研究業績

2024年

2023年


Ogawa T, Matsumura T, Yao T, Kimura H, Hashimoto K, Ishikawa-Yamauchi Y, Sato T. Improvements in in vitro spermatogenesis: oxygen concentration, antioxidants, tissue-form design, and space control. J Reprod Dev. 2023 Dec 23. doi: 10.1262/jrd.2023-093.

Hashimoto K, Odaka H, Ishikawa-Yamauchi Y, Nagata S, Nakamura H, Kimura H, Sato T, Makiyama K, Ogawa T. Culture-space control is effective in promoting haploid cell formation and spermiogenesis in vitro in neonatal mice. Sci Rep. 2023 Jul 31; 13(1): 12354. doi: 10.1038/s41598-023-39323-y.

Matsumura T, Katagiri K, Yao T, Ishikawa-Yamauchi Y, Nagata S, Hashimoto K, Sato T, Kimura H, Shinohara T, Sanbo M, Hirabayashi M, Ogawa T. Generation of rat offspring using spermatids produced through in vitro spermatogenesis. Sci Rep. 2023 Jul 26;13(1):12105. doi: 10.1038/s41598-023-39304-1.

Feng X, Matsumura T, Yamashita Y, Sato T, Hashimoto K, Odaka H, Makino Y, Okada Y, Nakamura H, Kimura H, Fujii T, Ogawa T. In vitro spermatogenesis in isolated seminiferous tubules of immature mice. PLoS One 2023 Apr 6;18(4): e0283773. doi: 10.1371/journal.pone.0283773.

2022年

Oba T, Okamoto S, Ueno Y, Matsuo M, Tadokoro T , Kobayashi S, Yasumura K, Kagimoto S, Inaba Y, Taniguchi H. In vitro elastic cartilage reconstruction using human auricular perichondrial chondroprogenitor cell-derived micro 3D spheroids.
J Tissue Eng. 2022 Dec 23;13:20417314221143484. doi: 10.1177/20417314221143484.

Koike N, Tadokoro T , Ueno Y, Okamoto S, Kobayashi T, Murata S, Taniguchi H. Development of the nervous system in mouse liver.
World J Hepatol. 2022 Feb 27;14(2):386-399. doi: 10.4254/wjh.v14.i2.386.

2021年

Tadokoro T , Tanaka K, Osakabe S, Kato M, Kobayashi H, Hogan BLM, Taniguchi H. Dorso-ventral heterogeneity in tracheal basal stem cells. Biol Open. 2021 Sep 15;10(9):bio058676. doi: 10.1242/bio.058676. Epub 2021 Sep 14.

Ishikura Y, Ohta H, Sato T , Murase Y, Yabuta Y, Kojima Y, Yamashiro C, Nakamura T, Yamamoto T, Ogawa T , Saitou M. In vitro reconstitution of the whole male germ-cell development from mouse pluripotent stem cells. Cell Stem Cell 2021 Sep 1; S1934-5909 (21) 00342-8. doi: 10.1016/j.stem.2021.08.005. Online ahead of print.

Qiu R , Murata S, Cheng C, Mori A, Nie Y, Mikami S, Hasegawa S, Tadokoro T, Okamoto S , Taniguchi H. A Novel Orthotopic Liver Cancer Model for Creating a Human-like Tumor Microenvironment. Cancers (Basel) 2021 Aug 8;13(16):3997. doi: 10.3390/cancers13163997

Higuchi K, Matsumura T , Akiyama H, Kanai Y,  Ogawa T , Sato T . Sertoli cell replacement in explanted mouse testis tissue supporting host spermatogenesis. Biol Reprod. 2021 May 31:ioab104. doi: 10.1093/biolre/ioab104. Online ahead of print.PMID: 34057178

Matsumura TSato T, Abe T, Sanjo H, Katagiri K, Kimura H, Fujii T, Tanaka H, Hirabayashi M, Ogawa T. Rat in vitro spermatogenesis promoted by chemical supplementations and oxygen-tension controlScientific Reports 2021 Feb 10

Mori A, Murata S, Tashiro N, Tadokoro T, Okamoto S, Otsuka R, Wada H, Murata T, Takahashi T, Seino KI, Taniguchi H. Establishment of Human Leukocyte Antigen-Mismatched Immune Responses after Transplantation of Human Liver Bud in Humanized Mouse Models. Cells. 2021 Feb 23; 10(2): 476.

2020年

Abe T, Nishimura H, Sato T, Suzuki H, Ogawa T, Suzuki T. Transcriptome analysis reveals inadequate spermatogenesis and immediate radical immune reactions during organ culture in vitro spermatogenesis. Biochem Biophys Res Commun 2020 Oct 1; 530(4):732-738.

Sanjo H, Yao T, Katagiri KSato TMatsumura TKomeya M, Yamanaka H, Yao M, Matsuhisa A, Asayama Y, Ikeda K, Kano K, Aoki J, Arita M, Ogawa T. Antioxidant vitamines and lysophospholipids are critical for inducing mouse spermatogenesis under organ culture conditions. FASEB J.  2020 Jul;34(7):9480-9497

Enomura M, Murata S, Terado Y, Tanaka M, Kobayashi S, Oba T, Kagimoto S, Yabuki Y, Morita K, Uemura T, Maegawa J, Taniguchi H. Development of a Method for Scaffold-Free Elastic Cartilage Creation. Int J Mol Sci. 2020 Nov 11; 21(22): 8496.

Qiu R, Murata S, Oshiro K, Hatada Y, Taniguchi H. Transplantation of fetal liver tissue coated by ultra-purified alginate gel over liver improves hepatic function in the cirrhosis rat model. Sci Rep. 2020 May 19; 10(1): 8231.

Matsuo M, Murata S, Hasegawa S, Hatada Y, Ohtsuka M, Taniguchi H. Novel liver fibrosis model in Macaca fascicularis induced by thioacetamide. Sci Rep. 2020 Feb 12; 10(1): 2450.

Tsuchida T, Murata S, Hasegawa S, Mikami S, Enosawa S, Hsu HC, Fukuda A, Okamoto S, Mori A, Matsuo M, Kawakatsu Y, Matsunari H, Nakano K, Nagashima H, Taniguchi H. Investigation of Clinical Safety of Human iPS Cell-Derived Liver Organoid Transplantation to Infantile Patients in Porcine Model. Cell Transplant. 2020 Jan-Dec; 29: 963689720964384.

2019年

Ogawa T. Live Offspring after Testis Tissue Transplantation. N Engl J Med. 2019 Oct 10; 381(15): 1477-1479.

Tsuchida T, Murata S, Matsuki K, Mori A, Matsuo M, Mikami S, Okamoto S, Ueno Y, Tadokoro T, Zheng YW, Taniguchi H. The Regenerative Effect of Portal Vein Injection of Liver Organoids by Retrorsine/Partial Hepatectomy in Rats. Int J Mol Sci. 2019 Dec 26; 21(1): 178.

2018年

Kojima K, Nakamura H, Komeya M, Yamanaka H, Makino Y, Okada Y, Akiyama H, Torikai N, Sato T, Fujii T, Kimura H, Ogawa T. Neonatal testis growth recreated in vitro by two-dimensional organ-spreading. Biotechnol Bioeng. doi: 10.1002/bit.26822. (2018).

Yamanaka H, Komeya M, Nakamura H, Sanjo H, Sato T, Yao M, Kimura H, Fujii T, Ogawa T. A monolayer microfluidic device supporting mouse spermatogenesis with improved visibility. Biochem Biophys Res Commun. 500: 885-891 (2018).

Nie YZ, Zheng YW, Miyakawa K, Murata S, Zhang RR, Sekine K, Ueno Y, Takebe T, Wakita T, Ryo A, Taniguchi H. Recapitulation of hepatitis B virus-host interactions in liver organoids from human induced pluripotent stem cells. EBioMedicine. 2018 Sep; 35: 114-123.

2017年

Komeya M, Hayashi K, Nakamura H, Yamanaka H, Sanjo H, Kojima K, Sato T, Yao M, Kimura H, Fujii T, Ogawa T. Pumpless microfluidic system driven by hydrostatic pressure induces and maintains mouse spermatogenesis in vitro. Sci Rep. Nov 13;7(1):15459 (2017)

2016年

Kojima K, Sato T, Naruse Y, Ogawa T. Spermatogenesis in Explanted Fetal Mouse Testis Tissues. Biol Reprod. 95(3); 63 (2016).

Komeya M, Kimura H, Nakamura H, Yokonishi T, Sato T, Kojima K, Hayashi K, Katagiri K, Yamanaka H, Sanjo H, Yao M, Kamimura S, Inoue K, Ogonuki N, Ogura A, Fujii T, Ogawa T. Long-term ex vivo maintenance of testis tissues producing fertile sperm in a microfluidic device. Sci Rep. Feb 19; 6: 21472. (2016)

2015年

Sato T, Sakuma T, Yokonishi T, Katagiri K, Kamimura S, Ogonuki N, Ogura A, Yamamoto T, Ogawa T. Genome Editing in Mouse Spermatogonial Stem Cell Lines Using TALEN and Double-Nicking CRISPR/Cas9. Stem Cell Reports Jul 14; 5(1): 75-82. (2015)

Sato T, Katagiri K, Kojima K, Komeya M, Yao M, Ogawa T. In Vitro Spermatogenesis in Explanted Adult Mouse Testis Tissues. PlosONE. Jun 12; 10(6): e0130171. (2015)

2014年

Yokonishi T, Sato TKomeya MKatagiri K, Kubota Y, Nakabayashi K, Hata K, Inoue K, Ogonuki N, Ogura A, Ogawa T. Offspring production with sperm grown in vito from cryopreserved testis tissues Nature Communications. 5, 4320. (2014)

2013年

Sato TKatagiri K, Kubota Y, Ogawa T. In vitro sperm production from mouse spermatogonial stem cell lines using an organ culture method. Nature protoc. 8, 2098-2104. (2013)

Yokonishi T, Sato TKatagiri KKomeya M, Kubota Y, Ogawa T. In Vitro Reconstruction of Mouse Seminiferous Tubules Supporting Germ Cell Differentiation. Biol Reprod. 89(1):15, 1-6 (2013)

2012年
Sato T, Yokonishi T, Komeya MKatagiri K, Kubota Y, Matoba S, Ogonuki N, Ogura A, Yoshida S, Ogawa T. Testis tissue explantation cures spermatogenic failure in c-Kit ligand mutant mice. Proc Natl Acad Sci U S A. 109, 16934-16938 (2012).

2011年
Sato TKatagiri K, Yokonishi T, Kubota Y, Inoue K, Ogonuki N, Matoba S, Ogura A, Ogawa TIn vitro production of fertile sperm from murine spermatogonial stem cell lines. Nature Communications 2, 472 (2011).

Sato TKatagiri K, Gohbara A, Inoue K, Ogonuki N, Ogura A, Kubota Y, Ogawa TIn vitro production of functional sperm in cultured neonatal mouse testes. Nature 471, 504-507 (2011).

2010年

Gohbara A, Katagiri KSato T, Kubota Y, Kagechika H, Araki Y, Araki Y, Ogawa T. In Vitro Murine Spermatogenesis in an Organ Culture System. Biology of Reproduction 83: 261-267 (2010).