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2017年 8月現在

2017年

論文発表

  • Kim JH, Eguchi H, Umemura M, Sato I, Yamada S, Hoshino Y, Masuda T, Aoki I, Sakurai S, Yamamoto M, and Ishikawa Y: Magnetic metal complex-conducting copolymer core-shell nanoassemblies for single-drug anticancer platform. NPG Asia Materials. 9;e367, doi:10.1038/am.2017.29,2017. [Link]
  • Yokoyama U, Tonooka Y, Koretake R, Akimoto T, Gonda Y, Saito J, Umemura M, Fujita T, Sakuma S, Arai F, Kaneko M, and Ishikawa Y: Arterial graft with elastic layer structure grown from cells. Sci.Rep. 7;40, doi:10.1038/s41598-017-00237-1,2017. [Link]
  • Ohtake M, Umemura M, Sato I, Akimoto T, Oda K, Nagasako A, Kim JH, Fujita T, Yokoyama U, Nakayama T, Hoshino Y, Ishiba M, Tokura S, Hara M, Muramoto T, Yamada S, Masuda T, Aoki I, Takemura Y, Murata H, Eguchi H, Kawahara N, and Ishikawa Y: Hyperthermia and chemotherapy using Fe(Salen) nanoparticles might impact glioblastoma treatment. Sci.Rep. 20;7:42783, doi:10.1038/srep42783,2017. [Link]
  • Kim JH, Eguchi H, and Ishikawa Y: Anticancer luminescent gold quantum clusters for in situ cancer-selective marking-imaging-targeting.Nanoscale. 9;9071-9082, doi:10.1039/c7nr02229h,2017. [Link]
  • Jin H, Fujita T, Jin MF, Kurotani R, Namakata I, Hamaguchi S, Hidaka Y, Cai WQ, Suita K, Ohnuki Y, Mototani Y, Shiozawa K, Prajapati R, Liang C, Umemura M, Yokoyama U, Sato M, Tanaka H, Okumura S, and Ishikawa Y: Cardiac overexpression of Epac1 in transgenic mice rescues lipopolysaccharide-induced cardiac dysfunction and inhibits Jak-STAT pathway. J.Mol.Cell.Cardiol. 108;170-180, doi:10.1016/j.yjmcc.2017.05.014,2017. [Link]
  • Mogi Y, Abedin T, Ahmed S, Gill G, Al Mamun M, Kanda H, Ishikawa Y, and Turin TC. Social Networking Sites for Peer-Driven Health Communication: Diabetes Related Communities in Google+. Diabetol.Int. in press.
  • Ohigashi A, Ahmed S, Afzal AR, Shigeta N, Tam-Tham H, Kanda H, Ishikawa Y, and Turin TC. Breast cancer information communicated on a public online platform: an analysis of 3Yahoo! Answer Japan2. J.Prim Health Care. in press.
  • Umemura M, Kim JH, Hoshino Y, Fkumura H, Nakakaji R, Sato I, Ohtake M, Akimoto T, Narikawa M, Tanaka R, Fujita T, Yokoyama U,Taguri M, Okumura S, Sato M, Eguchi H, and Ishikawa Y. The iron chelating agent, deferoxamine detoxifies Fe(Salen)-induced cytotoxicity. J Pharmacol Sci. in press 2017.
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2016年

論文発表

  • Chetprayoon P, Michiya Matsusaki M, Yokoyama U, Tejima T, Ishikawa Y, and Akashi M: Three-dimensional arterial models predict the in vivo behavior of nanoparticles for drug delivery. Angew Chem Int Ed Engl. 55(14):4461-6, 2016. [Link]
  • Shimura D, Kusakari Y, Sasano T, Nakashima Y, Nakai G, Jiao Q, Jin M, Yokota T, Ishikawa Y, Nakano A, Goda N, and Minamisawa S: Heterozygous deletion of sarcolipin maintains normal cardiac function. Am J Physiol Heart Circ Physiol. 310(1):H92-H103, 2016. [Link]
  • Cai W, Fujita T, Hidaka Y, Jin H, Suita K, Liang C, Prajapati R, Masanari Umemura M, Yokoyama U, Sato M, Okumura S and Ishikawa Y:Disruption of Epac1 protects the heart from adenylyl cyclase type 5-mediated cardiac dysfunction. Biochem. Biophys. Res. Commun. 475(1):1-7, 2016. [Link]
  • Sato I, Umemura M, Mitsudo K, Fukumura H, Kim J-H, Hoshino Y, Nakashima H, Kioi M, Nakakaji R, Sato M, Fujita T, Yokoyama U, Okumura S, Oshiro H, Eguchi H, Tohnai I, and Ishikawa Y: Simultaneous hyperthermia-chemotherapy with controlled drug delivery using single-drug nanoparticles. Scientific Reports, 6:24629, 2016. [Link]
  • Ohnuki Y, Umeki D, Mototani Y, Shiozawa K, Nariyama M, Ito A, Kawamura N, Yagisawa Y, Jin H, Cai W, Suita K, Saeki Y, Fujita T, Ishikawa Y, and Okumura S: Role of phosphodiesterase 4 expression in the Epac1 signaling-dependent skeletal muscle hypertrophic action of clenbuterol. Physiol Rep. 4(10). pii: e12791, 2016. [Link]
  • Oda K,Umemura M,Nakakaji R,Tanaka R,Sato I,Nagasako A,Oyamada C,Baljinnyam E,Katsumata M,Xie L,Narikawa M,Yamaguchi Y,Akimoto T,Ohtake M,Fujita T,Yokoyama U,Iwatsubo K,Aihara M and Ishikawa Y:Transient receptor potential cation 3 channel regulates melanoma proliferation and migration.J Physiol Sci,DOI:10.1007/s12576-016-0480-1,2016. [Link]
  • Fujita S*,Yokoyama U*,Ishiwata R,Aoki R,Nagao K,Masukawa D,Umemura M,Fujita T,Iwasaki S,Nishimaki S,Seki K,Ito S,Goshima Y,Asou T,Masuda M,Ishikawa Y:Glutamate promotes contraction of the rat ductus arteriosus.Circ J,80:2388-2396,2016. *eaqual contribution [Link]
  • Nakamura T,Fujita T,Kishimura M,Suita K,Hidaka Y,Cai W,Umemura M,Yokoyama U,Uechi M,Ishikawa Y:Vidarabine,an anti-herpes virus agent,protects against the development of heart failure with relatively mild side effects on cardiac function in canine model of pacing-induced dilated cardiomyopathy.Circ J,80:2496-2505,2016. [Link]
  • Jin H,Fujita T,Jin M,Kurotani R,Hidaka Y,Cai W,Suita K,Prajapati R,Liang C,Ohnuki Y,Mototani Y,Umemura M,Yokoyama U,Sato M,Okumura S,Ishikawa Y:Epac activation inhibits IL-6-induced cardiac myocyte dysfunction.The Journal of Physiological Sciences,DOI:10.1007/s12576-016-0509-5,2016. [Link]
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2015年

論文発表

  • ★注目の論文 Eguchi H, Umemura M, Kurotani R, Fukumura H, Sato I, Kim J-H, Hoshino Y, Lee J, Amemiya N, Sato M, Hirata K, Sigh DJ, Masuda T, Yamamoto M, Urano T, Yoshida K, Tanigaki K, Yamamoto M, Sato M, Inoue S, Aoki I and Ishikawa Y: A magnetic anti-cancer compound for magnet-guided delivery and magnetic resonance imaging. Sci. Rep. 5:9194, 2015. [Link]
  • Oshiro H, Fukumura H, Nagahama K, Sato I, Sugiura K, Iobe H, Okiyama E, Nagao T, Nagashima Y, Aoki I, Yamanaka Y, Murakami A, Maegawa J, Chishima T, Ichikawa Y, Ishikawa Y, Nagai T, Nomura M, Ohashi K, and Okudela K: Establishment of successively transplantable rabbit VX2 cancer cells expressing enhanced green fluorescent protein. Med. Mol. Morphol. 48(1):13-23, 2015. [Link]
  • Kamide T, Okumura S, Ghosh S, Shinoda Y, Mototani Y, Ohnuki Y, Jin H, Cai W, Suita K, Sato I, Umemura M, Fujita T, Yokoyama U, Sato M, Frutani K, Kitano H, and Ishikawa Y: Oscillation of cAMP and Ca2+ in cardiac myocytes: a systems biology approach. J. Physiol. Sci. 65(2):195-200,2015. [Link]
  • Tsunematsu T, Okumura S, Mototani Y, Ohnuki Y, Jin H, Cai W, SuitaK, Sato I, Umemura M, Yokoyama U, Sato M, Fujita T, and Ishikawa Y: Coupling of beta1-adrenergic receptor to type 5 adenylyl cyclase and its physiological relevance in cardiac myocytes. Biochem. Biophys. Res. Commun. 13;458(3):531-5, 2015. [Link]
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2014年

論文発表

  • Yokoyama U, Minamisawa S, Shioda A, Ishiwata R, Jin MH, Masuda M, Asou T, Sugimoto Y, Aoki H, Nakamura T, and Ishikawa Y: Prostaglandin E2 Inhibits Elastogenesis in the Ductus Arteriosus via EP4 Signaling. Circulation, 28;129(4):487-96, 2014. [Link]
  • Ishiwata R, Yokoyama U, Matsusaki M, Yoshiya A, Kadowaki K, Ichikaww Y, Umemura M, Fujita T, Minamisawa S, Shimoda H, Mitsuru Akashi M, and Ishikawa Y: Three-Dimensional Multilayers of Smooth Muscle Cells as a New Experimental Model for Vascular Elastic Fiber Formation Studies. Atherosclerosis, 233;2:590?600, 2014. [Link]
  • Umemura M, Baljinnyam E, Feske S, De Lorenzo MS ,Lai-Hua Xie LH, Feng X, 1, Itoh K, Makino A, Fujita T,Yokoyama U, Iwatsubo M, Chen S, Goydos JS, Ishikawa Y, and Kousaku Iwatsubo K: Store-operated Ca2? entry (SOCE) Regulates Melanoma Proliferation and Cell Migration. Plos One, 9(2):e89292, 2014. [Link]
  • Sato M, Hiraoka M, Suzuki H, Sakima M, Mamun, AA, Yamane Y, Fujita T, Yokoyama U, Okumura S, and Ishikawa Y: Protection of Cardiomyocytes from the Hypoxia-mediated Injury by a Peptide Targeting the Activator of G-Protein Signaling 8. PlosOne ,14;9(3):e91980, 2014. [Link]
  • Tsutsumi YM, Tsutsumi R, Hirokawa YT, Sakai Y, Hamaguchi E, Ishikawa Y, Yokoyama U, Kasai A, Kambe N, and Tanaka K: Geranylgeranylacetone protects the heart via caveolae and caveolin-3. Life Sciences 101;43-48, 2014 [Link]
  • Okumura S, Fujita T, Cai W, Jin M, Namekata I, Mototani Y, Jin HL, Ohnuki Y, Tsuneoka Y, Kurotani R, Suita Km Kawakami Y, Hamaguchi S, Abe T, Kiyonari H, Tsunematsu T, Bai Y, Suzuki S, Hidaka Y, Umemura M, Ichikawa Y, Yokoyama U, Sato M, Ishikawa F, Izumi-Nakaseko H, Adachi-Akahane S, Tanaka H, and Ishikawa Y: Disruption of Epac1 decreasesphosphorylation of phospholamban and protects theheart against stresses. J. Clin. Invest. 2;124(6):2785-801, 2014. [Link]
  • Baljinnyam E, Umemura M, Chuang C, De Lorenzo M, Iwatsubo M, Chen S, Goydos J, Ishikawa Y, Whitelock J, Iwatsubo K: Epac1 increases migration of endothelial cells and melanoma cells via FGF2-mediated paracrine signaling. Pigment Cell & Melanoma Research 27:611-20, 2014. [Link]
  • Sato I, Umemura M, Mitsudo K, Kioi M, Nakashima H, Iwai T, Feng X, Oda K, Miyajima A, Makino A, Iwai M, Fujita T, Yokoyama U, Okumura S, Sato M, Eguchi H, Tohnai I, and Ishikawa Y: Hyperthermia generated with ferucarbotran (ResovistR) in an alternating magnetic field enhances cisplatin-induced apoptosis of cultured human oral cancer cells. J Physiol Sci. 64:177-83, 2014 [Link]
  • Fujiwara A, Hirawa N, Fujita M, Kobayashi Y, Okuyama Y, Yatsu K, Katsumata M, Yamamoto y, Ichihara N, Saka S, Toya Y, Yasuda G, Tabara Y, Miki T, Ueshima H, Ishikawa Y, and Umemura S: Impaired NO Production and Increased Blood Pressure in Systemic Heterozygous ATP2B1 Null Mice. J Hypertension 32:1415-23. 2014 [Link]
  • Oshiro H, Fukumura H, Nagahama K, Sato I, Sugiura K, Iobe H, Okiyama E, Nagao T, Nagashima Y, Aoki I, Yamanaka Y, Murakami A, Maegawa J, Chishima T, Ichikawa Y, Ishikawa Y, Nagai T, Nomura M, Ohashi K, and Okudela K: Establishment of successively transplantable rabbit VX2 cancer cells expressing enhanced green fluorescent protein. Medical Molecular Morphology in press, 2014
  • Ohsawa M, Tamura K, Wakui H, Maeda A, Dejima T, Kanaoka T, Azushima K, Uneda K, Tsurumi-Ikeya Y, Kobayashi R, Matsuda M, Uchida S, Toya Y, Kobori H, Nishiyama A, Yamashita A, Ishikawa Y, and Umemura S: Deletion of the angiotensin II type 1 receptor-associated protein enhances renal sodium reabsorption and exacerbates angiotensin II-mediated hypertension. Kidney International Sep;86(3):570-81. 2014 [Link]
  • Aoki R, Yokoyama U, Ichikawa Y, Taguri M, Kumagaya S, Ishiwata R, Yanai C, Fujita S, Umemura M, Fujita T, Okumura S, Sato M, Minamisawa S, Asou T, Masuda M, Iwasaki S, Nishimaki S, Seki K, Yokota S, and Ishikawa Y: Decreased serum osmolality promotes ductus arteriosus constriction. Cardiovasc. Res. 104:326-36, 2014 [Link]
  • Tsutsumi Y, Tsutsumi R, Hamaguchi E, Sakai Y, Kasai A, Ishikawa Y, Yokoyama U, and Tanaka K: Exendin-4 ameliorates cardiac ischemia/reperfusion injury via caveolae and caveolins-3. Cardiovascular Diabetology Sep 7;13(1):132. 2014 [Link]
  • Ishikawa Y: Obstructive Sleep Apnea and Hypertension; A New Way to Go. J Sleep Disorders Ther 3:4, 2014 [Link]
  • Ohnuki Y, Umeki D, Mototani Y, Jin H, Cai W, Shiozawa K, Suita K, Saeki Y, FujitaT, Ishikawa Y, and Okumura S: Role of Cyclic AMP Sensor Epac1 in Masseter Muscle Hypertrophy and Myosin Heavy Chain Transition Induced by 2-Adrenoceptor Stimulation. J. Physiol. 592(Pt 24):5461-75, 2014 [Link]
2013年

論文発表

  • Lai L , Yan L, Gao S, Hu CL, Hui G, Davidow A, Park M, Bravo C, Iwatsubo K, Ishikawa Y, Auwerx, J, Sinclair D, Vatner SF, and Vatner DE: Type 5 Adenylyl Cyclase Increases Oxidative Stress by Transcriptional Regulation of MnSOD via the Sirt1/FoxO3a Pathway. Circulation, 127(16):1692-701, 2013. [Link]
  • Eijkelkamp N, Linley JE, Torres JM, Bee L , Dickenson AH,Gringhuis M , Minett MS, Hong GS, Lee E, Oh U, Ishikawa Y, Zwartkuis FJ , Cox JJ, an Wood, JN:A role for Piezo2 in EPAC1-dependent mechanical allodynia. Nature Commun, 4:1682, 2013. [Link]
  • Vatner SF, Park M, Yan L, Lee G, Lai L, Iwatsubo K, Ishikawa Y, Pessin J, and Vatner DE: Adenylyl cyclase type 5 in cardiac disease, metabolism and aging, Adenylyl Cyclase Type 5 in Cardiac Disease, Metabolism and Aging. Am J Physiol Heart Circ Physiol, 305:H1-8, 2013. [Link]
  • Wang H, Heijnen CJ, van Velthoven CTJ, Willemen HLDM, Ishikawa Y, Zhang X, Sood AK, Vroon A, Eijkelkamp N, and Kavelaars A: Targeting GRK2/ Epac1 to prevent and treat chronic pain. J. Clin. Invest, Nov 15, 2013. [Link]
  • Lu D, Aroonsakool N, Yokoyama U, Patel HH, Insel PA: Increase in cellular cyclic AMP concentrations reverses the pro-fibrogenic phenotype of cardiac myofibroblasts: a novel therapeutic approach for cardiac fibrosis. Mol Pharmacol, Oct 1, 2013. [Epub ahead of print] [Link]
  • Yokoyama U, Iwatsubo K, Umemura M, Fujita T, Ishikawa Y: The prostanoid EP4 receptor and its signaling pathway. Pharmacol Rev, 65(3):1010-52, 2013. [Link]
  • Liu NM, Yokota T, Maekawa S, Lu P, Tei I, Taniguchi H, Yokoyama U, Kato T, Minamisawa S: Transcription profiles of endothelial cells in the rat ductus arteriosus during a perinatal period. PLoS ONE, 27:8(9):e73685, 2013. [Link]

就任

  • 横山 詩子:PLoS ONE academic editorに就任

受賞決定

  • 横山 詩子:第117回日本小児科学会学術集会(2014年4月12日 名古屋国際会議場)で「血管の分化発達の病態生理の解明とその分子標的治療の確立」 日本小児科学会学術研究賞受賞が決まりました。
2012年

論文発表

  • Jiao Q, Takeshima H, Ishikawa Y, and Minamisawa S: Sarcalumenin plays a critical role in age-related cardiac dysfunction due to decreases in SERCA2a expression and activity. Cell Calcium 51:31-39, 2012 [Link]
  • Umemura M, Ho D, Nozawa N, Balginnyam E, Iwatsubo K, Saito T, Endo T, Ishikawa Y, Umeura S, and Kimura K. Acute pulmonary embolism induced by renal obstruction with benign prostatic hyperplasia; Case Report Journal of Cardiology Cases. 5: e39-e43, 2012 [Link]
  • Umemura M, Ho D, Nozawa N, Balginnyam E, Iwatsubo K, Saito T, Endo T, Ishikawa Y, Umemura S, Kimura K: Acute myocardial infarction with isolated conus branch occlusion. J. Electrocardiol. 45:285-287, 2012 [Link]
  • Kobayashi Y, Hirawa N, Tabara Y, Muraoka H, Fujita M, Miyazaki N, Fujiwara A, Ichikawa Y, Yamamoto Y, Ichihara N, Saka S, Wakui H, Yoshida S, Yatsu K, Toya Y, Yasuda G, Kohara K, Kita Y, Takei K, Goshima Y, Ishikawa Y, Ueshima H, Miki T, and Umemura S: Mice Lacking Hypertension Candidate Gene ATP2B1 in Vascular Smooth Muscle Cells showSignificant Blood Pressure Elevation. Hypertension 59: 854-860, 2012 [Link]
  • Fukumura H, Sato M, Kezuka K, Sato I, Feng X, Okumura S, Fujita T, Yokoyama U, Eguchi H, Ishikawa Y, ad Saito T: Effect of ascorbic acid on reactive oxygen species production in chemotherapy and hyperthermia in prostate cancer cells. J. Physiol. Sci. 62:251-257, 2012 [Link]
  • Yokoyama U, Ishiwata R, Jin M-H, Kato Y, Suzuki O, Jin H, Ichikawa Y, Kumagaya S, Katayama Y, Fuijita T, Okumura S, Sato M, Sugimoto Y, Aoki H, Suzuki S, Masuda M, Minamisawa S, and Ishikawa Y: Inhibition of EP4 signaling attenuates aortic aneurysm formation. Plos One 7(5):e36724, 2012 [Link]
  • Iwatsubo K, Bravo C, Uechi M, Baljinnyam E, Nakamura T, Umemura M, Lai L, Gao S, Yan L, Park M, Qiu H, Okumura S, Iwatwsubo M, Vatner DE, Vatner SF, and Ishikawa Y: Prevention of heart failure in mice by an antiviral agent that inhibits type 5 cardiac adenylyl cyclase. Am. J. Physiol Heart Circ. Physiol. 15;302(12):H2622-8, 2012 [Link]
  • Ichikawa Y, Yokoyama U, Iwamoto M, Oshikawa J, Okumura S, Sato M, Yokota S, Masuda M, Asou T, and Ishikawa Y: Inhibition of Phosphodiesterase Type 3 Dilates the Rat Ductus Arteriosus without Inducing Intimal Thickening. Circ. J. 76(10):2456-64, 2012 [Link]
  • Matsusaki M, Kadowaki K, Adachi E, Sakura T, Yokoyama U, Ishikawa Y, and Akashi M. Morphological and Histological Evaluations of 3D-Layered Blood Vessel Constructs Prepared by Hierarchical Cell Manipulation. J. Biomaterials Sci. 23; 63-79, 2012 [Link]
2011年

論文発表

  • Fujita T, and Ishikawa Y: Apoptosis in heart failure. -The role of the beta-adrenergic receptor-mediated signaling pathway and p53-mediated signaling pathway in the apoptosis of cardiomyocytes. Circ. J .75: 1811-1818, 2011 [Link]
  • Jin M-H, Yokoyama U, Sato Y, Shioda A, Jiao Q, Ishikawa Y and Minamisawa S: DNA microarray profiling identified a new role of growth hormone in vascular remodeling of rat ductus arteriosus. J. Physiol. Sci. 61:167-179, 2011 [Link]
  • Kurotani R, Okumura S, Matsubara T, Yokoyama U, Buckley JR, Tomita T, Kezuka K, Nagano T, Esposito D, Taylor TE, Gillette WK, Ishikawa Y, Abe H, Ward JM, and Kimura S: Secretoglobin 3A2 suppresses bleomycin-induced pulmonary fibrosis by TGFbeta signaling down-regulation. J. Biol. Chem. 286; 19682-19692, 2011 [Link]
  • Sato M, Yokoyama U, Fujita T, Okumura S and Ishikawa Y: The roles of cytochrome P450 in ischemic heart disease. Current Drug Metabolism 12:526-532. 2011 [Link]
  • Balkommyam E, Umemura S, De Lorenzo MS, Iwatsubo M, Chen S,Goydos JS, Iwatsubo K : Epac1 Promotes Melanoma Metastasis via Modification of Heparan Sulfate. Pigment Cell Melanoma Res. 24(4); 680-687, 2011. [Link]
  • Sato M, Hiraoka M, Suzuki H, Bai Y, Kurotani R, Yokoyama U, Okumura S, Cismowski MJ, Lanier SM, Ishikawa Y: Identification of Transcription Factor E3 (TFE3) as a Receptor- independent Activator of Gα16: GENE REGULATION BY NUCLEAR Gα SUBUNIT AND ITS ACTIVATOR. J. Biol. Chem. 286(20):17766-17776, 2011. [Link]

受賞

  • 金 美花:第89回日本生理学会大会 ポスターアワード受賞
2010年

論文発表

  • Sato M and Ishikawa Y: Accesory proteins for heterotrimeric G protein: Implication in the cardiovascular system. Pathophysiology. 17: 89-99, 2010.
  • Yokoyama U, Minamisawa S, and Ishikawa Y: Regulation of vascular tone and remodeling of the ductus arteriosus.J. Smooth Muscle Res. 46(2):77-87, 2010. [Link]
  • Yokoyama U, Minamisawa S, Katayama A, Tang T, Suzuki S, Iwatsubo K, Iwasaki S, Kurotani R, Okumura S, Sato M, Yokota S, Hammond HK, and Ishikawa Y: Differential regulation of vascular tone and remodeling via stimulation of type 2 and type 6 adenylyl cyclases in the ductus arteriosus.Circ. Res. 106:1882-1892, 2010. [Link]
  • Guellich A, Vatner DE, Gao S, Hong C, Yan L, Wagner TE, Dhar S, Ghaleh B, Hittinger L, Kosaku Iwatsubo K, Ishikawa Y, and Vatner SF: Effect of cardiac overexpression of type 6 adenylyl cyclase affects on the response to chronic pressure overload. Am. J. Physiol.Heart Circ. Physiol. 299(3): H707-712, 2010. [Link]
  • Suzuki S, Yokoyama U, Abe T, Kiyonari H, Yamashita N, Kurotani R, Sato M, Okumura S, and Ishikawa Y: Differential roles of Epac in regulating cell death in neuronal and myocardiacl cells. J. Biol. Chem. 285:24248-24259, 2010. [Link]
  • Kurotani R, Kumaki N, Linnoila RI, Ward JM, Kimura S:SCGB3A2/UGRP1 is a novel carcinoma marker for mouse pulmonary tumorigenesis. Lung Cancer, 2010 in press [Link]
  • Otsu K, Toya Y, Oshikawa J, Kurotani R, Yazawa T, Sato M, Yokoyama U, Umemura S, Minamisawa S, Okumura S, and Ishikawa Y: Caveolin gene transfer improves glucose metabolisms in diabetic mice. Am. J. Physiol. Cell Physiol. 298(3):C450-456, 2010. (selected as Editorial Focus C442-445, 2010).
  • Kheirbek MA, Beeler JA, Chi W, Ishikawa Y, and Zhuang X: A molecular dissociation between cued and contextual appetitive learning. Learn. Mem.17:148-154, 2010. [Link]
  • 黒谷玲子, 福村英信, 佐藤格, 江口晴樹, 石川義弘: 磁性体を利用した薬剤送達法. 磁気と健康. 23: 10-13, 2010.

受賞

  • 佐藤元彦:第10回医学奨励賞(学術奨励賞) 旭川医科大学
  • 福村英信:第43回日本骨軟部腫瘍学会(2010年7月15日~16日)で優秀ポスター賞 「磁性体粒子を用いた温熱化学療法の開発」
  • 金 美花:第75回日本循環器学会総会 国際留学生 Young Investigators Award受賞
2009年

論文発表

  • Shimada C, Kurotani R, Fukumura H, Ono S, Eguchi H, Ishikawa Y: Drug delivery system using magnetic materials. 日本病態生理学会雑誌. 第18巻第1号, 24-27, 2009.
  • Kawagoe T, Takeuchi O,Takabatake Y,Kato H, Isaka Y,Tsujimura T & Akira S: TANK is a negative regulator of Toll-like receptor signaling and is critical for the prevention of autoimmune nephritis. Nature Immunology. 10(9): 965-972, 2009. [Link]
  • Matsushita K, Takeuchi O, Standley DM, Kumagai Y, Kawagoe T, Miyake T, Sato T, Kato H, Tsujimura T, Nakamura H, Akira S: Zc3h12a is an RNase essential for controlling immune responses by regulating mRNA decay. Nature. 458(7242): 1185-1190, 2009. [Link]
  • Okumura S, Suzuki S, Ishikawa Y: New aspects for the treatment of cardiac deseases based on the diversity of functional controls on cardiac muscles:effects of targeted disruption of the type 5 adenylyl cyclase gene. J. Pharmacol Sci. 109(3): 354-359, 2009. [Link]
  • Sato M, Honda T,Jiao Q, Kurotani R, Toyota E, Okumura S, Yakeya T, Minamisawa S, Lanier SM, Ishikawa Y: Activator of G protein signaling 8 (AGS8) is required for hypoxia-induced apoptosis of cardiomyocytes: Role of Gbetagamma and connexin 43(CX43). J. Biol. Chem. 284:31431-31440, 2009. [Link]
  • Ebina T, Ishikawa Y, Uchida K, Suzuki S, Imoto K, Okuda J, Tsukahara K, Hibi K, Kosuge M, Sumita S, Mochida Y, Ishikawa T, Uchino K, Umemura S, and Kimura K: A case of giant coronary aneurysm and literature review. J. Cardiol. 53: 293-300, 2009 [Link]
  • Jiao Q, Bai Y, Akaike T, Takeshima H, Ishikawa Y, and Minamisawa S: Sarcalumenin is essential for maintaing cardiac function during endurance exercise training. Am. J. Physiol. Heart Circ. Physiol. 297: H576-82, 2009. [Link]
  • Akaike T, Jin MH, Yokoyama U, Izumi-Nakaseko H, Jiao Q, Iwasaki S, Iwamoto M, Nishimaki S, Sato M, Yokota S, Kamiya Y, Adachi-Akahane S, Ishikawa Y and Minamisawa S: T-type Ca2+ channels promote oxygenation-induced closure of the rat ductus arteriosus not only by vasoconstriction but also by neointima formation. J. Biol. Chem. 284:24025-24034, 2009. [Link]
  • Hu CL, Chandra R, Ge H, Pain J, Yan L, Babu G, Depre C, Ishikawa Y, Sadoshima J, Vatner SF, and Vatner DE: Adenylyl cyclase type 5 protein expression during cardiac development. Am. J. Physiol. Heart Circ. Physiol. 297: H1776-1782, 2009. [Link]
  • Baljinnyam E, Iwatsubo K, Kurotani R, Wang X, Ulucan C, Iwatsubo M, Lagunoff D and Ishikawa Y: Epac Increases Melanoma cell migration by Heparan Sulfate-Related Mechanism. Am. J. Physiol. Cell Physiol. 297: C802-813, 2009. [Link]
  • Kheirbek M, Britt J, Beeler J, Ishikawa Y, McGehee D, and Zhuang X: Adenylyl cyclase type 5 is critical for corticostriatal plasticity and striatum-dependent learning. J. Neurosci. 29:12115-12124, 2009. [Link]
  • Hamanoue H, Rahayuningsih SE, Hirahara Y, Itoh J, Yokoyama U, Mizoguschi T, Saitsu H, Miyake N, Hirahara F, Matsumoto N: Genetic screening of 104 patients with congenitally malformed hearts revealed a fresh mutation of GATA4 in those with atrial septal defects. Cardiol Young. 19(5):482-485, 2009. [Link]
  • Kumamoto K, Fujita K, Kurotani R, Saito M, Unoki M, Hagiwara N, Shiga H, Bowman ED, Yanaihara N, Okamura S, Nagashima M, Miyamoto K, Takenoshita S, Yokota J, Harris CC: ING2 is upregulated in colon cancer and increases inbasion by enhanced MMP13 expression. Int J Cancer .125(6): 1306-1315, 2009. [Link]
  • Mann L, Heldman E, Bersudsky Y, Almog O, Belmaker RH, Ishikawa Y, Vatner SF, and Agam G. Inhibition of specific adenylyl cyclase isoforms by mood stabilizers may be related to their mechanism of action. Bipolar Disorders 11:885-896, 2009. [Link]
  • 佐藤元彦: G蛋白活性制御因子による三量体G蛋白の制御と病態への関与. 横浜医学. 60(1.2): 37-47, 2009.

受賞

  • 横山詩子 第二回女性研究者奨励賞 : 第73回日本循環器学会学術集会
    日本平滑筋学会 栗山熙賞 : 日本平滑筋学会
  • 島田千恵美(修士2年次) 日本病態生理学会奨励賞 : 第19回日本病態生理学会
2008年

論文発表

  • Tsutsumi YM, Horikawa YT, Jennings MM, Kidd MW, Niesman IR, Yokoyama U, Head BP, Hagiwara Y, Ishikawa Y, Miyanohara A, Patel PM, Insel PA, Patel HH, Roth DM. Cardiac-Specific Overexpression of Caveolin-3 Induces Endogenous Cardiac Protection by Mimicking Ischemic Preconditioning. Circulation. 4;118(19):1979-1988. 2008. [Link]
  • Yokoyama U, Minamisawa S, Quan H, Akaike T, Suzuki S, Jin M, Jiao Q, Watanabe M, Otsu K, Iwasaki S, Nishimaki S, Sato M, Ishikawa Y. Prostaglandin E2-activated Epac promotes neointimal formation of the rat ductus arteriosus by a process distinct from that of cAMP-dependent protein kinase A. J Biol Chem. 283(42): 28702-:28709. 2008 [Link]
  • Yokoyama U, Minamisawa S, Quan H, Akaike T, Jin M, Otsu K, Ulucan C, Wang X, Baljinnyam E, Takaoka M, Sata M, Ishikawa Y.Epac1 is upregulated during neointima formation and promotes vascular smooth muscle cell migration. Am. J. Physiol. Heart Circ. Physiol. 295(4): H1547-1555. 2008 [Link]
  • Okumura S, Tsunematsu T, Yunzhe B, Qibin J, Ono S, Suzuki S, Kurotani R, Sato M, Minamisawa S, Umemura S, and Ishikawa Y: Type 5 adenylyl cyclase plays a major role in regulating autonomic response to microgravity in the heart. J Appl Physiol. 105: 173-179, 2008. [Link]
  • Shimura M, Minamisawa S, Takeshima H, Bai Y, Mouri M, Umemura S, and Ishikawa Y: Sarcalumenin alleviates stress-induced cardiac dysfunction by improving Ca2+ handling of the sarcoplasmic reticulum. Cardiovascular Res. 77:362-370, 2008. [Link]
  • Horikawa Y, Patel HH, Tsusumi YM, Jennings M, Kidd MW, Hagiwara Y, Ishikawa Y, Insel PA, and Roth DM: Loss of caveolae and caveolin-3 expression prevents volatile anesthetic-induced myocardial protection from hypoxia and ischemia reperfusion injury. J. Mol. Cell. Cardiol. 44: 123-130, 2008. [Link]
  • Iwatsubo K and Ishikawa Y: Therapeutic targets for heart failure: Beyond beta-adrenergic and rennin-angiotensin sytem blockade. Recent Patent on Cardiovascular Drug Discovery. 3: 37-44, 2008. [Link]
  • Ishikawa Y and Kurotani R: Cardiac myosin light chain kinase; a new player in the regulation of myosin light chain in the heart. Circ Res. 102: 516-518, 2008. [Link]
  • Kheirbek MA , Beeler JA, Ishikawa Y and Zuang X : A cyclic AMP pathway selectively required for reward prediction. J.Neurosci. 28:11401-11408,2008. [Link]
  • Yokoyama U, Patel HH, Lai NC, Aroonsakool N, Roth DM, Insel PA: The cyclic AMP effector Epac Integrates Pro and Anti-fibrotic Signals. Proc Natl Acad Sci USA. 105(17):6383-6391, 2008. [Link]
  • Ahn SH, Shah YM, Inoue J, Morimura K, Kim I, Yim s, Lambert G, Kurotani R, Nagashima K, Gonzalez FJ, Inoue Y: Hepatocyte nuclear factor 4alpha in the intestinal epithelial cells protects against inflammatory bowel disease. Inflamm Bowel Dis. 14(7):908-920, 2008. [Link]
  • Kurotani R, Tomita T, Yang Q, Carlson BA, Chen C, Kimura S: Role of Secretoglobin (SCGB) 3A2 in Lung Development. Am J Respir Crit Care Med. 178(4):389-398, 2008. [Link]
  • Tomita T, Kido T, Kurotani R, Iemura SI, Sterneck E, Natsume T, Vinson C, Kimura S: CAATT/enhancer binding proteins alpha and delta interact with NKX2-1 to synergistically activate mouse secretoglobin 3A2 gene expression. J Biol Chem. 283(37):25617-25627, 2008. [Link]

受賞

  • 佐藤元彦   横浜医学会賞 : 横浜市立大学医学会
    循環制御医学会優秀演題賞 : 循環制御医学会
  • 横山詩子   Young Investigator's Awards : 2008年日本小児循環器学会
  • 黒谷玲子    呼吸器疾患研究賞 : 財団法人 横浜総合医学振興財団
  • 赤池徹      Young Investigator's Awards: The 4th Congress of Asian Society of Pediatric Research
2007年

論文発表

  • Iwasaki S, Minamisawa S, Yokoyama U, Akaike T, Quan H, Nagashima Y, Nishimaki S, Ishikawa Y, and Yokota S: Interleukin-15 Inhibits Smooth Muscle Cell Proliferation and Hyaluronan Production in Rat Ductus Arteriosus. Pediatr Res. 62:392-398, 2007. [Link]
  • Okumura S, Vatner DE, Kurotani R, Bai Y, Gao S, Yuan Z, Iwatsubo K, Ulucan C, Kawabe J, Ghosh K, Vatner FS, and Ishikawa Y: Disruption of Type 5 adenylyl cyclase enhances desensitization of the cyclic adenosine monophsphate signal and increases the Akt signal with chronic catecholamine stress. Circulation. 116:1776-1783, 2007. [Link]
  • Yokoyama U, Sato Y, Akaike T, Ishida S, Sawada J, Nagao T, Quan H, Jin M, Iwamoto M, Yokota S, Ishikawa Y, and Minamisawa S: Maternal vitamin A alters gene profiles and structural maturation of the rat ductus arteriosus. Physiol. Genmics. 31:139-157, 2007. [Link]
  • Ulucan C, Wang X, Baljinnyam E, Bai Y-Z, Okumura S, Sato M, Minamisawa S, Hirotani S, and Ishikawa Y: Developmental changes in gene expression of Epac and its upregulation in myocardial hypertrophy. Am.J.Physiol.Heart Circ.Physiol. 293(3):H1662-1672. 2007. [Link]
  • Iwatsubo K*, Suzuki S*, Li C, Tsunematsu T, Nakamura F, Okumura S, Sato M, Minamisawa S, Toya Y, Umemura S, and Ishikawa Y: Dopamine induces apoptosis in young, but not in neonatal, neurons via Ca (2+)-dependent signal. Am. J. Physiol. Cell. Physiol. 293:C1498-1508 2007 *equal contribution. [Link]
  • Nishizawa T, Shen Y-T, Rossi F, Hong C, Robbins J, Ishikawa Y, Sadoshima J, Vatner DE, and Vatner SF: Altered autonomic control in conscious transgenic rabbits with overexpressed cardiac Gsalpha. Am. J. Physiol. Heart Circ. Physiol. 292:H971-975, 2007. [Link]
  • Yan L, Vatner DE, Ivessa A, Ge H, Chen W, Hirotani S, Ishikawa Y, Sadoshima J, and Vatner SF: Type 5 adenylyl cyclase disruption increases longevity and protect against stress. Cell. 130:247-258, 2007. [Link]
  • Eguchi H, Iwatsubo K, and Ishikawa Y: Isoform-selective regulation of adenylyl cyclase by forskolin derivatives: Prediction of selectivity by computer-based analysis. Letters in Drug Design & Discovery. 4:434-441, 2007 [Link]
  • Ishikawa Y, Suzuki S, Ohtsu K, Coskun Ulucan, Iwatsubo K, and Eguchi H: cAMP-mediated regulation of CYP enzyme and its application in chemotherapy. Drug and Metabolism Letter. 1;176-178, 2007
  • Yuan C, Sato M, Lanier SM, Smrcka AV: Signaling by a non-dissociated comlex of G-protein beta gamma and alpha subunits stimulated by a receptor-independent activator of G protein signaling , AGS8. J Biol Chem. 282:19938-19947,2007. [Link]
  • Blumer JB, Sato M, Lanier SM: AGS3. UCSD-Nature Molecule Pages, 2007.
  • Que J, Okubo T, Goldenring JR, Nam Kt, Kurotani R, Morrisey EE, Taranova O, Pevny LH, Hogan BL: Multiple dose-dependent roles Sox2 in the patterning and differentiation of anterior foregut endoderm. Development. 134(13):2521-2531,2007. [Link]
2006年

論文発表

  • Nicol X, Bennis M, Ishikawa Y, Chang G, Reperant J, Storm DR, and Gaspar P: Role of the calcium modulated cyclases in the development of the retinal projections. Eur. J. Neurosci. 24;3401-3414.2006. [Link]
  • Yokoyama U, Minamisawa S, Hong Q, Segi-Nishida E, Ghatak S, Iwasaki S, Iwamoto M, Misra S, Tamura K, Hori H, Yokota S, Tool BP, Sugimoto Y, and Ishikawa Y :Chronic activation of the prostaglandin receptor EP4 promotes hyaluronan-mediated neointimal formation in the ductus arterious. J. Clin. Invest.116;3026-3034,2006. [Link]
  • Iwatsubo K, Okumura S, and Ishikawa Y: Drug therapy aimed at adenylyl cyclase to regulate cyclic nucleotide signaling Endor Metab Immune Disord Drug Targets, 6:239-247.2006.
  • Nishizawa T, Vatner SF, Hong C, Shen Y-T, Hardt SE, Robbins J. Ishikawa Y, Sadoshima J, Vatner SF, and Vatner DE: Overexpressed cardiac Gsalpha in rabbites. J. Mol. Cell. Cardiol. 41;44-50,2006. [Link]
  • Minamisawa S, Uemura N, Sato Y, Yokoyama U, Yamaguchi T, Inoue K, Nakagome M, Bat Y, Hori H, Shimizu M, Mochizuki S, and Ishikawa Y: Post-transcriptional down-regulation of sarcolipin mRNA by triiodothyronine in the atrial myocardium. FEBS Letters, Volume 580, 2247-2253. [Link]
  • Fujita T, Otsu K, Oshikawa J, Hori H, Minamisawa S, Umemura S, Kitamura H, Ito T, and Ishikawa Y: Caveolin-3 inhibits growth signal in cardiac myoblasts in a Ca2+- dependent manner. J. Cell. Mol. Med. 10; 2166-2224, 2006. [Link]
  • Kawabe J, Okumura S, Nathanson MA, Hasebe N and Ishikawa Y: Caveolin regulates microtubule polymerization in the vascular smooth muscle cells. Biochem. Biophys. Res. Commun. 342;164-169, 2006. [Link]
  • Yokoyama U, Minamisawa S, Adachi-Akahane S, Akaike T, Naguro I, Funakoshi K, Iwamoto M, Nakagome M, Uemura N, Hori H, Yokota S, Ishikawa Y: Multipule transcripts of Ca2+ channel subunits and a novel spliced variant of alpha 1C subunit in the rat ductus arterious. Am.J. Physiol. Heart Circ. Physiol. 290; H1660-1670, 2006. [Link]
  • Kitano S, Kageyama S, Nagata Y, Miyahara Y, Hiasa A, Naota H, Okumura S, Imai H, Shiraishi T, Masuya M, Nishikawa M, Sunamoto J, Akiyoshi K, Kanematsu T, Scotto AM, Murphy R, Hoffman EW, Old LJ, Shiku H: HER2-specific T-cell immune responses in patients vaccinated with truncated HER2 protein complexed with nanogels of cholesteryl pullulan. Clin Cancer Res.12(24):7397-7405,2006. [Link]
  • Naota H, Miyahara Y, Okumura S, Kuzushima K, Akatsuka Y, Hiasa A, Kitano S, Takahashi T, Yuta A, Majima y, Shiku H: Generation of peptide-specific CD8+T cells by phytohemaggulutinin-stimulated antigen-mRNA-transduced CD4+Tcells.J Immunol Methods, 314(1-2):54-66.2006. [Link]
  • Sato M, Cismowski MJ, Toyota E, Smrcka AV, Lucchesi PA, Chilian WM, Lanier SM: Identification of a receptor independent activator of G protein signaling(AGS8) in ischemic heart and its interaction with Gbetagamma. Proc Natl Acad Sci USA, 103:797-802, 2006. [Link]
  • Song KS, Peterson YK,Fredman A,Blumer JB,Sato M,Lanier SM: Identification and characterization of a G-protein regulatory motif in WAVE1. FEBS Lett, 580: 1993-1998, 2006. [Link]
  • Sato M, Blumer JB, Simon V, Lanier SM: Accessory proteins for G-proteins:Patners in signaling. Annu Rev Pharmacol Toxicol, 46:151-187, 2006.
2005年

論文発表

  • Ishikawa Y, Iwatsubo K, Tsunematsu T, and Okumura S: Genetic manipulation and functional analysis of cAMP signalling in cardiac muscle; implications for a new target of pharmacotherapy. Biochemical Society Transactions 33; 1337-40, 2005. [Link]
  • Shimura M, Yokoyama U, Umemura S, and Ishikawa Y: Mechanical Stress-dependent transcriptional regulation of sarcolipin gene in the rodent atrium. Biochem. Biophys. Res. Commun. 334;861-866, 2005. [Link]
  • Yoshida M, Minamisawa S, Shimura M, Komazaki S, Kume H, Zhang M, Matsumura K, Nishi M, Saito M, Saeki Y, Ishikawa Y, Yanagisawa T, and Takeshima H. Impaired Ca2+ store functions in skeletal and cardiac muscle cells from sarcalumenin-deficient mice. J. Biol.Chem. 280:3500-3506, 2005. [Link]
  • Tadano M, Edamatsu H, Minamisawa S, Yokoyama U, Ishikawa Y, Susuki N, Saito H, Setsu T, Terashima T, Maeda S, Sato T and Kataoka T: Congenital semilunar valvulogenesis defect in mice deficient in phospholipase Cepsilon. Mol. Cell. Biol. 25: 2191-9, 2005. [Link]
  • Ishikawa Y, Ohtsu K, and Oshikawa J: Caveolin; different roles for insulin signal? Cellular Signal 10; 1175-1182, 2005. [Link]
2004年

論文発表

  • Oshikawa J, Ohtsu K, Toya Y, Tsunematsu T, Hankins RW, Kawabe J, Minamisawa S, Umemura S, Hagiwara Y, Ishikawa Y: Insulin resistance in skeletal muscles of caveolin-3 null mice. Proc Natl. Acad. Sci. USA 101: 12670-12675, 2004. [Link]
  • Iwatsubo K, Minamisawa S, Tsunematsu T, Nakagome M, Toya Y, Tomlison JE, Uemura S, Scarborough RM, Levy DE, Ishikawa Y: Direct inhibition of type 5 adenylyl cyclase prevents myocardial apoptosis without functional deterioration. J. Biol. Chem. 279; 40938-40945, 2004. [Link]
  • Kawabe J, Okumura S, Lee MC, Sadoshima J, and Ishikawa Y: Translocation of caveolin regulates strech-induced extracellular signal-regulated kinase activity in vascular smooth muscle cells. Am. J. Physiol. 286; H1845-1852, 2004. [Link]
  • Nishizawa T, Iwase M, Kanazawa H, Ichihara S, Ichihara G, Nagata K, Obata K, Kitaichi K, Yokoi T, Watanabe M, Tsunematsu T, Ishikawa Y, Murohata T, and Yokota M: Myocardial oxidative stress may initiate impairment of β-adrenergic sinaling at the level of adenylyl cyclase in dilated cardiomyopathic hamsters. Circ. J. 68; 1051-1060, 2004.
  • Uemura N, Ohkusa T, Hamano K, Nakagome M, Hori H, Shimizu M, Matsuzaki M, Mochizuki S, Minamisawa S, and Ishikawa Y: Down-regulation of sarcolipin mRNA expression in the atrial tissue of patients with chronic atrial fibrillation. Eur. J. Clin. Invest 34; 723-730, 2004.
  • Minamisawa S, Sato Y, Cho MC: Calcium cycling proteins in heart failure, cardiomyopathy, and arrhythmias. Exp Mol Med 36: 193-203, 2004.
  • Iwamoto T, Iwatsubo K, Okumura S, Hashimoto Y, Tsunematsu T, Toya Y, Herve D, Uemura S, Ishikawa Y: Disruption of type 5 adenylyl cyclase negates the developmental increase in Galphaolf expression in the striatum. FEBS Lett 564; 153-156, 2004. [Link]
  • Minamisawa S, Oshikawa J, Takeshima H, Hoshijima M, Wang Y, Chien KR, Ishikawa Y, and Matsuoka R: Junctophilin type 2 is associated with caveolin-3 and is down-regulated in the hypertrophic and dilated cardiomyopathies. Biochem. Biophys. Res Commun. 325; 852-856, 2004.
  • Horie H, Kadoya T, Hikawa N, Sango K, Inoue H, Takeshita K, Asawa R, Hiroi T, Sato M, Yoshioka T, and Ishikawa Y: Oxidized galectin-1 stimulates macrophages to promote axonal regeneration in peripheral nerves after axotomy. J. Neuroscience. 24; 1873-1880, 2004. [Link]
  • Hikawa N, Ishikawa Y, and Takenaka T: Interleukin-12 p40-homodimer Production in sensory dorsal root ganglion neurons. Neuroscience 129; 75-83 2004.

著書

  • Ishikawa Y: A new Paradigm in cAMP signal. Cardiovascular Anesthesia Suppl. 8; 62-65,2004.
  • Hoshijima M, Minamisawa S, Yasukawa H, Chien KR: Molecular pathways for cardiac hypertrophy and heart failure progression in Molecular Basis of Cardiovascular Disease 2nd ed (ed Chien KR) pp273-292, 2004.
2003年

論文発表

  • Okumura S, Tkagi G, Kawabe J, Yang G, Lee MC, Hong C, Liu J, Vatner DE, Sadoshima J, Vatner SF, Ishikawa Y: Disruption of type 5 adenylyl cyclase gene preserves cardiac function against pressure overload. Proc Natl Acad Sci USA 100: 9986-90, 2003.
  • Okumura S, Kawabe J, Takagi G, Lee L, Hong C, Liu J, Takagi I, Sadoshima J, Yatani A, Vatner DE, Vatner SF,and Ishikawa Y: Type 5 adenylyl cyclase disruption alters not only sympathetic, but also parasympathetic and calcium-mediated regulation of cardiac function. Circ Res 93: 364-371, 2003. [Link]
  • Minamisawa S, Wang Y, Chen J, Ishikawa Y, Chien KR, and Matsuoka R: Atrial chamber-specific expression of sarcolipin is regulated during development and by hypertrophy. J Biol Chem 278: 9570-9575, 2003. [Link]
  • Iwamoto T, Okumura S, Iwatsubo K, Kawabe J, Ohtsu K, Sakai I, Hashimoto Y, Izumitani A, Sango K, Ajiki K, Toya Y, Uemura S, Goshima Y, Arai N, Vatner SF, and Ishikawa Y: Motor dysfunction in type 5 adenylyl cyclase null-mice. J Biol Chem 278: 16936-16940, 2003. [Link]
  • Iwatsubo K, Toya T, Fujita T, Ebina T, Schwencke C, Minamisawa S, Uemura S, Ishikawa Y. Ischemic preconditioning prevents ischemia-induced beta-adrenergic receptor sequestration. J. Mol. Cell. Cardiol. 35: 923-929, 2003. [Link]
  • Oshikawa J, Toya Y, Fujita T, Sakai I, Hashimoto Y, Kawabe J, Uemura S, Ishikawa Y: Nicotinic acetylcholine receptor alpha7 regulates cAMP signal via inhibiting a calcium-sensitive adenylyl cyclase isoform. Am. J. Physiol. 285: C567-574, 2003. [Link]
  • Takenaka T, Himura H, Hori H, Hashimoto Y, Ichikawa T, Kawakami T: Fatty acids as an energy source for the operation of axoplasmic transport. Brain Res 972: 38-43, 2003. [Link]
  • Iwatsubo K, Tao Y, Onda T, Toya Y, Schwencke C, Fujita T, Ebina T, Iwamoto T, Hori H, Minamisawa S, Uemura S, Ishikawa Y: Characterization of beta adrenergic receptor sequestration by newly developed whole cell binding assays. J. Cardiovasc. Pharmacol. 41: S53-56, 2003.
  • Minamisawa S, Sato Y, Tatsuguchi Y, Fujino T, Imamura S, Uetsuka Y, Nakazawa M, Matsuoka R: Mutation of the phosholanbam promter associated with hypertrophic cardiomyopathy. Biochem Biophys Res Commun 304: 1-4, 2003. [Link]
  • Ikoma E, Tsunematsu Y, Nakazawa I, Shiwa T, Hibi K, Ebina T, Mochida Y, Toya Y, Hori H, Uchino K, Minamisawa S, Kimura K, Umemura S, and Ishikawa Y: Polymorphism of the type 6 adenylyl cyclase gene and cardiac hypertrophy. J. Cardiovasc. Pharmacol. 42; S27-S32, 2003.
  • Iwatsubo K, Tsunematsu T, and Ishikawa Y: Inform-specific regulation of adenylyl cyclase; a potential target in future pharmacotherapy. Expert Opinion on Therapeutic Targets 7: 441-451, 2003.

著書

  • Ishikawa Y: Isoform-targeted regulation of cardiac adenylyl cyclase. J Cardiovasc Pharmacol. 41; S1-S4, 2003.
2002年
  • Jin GB, Hong T, Inoue S, urano T, Cho S, Otsu K, Kitahara M, Ouchi Y, Cyong JC: Augmentation of immune cell activity against tumor cells by Rauwolfia radix. J Ethnopharmacol 81: 365-372, 2002. [Link]