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2022年 12月現在

２０２２年

論文発表

  • Takeuchi M，Meguro A，Yoshida M，Yamane T，Yatsu K，Okada E，and Mizuki N：Longitudinal analysis of 5-year refractive changes in a large Japanese population．Sci Rep，8；2879，2022． [DOI]
  • Netomo H, Umemura M, Suzuki F, Nagasako A, Nagao K, Hidaka Y, Nakakaji R, Uchida K, Suzuki S, Masuda M, and Ishikawa Y：Store-operated calcium entry via ORAI1 regulates doxorubicin-induced apoptosis and prevents cardiotoxicity in cardiac fibroblasts [DOI]
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受賞

  • 循環制御医学：令和3年度ベストティーチャー賞(団体賞 基礎系)
  • 梅村将就：令和3年度ベストティーチャー賞(個人賞)
２０２１年

論文発表

  • Saito J, Yokoyama U, Nakamura T, Kanaya T, Ueno T, Naito Y, Takayama T, Kaneko M, Miyagawa S, Sawa Y, and Ishikawa Y: Scaffold-free tissue-engineered arterial grafts derived from human skeletal myoblasts. Artif Organs, 45(8)；919-932, 2021. [DOI]
  • Nakamura T, Yokoyama U, Kanaya T, Ueno T, Yoda T, Ishibe A, Hidaka Y, Umemura M, Takayama T, Kaneko M, Miyagawa S, Sawa Y, Endo I, and Ishikawa Y: Multilayered Human Skeletal Muscle Myoblast Sheets Promote the Healing Process After Colonic Anastomosis in Rats. Cell Transplant, 30; 1-15, 2021. [DOI]
  • Takahashi L, Ishigami T, Tomiyama H, Kato Y, Kikuchi H, Tasaki K, Yamashita J, Inoue S, Taguri M, Nagao T, Chikamori T, Ishikawa Y, and Yokoyama U: Increased plasma levels of myosin heavy chain 11 is associated with atherosclerosis. J Clin Med, 10(14); 3155, 2021. [DOI]
  • 【総説】Saito J, Kaneko M, Ishikawa Y, and Yokoyama U: Challenges and Possibilities of Cell-Based Tissue-Engineered Vascular Grafts. Cyborg and Bionic Systems, 2021(1532103); 1-16, 2021. [DOI]
  • 【総説】梅村将就, 成川雅俊, 田中　遼, 根本寛子, 中鍛治里奈, 永迫　茜, 石川義弘: ドキソルビシンの心臓線維芽細胞に注目した心毒性メカニズムの解明と治療戦略. 日本薬理学雑誌, 156（3)；146-151, 2021. [DOI]
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受賞

  • 大澤昂平：第18回鶴見大学歯学部同窓会最優秀論文賞
  • 梅村将就：2020年度横浜市立大学医学会医学会賞
  • 循環制御医学：令和２年度ベストティーチャー賞(団体賞 基礎系)
２０２０年

論文発表

  • Osawa K, Umemura M, Nakakaji R, Tanaka R, Islam R, Nagasako A, Fujita T, Yokoyama U, Koizumi T, Mitsudo K, and Ishikawa Y: Prostaglandin E2 receptor EP4 regulates cell migration through Orai1. Cancer Sci, 111(1); 160-174, 2020. [DOI]　2021年2月 第18回鶴見大学歯学部同窓会最優秀論文賞受賞
  • Nitta M，Ishikawa Y，Machida D，Masuda M，Tamura K，and Kimura K：Minimally invasive thoracoscopic surgery for scimitar syndrome variant．Asian Cardiovasc Thorac Ann，28(1); 48-51，2020． [DOI]　
  • Tanaka R, Umemura M, Narikawa M, Hikichi M, Osawa K, Fujita T, Yokoyama U, Ishigami T, Tamura K, and Ishikawa Y: Reactive fibrosis precedes doxorubicin‐induced heart failure through sterile inflammation. ESC Heart Failure, 7(2); 588-603, 2020. [DOI]　
  • Yokoyama U, Aoki R, Fujita S, Iwasaki S, Seki K, Asou T, Masuda M, Minamisawa S, and Ishikawa Y: New Insights on How to Treat Patent Ductus Arteriosus. Molecular Mechanism of Congenital Heart Disease and Pulmonary Hypertension, 259-264, 2020. [DOI]　
  • Kemmotsu T, Yokoyama U, Saito J, Ito S, Uozumi A, Iwasaki S, Nishimaki S, Ito S, Masuda M, Asou T, and Ishikawa Y: Antenatal Administration of Betamethasone Contributes to Intimal Thickening of the Ductus Arteriosus. Molecular Mechanism of Congenital Heart Disease and Pulmonary Hypertension, 265-266, 2020. [DOI]　
  • Ito S, Yokoyama U, Saito J, Masuda M, Asou T, and Ishikawa Y: Prostaglandin E-EP4-Mediated Fibulin-1 Up-regulation Plays a Role in Intimal Thickening of the Ductus Arteriosus. Molecular Mechanism of Congenital Heart Disease and Pulmonary Hypertension, 267-268, 2020. [DOI]　
  • Saito J, Yokoyama U, Takayama T, Ito H, Tadokoro T, Sugo Y, Kurasawa K, Ogawa M, Miyagi E, Taniguchi H, Kaneko M, and Ishikawa Y: Fabrication of Implantable Human Arterial Graft by Periodic Hydrostatic Pressure. Molecular Mechanism of Congenital Heart Disease and Pulmonary Hypertension, 289-291, 2020. [DOI]
  • Bender C, Sun X, Farooq M, Yang Q, Davison C, Maroteaux M, Huang Y, Ishikawa Y, and Liu S: Emotional Stress Induces Structural Plasticity in Bergmann Glial Cells via an AC5-CPEB3-GluA1 Pathway. J Neurosci, 40(17); 3374-3384, 2020. [DOI]　
  • Hiromi T, Yokoyama U, Kurotaki D, Mamun A, Ishiwata R, Ichikawa Y, Nishihara H, Umemura M, Fujita T, Yasuda S, Minami T, Goda M, Uchida K, Suzuki S, Takeuchi I, Masuda M, Breyer R, Tamura T, and Ishikawa Y: Excessive EP4 Signaling in Smooth Muscle Cells Induces Abdominal Aortic Aneurysm by Amplifying Inflammation. Arterioscler Thromb Vasc Biol, 40(6); 1559-1573, 2020. [DOI]　
  • Ito S, Yokoyama U, Nakakoji T, Cooley M, Sasaki T, Hatano S, Kato Y, Saito J, Nicho N, Iwasaki S, Umemura M, Fujita T, Masuda M, Asou T, and Ishikawa Y: Fibulin-1 Integrates Subendothelial Extracellular Matrices and Contributes to Anatomical Closure of the Ductus Arteriosus. Arterioscler Thromb Vasc Biol, 40(9); 2212-2226, 2020. [DOI]　
  • 【総説】Saito J, Ishikawa Y, and Yokoyama U: Role of Tissue-Type Plasminogen Activator in Remodeling of the Ductus Arteriosus. Circ Rep, 2(4); 211-217, 2020. [DOI]　
  • 【総説】石川義弘, 中村　隆, 小嶋朋之, 横山詩子: 心不全と血管モデルの研究開発. 循環器内科, 87(4); 495-500, 2020.
  • 【総説】内藤孝雄, 小部正人, 宮脇裕治, 武田　裕, 山末耕太郎, 杤久保修, 石川義弘: 就労者の生活習慣病に関連した健診データ可視化の提案. 医療情報学, 39(5); 257-266, 2020. [DOI]　
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就任

  • 石川義弘：一般社団法人 日本生理学会 理事長
  • 石川義弘：横浜市立大学 副学長（研究担当）2020年度

受賞

  • 大澤昂平：第38回日本口腔腫瘍学会総会・学術大会 優秀ポスター賞
  • 梅村将就：令和元年度横浜市立大学 学長表彰 奨励賞
  • 加藤優子他：第10回入澤宏・彩記念ＪＰＳ心臓・循環論文賞（入澤記念循環賞）
  • 梅村将就：令和元年度横浜市立大学 ベストティーチャー賞(2年生個人賞)
  • 中川路太一(平成30年度リサーチ・クラークシップ)：令和2年度医学部長賞　金賞
２０１９年

論文発表

  • Umemura M, Islam R, Fukumura H, Sato I, Kawabata Y, Matsuo K, Nakakaji R, Nagasako A, Ohtake M, Fujita T, Yokoyama U, Nakayama T, Eguchi H, and Ishikawa Y: Simultaneous hyperthermia-chemotherapy effect by arterial injection of Fe(Salen) for femur tumor. Cancer Sci, 110(1); 356-365, 2019. [DOI]　
  • Prajapati R, Fujita T, Suita K, Nakamura T, Cai W, Hidaka Y, Umemura M, Yokoyama U, Knollmann BC, Okumura S, and Ishikawa Y: Usefulness of Exchanged Protein Directly Activated by cAMP (Epac)1-Inhibiting Therapy for Prevention of Atrial and Ventricular Arrhythmias in Mice. Circ J, 83(2); 295-303, 2019. [DOI]　
  • Kemmotsu T, Yokoyama U, Saito J, Ito S, Uozumi A, Nishimaki S, Iwasaki S, Seki K, Ito S, Yoshihiro, and Ishikawa Y: Antenatal Administration of Betamethasone Contributes to Intimal Thickening of the Rat Ductus Arteriosus. Circ J, 83(3); 654-661, 2019. [DOI]　
  • Jin H, Fujita T, Jin M, Kurotani R, Hidaka Y, Cai W, Suita K, Prajapati R, Liang C, Ohnuki Y, Mototani Y, Umemura M, Yokoyama U, Sato M, Okumura S, and Ishikawa Y: Correction to: Epac activation inhibits IL-6- induced cardiac myocyte dysfunction. J Physiol Sci, 69; 557, 2019. [DOI]　
  • Kato Y, Yokoyama U, Fujita T, Umemura M, Kubota T, and Ishikawa Y: Epac1 deficiency inhibits basic fibroblast growth factor-mediated vascular smooth muscle cell migration. J Physiol Sci, 69(2); 175-184, 2019. [DOI]　2020年3月 第10回入澤宏・彩記念ＪＰＳ心臓・循環論文賞（入澤記念循環賞）受賞Link
  • Yasuda S, Goda M, Shibuya T, Uchida K, Suzuki S, Noishiki Y, Yokoyama U, Ishikawa Y, and Masuda M: An appropriately sized soft polyester external stent prevents enlargement and neointimal hyperplasia of a saphenous vein graft in a canine model. Artif Organs, 43(6); 577-583, 2019. [DOI]　
  • Cai W, Fujita T, Hidaka Y, Jin H, Suita K, Shigeta M, Kiyonari H, Umemura M, Yokoyama U, Sadoshima J, and Ishikawa Y: Translationally controlled tumor protein (TCTP) plays a pivotal role in cardiomyocyte survival through a Bnip3-dependent mechanism. Cell Death Dis, 10; 549, 2019. [DOI]　
  • Narikawa M, Umemura M, Tanaka R, Fujita T, Yokoyama U, Ishigami T, Kimura K, Tamura K, and Ishikawa Y: Doxorubicin induces trans-differentiation and MMP1 expression in cardiac fibroblasts via cell death-independent pathways. PLOS ONE, 14(9); e0221940, 2019. [DOI]　
  • 【総説】石川義弘, 吹田憲治, Prajapati R, 藤田孝之, 奥村　敏: 心房細動の新規治療標的. 心電図, 39(2); 155-159, 2019. [DOI]
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受賞

  • 梅村将就：平成30年度横浜市立大学 学長表彰 奨励賞
  • 秋本大輔：平成30年度横浜市立大学 医学研究科博士課程 優秀論文賞
  • 中鍛治里奈：平成30年度横浜市立大学 医学研究科博士課程 優秀論文賞
  • 梅村将就：平成30年度横浜市立大学 ベストティーチャー賞(2年生、3年生個人賞)
  • Jin H他：第9回入澤宏・彩記念ＪＰＳ心臓・循環論文賞（入澤記念循環賞）
  • 齋藤純一：日本循環器学会 小児循環器賞
  • 齋藤純一：日本新生児成育医学会 学術奨励賞
  • 伊藤智子：第51回日本結合組織学会学術大会 Young Investigator Award
  • 伊藤智子：第55回日本小児循環器学会総会・学術集会 会長賞 (口演の部)
  • 内藤孝雄：健康“生き活き”羅針盤リサーチコンプレックスのヘルスケアビジコンinKOBE 三井住友銀行賞
  • 大澤昂平：第29回日本病態生理学会大会 博士課程大学院生セッション 優秀賞
  • 内藤孝雄：電子情報通信学会 ヘルスケア・医療情報通信技術研究専門委員会(MICT) ヘルスケア・医療情報通信技術研究賞 企業奨励賞
２０１８年

論文発表

  • Saito J, Yokoyama U, Nicho N, Zheng YW, Ichikawa Y, Ito S, Umemura M, Fujita T, Ito S, Taniguchi H, Asou T, Masuda M, and Ishikawa Y: Tissue-type plasminogen activator contributes to remodeling of the rat ductus arteriosus. PLoS One, 13; e0190871, 2018. [DOI]　2019年3月 日本循環器学会小児循環器賞受賞
  • Jin H, Fujita T (co-first author), Jin M, Kurotani R, Hidaka Y, Cai W, Suita K, Prajapati R, Liang C, Ohnuki Y, Mototani Y, Umemura M, Yokoyama U, Sato M, Okumura S, and Ishikawa Y: Epac activation inhibits IL-6-induced cardiac myocyte dysfunction. J Physiol Sci, 68; 77-87, 2018. [DOI] 2019年3月 平成30年度第9回入澤宏・彩記念ＪＰＳ心臓・循環論文賞（入澤記念循環賞）受賞Link
  • Nakakaji R, Umemura M, Mitsudo K, Kim JH, Hoshino Y, Sato I, Masuda T, Yamamoto M, Kioi M, Koizumi T, Fujita T, Yokoyama U, Iida M, Sato M, Sato H, Murofushi S, Shibata S, Aoki I, Eguchi H, Tohnai I, and Ishikawa Y: Treatment of oral cancer using magnetized paclitaxel. Oncotarget, 9; 15591-15605, 2018. [DOI]2019年3月 平成30年度医学研究科博士課程優秀論文賞受賞
  • Narikawa M, Umemura M, Tanaka R, Fujita T, Yokoyama U, Ishigami T, Kimura K, Tamura K, and Ishikawa Y: Acute Hyperthermia Inhibits TGF-beta1-induced Cardiac Fibroblast Activation via Suppression of Akt Signaling. Sci Rep, 8; 6277, 2018. [DOI]
  • Masuda T, Ukiki M, Yamagishi Y, Matsusaki M, Akashi M, Yokoyama U, Arai F: Fabrication of engineered tubular tissue for small blood vessels via three-dimensional cellular assembly and organization ex vivo. J Biotechnol, 276-277; 46-53, 2018. [DOI]
  • Tanaka R, Umemura M, Narikawa M, Fujita T, Yokoyama U, Ishigami T, Kimura K, Tamura K, and Ishikawa Y: Hydrostatic pressure suppresses fibrotic changes via Akt/GSK-3 signaling in human cardiac fibroblasts. Physiol Rep, 6(9); e13687, 2018. [DOI]
  • Suita K, Fujita T (co-first author), Cai W, Hidaka Y, Jin H, Prajapati R, Umemura M, Yokoyama U, Sato M, Knollmann BC, Okumura S, and Ishikawa Y: Vidarabine, an anti-herpesvirus agent, prevents catecholamine-induced arrhythmias without adverse effect on heart function in mice. Pflug Arch Eur J Phy, 470(6); 923-935, 2018. [DOI]
  • Mamun A, Yokoyama U, Saito J, Ito S, Hiromi T, Umemura M, Fujita T, Yasuda S, Minami T, Goda M, Uchida K, Suzuki S, Masuda M, and Ishikawa Y: A selective antagonist of prostaglandin E receptor subtype 4 attenuates abdominal aortic aneurysm. Physiol Rep, 6(18); e13878, 2018. [DOI]
  • Yokoyama U, Arakawa N, Ishiwata R, Yasuda S, Minami T, Goda M, Uchida K, Suzuki S, Matsumoto M, Koizumi N, Taguri M, Hirano H, Yoshimura K, Ogino H, Masuda M, and Ishikawa Y: Proteomic analysis of aortic smooth muscle cell secretions reveals an association of myosin heavy chain 11 with abdominal aortic aneurysm. Am J Physiol Heart Circ Physiol, 315(4); H1012-H1018, 2018. [DOI]
  • Akimoto T, Umemura M, Nagasako A, Ohtake M, Fujita T, Yokoyama U, Eguchi H, Yamamoto T, and Ishikawa Y: Alternating magnetic field enhances cytotoxicity of Compound C. Cancer Sci, 109(11); 3483-3493, 2018. [DOI]2019年3月 平成30年度医学研究科博士課程優秀論文賞受賞
  • 【総説】 横山詩子, 齋藤純一, 石川義弘: 動脈管閉鎖におけるt-PA活性の役割. 日本血栓止血学会誌, 29(5); 495-497, 2018. [DOI]
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受賞

  • 大竹誠：平成29年度横浜市立大学 医学研究科博士課程 優秀論文賞
  • 梅村将就：平成29年度横浜市立大学 ベストティーチャー賞(2年生、3年生個人賞)
２０１７年

論文発表

  • Mogi Y, Abedin T, Ahmed S, Gill G, Al Mamun M, Kanda H, Ishikawa Y, and Turin TC: Social Networking Sites for Peer-Driven Health Communication: Diabetes Related Communities in Google+. Diabetology International, 8(3); 323-327, 2017. [DOI]　
  • Ohtake M, Umemura M, Sato I, Akimoto T, Oda K, Nagasako A, Kim JH, Fujita T, Yokoyama U, Nakayama T, Hoshino Y, Ishiba M, Tokura S, Hara M, Muramoto T, Yamada S, Masuda T, Aoki I, Takemura Y, Murata H, Eguchi H, Kawahara N,and Ishikawa Y: Hyperthermia and chemotherapy using Fe(Salen) nanoparticles might impact glioblastoma treatment. Sci Rep, 7; 42783, 2017. [DOI]平成29年度医学研究科博士課程優秀論文賞受賞
  • Akagi S, Nakamura K, Yokoyama U, Kasahara S, Sarashina T, Ejiri K, Sano S, and Ito H: Enhanced EP4 Expression in a Pulmonary Artery Aneurysm with Dissection in a Patient with Pulmonary Arterial Hypertension. Circ Cardiovasc Imaging, 10(2); e005839, 2017. [DOI]
  • Yokoyama U, Tonooka Y, Koretake R, Akimoto T, Gonda Y, Saito J, Umemura M, Fujita T, Sakuma S, Arai F, Kaneko M, and Ishikawa Y: Arterial graft with elastic layer structure grown from cells. Sci Rep, 7(1); 140, 2017. [DOI]
  • Kim JH, Eguchi H, Umemura M, Sato I, Yamada S, Hoshino Y, Masuda T, Aoki I, Sakurai K, Yamamoto M, and Ishikawa Y: Magnetic metal complex-conducting copolymer core-shell nanoassemblies for single-drug anticancer platform. NPG Asia Materials, 9; e367, 2017. [DOI]
  • Jin H, Fujita T, Jin M, Kurotani R, Namekata I, Hamaguchi S, Hidaka Y, Cai W, Suita K, Ohnuki Y, Mototani Y, Shiozawa K, Prajapati R, Liang C, Umemura M, Yokoyama U, Sato M, Tanaka H, Okumura S, and Ishikawa Y: Cardiac overexpression of Epac1 in transgenic mice rescues lipopolysaccharide-induced cardiac dysfunction and inhibits Jak-STAT pathway. J Mol Cell Cardiol, 108; 170-180, 2017. [DOI]
  • Ohigashi A, Ahmed S, Afzal AR, Shigeta N, Tam-Tham H, Kanda H, Ishikawa Y, and Turin TC: Breast cancer information communicated on a public online platform: an analysis of ‘Yahoo! Answer Japan’. J Prim Health Care, 9(2); 167-172, 2017. [DOI]
  • Oda K, Umemura M, Nakakaji R, Tanaka R, Sato I, Nagasako A, Oyamada C, Baljinnyam E, Katsumata M, Xie L, Narikawa M, Yamaguchi Y, Akimoto T, Ohtake M, Fujita T, Yokoyama U, Iwatsubo K, Aihara M, and Ishikawa Y: Transient receptor potential cation 3 channel regulates melanoma proliferation and migration. J Physiol Sci, 67; 497-505, 2017. [DOI]
  • Kim JH, Eguchi H, and Ishikawa Y: Anticancer luminescent gold quantum clusters for in situ cancer-selective marking-imaging-targeting. Nanoscale, 9; 9071-9082, 2017. [DOI]
  • Umemura M, Kim JH, Aoyama H, Hoshino Y, Fukumura H, Nakakaji R, Sato I, Ohtake M, Akimoto T, Narikawa M, Tanaka R, Fujita T, Yokoyama U, Taguri M, Okumura S, Sato M, Eguchi H, and Ishikawa Y: The iron chelating agent, deferoxamine detoxifies Fe(Salen)-induced cytotoxicity. J Pharmacol Sci, 134(4); 203-210, 2017. [DOI]
  • Ito S, Yokoyama U, Saito J, Sato S, Usuda H, Watanabe S, Kitanishi R, Miura Y, Saito M, Hanita T, Matsuda T, and Ishikawa Y: Attenuation of ductus arteriosus intimal thickening in preterm sheep twins compared with singletons. J Physiol Sci, 67(6); 723-729, 2017. [DOI]
  • Masukawa D, Koga M, Sezaki A, Nakao Y, Kamikubo Y, Hashimoto T, Okuyama-Oki Y, Aladeokin AC, Nakamura F, Yokoyama U, Wakui H, Ichinose H, Sakurai T, Umemura S, Tamura K, Ishikawa Y, and Goshima Y: L-DOPA sensitizes vasomotor tone by modulating the vascular alpha1-adrenergic receptor. JCI Insight, 2(18); e90903, 2017. [DOI]
  • Ohtake M, Tateishi K, Ikegaya N, Iwata J, Yamanaka S, and Murata H: Initial treatment for intracranial mycotic aneurysms：Two case reports and literature review. World Neurosurgery, 106; 1051.e9-1051.e16, 2017. [DOI]
  • 【総説】Fujita T, Umemura M, Yokoyama U, Okumura S, and Ishikawa Y: The role of epac in the heart. Cellular and molecular life sciences: Cell Mol Life Sci, 74; 591-606, 2017. [DOI]
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受賞

  • 中鍛冶里奈：第35回日本口腔腫瘍学会総会・学術大会　優秀ポスター賞
  • 齋藤純一：The 8th TAKAO International Symposium on Molecular Mechanism of Cardiopulmonary Disease　Poster Award
  • 吉田裕紀(平成29年度リサーチ・クラークシップ)：平成29年度医学部長賞　銀賞
２０１６年

論文発表

  • Shimura D, Kusakari Y, Sasano T, Nakashima Y, Nakai G, Jiao Q, Jin M, Yokota T, Ishikawa Y, Nakano A, Goda N, and Minamisawa S: Heterozygous deletion of sarcolipin maintains normal cardiac function. Am J Physiol Heart Circ Physiol, 310(1); H92-H103, 2016. [DOI]
  • Chetprayoon P, Matsusaki M, Yokoyama U, Tejima T, Ishikawa Y, and Akashi M: Use of three-dimensional arterial models to predict the in vivo behavior of nanoparticles for drug delivery. Angew Chem Int Ed Engl, 55(14); 4461-4466, 2016. [DOI]
  • Sato I, Umemura M, Mitsudo K, Fukumura H, Kim J, Hoshino J, Nakashima H, Kioi M, Nakakaji R, Sato M, Fujita T, Yokoyama U, Okumura S, Oshiro H, Eguchi H, Tohnai I, and Ishikawa Y: Simultaneous hyperthermia-chemotherapy with controlled drug delivery using single-drug nanoparticles. Sci Rep, 6; 24629, 2016. [DOI]
  • Cai W, Fujita T, Hidaka Y, Jin H, Suita K, Prajapati R, Liang C, Umemura M, Yokoyama U, Sato M, Okumura S, and Ishikawa Y: Disruption of Epac1 protects the heart from adenylyl cyclase type 5-mediated cardiac dysfunction. Biochem Biophys Res Commun, 475(1); 1-7, 2016. [DOI]
  • Fujita S*, Yokoyama U*, Ishiwata R, Aoki R, Nagao K, Masukawa D, Umemura M, Fujita T, Iwasaki S, Nishimaki S, Seki K, Ito S, Goshima Y, Asou T, Masuda M, and Ishikawa Y: Glutamate promotes contraction of the rat ductus arteriosus. Circ J, 80; 2388-2396, 2016. *eaqual contribution [DOI]
  • Nakamura T, Fujita T, Kishimura M, Suita K, Hidaka Y, Cai W, Umemura M, Yokoyama U, Uechi M, and Ishikawa Y: Vidarabine, an anti-herpes virus agent, protects against the development of heart failure with relatively mild side effects on cardiac function in canine model of pacing-induced dilated cardiomyopathy. Circ J, 80; 2496-2505, 2016. [DOI]
  • Ohnuki Y, Umeki D, Mototani Y, Shiozawa K, Nariyama M, Ito A, Kawamura N, Yagisawa Y, Jin H, Cai W, Suita K, Saeki Y, Fujita T, Ishikawa Y, and Okumura S: Role of phosphodiesterase 4 expression in the epac1 signaling-dependent skeletal muscle hypertrophic action of clenbuterol. Physiol Rep, 4(10); e12791, 2016. [DOI]
  • 【総説】赤池　徹, 梶村いちげ, 横山詩子, 南沢　享: 動脈管閉鎖のメカニズム－分子機序に基づく治療への再考. 日本小児科学会雑誌, 120; 1444-1452, 2016.
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２０１５年

論文発表

  • Oshiro H, Fukumura H, Nagahama K, Sato I, Sugiura K, Iobe H, Okiyama E, Nagao T, Nagashima Y, Aoki I, Yamanaka Y, Murakami A, Maegawa J, Chishima T, Ichikawa Y, Ishikawa Y, Nagai T, Nomura M, Ohashi K, and Okudela K: Establishment of successively transplantable rabbit VX2 cancer cells expressing enhanced green fluorescent protein. Medical Molecular Morphology, 48; 13-23, 2015. [DOI]
  • TsunematsuT, Okumura S, Mototani Y, Ohnuki Y, Jin H, Cai W, Suita K, Sato I, Umemura M, Yokoyama U, Sato M, Fujita T, and Ishikawa Y: Coupling of beta1-adrenergic receptor to type 5 adenylyl cyclase and its physiological relevance in cardiac myocytes. Biochemical and Biophysical Research Communications (BBRC), 458(3); 531-535, 2015. [DOI]
  • Kamide T, Okumura S, Ghosh S, Shinoda Y, Mototani Y, Ohnuki Y, Jin H, Cai W, Suita K, Sato I, Umemura M, Fujita T, Yokoyama U, Sato M, Furutani K, Kitano H, and Ishikawa Y: Oscillation of cAMP and Ca2+ in cardiac myocytes: a systems biology approach. J Physiol Sci, 65(2); 195-200, 2015. [DOI]
  • ★注目の論文　Eguchi H, Umemura M, Kurotani R, Fukumura H, Sato I, Kim J-H, Hoshino Y, Lee J, Amemiya N, Sato M, Hirata K, Sigh DJ, Masuda T, Yamamoto M, Urano T, Yoshida K, Tanigaki K, Yamamoto M, Sato M, Inoue S, Aoki I, and Ishikawa Y: A magnetic anti-cancer compound for magnet-guided delivery and magnetic resonance imaging. Sci Rep, 5; 9194, 2015. [DOI]
  • Kato Y, Yokoyama U, Yanai C, Ishige R, Kurotaki D, Umemura M, Fujita T, Kubota T, Okumura S, Sata M, Tamura T, and Ishikawa Y: Epac1 deficiency attenuated vascular smooth muscle cell migration and neointimal formation. Arterioscler Thromb Vasc Biol, 35(12); 2617-2625, 2015. [DOI]
  • Suita K, Fujita T, Hasegawa N, Cai W, Jin H, Hidaka Y, Prajapati R, Umemura M, Yokoyama U, Sato M, Okumura S, and Ishikawa Y: Norepinephrine-induced adrenergic activation strikingly increased the atrial fibrillation duration through β1- and α1-adrenergic receptor-mediated signaling in mice. PLoS One, 10(7); e0133664, 2015. [DOI]
  • 【総説】Yokoyama U: Prostaglandin E-mediated molecular mechanisms driving remodeling of the ductus arteriosus. Pediatr Int, 57(5); 820-827, 2015. [DOI]
  • 【総説】Yokoyama U, Ishiwata R, and Ishikawa Y: Eicosanoids and Aortic Aneurysm. Bioactive Lipid Mediators, Springer, 267-278, 2015. [DOI]
    • 　　　　　　　　　

受賞

  • 勝亦真弓：第92回日本生理学会大会 優秀演題賞
　　　　
２０１４年

論文発表

  • Yokoyama U, Minamisawa S, Shioda A, Ishiwata R, Jin MH, Masuda M, Asou T, Sugimoto Y, Aoki H, Nakamura T, and Ishikawa Y: Prostaglandin E2 inhibits elastogenesis in the ductus arteriosus via EP4 signaling. Circulation, 129(4); 487-96, 2014. [DOI]
  • Umemura M, Baljinnyam E, Feske S, De Lorenzo MS, Xie LH, Feng X, Oda K, Makino A, Fujita T, Yokoyama U, Iwatsubo M, Chen S, Goydos JS, Ishikawa Y, and Iwatsubo K: Store-operated Ca2? entry (SOCE) Regulates Melanoma Proliferation and CellMigration. PlosOne, 9(2); e89292, 2014. [DOI]
  • Sato I, Umemura M, Mitsudo K, Kioi M, Nakashima H, Iwai T, Feng X, Oda K, Miyajima A, Makino A, Iwai M, Fujita T, Yokoyama U, Okumura S, Sato M, Eguchi H, Tohnai I, and Ishikawa Y: Hyperthermia generated with ferucarbotran (ResovistR) in an alternating magnetic field enhances cisplatin-induced apoptosis of cultured human oral cancer cells. J Physiol Sci, 64(3); 177-83, 2014. [DOI]
  • Baljinnyam E, Umemura M, Chuang C, De Lorenzo M, Iwatsubo M, Chen S, Goydos J, Ishikawa Y, Whitelock J, and Iwatsubo K: Epac1 increases migration of endothelial cells and melanoma cells via FGF2-mediated paracrine signaling. Pigment Cell & Melanoma Research, 27(4); 611?620, 2014. [DOI]
  • Tsutsumi YM, Tsutsumi R, Hirokawa YT, Sakai Y, Hamaguchi E, Ishikawa Y, Yokoyama U, Kasai A, Kambe N, and Tanaka K: Geranylgeranylacetone protects the heart via caveolae and caveolin-3. Life Sciences, 101(1-2); 43-48, 2014. [DOI]
  • Ishiwata R, Yokoyama U, Matsusaki M, Asano Y, Kadowaki K, Ichikawa Y, Umemura M, Fujita T, Minamisawa S, Shimoda H, Akashi M, and Ishikawa Y: Three-dimensional multilayers of smooth muscle cells as a new experimental model for vascular elastic fiber formation studies. Atherosclerosis, 233; 590-600, 2014. [DOI]
  • Sato M, Hiraoka M, Suzuki H, Sakima M, Mamun AA, Yamane Y, Fujita T, Yokoyama U, Okumura S, Ishikawa Y: Protection of cardiomyocytes from the hypoxia-mediated injury by a Peptide targeting the activator of G-protein signaling 8. PLoS One, 9(3); e91980, 2014. [DOI]
  • Okumura S, Fujita T, Cai W, Jin M, Namekata I, Mototani Y, Jin H, Ohnuki Y, Tsuneoka Y, Kurotani R, Suita K, Kawakami Y, Hamaguchi S, Abe T, Kiyonari H, Tsunematsu T, Bai Y, Suzuki S, Hidaka Y, Umemura M, Ichikawa Y, Yokoyama U, Sato M, Ishikawa F, Izumi-Nakaseko H, Adachi-Akahane S, Tanaka H, and Ishikawa Y: Epac1-dependent phospholamban phosphorylation mediates the cardiac response to stresses. J Clin Invest, 124(6); 2785-2801, 2014. [DOI]
  • Fujiwara A, Hirawa N, Fujita M, Kobayashi Y, Okuyama Y, Yatsu K, Katsumata M, Yamamoto y, Ichihara N, Saka S, Toya Y, Yasuda G, Tabara Y, Miki T, Ueshima H, Ishikawa Y, and Umemura S: Impaired nitric oxide production and increased blood pressure in systemic heterozygous ATP2B1 null mice. J Hypertension, 32(7); 1415-1423. 2014. [DOI]
  • Tsutsumi YM, Tsutsumi R, Hamaguchi E, Sakai Y, Kasai A, Ishikawa Y, Yokoyama U, and Tanaka K: Exendin-4 ameliorates cardiac ischemia/reperfusion injury via caveolae and caveolins-3. Cardiovasc Diabetol, 13; 132, 2014. [DOI]
  • Ohsawa M, Tamura K, Wakui H, Maeda A, Dejima T, Kanaoka T, Azushima K, Uneda K, Tsurumi-Ikeya Y, Kobayashi R, Matsuda M, Uchida S, Toya Y, Kobori H, Nishiyama A, Yamashita A, Ishikawa Y, and Umemura S: Deletion of the angiotensin II type 1 receptor-associated protein enhances renal sodium reabsorption and exacerbates angiotensin II-mediated hypertension. Kidney Int, 86(3); 570-581, 2014. [DOI]
  • Aoki R, Yokoyama U, Ichikawa Y, Taguri M, Kumagaya S, Ishiwata R, Yanai C, Fujita S, Umemura M, Fujita T, Okumura S, Sato M, Minamisawa S, Asou T, Masuda M, Iwasaki S, Nishimaki S, Seki K, Yokota S, and Ishikawa Y: Decreased serum osmolality promotes ductus arteriosus constriction. Cardiovasc Res, 104(2); 326-336, 2014. [DOI]
  • Ohnuki Y, Umeki D, Mototani Y, Jin H, Cai W, Shiozawa K, Suita K, Saeki Y, Fujita T, Ishikawa Y, and Okumura S: Role of Cyclic AMP Sensor Epac1 in Masseter Muscle Hypertrophy and Myosin Heavy Chain Transition Induced by β2-Adrenoceptor Stimulation. J Physiol, 592(24); 5461-5475, 2014. [DOI]
  • Narikawa M, Kiyokuni M, Umemura M, Kawashima C, Doi H, Hisa A, Tomari S, Mitsuhashi T, Ishikawa Y and Endo T: A Case of R-II-B Type Single Coronary Artery Evaluated by Multi-Detector Computed Tomography and Coronary Angiography. J Clin Exp Cardiolog, 5; 11, 2014. [DOI]
  • 【総説】Ishikawa Y: Obstructive Sleep Apnea and Hypertension; A New Way to Go. J Sleep Disorders Ther, 3; 4, 2014. [DOI]
  • 【総説】横山詩子: 動脈管閉鎖の分子メカニズムと新たな薬物療法の可能性. 小児科, 55(1); 11-20, 2014.

受賞

  • 横山詩子：第117回日本小児科学会学術集会　日本小児科学会学術研究賞
２０１３年

論文発表

  • Eijkelkamp N, Linley JE, Torres JM, Bee L , Dickenson AH, Gringhuis M , Minett MS, Hong GS, Lee E, Oh U, Ishikawa Y, Zwartkuis FJ, Cox JJ, and Wood, JN: A role for Piezo2 in EPAC1-dependent mechanical allodynia. Nature Commun, 4; 1682, 2013. [DOI]
  • Lai L, Yan L, Gao S, Hu CL, Hui G, Davidow A, Park M, Bravo C, Iwatsubo K, Ishikawa Y, Auwerx, J, Sinclair D, Vatner SF, and Vatner DE: Type Type 5 Adenylyl Cyclase Increases Oxidative Stress by Transcriptional Regulation of MnSOD via the Sirt1/FoxO3a Pathway. Circulation, 127(16); 1692-1701, 2013. [DOI]
  • Liu NM, Yokota T, Maekawa S, Lu P, Tei I, Taniguchi H, Yokoyama U, Kato T, Minamisawa S: Transcription profiles of endothelial cells in the rat ductus arteriosus during a perinatal period. PLoS ONE, 8(9); e73685, 2013. [DOI]
  • Okamoto Y, Hirota M, Monden Y, Murata S, Koyama C, Mitsudo K, Iwai T, Ishikawa Y, and Tohnai I: Hight-dose zoledronic acid narrows the periodontal space in rats. Int J Oral Maxillofac Surg, 42(5); 627-631, 2013. [DOI]
  • Wang H, Heijnen CJ, van Velthoven CTJ, Willemen HLDM, Ishikawa Y, Zhang X, Sood AK, Vroon A, Eijkelkamp N, and Kavelaars A: Balancing GRK2 and EPAC1 levels prevents and relieves chronic pain. J Clin Invest, 123(12); 5023-5034, 2013. [DOI]
  • Lu D, Aroonsakool N, Yokoyama U, Patel HH, Insel PA: Increase in cellular cyclic AMP concentrations reverses the pro-fibrogenic phenotype of cardiac myofibroblasts: a novel therapeutic approach for cardiac fibrosis. Mol Pharmacol, 84(6); 787-793, 2013. [DOI]
  • 【総説】Vatner SF, Park M, Yan L, Lee G, Lai L, Iwatsubo K, Ishikawa Y, Pessin J, and Vatner DE: Adenylyl cyclase type 5 in cardiac disease, metabolism and aging, Adenylyl Cyclase Type 5 in Cardiac Disease, Metabolism and Aging. Am J Physiol Heart Circ Physiol, 305(1); H1-H8, 2013. [DOI]
  • 【総説】Yokoyama U, Iwatsubo K, Umemura S, Fujita T, and Ishikawa Y: The prostanoid EP4 receptor and its signaling pathway. Pharmacol Rev, 65(3); 1010-1052, 2013. [DOI]
  • 【総説】横山詩子: 動脈硬化・動脈瘤病態形成におけるプロスタグランディンE2の役割(The role of prostaglandin E2 in atherosclerosis and aortic aneurysm). 血栓と循環, 21(3); 29-33, 2013.
  • 【総説】横山詩子, 金 美花, 石川義弘: 動脈瘤とPGE2. 遺伝子医学MOOK, 24; 296-300, 2013.

就任

  • 横山詩子：PLoS ONE　academic editor

受賞

  • 井上栞・佐藤綾美・山地寿実鼓：第90回日本生理学会大会　Young Investigator's Award
  • 井上栞・佐藤綾美：医学部長賞
　　　　　
２０１２年

論文発表

  • Jiao Q, Takeshima H, Ishikawa Y, and Minamisawa S: Sarcalumenin plays a critical role in age-related cardiac dysfunction due to decreases in SERCA2a expression and activity. Cell Calcium, 51(1); 31-39, 2012. [DOI]
  • Umemura M, Ho D, Nozawa N, Balginnyam E, Iwatsubo K, Saito T, Endo T, Ishikawa Y, Umeura S, and Kimura K: Acute pulmonary embolism induced by renal obstruction with benign prostatic hyperplasia: Case Report. Journal of Cardiology Cases, 5(1); e39-e43, 2012. [DOI]
  • Kobayashi Y, Hirawa N, Tabara Y, Muraoka H, Fujita M, Miyazaki N, Fujiwara A, Ichikawa Y, Yamamoto Y, Ichihara N, Saka S, Wakui H, Yoshida S, Yatsu K, Toya Y, Yasuda G, Kohara K, Kita Y, Takei K, Goshima Y, Ishikawa Y, Ueshima H, Miki T, and Umemura S: Mice Lacking Hypertension Candidate Gene ATP2B1 in Vascular Smooth Muscle Cells showSignificant Blood Pressure Elevation. Hypertension, 59; 854-860, 2012. [DOI]
  • Fukumura H, Sato M, Kezuka K, Sato I, Feng X, Okumura S, Fujita T, Yokoyama U, Eguchi H, Ishikawa Y, and Saito T: Effect of ascorbic acid on reactive oxygen species production in chemotherapy and hyperthermia in prostate cancer cells. J Physiol Sci, 62; 251-257, 2012. [DOI]
  • Yokoyama U, Ishiwata R, Jin M-H, Kato Y, Suzuki O, Jin H, Ichikawa Y, Kumagaya S, Katayama Y, Fuijita T, Okumura S, Sato M, Sugimoto Y, Aoki H, Suzuki S, Masuda M, Minamisawa S, and Ishikawa Y: Inhibition of EP4 signaling attenuates aortic aneurysm formation. PlosOne, 7(5); e36724, 2012. [DOI]
  • Matsusaki M, Kadowaki K, Adachi E, Sakura T, Yokoyama U, Ishikawa Y, and Akashi M: Morphological and Histological Evaluations of 3D-Layered Blood Vessel Constructs Prepared by Hierarchical Cell Manipulation. J Biomaterials Sci, 23(1-4); 63-79, 2012. [DOI]
  • Iwatsubo K, Bravo C, Uechi M, Baljinnyam E, Nakamura T, Umemura M, Lai L, Gao S, Yan L, Park M, Qiu H, Okumura S, Iwatwsubo M, Vatner DE, Vatner SF, and Ishikawa Y: Prevention of heart failure in mice by an antiviral agent that inhibits type 5 cardiac adenylyl cyclase. Am J Physiol Heart Circ Physiol, 302(12); H2622-H2628, 2012. [DOI]
  • Umemura M, Ho D, Nozawa N, Balginnyam E, Iwatsubo K, Saito T, Endo T, Ishikawa Y, Umemura S, and Kimura K: Acute myocardial infarction with isolated conus branch occlusion. J Electrocardiol, 45(3); 285-287, 2012. [DOI]
  • Ichikawa Y, Yokoyama U, Iwamoto M, Oshikawa J, Okumura S, Sato M, Yokota S, Masuda M, Asou T, and Ishikawa Y: Inhibition of Phosphodiesterase Type 3 Dilates the Rat Ductus Arteriosus without Inducing Intimal Thickening. Circ J, 76(10); 2456-2464, 2012. [DOI]
  • Bai Y, Tsunematsu T, Jiao Q, Ohnuki Y, Mototani Y, Shiozawa K, Jin M, Cai W, Jin HL, Fujita T, Ichikawa Y, Suita K, Kurotani R, Yokoyama U, Sato M, Iwatsubo K, Isihkawa Y, and Okumura S: Pharmacological Stimulation of Type 5 Adenylyl Cyclase Stabilizes Heart Rate Under Both Microgravity and Hypergravity Induced by Parabolic Flight. J Pharmacol Sci, 119(4); 381-389, 2012. [DOI]
  • 【総説】Insel PA, Murray F, Yokoyama U, Romano S, Yun H, Brown L, Snead A, Lu D, and Aroonsakool N: Cyclic AMP and Epac in the regulation of tissue fibrosis. Br J Pharmacol, 166(2); 447-456, 2012. [DOI]

受賞

  • 市川泰弘：8th Asian Society for Pediatric Research　Young Investigators Awards. Phosphodiesterase Type 3 Inhibitor, Milrinone, Dilates the Rat Ductus Arteriosus without Inducing Intimal Thickening.
  • 金美花：第89回日本生理学会大会　ポスターアワード
２０１１年

論文発表

  • Kurotani R, Kumaki N, Linnoila RI, Ward JM, Kimura S: Secretoglobin 3A2/uteroglobin-related protein 1 is a novel marker for pulmonary carcinoma in mice and humans. Lung Cancer, 71(1); 42-48, 2011. [DOI]
  • Kurotani R, Okumura S, Matsubara T, Yokoyama U, Buckley JR, Tomita T, Kezuka K, Nagano T, Esposito D, Taylor TE, Gillette WK, Ishikawa Y, Abe H, Ward JM, and Kimura S: Secretoglobin 3A2 suppresses bleomycin-induced pulmonary fibrosis by TGFbeta signaling down-regulation. J Biol Chem, 286; 19682-19692, 2011. [DOI]
  • Jin M-H, Yokoyama U, Sato Y, Shioda A, Jiao Q, Ishikawa Y, and Minamisawa S: DNA microarray profiling identified a new role of growth hormone in vascular remodeling of rat ductus arteriosus. J Physiol Sci, 61; 167-179, 2011. [DOI]
  • Sato M, Hiraoka M, Suzuki H, Yunze B, Kurotani R, Yokoyama U, Okumura S, Cismowski MJ, Lanier SM, and Ishikawa Y: Identification of Transcription Factor E3 (TFE3) as a Receptor-independent Activator of Gα16 GENE REGULATION BY NUCLEAR Gα SUBUNIT AND ITS ACTIVATOR. J Biol Chem, 286; 17766-17776, 2011. [DOI]
  • Balkommyam E, Umemura S, De Lorenzo MS, Iwatsubo M, Chen S,Goydos JS, Iwatsubo K: Epac1 Promotes Melanoma Metastasis via Modification of Heparan Sulfate. Pigment Cell Melanoma Res. 24(4); 680-687, 2011. [DOI]
  • 【総説】Sato M, Yokoyama U, Fujita T, Okumura S and Ishikawa Y: The roles of cytochrome P450 in ischemic heart disease. Current Drug Metabolism, 12(6); 526-532. 2011. [DOI]
  • 【総説】Fujita T, and Ishikawa Y: Apoptosis in heart failure. -The role of the beta-adrenergic receptor-mediated signaling pathway and p53-mediated signaling pathway in the apoptosis of cardiomyocytes. Circ J, 75(8); 1811-1818, 2011. [DOI]

受賞

  • 横山詩子：第二十三回横浜市立大学医学会賞
  • 鈴木オリエ：医学部長賞
２０１０年

論文発表

  • Otsu K, Toya Y, Oshikawa J, Kurotani R, Yazawa T, Sato M, Yokoyama U, Umemura S, Minamisawa S, Okumura S, and Ishikawa Y: Caveolin gene transfer improves glucose metabolisms in diabetic mice. Am. J. Physiol. Cell Physiol, 298(3); C450- C456, 2010. [DOI]
  • Kheirbek MA, Beeler1 JA, Chi W, Ishikawa Y, and Zhuang X: A molecular dissociation between cued and contextual appetitive learning. Lern Mem, 17; 148-154, 2010. [DOI]
  • Yokoyama U, Minamisawa S, Katayama A, Tang T, Suzuki S, Iwatsubo K, Iwasaki S, Kurotani R, Okumura S, Sato M, Yokota S, Hammond HK, and Ishikawa Y: Differential regulation of vascular tone and remodeling via stimulation of type 2 and type 6 adenylyl cyclases in the ductus arteriosus. Circ Res, 106(12);1882-1892, 2010. [DOI]
  • Suzuki S, Yokoyama U, Abe T, Kiyonari H, Yamashita N, Kurotani R, Sato M, Okumura S, and Ishikawa Y: Differential roles of Epac in regulating cell death in neuronal and myocardiacl cells. J Biol Chem, 285;24248-24259, 2010. [DOI]
  • Guellich A, Vatner DE, Gao S, Hong C, Yan L, Wagner TE, Dhar S, Ghaleh B, Hittinger L, Kosaku Iwatsubo K, Ishikawa Y, and Vatner SF: Effect of cardiac overexpression of type 6 adenylyl cyclase affects on the response to chronic pressure overload. Am J Physiol Heart Circ Physiol, 299(3); H707-H712, 2010. [DOI]
  • 【総説】Sato M and Ishikawa Y: Accesory proteins for heterotrimeric G protein: Implication in the cardiovascular system. Pathophysiology, 17(2); 89-99, 2010. [DOI]
  • 【総説】Yokoyama U, Minamisawa S, and Ishikawa Y: Regulation of vascular tone and remodeling of the ductus arteriosus. J Smooth Muscle Res, 46(2);77-87, 2010. [DOI]
  • 【総説】Oshikawa J, Toya Y, Umemura S, and Ishikawa Y: The role of caveolae, lipid rafts and caveolin in insulin signaling. Trends in Cell & Molecular Biology, 5; 23-33, 2010.
  • 黒谷玲子, 福村英信, 佐藤　格, 江口晴樹, 石川義弘: 磁性体を利用した薬剤送達法. 磁気と健康, 23; 10-13, 2010.

受賞

  • 佐藤元彦：旭川医科大学　第10回医学奨励賞（学術奨励賞）
  • 福村英信：第43回日本骨軟部腫瘍学会(2010年7月15日～16日）優秀ポスター賞　「磁性体粒子を用いた温熱化学療法の開発」
  • 金美花：第75回日本循環器学会総会　国際留学生　Young Investigators Award
２００９年

論文発表

  • Matsushita K, Takeuchi O, Standley DM, Kumagai Y, Kawagoe T, Miyake T, Sato T, Kato H, Tsujimura T, Nakamura H, and Akira S: Zc3h12a is an RNase essential for controlling immune responses by regulating mRNA decay. Nature. 458(7242); 1185-1190, 2009. [DOI]
  • Ebina T, Ishikawa Y, Uchida K, Suzuki S, Imoto K, Okuda J, Tsukahara K, Hibi K, Kosuge M, Sumita S, Mochida Y, Ishikawa T, Uchino K, Umemura S, and Kimura K: A case of giant coronary aneurysm and literature review. J Cardiol, 53(2); 293-300, 2009. [DOI]
  • Akaike T, Jin MH, Yokoyama U, Izumi-Nakaseko H, Jiao Q, Iwasaki S, Iwamoto M, Nishimaki S, Sato M, Yokota S, Kamiya Y, Adachi-Akahane S, Ishikawa Y and Minamisawa S: T-type Ca2+ channels awk awk promote oxygenation-induced closure of the rat ductus arteriosus not only by vasoconstriction but also by neointima formation. J Biol Chem, 284; 24025-24034 2009. [DOI]
  • Kumamoto K, Fujita K, Kurotani R, Saito M, Unoki M, Hagiwara N, Shiga H, Bowman ED, Yanaihara N, Okamura S, Nagashima M, Miyamoto K, Takenoshita S, Yokota J, and Harris CC: ING2 is upregulated in colon cancer and increases inbasion by enhanced MMP13 expression. Int J Cancer. 125(6); 1306-1315, 2009. [DOI]
  • Kawagoe T, Takeuchi O,Takabatake Y,Kato H, Isaka Y,Tsujimura T and Akira S: TANK is a negative regulator of Toll-like receptor signaling and is critical for the prevention of autoimmune nephritis. Nature Immunology. 10(9); 965-972, 2009. [DOI]
  • Jiao Q, Bai Y, Akaike T, Takeshima H, Ishikawa Y, and Minamisawa S: Sarcalumenin is essential for maintaing cardiac function during endurance exercise training. Am. J. Physiol. Heart Circ Physiol, 297; H576-582, 2009. [DOI]
  • Kheirbek M, Britt J, Beeler J, Ishikawa Y, McGehee D, and Zhuang X: Adenylyl cyclase type 5 is critical for corticostriatal plasticity and striatum-dependent learning. J Neurosci, 29(39); 12115-12124, 2009. [DOI]
  • Sato M, Honda T, Jiao Q, Kurotani R, Toyota E, Okumura S, Lanier SM, and Ishikawa Y: An involvement of activator of G protein signaling 8 on hypoxia-induced apoptosis of cardiomuyocytes and its interaction with connexin 43. J Biol Chem, 284; 31431-40, 2009. [DOI]
  • Baljinnyam E, Iwatsubo K, Kurotani R, Wang X, Ulucan C, Iwatsubo M, Lagunoff D and Ishikawa Y: Epac increases melanoma cell migration by heparan sulfate-related mechanism. Am J Physiol Cell Physiol, 297(4); C802-C813, 2009. [DOI]
  • Hamanoue H, Rahayuningsih SE, Hirahara Y, Itoh J, Yokoyama U, Mizoguschi T, Saitsu H, Miyake N, Hirahara F, and Matsumoto N: Genetic screening of 104 patients with congenitally malformed hearts revealed a fresh mutation of GATA4 in those with atrial septal defects. Cardiol Young. 19(5); 482-485, 2009. [DOI]
  • Hu CL, Chandra R, Ge H, Pain J, Yan L, Babu G, Depre C, Iwatsubo K, Ishikawa Y, Sadoshima J, Vatner SF, Vatner DE: Adenylyl cyclase type 5 protein expression during cardiac development and stress. Am J Physiol Heart Circ Physiol, 297(5); H1776-H1782, 2009. [DOI]
  • Mann L, Heldman E, Bersudsky Y, Almog O, Belmaker RH, Ishikawa Y, Vatner SF, and Agam G: Inhibition of specific adenylyl cyclase isoforms by mood stabilizers may be related to their mechanism of action. Bipolar Disorders, 11(8); 885-896, 2009. [DOI]
  • 【総説】Okumura S, Suzuki S, and Ishikawa Y: New aspects for the treatment of cardiac deseases based on the diversity of functional controls on cardiac muscles:effects of targeted disruption of the type 5 adenylyl cyclase gene. J Pharmacol Sci. 109(3); 354-359, 2009. [DOI]
  • 【総説】Shimada C, Kurotani R, Fukumura H, Ono S, Eguchi H, and Ishikawa Y: Drug delivery system using magnetic materials. 日本病態生理学会雑誌, 18(1); 24-27, 2009.
  • 【総説】佐藤元彦: Ｇ蛋白活性制御因子による三量体Ｇ蛋白の制御と病態への関与. 横浜医学. 60(1.2); 37-47, 2009. [Link]　平成19年度横浜市立大学医学会賞受賞

受賞

  • 横山詩子：第７３回日本循環器学会学術集会　第二回女性研究者奨励賞
  • 横山詩子：日本平滑筋学会　栗山熙賞
  • 島田千恵美（修士2年次）：第19回日本病態生理学会　日本病態生理学会奨励賞
２００８年

論文発表

  • Shimura M, Minamisawa S, Takeshima H, Jiao Q, Bai Y, Umemura S, and Ishikawa Y: Sarcalumenin alleviates stress-induced cardiac dysfunction by improving Ca2+ handling of the sarcoplasmic reticulum. Cardiovasc Res. 77(2); 362-370, 2008. [DOI]
  • Horikawa Y, Patel HH, Tsusumi YM, Jennings M, Kidd MW, Hagiwara Y, Ishikawa Y, Insel PA, and Roth DM: Caveolin-3 expression and caveolae are required for isoflurane-induced cardiac protection from hypoxia and ischemia/reperfusion injury. J Mol Cell Cardiol, 44(1); 123-130, 2008. [DOI]
  • Yokoyama U, Patel HH, Lai NC, Aroonsakool N, Roth DM, Insel PA: The cyclic AMP effector Epac Integrates Pro and Anti-fibrotic Signals. Proc Natl Acad Sci USA, 105(17);6383-6391, 2008. [DOI]
  • Ahn SH, Shah YM, Inoue J, Morimura K, Kim I, Yim s, Lambert G, Kurotani R, Nagashima K, Gonzalez FJ, Inoue Y: Hepatocyte nuclear factor 4alpha in the intestinal epithelial cells protects against inflammatory bowel disease. Inflamm Bowel Dis, 14(7); 908-920, 2008. [DOI]
  • Okumura S, Tsunematsu T, Bai Y, Jiao Q, Ono S, Suzuki S, Kurotani R, Sato M, Minamisawa S, Umemura S, and Ishikawa Y: Type 5 adenylyl cyclase plays a major role in stabilizing heart rate in response to microgravity induced by parabolic flight. J Appl Physiol. 105(1); 173-179, 2008. [DOI]
  • Kurotani R, Tomita T, Yang Q, Carlson BA, Chen C, Kimura S: Role of Secretoglobin (SCGB) 3A2 in Lung Development. Am J Respir Crit Care Med. 178(4):389-398, 2008. [DOI]
  • Yokoyama U, Minamisawa S, Hong Q, Akaike T, Jin M, Otsu K, Ulucan C, Wang X, Baljinnyam E, Takaoka M, Sata M, and Ishikawa Y: Epac1 is upregulated during neointima formation and promotes vascular smooth muscle cell migration. Am. J. Physiol. Heart Circ Physiol, 295(4); H1547-H1555, 2008. [DOI]
  • Yokoyama U, Minamisawa S, Quan H, Akaike T, Suzuki S, Jin M, Jiao Q, Watanabe M, Otsu K, Iwasaki S, Nishimaki S, Sato M, and Ishikawa Y: PGE2-activated Epac promotes neointimal cushin formation of the rat ductus arteriosus by a process distinct from that of PKA. J Biol Chem, 283; 28702-28709, 2008. [DOI]
  • Tomita T, Kido T, Kurotani R, Iemura SI, Sterneck E, Natsume T, Vinson C, Kimura S: CAATT/enhancer binding proteins alpha and delta interact with NKX2-1 to synergistically activate mouse secretoglobin 3A2 gene expression. J Biol Chem, 283(37); 25617-25627, 2008. [DOI]
  • Kheirbek MA, Beeler JA, Ishikawa Y and Zhuang X: A cyclic AMP pathway selectively required for reward prediction. J Neurosci, 28(44); 11401-11408, 2008. [DOI]
  • Tsutsumi YM, Horikawa YT, Jennings M, Kidd MW, Niesman IR, Yokoyama U, Head BP, Hagiwara Y, Ishikawa Y, Miyanohara A, Patel PM, Insel PA, Patel HH, and Roth DM: Cardiac specific overexpression of caveolin-3 induces endogenous cardiac protection by mimicking ischemic predoncitioning. Circulation, 118(19); 1979-1988, 2008. [DOI]
  • 【総説】Iwatsubo K and Ishikawa Y: Therapeutic targets for heart failure: Beyond beta-adrenergic and rennin-angiotensin sytem blockade. Recent Patent on Cardiovascular Drug Discovery, 3; 37-44, 2008. [DOI]
  • 【総説】Ishikawa Y and Kurotani R: Cardiac myosin light chain kinase; a new player in the regulation of myosin light chain in the heart. Circ Res, 102; 516-518, 2008. [DOI]
  • 【総説】Vatner SF, Yan L, Ishikawa Y, Vatner DE, and Sadoshima J: Adenylyl cyclase type 5 disruption prolongs longevity and protects the heart against stress. Circ J, 73(2); 195-200, 2008. [DOI]

受賞

  • 佐藤元彦：横浜市立大学医学会 横浜医学会賞
  • 佐藤元彦：循環制御医学会　循環制御医学会優秀演題賞
  • 横山詩子：2008年日本小児循環器学会　Young Investigator's Awards
  • 黒谷玲子：財団法人横浜総合医学振興財団　呼吸器疾患研究賞
  • 赤池徹：The 4th Congress of Asian Society of Pediatric Research　Young Investigator's Awards
２００７年

論文発表

  • Nishizawa T, Shen Y-T, Rossi F, Hong C, Robbins J, Ishikawa Y, Sadoshima J, Vatner DE, and Vatner SF: Altered autonomic control in conscious transgenic rabbits with overexpressed cardiac Gsalpha. Am. J. Physiol. Heart Circ Physiol, 292(1); H971-H95, 2007. [DOI]
  • Eguchi H, Iwatsubo K, and Ishikawa Y: Isoform-selective regulation of adenylyl cyclase by forskolin derivatives: Prediction of selectivity by computer-based analysis. Letters in Drug Design & Discovery, 4(6); 434-441, 2007. [DOI]
  • Yan L, Vatner DE, Ivessa A, Ge H, Chen W, Hirotani S, Ishikawa Y, Sadoshima J, and Vatner SF: Type 5 adenylyl cyclase disruption increases longevity and protect against stress. Cell, 130(2); 247-258, 2007. [DOI]
  • Yuan C, Sato M, Lanier SM, and Smrcka AV: Signaling by a non-dissociated comlex of G-protein beta gamma and alpha subunits stimulated by a receptor-independent activator of G protein signaling, AGS8. J Biol Chem. 282; 19938-19947, 2007. [DOI]
  • Que J, Okubo T, Goldenring JR, Nam Kt, Kurotani R, Morrisey EE, Taranova O, Pevny LH, Hogan BL: Multiple dose-dependent roles Sox2 in the patterning and differentiation of anterior foregut endoderm. Development. 134(13); 2521-2531, 2007. [DOI]
  • Ulucan C, Wang X, Baljinnyam E, Bai Y-Z, Okumura S, Sato M, Minamisawa S, Hirotani S, and Ishikawa Y: Developmental changes in gene expression of Epac and its upregulation in myocardial hypertrophy. Am J Physiol Heart Circ Physiol, 293(3); H1662- H1672, 2007. [DOI]
  • Yokoyama U, Sato Y, Akaike T, Ishida S, Sawada J, Nagao T, Quan H, Jin M, Iwamoto M, Yokota S, Ishikawa Y, and Minamisawa S: Maternal vitamin A alters gene profiles and structural maturation of the rat ductus arteriosus. Physiol Genmics, 31(1); 139-157, 2007. [DOI]
  • Iwasaki S, Minamisawa S, Yokoyama U, Akaike T, Quan H, Nagashima Y, Nishimaki S, Ishikawa Y, and Yokota S: Interleukin-15 inhibits smooth muscle cell proliferation and hyaluronan production in rat ductus arteriosus. Pediatr Res, 62; 392-398, 2007. [DOI]
  • Okumura S, Vatner DE, Kurotani R, Bai Y, Gao S, Yuan Z, Iwatsub K, Ulucan C, Kawabe J, Ghosh K, Vatner FS, and Ishikawa Y: Disruption of Type 5 adenylyl cyclase enhances desensitization of cyclic adenosine monophsphate signal and increases Akt signal with chronic catecholamine stress. Circulation, 116(16); 1776-83, 2007. [DOI]
  • Iwatsubo K＊, Suzuki S＊, Li C, Tsunematsu T, Nakamura F, Okumura S, Sato M, Minamisawa S, Toya Y, Umemura S, and Ishikawa Y: Dopamine induces apoptosis in young, but not in neonatal, neurons via Ca2+-dependent signal. Am J Physiol Cell Physiol, 293(5); C1498- C1508, 2007. ＊equal contribution [DOI]
  • 【総説】Ishikawa Y, Suzuki S, Ohtsu K, Coskun Ulucan, Iwatsubo K, and Eguchi H: cAMP-mediated regulation of CYP enzyme and its application in chemotherapy. Drug Metab Lett, 1(3);176-178, 2007. [DOI]
  • 【総説】Blumer JB, Cismowski MJ, Sato M, and Lanier SM: AGS3. UCSD-Nature Molecule Pages, 2007. [DOI]
２００６年

論文発表

  • Fujita T, Otsu K, Oshikawa J, Hori H, Minamisawa S, Umemura S, Kitamura H, Ito T, and Ishikawa Y: Caveolin-3 inhibits growth signal in cardiac myoblasts in a Ca2+-dependent manner. J Cell Mol Med, 10(1); 216-224, 2006. (selected as Key articles from 2005-2006) [DOI]
  • Song KS, Peterson YK,Fredman A,Blumer JB,Sato M,Lanier SM: Identification and characterization of a G-protein regulatory motif in WAVE1. FEBS Lett, 580: 1993-1998, 2006. [DOI]
  • Kawabe J, Okumura S, Nathanson MA, Hasebe N and Ishikawa Y: Caveolin regulates microtubule polymerization in the vascular smooth muscle cells. Biochem Biophys Res Commun, 342(1);164-169, 2006. [DOI]
  • Yokoyama U, Minamisawa S, Adachi-Akahane S, Akaike T, Naguro I, Funakoshi K, Iwamoto M, Nakagome M, Uemura N, Hori H, Yokota S, Ishikawa Y: Multiple transcripts of Ca2+ channel α1c-subunits and a novel spliced variant of the alpha1C subunit in rat ductus arteriosus. Am J Physiol.Heart Circ Physiol, 290(4); H1660- H1670, 2006. [DOI]
  • Minamisawa S, Uemura N, Sato Y, Sato Y, Yokoyama U, Yamaguchi T, Inoue K, Nakagome M, Bat Y, Hori H, Simizu M, Mochizuki S, and Ishikawa Y: Post-transcriptional down- regulation of sarcolipin mRNA by triiodothyronine in the atrial myocardium. FEBS Lett, 580(9); 2247-2253, 2006. [DOI]
  • Nishizawa T, Vatner SF, Hong C, Shen Y-T, Hardt SE, Robbins J, Ishikawa Y, Sadoshima J, Vatner SF, and Vatner DE: Overexpressed cardiac Gsalpha in rabbits. J Mol Cell Cardiol, 41(1);44-50, 2006. [DOI]
  • Sato M, Cismowski MJ, Toyota E, Smrcka AV, Lucchesi PA, Chilian WM, Lanier SM: Identification of a receptor independent activator of G protein signaling(AGS8) in ischemic heart and its interaction with Gbetagamma. Proc Natl Acad Sci USA, 103; 797-802, 2006. [DOI]
  • Yokoyama U, Minamisawa S, Hong Q, Segi-Nishida E, Ghatak S, Iwasaki S, Iwamoto M, Misra S, Tamura K, Hori H, Yokota S, Tool BP, Sugimoto Y, and Ishikawa Y: Chronic activation of the prostaglandin receptor EP4 promotes hyaluronan-mediated neointimal formation in the ductus arteriosus. J Clin Invest, 116; 3026-3034, 2006. [DOI]　also in Science 2006 Nov 10; 314(5801): 895 [Editor’s Choice]
  • Nicol X, Bennis M, Ishikawa Y, Chan G, Reperant J, Storm DR, and Gaspar P: Role of the calcium modulated cyclases in the development of the retinal projections. Eur J Neurosci, 24(12); 3401-3414. 2006. [DOI]
  • Kitano S, Kageyama S, Nagata Y, Miyahara Y, Hiasa A, Naota H, Okumura S, Imai H, Shiraishi T, Masuya M, Nishikawa M, Sunamoto J, Akiyoshi K, Kanematsu T, Scotto AM, Murphy R, Hoffman EW, Old LJ, Shiku H: HER2-specific T-cell immune responses in patients vaccinated with truncated HER2 protein complexed with nanogels of cholesteryl pullulan. Clin Cancer Res, 12(24); 7397-7405, 2006. [DOI]
  • Naota H, Miyahara Y, Okumura S, Kuzushima K, Akatsuka Y, Hiasa A, Kitano S, Takahashi T, Yuta A, Majima y, Shiku H: Generation of peptide-specific CD8+T cells by phytohemaggulutinin-stimulated antigen-mRNA-transduced CD4+Tcells. J Immunol Methods, 314(12); 54-66, 2006.
  • 【総説】Sato M, Blumer JB, Simon V, and Lanier SM: Accessory proteins for G-proteins:Patners in signaling. Annu Rev Pharmacol Toxicol, 46; 151-187, 2006. [DOI]
  • 【総説】Iwatsubo K, Okumura S, and Ishikawa Y: Drug therapy aimed at adenylyl cyclase to regulate cyclic nucleotide signaling. Endocr Metab Immune Disord Drug Targets, 6(3); 239-47, 2006. [DOI]
２００５年

論文発表

  • Yoshida M, Minamisawa S, Shimura M, Komazaki S, Kume H, Zhang M, Matsumura K, Nishi M, Saito M, Saeki Y, Ishikawa Y, Yanagisawa T, and Takeshima H: Impaired Ca2+ store functions in skeletal and cardiac muscle cells from sarcalumenin-deficient mice. J Biol Chem, 280; 3500-3506, 2005. [DOI]
  • Tadano M, Edamatsu H, Minamisawa S, Yokoyama U, Ishikawa Y, Suzuki N, Saito H, Setsu T, Terashima T, Maeda S, Sato T and Kataoka T: Congenital semilunar valvulogenesis defect in phospholipase Cε. Mol Cell Biol, 25(6); 2191-2199, 2005. [DOI]
  • Shimura M, Yokoyama U, Umemura S, and Ishikawa Y: Mechanical Stress-dependent transcriptional regulation of sarcolipin gene in the rodent atrium. Biochem Biophys Res Commun, 334(3); 861-866, 2005. [DOI]
  • 【総説】Ishikawa Y, Ohtsu K, and Oshikawa J: Caveolin; different roles for insulin signal? Cell Signal, 17(10);1175-1182, 2005. [DOI]
  • 【総説】Ishikawa Y, Iwatsubo K, Tsunematsu T, and Okumura S: Genetic manipulation and functional analysis of cAMP signalling in cardiac muscle; implications for a new target of pharmacotherapy. Biochem Soc Trans, 33(6); 1337-1340, 2005. [DOI]
２００４年

論文発表

  • Horie H, Kadoya T, Hikawa N, Sango K, Takeshita K, Asawa R, Hiroi T, Sato M, Yoshioka T, and Ishikawa Y: Oxidized galectin-1 stimulates macrophages to promote axonal regeneration in peripheral nerves after axotomy. J Neuroscience, 24(8); 1873-1880, 2004. [DOI]
  • Iwamoto T, Iwatsubo K, Okumura S, Hashimoto Y, Tsunematsu H, Toya Y, Herve D, Umemura S, and Ishikawa Y: Disruption of type 5 adenylyl cyclase negates the developmental increase in Golf haolf expression in the striatum. FEBS Lett, 564(1-2); 153-156, 2004. [DOI]
  • Kawabe J, Okumura S, Lee M-C, Sadoshima J, and Ishikawa Y: Translocation of caveolin regulates stretch-induced extracellular signal-regulated kinase activity in vascular smooth muscle cells. Am J Physiol, 286(5); H1845- H1852, 2004. [DOI]
  • Iwatsubo K, Minamisawa S, Tsunematsu T, Nakagome M, Toya Y, Tomlison JE, Umemura S, Scarborough RM, Levy DE, and Ishikawa Y: Direct inhibition of type 5 adenylyl cyclase prevents myocardial apoptosis without functional deterioration. J Biol Chem, 279; 40938-40945, 2004. [DOI]
  • Oshikawa J, Ohtu K, Toya Y, Tsunematsu T, Hankins RW, Kawabe J, Minamisawa S, Umemura S, Hagiwara Y, and Ishikawa Y: Insulin resistance in skeletal muscles of caveolin-3-null mice. Proc Natl Acad Sci USA, 101(34); 12670-12675, 2004. [DOI]
  • Nishizawa T, Iwase M, Kanazawa H, Ichihara S, Ichihara G, Nagata K, Koji Obata, Kitaichi K, Yokoi Y, Watanabe M, Tsunematsu T, Ishikawa Y, Murohara T, and Yokota M: Serial alterations of β-adrenergic signaling in dilated cardiomyopathic hamsters: possible role of my ocardial oxidatire stress. Circ J, 68(11);1051-1060, 2004. [DOI]
  • Uemura N, Ohkusa T, Hamano K, Nakagome M, Hori H, Shimizu M, Matsuzaki M, Mochizuki S, Minamisawa S, and Ishikawa Y: Down-regulation of sarcolipin mRNA expression in chronic atrial fibrillation. Eur J Clin Invest, 34(11); 723-730, 2004. [DOI]
  • Minamisawa S, Oshikawa J, Takeshima H, Hoshijima M, Wang Y, Chien K R, Ishikawa Y, and Matsuoka R: Junctophilin type 2 is associated with caveolin-3 and is down-regulated in the hypertrophic and dilated cardiomyopathies. Biochem Biophys Res Commun, 325(3); 852-856, 2004. [DOI]
  • Hikawa N, Ishikawa Y, and Takenaka T: Interleukin-12 p40-homodimer production in sensory dorsal root ganglion neurons. Neuroscience, 129(1); 75-83, 2004. [DOI]
  • 【総説】Minamisawa S, Sato Y, Cho MC: Calcium cycling proteins in heart failure, cardiomyopathy, and arrhythmias. Exp Mol Med, 36; 193-203, 2004. [DOI]
  • 【総説】Hoshijima M, Minamisawa S, Yasukawa H, Chien KR: Molecular pathways for cardiac hypertrophy and heart failure progression. Molecular Basis of Cardiovascular Disease 2nd ed (ed Chien KR), 273-292, 2004. [DOI]
  • 【総説】Ishikawa Y: A new paradigm in cAMP signal. Cardiovascular Anesthesia 8(Suppl); 62-64, 2004.
２００３年

論文発表

  • Minamisawa S, Wang Y, Chen J, Ishikawa Y, Chien KR, and Matsuoka R: Atrial chamber-specific expression of sarcolipin is regulated during development and hypertrophy. J Biol Chem, 278; 9570-9575, 2003. [DOI]
  • Iwatsubo K, Tao Y, Onda T, Toya Y, Schwencke C, Fujita T, Ebina T, Iwamoto T, Hori H, Minamisawa S, Uemura S, and Ishikawa Y: Characterization of beta adrenergic receptor sequestration by newly developed whole cell binding assays. J Cardiovasc Pharmacol, 41; S53-56, 2003. [Link]
  • Iwamoto T, Okumura S, Iwatsubo K, Kawabe J, Ohtsu K, Sakai I, Hashimoto Y, Izumitani A, Sango K, Ajiki K, Toya Y, Uemura S, Goshima Y, Arai N, Vatner SF, and Ishikawa Y: Motor dysfunction in type 5 adenylyl cyclase null-mice. J Biol Chem, 278; 16936-16940, 2003. [DOI]
  • Minamisawa S, Sato Y, Tatsuguchi Y, Fujino T, Imamura S, Uetsuka Y, Nakazawa M, and Matsuoka R: Mutation of the phosholanbam promter associated with hypertrophic cardiomyopathy. Biochem Biophys Res Commun, 304(1); 1-4, 2003. [DOI]
  • Takenaka T, Himura H, Hori H, Hashimoto Y, Ichikawa T, and Kawakami T: Fatty acids as an energy source for the operation of axoplasmic transport. Brain Res, 972(1-2); 38-43, 2003. [DOI]
  • Iwatsubo K, Toya T, Fujita T, Ebina T, Schwencke C, Minamisawa S, Uemura S, and Ishikawa Y: Ischemic preconditioning prevents ischemia-induced beta-adrenergic receptor sequestration. J Mol Cell Cardiol, 35(8); 923-929, 2003. [DOI]
  • Okumura S, Tkagi G, Kawabe J, Yang G, Lee MC, Hong C, Liu J, Vatner DE, Sadoshima J, Vatner SF, and Ishikawa Y: Disruption of type 5 adenylyl cyclase gene preserves cardiac function against pressure overload. Proc Natl Acad Sci USA, 100(17); 9986-9990, 2003. [DOI]
  • Okumura S, Kawabe J, Takagi G, Lee L, Hong C, Liu J, Takagi I, Sadoshima J, Yatani A, Vatner DE, Vatner SF, and Ishikawa Y: Type 5 adenylyl cyclase disruption alters not only sympathetic, but also parasympathetic and calcium-mediated regulation of cardiac function. Circ Res, 93(4); 364-371, 2003. [DOI]
  • Oshikawa J, Toya Y, Fujita T, Sakai I, Hashimoto Y, Kawabe J, Uemura S, and Ishikawa Y: Nicotinic acetylcholine receptor alpha7 regulates cAMP signal via inhibiting a calcium-sensitive adenylyl cyclase isoform. Am J.Physiol, 285(3); C567-C574, 2003. [DOI]
  • Ikoma E, Tsunematsu Y, Nakazawa I, Shiwa T, Hibi K, Ebina T, Mochida Y, Toya Y, Hori H, Uchino K, Minamisawa S, Kimura K, Umemura S, and Ishikawa Y: Polymorphism of the type 6 adenylyl cyclase gene and cardiac hypertrophy. J Cardiovasc Pharmacol, 42; S27-S32, 2003. [DOI]
  • 【総説】Iwatsubo K, Tsunematsu T, and Ishikawa Y: Isoform-specific regulation of adenylyl cyclase; a potential target in future pharmacotherapy. Expert Opinion on Therapeutic Target. 7(3); 441-451, 2003. [DOI]
  • 【総説】Ishikawa Y: Isoform-targeted regulation of cardiac adenylyl cyclase. J. Cardiovasc. Pharmacol. 41(1); S1-S4, 2003. [Link]
２００２年

論文発表

  • Jin GB, Hong T, Inoue S, urano T, Cho S, Otsu K, Kitahara M, Ouchi Y, Cyong JC: Augmentation of immune cell activity against tumor cells by Rauwolfia radix. J Ethnopharmacol 81(3); 365-372, 2002. [DOI]