Seyama, Y. : Molecular cloning and expression of human leukotriene A4 hydorolace cDNA. Ravan press, New York, 1989.
Wada, H., Ohno, S., Kubo, K., Taya, C., Tsuji, S., Yonehara, S., and Suzuki, K. (1989). Cell type-specific expression of the genes for the protein kinase C family: down regulation of mRNAs for PKC alpha and nPKC epsilon upon in vitro differentiation of a mouse neuroblastoma cell line neuro 2a. Biochem Biophys Res Commun 165,533-538. ( PubMed)
Hata, A., Akita, Y., Konno, Y., Suzuki, K. and Ohno, S. : Direct evidence that the kinase activity of protein kinase C is involved in transcriptional activation through a TPA-responsive element. FEBS Lett., 252, 144-146, 1989.
Sorimachi, H., Imajoh-Ohmi, S., Emori, Y., Kawasaki, H., Ohno, S., Minami, Y. and Suzuki, K. : Molecular cloning of a novel mammalian calcium-dependent protease distinct from both m- and μ-types : specific expression of the mRNA in skeletal muscle. J. Biol. Chem., 264, 20106-20111, 1989.
Konno, Y., Ohno, S., Akita, Y., Kawasaki, H., and Suzuki, K. (1989). Enzymatic properties of a novel phorbol ester receptor/protein kinase, nPKC. J Biochem (Tokyo) 106,673-678. ( PubMed)
Konno, Y., Ohno, S., Akita, Y., Saito, F., Yamamoto. K., Furusho, T. and Suzuki, K. : Detection of deletions in DNA by slotblot hybridization : application to Duchenne muscular dystrophr gene. Biomedical Res., 10, 65-69, 1989.
Asano, T., Shibasaki, Y., Ohno, S., Taira, H., Lin, J.-L., Kasuga, M., Kanagawa, Y., Akanuma, Y., Takaku, F. and Oka, Y. : Rabbit brain glucose transporter responds to insulin when expressed in insulin-sensitive CHO cells. J. Biol. Chem., 264, 3416-3420 , 1989.

Kubo, K., Ohno, S., Matsumoto, S., Yahara, I., and Suzuki, K. (1989). A novel yeast gene coding for a putative protein kinase. Gene 76,177-80. ( PubMed)

1988

Mizuguchi, J., Nakabayashi, H., Yoshida, Y., Huang, K. P., Uchida, T., Sasaki, T., Ohno, S., and Suzuki, K. (1988). Increased degradation of protein kinase C without diminution of mRNA level after treatment of WEHI-231 B lymphoma cells with phorbol esters. Biochem Biophys Res Commun 155, 1311-1317. ( PubMed)
Ohno, S., Akita, Y., Konno, Y., Imajoh, S., and Suzuki, K. (1988). A novel phorbol ester receptor/protein kinase, nPKC, distantly related to the protein kinase C family. Cell 53,731-741. ( PubMed)
Ohno, S., Kawasaki, H., Konno, Y., Inagaki, M., Hidaka, H., and Suzuki, K. (1988). A fourth type of rabbit protein kinase C. Biochemistry 27,2083-2087. ( PubMed)

1987

Kubo, K., Ohno, S., and Suzuki, K. (1987). Nucleotide sequence of the 3' portion of a human gene for protein kinase C beta I/beta II. Nucleic Acids Res 15,7179-7180. ( PubMed)
Ohno, S., Kawasaki, H., Imajoh, S., Suzuki, K., Inagaki, M., Yokokura, H., Sakoh, T., and Hidaka, H. (1987). Tissue-specific expression of three distinct types of rabbit protein kinase C. Nature 325, 161-166. ( PubMed)
Ohno, S., Aoshima, M., Matsumoto, S., Yahara, I., and Suzuki, K. (1987). A yeast gene coding for a putative protein kinase homologous to cdc25 suppressing protein kinase. FEBS Lett 222,279-285. ( PubMed)

(Publications after the molecular cloning of PKC in 1987 at the Tokyo Metropolitan Institute of Medical Science) Updated in 03.02.14 by Ohno S

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