Iwata A, Maruyama J, Shibata N, Nishiyama A, Tamura T, Tanaka M, Shichino S, Seki T, Komai T, Okamura T, Fujio K, Tanaka M, Asano K. Egr2 drives the differentiation of Ly6Chi monocytes into fibrosis-promoting macrophages in metabolic dysfunction-associated steatohepatitis in mice. Commun. Biol. 2024
Hiranuma R, Sato R, Yamaguchi K, Nakamizo S, Asano K, Shibata T, Fukui R, Furukawa Y, Kabashima K, Miyake
K. Aberrant
monocytopoiesis drives granuloma development in sarcoidosis. Int Immunol 2024
Anami T, Pan C, Fujiwara Y, Komohara Y, Yano H, Saito Y, Sugimoto M, Wakita D, Motoshima T, Murakami Y, Yatsuda
J,
Takahashi N, Suzu S, Asano K, Tamada K, Kamba T. Dysfunction of sinus macrophages in tumor-bearing host
induces
resistance to immunotherapy. Cancer Sci 2024
2023年
Ikeda N, Kubota H, Suzuki R, Morita M, Yoshimura A, Osada Y, Kishida K, Kitamura D, Iwata A, Yotsumoto S,
Kurotaki D,
Nishimura K, Nishiyama A, Tamura T, Kamatani T, Tsunoda T, Murakawa M, Asahina Y, Hayashi Y, Harada H, Harada Y,
Yokota
A, Hirai H, Seki T, Kuwahara M, Yamashita M, Shichino S, Tanaka M, Asano K. The early neutrophil-committed
progenitors aberrantly differentiate into immunoregulatory monocytes during emergency myelopoiesis. Cell
Rep 2023
Asano K, Kikuchi K, Takehara M, Ogasawara M, Yoshioka Y, Ohnishi K, Iwata A, Shimizu S, Tanaka M.
Identification of small compounds that inhibit multiple myeloma proliferation by targeting c-Maf transcriptional
activity. Biochem Biophys
Res Commun 2023
2022年
Song X, Li N, Liu Y, Wang Z, Wang T, Tan S, Li C, Qiu C, Gao L, Asano K, Tanaka M, Liang X, Liu X, Ma C.
CD169-positive
macrophages enhance abscopal effect of radiofrequency ablation therapy in liver cancer. Transl Oncol
2022
Kurematsu C, Sawada M, Ohmuraya M, Tanaka M, Kuboyama K, Ogino T, Matsumoto M, Oishi H, Inada H, Ishido Y,
Sakakibara Y,
Nguyen HB, Thai TQ, Kohsaka S, Ohno N, Yamada MK, Asai M, Sokabe M, Nabekura J, Asano K, Tanaka M, Sawamoto
K. Synaptic
pruning of murine adult-born neurons by microglia depends on phosphatidylserine. J Exp Med 2022
Camara A, Lavanant AC, Abe J, Desforges HL, Alexandre YO, Girardi E, Igamberdieva Z, Asano K, Tanaka M,
Hehlgans T,
Pfeffer K, Pfeffer S, Mueller SN, Stein JV, Mueller CG. CD169(+) macrophages in lymph node and spleen critically
depend
on dual RANK and LTbetaR signaling. Proc Natl Acad Sci U S A 2022
2021年
Takahashi N, Kikuchi H, Usui A, Furusho T, Fujimaru T, Fujiki T, Yanagi T, Matsuura Y, Asano K, Yamamoto K,
Ando F, Susa
K, Mandai S, Mori T, Rai T, Uchida S, Arita M, Sohara E. Deletion of Alox15 improves kidney dysfunction and
inhibits
fibrosis by increased PGD(2) in the kidney. Clin Exp Nephrol 2021
Shibuya T, Kamiyama A, Sawada H, Kikuchi K, Maruyama M, Sawado R, Ikeda N, Asano K, Kurotaki D, Tamura T,
Yoneda A,
Imada K, Satoh T, Akira S, Tanaka M, Yotsumoto S. Immunoregulatory Monocyte Subset Promotes Metastasis Associated
With
Therapeutic Intervention for Primary Tumor. Front Immunol 2021
Ogawa K, Asano K, Yotsumoto S, Yamane T, Arita M, Hayashi Y, Harada H, Makino-Okamura C, Fukuyama H, Kondo
K, Yamasoba
T, Tanaka M. Frontline Science: Conversion of neutrophils into atypical Ly6G(+) SiglecF(+) immune cells with
neurosupportive potential in olfactory neuroepithelium. J Leukoc Biol 2021
Honda F, Tsuboi H, Ono Y, Abe S, Takahashi H, Ito K, Yamada K, Kawano M, Kondo Y, Asano K, Tanaka M,
Malissen M,
Malissen B, Matsumoto I, Sumida T. Pathogenic roles and therapeutic potential of the CCL8-CCR8 axis in a murine
model of
IgG4-related sialadenitis. Arthritis Res Ther 2021
Grabowska J, Affandi AJ, van Dinther D, Nijen Twilhaar MK, Olesek K, Hoogterp L, Ambrosini M, Heijnen DAM, Klaase
L,
Hidalgo A, Asano K, Crocker PR, Storm G, van Kooyk Y, den Haan JMM. Liposome induction of CD8(+) T cell
responses
depends on CD169(+) macrophages and Batf3-dependent dendritic cells and is enhanced by GM3 inclusion. J
Control Release 2021
Friedrich SK, Schmitz R, Bergerhausen M, Lang J, Duhan V, Hardt C, Tenbusch M, Prinz M, Asano K, Bhat H,
Hamdan TA, Lang
PA, Lang KS. Replication of Influenza A Virus in Secondary Lymphatic Tissue Contributes to Innate Immune
Activation.
Pathogens 2021
2020年
Utz SG, See P, Mildenberger W, Thion MS, Silvin A, Lutz M, Ingelfinger F, Rayan NA, Lelios I, Buttgereit A,
Asano
K,
Prabhakar S, Garel S, Becher B, Ginhoux F, Greter M. Early Fate Defines Microglia and Non-parenchymal Brain
Macrophage
Development. Cell 2020
Uchida Y, Nishitai G, Kikuchi K, Shibuya T, Asano K, Tanaka M. CD204-positive monocytes and macrophages
ameliorate
septic shock by suppressing proinflammatory cytokine production in mice. Biochem Biophys Rep 2020
Maeta M, Miura N, Tanaka H, Nakamura T, Kawanishi R, Nishikawa Y, Asano K, Tanaka M, Tamagawa S, Nakai Y,
Tange K,
Yoshioka H, Harashima H, Akita H. Vitamin E Scaffolds of pH-Responsive Lipid Nanoparticles as DNA Vaccines in
Cancer
and
Protozoan Infection. Mol Pharm 2020
Friedrich SK, Schmitz R, Bergerhausen M, Lang J, Cham LB, Duhan V, Haussinger D, Hardt C, Addo M, Prinz M,
Asano
K, Lang
PA, Lang KS. Usp18 Expression in CD169(+) Macrophages is Important for Strong Immune Response after Vaccination
with
VSV-EBOV. Vaccines (Basel) 2020
Arai Y, Asano K, Mandai S, Ando F, Susa K, Mori T, Nomura N, Rai T, Tanaka M, Uchida S, Sohara E. WNK1-TAK1
signaling
suppresses lipopolysaccharide-induced cytokine production and classical activation in macrophages. Biochem
Biophys Res
Commun 2020
2019年以前
Takeya H, Ohnishi K, Shiota T, Saito Y, Fujiwara Y, Yagi T, Kiyozumi Y, Baba Y, Yoshida N, Asano K,
Tanaka
M, Baba H, Komohara Y. Maf expression in human macrophages and lymph node sinus macrophages in patients with
esophageal cancer. J Clin Exp Hematop 2019
Miyagawa T, Hasegawa K, Aoki Y, Watanabe T, Otagiri Y, Arasaki K, Wakana Y, Asano K, Tanaka M, Yamaguchi
H,
Tagaya M, Inoue H. MT1-MMP recruits the ER-Golgi SNARE Bet1 for efficient MT1-MMP transport to the plasma
membrane.
J Cell Biol 2019
Dodo K, Kuboki E, Shimizu T, Imamura R, Magarisawa M, Takahashi M, Tokuhiro T, Yotsumoto S, Asano K,
Nakao
S, Terayama N, Suda T, Tanaka M, Sodeoka M. Development of a Water-Soluble Indolylmaleimide Derivative IM-93
Showing
Dual Inhibition of Ferroptosis and NETosis. ACS Med Chem Lett 2019
Camara A, Cordeiro OG, Alloush F, Sponsel J, Chypre M, Onder L, Asano K, Tanaka M, Yagita H, Ludewig B,
Flacher V, Mueller CG. Lymph Node Mesenchymal and Endothelial Stromal Cells Cooperate via the RANK-RANKL Cytokine
Axis to Shape the Sinusoidal Macrophage Niche. Immunity 2019
Kikuchi K, Iida M, Ikeda N, Moriyama S, Hamada M, Takahashi S, Kitamura H, Watanabe T, Hasegawa Y, Hase K,
Fukuhara T, Sato H, Kobayashi EH, Suzuki T, Yamamoto M, Tanaka M, Asano K. Macrophages Switch Their
Phenotype
by Regulating Maf Expression during Different Phases of Inflammation. J Immunol 2018
Ikeda N, Asano K, Kikuchi K, Uchida Y, Ikegami H, Takagi R, Yotsumoto S, Shibuya T, Makino-Okamura C,
Fukuyama H, Watanabe T, Ohmuraya M, Araki K, Nishitai G, Tanaka M. Emergence of immunoregulatory Ym1(+)Ly6C(hi)
monocytes during recovery phase of tissue injury. Sci Immunol 2018
Deguchi Y, Nishina T, Asano K, Ohmuraya M, Nakagawa Y, Nakagata N, Sakuma T, Yamamoto T, Araki K, Mikami
T,
Tanaka M, Nakano H. Generation of and characterization of anti-IL-11 antibodies using newly established
Il11-deficient mice. Biochem Biophys Res Commun 2018
Asano K, Kikuchi K, Tanaka M. CD169 macrophages regulate immune responses toward particulate materials in
the circulating fluid. J Biochem 2018
Itoh M, Suganami T, Kato H, Kanai S, Shirakawa I, Sakai T, Goto T, Asakawa M, Hidaka I, Sakugawa H, Ohnishi K,
Komohara Y, Asano K, Sakaida I, Tanaka M, Ogawa Y. CD11c+ resident macrophages drive hepatocyte
death-triggered liver fibrosis in a murine model of nonalcoholic steatohepatitis. JCI Insight 2017
Arai Y, Takahashi D, Asano K, Tanaka M, Oda M, Ko SBH, Ko MSH, Mandai S, Nomura N, Rai T, Uchida S,
Sohara
E. Salt suppresses IFNgamma inducible chemokines through the IFNgamma-JAK1-STAT1 signaling pathway in proximal
tubular cells. Sci Rep 2017
Matsushita N, Suzuki M, Ikebe E, Nagashima S, Inatome R, Asano K, Tanaka M, Matsushita M, Kondo E, Iha H,
Yanagi S. Regulation of B cell differentiation by the ubiquitin-binding protein TAX1BP1. Sci Rep
2016
Tanaka M, Asano K. The physiological roles of dead cell clearance. Nihon Rinsho 2015
Motomura Y, Kanno S, Asano K, Tanaka M, Hasegawa Y, Katagiri H, Saito T, Hara H, Nishio H, Hara T,
Yamasaki
S. Identification of Pathogenic Cardiac CD11c+ Macrophages in Nod1-Mediated Acute Coronary Arteritis.
Arterioscler Thromb Vasc Biol 2015
Karasawa K, Asano K, Moriyama S, Ushiki M, Monya M, Iida M, Kuboki E, Yagita H, Uchida K, Nitta K, Tanaka
M. Vascular-resident CD169-positive monocytes and macrophages control neutrophil accumulation in the kidney with
ischemia-reperfusion injury. J Am Soc Nephrol 2015
Inoue H, Matsuzaki Y, Tanaka A, Hosoi K, Ichimura K, Arasaki K, Wakana Y, Asano K, Tanaka M, Okuzaki D,
Yamamoto A, Tani K, Tagaya M. gamma-SNAP stimulates disassembly of endosomal SNARE complexes and regulates
endocytic
trafficking pathways. J Cell Sci 2015
Asano K, Takahashi N, Ushiki M, Monya M, Aihara F, Kuboki E, Moriyama S, Iida M, Kitamura H, Qiu CH,
Watanabe T, Tanaka M. Intestinal CD169(+) macrophages initiate mucosal inflammation by secreting CCL8 that
recruits
inflammatory monocytes. Nat Commun 2015
Taguchi K, Okada A, Kitamura H, Yasui T, Naiki T, Hamamoto S, Ando R, Mizuno K, Kawai N, Tozawa K, Asano
K,
Tanaka M, Miyoshi I, Kohri K. Colony-stimulating factor-1 signaling suppresses renal crystal formation. J Am
Soc Nephrol 2014
Asano K, Nabeyama A, Miyake Y, Qiu CH, Kurita A, Tomura M, Kanagawa O, Fujii S, Tanaka M. CD169-positive
macrophages dominate antitumor immunity by crosspresenting dead cell-associated antigens. Immunity
2011
Tanaka M, Asano K, Qiu CH. Immune regulation by apoptotic cell clearance. Ann N Y Acad Sci
2010
Nabeyama A, Kurita A, Asano K, Miyake Y, Yasuda T, Miura I, Nishitai G, Arakawa S, Shimizu S, Wakana S,
Yoshida H, Tanaka M. xCT deficiency accelerates chemically induced tumorigenesis. Proc Natl Acad Sci U S
A 2010
Okamoto Y, Christen T, Shimizu K, Asano K, Kihara S, Mitchell RN, Libby P. Adiponectin inhibits allograft
rejection in murine cardiac transplantation. Transplantation 2009
Utomo A, Hirahashi J, Mekala D, Asano K, Glogauer M, Cullere X, Mayadas TN. Requirement for Vav proteins
in
post-recruitment neutrophil cytotoxicity in IgG but not complement C3-dependent injury. J Immunol
2008
Tsuboi N, Asano K, Lauterbach M, Mayadas TN. Human neutrophil Fcgamma receptors initiate and play
specialized nonredundant roles in antibody-mediated inflammatory diseases. Immunity 2008
Tanaka M, Miyake Y, Asano K. Maintenance of self-tolerance by apoptotic cell clearance. Front
Biosci 2008
Shimizu K, Libby P, Shubiki R, Sakuma M, Wang Y, Asano K, Mitchell RN, Simon DI. Leukocyte integrin Mac-1
promotes acute cardiac allograft rejection. Circulation 2008
Lauterbach M, O'Donnell P, Asano K, Mayadas TN. Role of TNF priming and adhesion molecules in neutrophil
recruitment to intravascular immune complexes. J Leukoc Biol 2008
Miyake Y, Asano K, Kaise H, Uemura M, Nakayama M, Tanaka M. Critical role of macrophages in the marginal
zone in the suppression of immune responses to apoptotic cell-associated antigens. J Clin Invest
2007
Asano K, Miwa M, Miwa K, Hanayama R, Nagase H, Nagata S, Tanaka M. Masking of phosphatidylserine inhibits
apoptotic cell engulfment and induces autoantibody production in mice. J Exp Med 2004
