発表論文

2024年

  • Watanuki S, Kobayashi H, Sugiura Y, Yamamoto M, Karigane D, Shiroshita K, Sorimachi Y, Fujita S, Morikawa T, Koide S, Oshima M, Nishiyama A, Murakami K, Haraguchi M, Tamaki S, Yamamoto T, Yabushita T, Tanaka Y, Nagamatsu G, Honda H, Okamoto S, Goda N, Tamura T, Nakamura-Ishizu A, Suematsu M, Iwama A, Suda T, Takubo K: Context-dependent modification of PFKFB3 in hematopoietic stem cells promotes anaerobic glycolysis and ensures stress hematopoiesis.eLife 12:RP87674, 2024(PubMed)
  • Kubara K, Yamazaki K, Miyazaki T, Kondo K, Kurotaki D, Tamura T, Suzuki Y: Lymph node macrophages drive innate immune responses to enhance the anti-tumor efficacy of mRNA vaccines. Mol Ther 32(3):61-73, 2024(PubMed)

2023年

  • Tsukamoto S, Suzuki T, Wakui H, Uehara T, Ichikawa J, Okuda H, Haruhara K, Azushima K, Abe E, Tanaka S, Taguchi S, Hirota K, Kinguchi S, Yamashita A, Tamura T, Tamura K: Angiotensin II type 1 receptor-associated protein in immune cells: a possible key factor in the pathogenesis of visceral obesity. Metabolism 149: 155706, 2023(PubMed)
  • Wei F, Azuma K, Nakahara Y, Saito H, Matsuo N, Tagami T, Kouro T, Igarashi Y, Tokito T, Kato T, Kondo T, Murakami S, Usui R, Himuro H, Horaguchi S, Tsuji K, Murotani K, Ban T, Tamura T, Miyagi Y, Sasada T: Machine learning for prediction of immunotherapeutic outcome in non-small-cell lung cancer based on circulating cytokine signatures. J Immunother Cancer 11(7): e006788, 2023(PubMed)
  • Jikuya R, Johnson TA, Maejima K, An J, Ju YS, Lee H, Ha K, Song W, Kim Y, Okawa Y, Sasagawa S, Kanazashi Y, Fujita M, Imoto S, Mitome T, Ohtake S, Noguchi G, Kawaura S, Iribe Y, Aomori K, Tatenuma T, Komeya M, Ito H, Ito Y, Muraoka K, Furuya M, Kato I, Fujii S, Hamanoue H, Tamura T, Baba M, Suda T, Kodama T, Makiyama K, Yao M, Shuch BM, Ricketts CJ, Schmidt LS, Linehan WM, Nakagawa H, Hasumi H: Comparative analyses define differences between BHD-associated renal tumour and sporadic chromophobe renal cell carcinoma. EBioMedicine 92: 104596, 2023(PubMed)
  • Yamazaki K, Kubara K, Suzuki Y, Hihara T, Kurotaki D, Tamura T, Ito M, Tsukahara K: Multivalent mannose-conjugated siRNA causes robust gene silencing in pancreatic macrophages in vivo. Eur J Pharm Biopharm 183: 61-73, 2023(PubMed)
  • Ono G, Kobayakawa K, Saiwai H, Tamaru T, Iura H, Haruta Y, Kitade K, Iida KI, Kawaguchi KI, Matsumoto Y, Tsuda M, Tamura T, Ozato K, Inoue K, Konno DJ, Maeda T, Okada S, Nakashima Y: Macrophages play a leading role in determining the direction of astrocytic migration in spinal cord injury via ADP-P2Y1R axis. Sci Rep 13(1): 11177, 2023(PubMed)
  • Ikeda N, Kubota H, Suzuki R, Morita M, Yoshimura A, Osada Y, Kishida K, Kitamura D, Iwata A, Yotsumoto S, Kurotaki D, Nishimura K, Nishiyama A, Tamura T, Kamatani T, Tsunoda T, Murakawa M, Asahina Y, Hayashi Y, Harada H, Harada Y, Yokota A, Hirai H, Seki T, Kuwahara M, Yamashita M, Shichino S, Tanaka M, Asano K: The early neutrophil-committed progenitors aberrantly differentiate into immunoregulatory monocytes during emergency myelopoiesis. Cell Rep 42(3): 112165, 2023 (PubMed)
  • 藩龍馬, 田村智彦: 全身性エリテマトーデスにおける転写因子IRF5の新規治療標的としての可能性. 臨床免疫・アレルギー科 79(2): 217-222, 2023
  • Ito T, Ohta M, Osada A, Nishiyama A, Ishiguro KI, Tamura T, Sekita Y, Kimura T: Switching defective/sucrose non-fermenting chromatin remodeling complex coordinates meiotic gene activation via promoter remodeling and Meiosin activation in female germline. Genes Cells 28(1): 15-28, 2023(PubMed)

2022年

  • Okuda H, Miyamoto R, Takahashi S, Kawamura T, Ichikawa J, Harada I, Tamura T, Yokoyama A: RNA-binding proteins of KHDRBS and IGF2BP families control the oncogenic activity of MLL-AF4. Nat Commun 13: 6688, 2022 (PubMed)(プレスリリース)
  • 藩龍馬, 田村智彦: 自己免疫疾患の治療標的分子としての転写因子IRF5. 実験医学 増刊 40(15): 138-143, 2022
  • Kurotaki D, Kikuchi K, Cui K, Kawase W, Saeki K, Fukumoto J, Nishiyama A, Nagamune K, Zhao K, Ozato K, Rocha PP, Tamura T: Chromatin structure undergoes global and local reorganization during murine dendritic cell development and activation. Proc Natl Acad Sci USA 119(34): e2207009119, 2022 (PubMed)(プレスリリース)
  • Jikuya R, Murakami K, Nishiyama A, Kato I, Furuya M, Nakabayashi M, Ramilowski JA, Hamanoue H, Maejima K, Fujita M, Mitome T, Ohtake S, Noguchi G, Kawaura S, Odaka H, Kawahara T, Komeya M, Shinoki R, Ueno D, Ito H, Ito Y, Muraoka K, Hayashi N, Kondo K, Nakaigawa N, Hatano K, Baba M, Suda T, Kodama T, Fujii S, Makiyama K, Yao M, Shuch BM, Schmidt LS, Linehan WM, Nakagawa H, Tamura T, Hasumi H: Single-cell transcriptomes underscore genetically distinct tumor characteristics and microenvironment for hereditary kidney cancers. iScience 25(6): 104463, 2022 (PubMed)
  • Hayashi Y, Kawabata KC, Tanaka Y, Uehara Y, Mabuchi Y, Murakami K, Nishiyama A, Kiryu S, Yoshioka Y, Ota Y, Sugiyama T, Mikami K, Tamura M, Fukushima T, Asada S, Takeda R, Kunisaki Y, Fukuyama T, Yokoyama K, Uchida T, Hagihara M, Ohno N, Usuki K, Tojo A, Katayama Y, Goyama S, Arai F, Tamura T, Nagasawa T, Ochiya T, Inoue D, Kitamura T: MDS cells impair osteolineage differentiation of MSCs via extracellular vesicles to suppress normal hematopoiesis. Cell Rep 39(6): 110805, 2022 (PubMed)
  • Haruhara K, Suzuki T, Wakui H, Azushima K, Kurotaki D, Kawase W, Uneda K, Kobayashi R, Ohki K, Kinguchi S, Yamaji T, Kato I, Ohashi K, Yamashita A, Tamura T, Tsuboi N, Yokoo T, Tamura K: Deficiency of the kidney tubular angiotensin II type1 receptor-binding molecule ATRAP exacerbates streptozotocin-induced diabetic glomerular injury via reducing protective macrophage polarization. Kidney Int 101(5): 912-928, 2022 (PubMed)

2021年

  • Ito T, Osada A, Ohta M, Yokota K, Nishiyama A, Niikura Y, Tamura T, Sekita Y, Kimura T: SWI/SNF chromatin remodeling complex is required for initiation of sex-dependent differentiation in mouse germline. Sci Rep 11(1): 24074, 2021 (PubMed)
  • Kimura Y, Nakai Y, Shin J, Hara M, Takeda Y, Kubo S, Jeremiah SS, Ino Y, Akiyama T, Moriyama K, Sakai K, Saji R, Nishii M, Kitamura H, Murohashi K, Yamamoto K, Kaneko T, Takeuchi I, Hagiwara E, Ogura T, Hasegawa H, Tamura T, Yamanaka T, Ryo A: Identification of serum prognostic biomarkers of severe COVID-19 using a quantitative proteomic approach. Sci Rep 11(1): 20638, 2021 (PubMed)
  • 西山晃, 田村智彦: 転写因子IRF8による樹状細胞の分化制御. 臨床免疫・アレルギー科 76(5): 549-554, 2021
  • Saji R, Nishii M, Sakai K, Miyakawa K, Yamaoka Y, Ban T, Abe T, Ohyama Y, Nakajima K, Hiromi T, Matsumura R, Suzuki N, Taniguchi H, Otsuka T, Oi Y, Ogawa F, Uchiyama M, Takahashi K, Iwashita M, Kimura Y, Fujii S, Furuya R, Tamura T, Ryo A, Takeuchi I: Combining IL-6 and SARS-CoV-2 RNAaemia-based risk stratification for fatal outcomes of COVID-19. PLoS One 2021 Aug 11;16(8): e0256022, 2021 (PubMed)
  • Kawase W*, Kurotaki D*, Suzuki Y, Ishihara H, Ban T, Sato GR, Ichikawa J, Yanai H, Taniguchi T, Tsukahara K, and Tamura T: Irf5 siRNA-loaded biodegradable lipid nanoparticles ameliorate concanavalin A-induced liver injury. Mol Ther Nucleic Acids 25: 708-715, 2021 (*Co-1st authors)(PubMed)(プレスリリース)
  • Harada I, Sasaki H, Murakami K, Nishiyama A, Nakabayashi J, Ichino M, Miyazaki T, Kumagai K, Matsumoto K, Hagihara M, Kawase W, Tachibana T, Tanaka M, Saito T, Kanamori H, Fujita H, Fujisawa S, Nakajima H, Tamura T: Compromised anti-tumor-immune features of myeloid cell components in chronic myeloid leukemia patients. Sci Rep 11: 18046, 2021 (PubMed)
  • Ban T*, Kikuchi M*, Sato GR*, Manabe A, Tagata N, Harita K, Nishiyama A, Nishimura K, Yoshimi R, Kirino Y, Yanai H, Matsumoto Y, Suzuki S, Hihara H, Ito M, Tsukahara K, Yoshimatsu K, Yamamoto T, Taniguchi T, Nakajima H, Ito S, Tamura T: Genetic and chemical inhibition of IRF5 suppresses pre-existing mouse lupus-like disease. Nat Commun 12: 4379, 2021 (*Co-1st authors)(PubMed)(プレスリリース)
  • Kato S, Fushimi K, Yabuki Y, Maru Y, Hasegawa S, Matsuura T, Kurotaki D , Suzuki A, Kobayashi N, Yoneda M, Higurashi T, Enaka M, Tamura T, Hippo Y, Nakajima A: Precision modeling of gall bladder cancer patients in mice based on orthotopic implantation of organoid-derived tumor buds. Oncogenesis 10: 33, 2021 (PubMed)
  • Ototake Y, Yamaguchi Y, Asami M, Komitsu N, Akita A, Watanabe T, Kanaoka M, Kurotaki D, Tamura T, Aihara M: Downregulated IRF8 in monocytes/macrophages of systemic sclerosis patients may aggravate the fibrotic phenotype. J Invest Dermatol 141(8): 1954-1963, 2021 (PubMed)
  • Murakami K*, Sasaki H*, Nishiyama A*, Kurotaki D, Kawase W, Ban T, Nakabayashi J, Kanzaki S, Sekita Y, Nakajima H, Ozato K, Kimura T, Tamura T: A RUNX–CBFβ-driven enhancer directs the Irf8 dose-dependent lineage choice between DCs and monocytes. Nat Immunol 22(3): 301-311, 2021 (*Co-1st authors)(PubMed)(プレスリリース)
  • Murakami K, Kurotaki D, Kawase W, Soma S, Fukuchi Y, Kunimoto H, Yoshimi R, Koide S, Oshima M, Hishiki T, Hayakawa N, Matsuura T, Oda M, Yanagisawa K, Kobayashi H, Haraguchi M, Atobe Y, Funakoshi K, Iwama A, Takubo K, Okamoto S, Tamura T, Nakajima H: OGT Regulates Hematopoietic Stem Cell Maintenance via PINK1-Dependent Mitophagy. Cell Rep 34: 108579, 2021 (PubMed)
  • Matsuki H, Hiroshima Y, Miyake K, Murakami T, Homma Y, Matsuyama R, Morioka D, Kurotaki D, Tamura T, Endo I: Reduction of gender-associated M2-like tumor-associated macrophages in the tumor microenvironment of patients with pancreatic cancer after neoadjuvant chemoradiotherapy. J Hepatobiliary Pancreat Sci 28(2): 174-182, 2021（PubMed)

2020年

  • Ochiai K, Yamaoka M, Swaminathan A, Shima H, Hiura H, Matsumoto M, Kurotaki D, Nakabayashi J, Funayama R, Nakayama K, Arima T, Ikawa T, Tamura T, Sciammas R, Bouvet P, Kundu TK, Igarashi K: Chromatin Protein PC4 Orchestrates B Cell Differentiation by Collaborating with IKAROS and IRF4. Cell Rep 33: 108517, 2020 (PubMed)
  • Konishi H, Okamoto T, Hara Y, Komine O, Tamada H, Maeda M, Osako F, Kobayashi M, Nishiyama A, Kataoka Y, Takai T, Udagawa N, Jung S, Ozato K, Tamura T, Tsuda M, Yamanaka K, Ogi T, Sato K, Kiyama H: Astrocytic phagocytosis is a compensatory mechanism for microglial dysfunction. EMBO J 39(22): e104464, 2020 (PubMed)
  • Kurotaki D, Yoshida H, Tamura T: Epigenetic and transcriptional regulation of osteoclast differentiation. Bone 138: 115471, 2020 (PubMed)
  • Hiromi T, Yokoyama U, Kurotaki D, Mamun A, Ishiwata R, Ichikawa Y, Nishihara H, Umemura M, Fujita T, Yasuda S, Minami T, Goda M, Uchida K, Suzuki S, Takeuchi I, Masuda M, Breyer RM, Tamura T, Ishikawa Y: Excessive EP4 signaling in smooth muscle cells induces abdominal aortic aneurysm by amplifying inflammation. Arterioscler Thromb Vasc Biol 40(6): 1559-1573, 2020 (PubMed)
  • Matsunaga S, Jeremiah SS, Miyakawa K, Kurotaki D, Shizukuishi S, Watashi K, Nishitsuji H, Kimura H, Tamura T, Yamamoto N, Shimotohno K, Wakita T, Ryo A: Engineering Cellular Biosensors with Customizable Antiviral Responses Targeting Hepatitis B Virus. iScience 23: 100867, 2020 (PubMed)
  • 黒滝大翼, 田村智彦: 転写因子IRF8による樹状細胞分化のエピジェネティック制御. 血液内科 80(1): 96-100, 2020

2019年

  • Guiliams M, Tamura T: Decrypting DC development. Nat Immunol 20: 1090-1092, 2019 (PubMed)
  • 田村智彦, 黒滝大翼: 造血におけるシングルセル解析の進歩. 臨床血液 60:1075-1083, 2019 (PubMed)
  • 黒滝大翼, 佐々木悠, 田村智彦: UP-TO-DATE赤脾髄マクロファージ. 血液内科78(6): 751-757, 2019
  • Kobayakawa K, Ohkawa Y, Yoshizaki S, Tamaru T, Saito T, Kijima K, Yokota K, Hara M, Kubota M, Matsumoto M, Harimaya K, Ozato K, Masuda T, Tsuda M, Tamura T, Inoue K, Edgerton VR, Iwamoto Y, Nakashima Y, Okada S: Macrophage centripetal migration drives spontaneous healing process after spinal cord injury. Sci Adv 5: eaav5086, 2019 (PubMed)
  • Miyakawa K, Matsunaga S, Yokoyama M, Nomaguchi M, Kimura Y, Nishi M, Kimura H, Sato H, Hirano H, Tamura T, Akari H, Miura T, Adachi A, Sawasaki T, Yamamoto N, Ryo A: PIM kinases facilitate lentiviral evasion from SAMHD1 restriction via Vpx phosphorylation. Nat Commun 10: 1844, 2019 (PubMed)
  • Kurotaki D*, Kawase W*, Sasaki H, Nakabayashi J, Nishiyama A, Morse HC III, Ozato K, Suzuki Y, Tamura T: Epigenetic control of early dendritic cell lineage specification by the transcription factor IRF8 in mice. Blood 133: 1803-1813, 2019(*equal contributors) (PubMed)(Commentary)(プレスリリース)
  • Bachu M, Tamura T, Chen C, Narain A, Nehru V, Sarai N, Ghosh SB, Ghosh A, Kavarthapu R, Dufau ML, Ozato K: A versatile mouse model of epitope-tagged histone H3.3 to study epigenome dynamics. J Biol Chem 294: 1904-1914, 2019 (PubMed)
  • Izawa N*, Kurotaki D*, Nomura S*, Fujita T, Omata Y, Yasui T, Hirose J, Matsumoto T, Saito T, Kadono Y, Okada H, Miyamoto T, Tamura T, Aburatani H, Tanaka S: Cooperation of PU.1 with IRF8 and NFATc1 defines chromatin landscapes during RANKL-induced osteoclastogenesis. J Bone Miner Res 34: 1143-1154, 2019 (*equal contributors) (PubMed)(Wiley Online Library)

2018年

  • Kamada R, Yang W, Zhang Y, Patel MC, Yang Y, Ouda R, Dey A, Wakabayashi Y, Sakaguchi K, Fujita T, Tamura T, Zhu J, Ozato K: Interferon stimulation creates chromatin marks and establishes transcriptional memory. Proc Natl Acad Sci USA 115: E9162–E9171, 2018 [Epub ahead of print] (PubMed)
  • 藩 龍馬, 田村智彦: TLR-MyD88経路と全身性エリテマトーデスにおける転写因子IRF5の制御と役割. 医学のあゆみ 265: 1185-1191, 2018
  • Ban T, Sato GR, Tamura T: Regulation and role of the transcription factor IRF5 in innate immune responses and systemic lupus erythematosus. Int Immunol 30: 529-536, 2018 (PubMed)(Oxford University Press)
  • 藩 龍馬: 全身性エリテマトーデスの治療法開発に向けた自然免疫応答制御機構の解明. 横浜医学 69: 59-65, 2018
  • Kurotaki D, Nakabayashi J, Nishiyama A, Sasaki H, Kawase W, Kaneko N, Ochiai K, Igarashi K, Ozato K, Suzuki Y, Tamura T: Transcription factor IRF8 governs enhancer landscape dynamics in mononuclear phagocyte progenitors. Cell Rep 22: 2628–2641, 2018 (PubMed)(プレスリリース)(Myeloid Chromatin Atlas)
  • Haruhara K, Wakui H, Azushima K, Kurotaki D, Kawase W, Uneda K, Haku S, Kobayashi R, Ohki K, Kinguchi S, Ohsawa M, Minegishi S, Ishigami T, Matsuda M, Yamashita A, Nakajima H, Tamura T, Tsuboi N, Yokoo T, Tamura K: Angiotensin receptor-binding molecule in leukocytes in association with the systemic and leukocyte inflammatory profile. Atherosclerosis 269: 236-244, 2018 (PubMed)

2017年

  • 黒滝大翼, 田村智彦: 血球系細胞のシングルセル解析のための細胞分取. 実験医学 別冊: 80-90, 2017
  • 田村智彦: 転写因子IRF8による単核貪食細胞の分化制御. 臨床血液 58(7): 798-805, 2017 (PubMed)(J-STAGE)
  • Sato GR, Ban T, Tamura T: Phos-tag immunoblot analysis for detecting IRF5 phosphorylation. Bio-protocol 7(10): e2295, 2017 (論文情報)
  • 藩龍馬, 田村智彦: 転写因子IRF5の活性を選択的に阻害する分子Lynの同定と全身性エリテマトーデス. 臨床免疫・アレルギー科 67(5): 532-538, 2017
  • Kurotaki D, Sasaki H, Tamura T: Transcriptional control of monocyte and macrophage development. Int Immunol 29(3): 97-107, 2017 (PubMed)(Oxford University Press)
  • 黒滝大翼, 佐々木悠, 田村智彦: 赤脾髄マクロファージの分化と機能. 細胞 49(4): 163-166, 2017

2016年

  • 田村智彦, 西山晃: 転写因子によるミエロイド系細胞の分化制御. 日本臨床 74(増刊号10): 481-486, 2016
  • Miyake N, Fukui R, Ohba C, Chihara T, Miura M, Shimizu H, Kakita A, Imagawa E, Shiina M, Ogata K, Okuno-Yuguchi J, Fueki N, Ogiso Y, Suzumura H, Watabe Y, Imataka G, Leong HY, Fattal-Valevski A, Kramer U, Miyatake S, Kato M, Okamoto N, Sato Y, Mitsuhashi S, Nishino I, Kaneko N, Nishiyama A, Tamura T, Mizuguchi T, Nakashima M, Tanaka F, Saitsu H, Matsumoto N: Biallelic TBCD Mutations Cause Early-Onset Neurodegenerative Encephalopathy. Am J Hum Genet 99, 950-961, 2016 (PubMed)
  • Ban T*, Sato GR*, Nishiyama A, Akiyama A, Takasuna M, Umehara M, Suzuki S, Ichino M, Matsunaga S, Kimura A, Kimura Y, Yanai H, Miyashita S, Kuromitsu J, Tsukahara K, Yoshimatsu K, Endo I, Yamamoto T, Hirano H, Ryo A, Taniguchi T, Tamura T: Lyn Kinase Suppresses the Transcriptional Activity of IRF5 in the TLR-MyD88 Pathway to Restrain the Development of Autoimmunity. Immunity 45, 319–332, 2016 (*equal contributors)(PubMed)(プレスリリース)(新着論文レビュー)
  • Saito E, Suzuki D, Kurotaki D, Mochizuki A, Manome Y, Suzawa T, Toyoshima Y, Ichikawa T, Funatsu T, Inoue T, Takami M, Tamura T, Inagaki K, Kamijo R: Down-regulation of Irf8 by Lyz2-cre/loxP accelerates osteoclast differentiation in vitro. Cytotechnology Aug 8, 2016 [Epub ahead of print](Pubmed)
  • Yamamizu K, Sharov AA, Piao Y, Amano M, Yu H, Nishiyama A, Dudekula DB, Schlessinger D, Ko MS: Generation and gene expression profiling of 48 transcription-factor-inducible mouse embryonic stem cell lines. Sci Rep 6, 25667, 2016 (PubMed)
  • Kurotaki D, Tamura T: Transcriptional and epigenetic regulation of innate immune cell development by the transcription factor IRF8. J Interferon Cytokine Res 36, 433-441, 2016 (PubMed)
  • Sasaki H, Kurotaki D, Tamura T: Regulation of basophil and mast cell development by transcription factors. Allergol Int 65, 127-134, 2016 (PubMed)

2015年

  • Suzuki S, Ichikawa Y, Nakagawa K, Kumamoto T, Mori R, Matsuyama R, Takeda K, Ota M, Tanaka K, Tamura T, Endo I: High infiltration of mast cells positive to tryptase predicts worse outcome following resection of colorectal liver metastases. BMC Cancer 15: 840, 2015 (PubMed)
  • 田村智彦, 小泉真一, 黒滝大翼: ミエロイド系細胞の分化と転写因子. 臨床血液 56(10): 1861-1870, 2015 (PubMed)
  • Kato Y, Yokoyama U, Yanai C, Ishige R, Kurotaki D, Umemura M, Fujita T, Kubota T, Okumura S, Sata M, Tamura T, Ishikawa Y: Epac1 Deficiency Attenuated Vascular Smooth Muscle Cell Migration and Neointimal Formation. Arterioscler Thromb Vasc Biol 35, 2617-2625, 2015 (PubMed)
  • Masuda T, Iwamoto S, Mikuriya S, Tozaki-Saitoh H, Tamura T, Tsuda M, Inoue K: Transcription factor IRF1 is responsible for IRF8-mediated IL-1β expression in reactive microglia. J Pharmacol Sci 128, 216-220, 2015 (PubMed)
  • 佐々木悠, 黒滝大翼, 田村智彦: 転写因子IRF8による好塩基球とマスト細胞の分化制御. 臨床免疫・アレルギー科 63(6): 593-596, 2015
  • Miyakawa K, Matsunaga S, Kanou K, Matsuzawa A, Morishita R, Kudoh A, Shindo K, Yokoyama M, Sato H, Kimura H, Tamura T, Yamamoto N, Ichijo H, Takaori-Kondo A, Ryo A: ASK1 restores the antiviral activity of APOBEC3G by disrupting HIV-1 Vif-mediated counteraction. Nat Commun 6, 6945, 2015 (PubMed)
  • Yamashita N, Jitsuki-Takahashi A, Ogawara M, Ohkubo W, Araki T, Hotta C, Tamura T, Hashimoto SI, Yabuki T, Tsuji T, Sasakura Y, Okumura H, Takaiwa A, Koyama C, Murakami K, Goshima Y: Anti-Semaphorin 3A neutralization monoclonal antibody prevents sepsis development in　lipopolysaccharide-treated mice. Int Immunol 27, 459-466, 2015 (PubMed)
  • Tamura T: Guest editorial: Transcriptional control in myeloid cell development and related diseases. Int J Hematol 101, 317-318, 2015 (PubMed)
  • Tamura T, Kurotaki D, Koizumi S: Regulation of myelopoiesis by the transcription factor IRF8. Int J Hematol 101, 342-351, 2015 (PubMed)
  • Kurotaki D, Uede T, Tamura T: Functions and development of red pulp macrophages. Microbial Immunol 59, 55-62, 2015 (PubMed)
  • Sasaki H*, Kurotaki D*, Osato N, Sato H, Sasaki I, Koizumi S, Wang H, Kaneda C, Nishiyama A, Kaisho T, Aburatani H, Morse HC 3rd, Ozato K, Tamura T: Transcription factor IRF8 plays a critical role in the development of murine basophils and mast cells. Blood 125, 358-369, 2015 (*equal contributors)(PubMed)(プレスリリース)

2014年

  • 小泉真一, 田村智彦: 転写因子による樹状細胞の分化制御. 臨床免疫・アレルギー科 62(5): 510-518, 2014
  • Akagi T, Matsumura Y, Yasui M, Minami E, Inoue H, Masuda T, Tozaki-Saitoh H, Tamura T, Mizumura K, Tsuda M, Kiyama H, Inoue K: Interferon regulatory factor 8 expressed in microglia contributes to tactile allodynia induced by repeated cold stress in rodents. J Pharmacol Sci 126, 172-176, 2014 (PubMed)
  • Kurotaki D*, Yamamoto M*, Nishiyama A, Uno K, Ban T, Ichino M, Sasaki H, Matsunaga S, Yoshinari M, Ryo A, Nakazawa M, Ozato K, Tamura T: IRF8 inhibits C/EBPα activity to restrain mononuclear phagocyte progenitors from differentiating into neutrophils. Nat Commun 5, 4978, 2014 (*equal contributors)(PubMed)(プレスリリース)
  • Chiba S, Ikushima H, Ueki H, Yanai H, Kimura Y, Hangai S, Nishio J, Negishi H, Tamura T, Saijo S, Iwakura Y, Taniguchi T: Recognition of tumor cells by Dectin-1 orchestrates innate immune cells for anti-tumor responses. eLife 3, e04177, 2014 (PubMed)
  • Sharov AA, Nishiyama A, Qian Y, Dudekula D, Longo DL, Schlessinger D, Ko MSH: Chromatin properties of regulatory DNA probed by manipulation of transcription factors. J Comput Biol 21, 569-577, 2014 (PubMed)
  • Masuda T, Iwamoto S, Yoshinaga R, Tozaki-Saitoh H, Nishiyama A, Mak TW, Tamura T, Tsuda M, Inoue K: Transcription factor IRF5 drives P2X4R(+)-reactive microglia gating neuropathic pain. Nat Commun 5, 3771, 2014 (PubMed)
  • Masuda T, Nishimoto N, Tomiyama D, Matsuda T, Tozaki-Saitoh H, Tamura T, Kohsaka S, Tsuda M, Inoue K: IRF8 is a transcriptional determinant for microglial motility. Purinergic Signal 10, 515-521, 2014 (PubMed)
  • Ito K, Morimoto J, Kihara A, Matsui Y, Kurotaki D, Kanayama M, Simmons S, Ishii M, Sheppard D, Takaoka A, Uede T: Integrin α9 on lymphatic endothelial cells regulates lymphocyte egress. Proc Natl Acad Sci USA 111, 3080-3085, 2014 (PubMed)

2013年

  • Watanabe T*, Hotta C*, Koizumi S, Miyashita K, Nakabayashi J, Kurotaki D, Sato GR, Yamamoto M, Nakazawa M, Fujita H, Sakai R, Fujisawa S, Nishiyama A, Ikezawa Z, Aihara M, Ishigatsubo Y, Tamura T: The transcription factor IRF8 counteracts BCR-ABL to rescue dendritic cell development in chronic myeloid leukemia. Cancer Res 73, 6642-6653, 2013 (*equal contributors)(PubMed)(プレスリリース)
  • 黒滝大翼, 田村智彦: IRF8-KLF4転写因子カスケードによる単球分化制御. 実験医学 31(18): 2971-2975, 2013
  • Sarai N, Nimura K, Tamura T, Kanno T, Patel MC, Heightman TD, Ura K, Ozato K: WHSC1 links transcription elongation to HIRA-mediated histone H3.3 deposition. EMBO J 32, 2392-2406, 2013 (PubMed)
  • Patel MC, Debrosse M, Smith M, Dey A, Huynh W, Sarai N, Heightman TD, Tamura T, Ozato K: BRD4 coordinates recruitment of pause-release factor P-TEFb and the pausing complex NELF/DSIF to regulate transcription elongation of interferon stimulated genes. Mol Cell Biol 33, 2497-2507, 2013 (PubMed)
  • Nishiyama A, Sharov AA, Piao Y, Amano M, Amano T, Hoang H, Binder BY, Tapnio R, Bassey U, Malinou J, Correa-Cerro LS, Yu H, Xin L, Meyers E, Zalzman M, Nakatake Y, Stagg C, Sharova L, Qian Y, Dudekula D, Sheer S, Cadet JS, Hirata T, Yang HT, Goldberg I, Evans MK, Longo DL, Schlessinger D, Ko MS: Systematic repression of transcription factors reveals limited patterns of gene expression changes in ES cells. Sci Rep 3, 1390, 2013 (PubMed)
  • Iwasaki Y, Fujio K, Okamura T, Yanai A, Sumitomo S, Shoda H, Tamura T, Yoshida H, Charnay P, Yamamoto K: Egr-2 transcription factor is required for Blimp-1 mediated IL-10 production in IL-27 stimulated CD4(+) T cells. Eur J Immunol 43, 1-11, 2013 (PubMed)
  • *Kurotaki D, *Osato N, *Nishiyama A, *Yamamoto M, Ban T, Sato H, Nakabayashi J, Umehara M, Miyake N, Matsumoto N, Nakazawa M, Ozato K, Tamura T: Essential role of the IRF8-KLF4 transcription factor cascade in murine monocyte differentiation. Blood 121, 1839-1849, 2013 (*equal contributors)(PubMed)(プレスリリース)

2012年

  • Nishiyama A, Dey A, Tamura T, Ko M, Ozato K: Activation of JNK triggers release of Brd4 from mitotic chromosomes and mediates protection from drug-induced mitotic stress. PLoS ONE 7, e34719, 2012 (PubMed)
  • Masuda T, Tsuda M, Yoshinaga R, Tozaki-Saitoh H, Ozato K, Tamura T, Inoue K: IRF8 is a critical transcription factor for transforming microglia into a reactive phenotype. Cell Rep 1, 334-340, 2012 (PubMed)
  • Danzaki K, Matsui Y, Ikesue M, Ohta D, Ito K, Kanayama M, Kurotaki D, Morimoto J, Iwakura Y, Yagita H, Tsutsui H, Uede T: Interleukin-17A deficiency accelerates unstable atherosclerotic plaque formation in apolipoprotein E-Deficient mice. Arterioscler Thromb Vasc Biol 32 (2) : 273-280, 2012 (PubMed)
  • Nakabayashi J: Optimal ratio of scaffold complex to free Fus3 to maximise the accumulation of phosphorylated Fus3 in yeast pheromone signaling pathway. IET Syst Biol 6 (1) : 9-21, 2012 (PubMed)
  • Koizumi S, Masuko K, Wakita D, Tanaka S, Mitamura R, Kato Y, Tabata H, Nakahara M, Kitamura H, Nishimura T: Extracts of Larix Leptolepsis effectively augments the generation of tumor antigen-specific cytotoxic T lymphocytes via activation of dendritic cells in TLR-2 and TLR-4-dependent manner. Cell Immunol 276 (1-2) : 153-161, 2012 (PubMed)
  • Yoshida T, Katsuya K, Oka T, Koizumi S, Wakita D, Kitamura H, Nishimura T: Effects of AhR ligands on the production of immunoglobulins in purified mouse B cells. Biomed Res 33 (2) : 67-74, 2012 (PubMed)
  • Nakabayashi J: A compartmentalization model of hepatitis C virus replication: an appropriate distribution of HCV RNA for the effective replication. J Theor Biol 300: 110-117, 2012 (PubMed)
  • Kominami K, Nakabayashi J, Nagai T, Tsujimura Y, Chiba K, Kimura H, Miyawaki A, Sawasaki T, Yokota H, Manabe N, Sakamaki K: The molecular mechanism of apoptosis upon caspase-8 activation: quantitative experimental validation of a mathematical model. Biochim Biophys Acta 1823 (10) : 1825-1840, 2012 (PubMed)
  • Kominami K, Nagai T, Sawasaki T, Tsujimura Y, Yashima K, Sunaga Y, Tsuchimochi M, Nishimura J, Chiba K, Nakabayashi J, Koyamada K, Endo Y, Yokota H, Miyawaki A, Manabe N, Sakamaki K: In vivo imaging of hierarchical spatiotemporal activation of caspase-8 during apoptosis. PLoS ONE 7 (11) : e50218, 2012 (PubMed)
  • Yanai H, Ban T, Taniguchi T: High-mobility group box family of proteins: ligand and sensor for innate immunity. Trends Immunol 33 (12) : 633-640, 2012 (PubMed)
  • 森本純子，黒滝大翼，上出利光：赤脾髄マクロファージによるT細胞の抑制とその機序. 臨床免疫・アレルギー科 57 (2) : 203-210, 2012
  • 中武悠樹，西山晃，洪実：転写調節因子を自在に誘導できるES細胞バンクの作製とその応用. 実験医学 増刊 30 (10) : 1639-1645, 2012
  • 中林潤：肝炎ウイルスの細胞内複製動態の数理モデル. 応用数理 22 (3) : 173-182, 2012.

2011年

  • Yamamoto M, Kato T, Hotta C, Nishiyama A, Kurotaki D, Yoshinari M, Takami M, Ichino M, Nakazawa M, Matsuyama T, Kamijo R, Kitagawa S, Ozato K, Tamura T: Shared and distinct functions of the transcription factors IRF4 and IRF8 in myeloid cell development. PLoS ONE 6, e25812, 2011 (PubMed)
  • Sharov AA, Nishiyama A, Piao Y, Correa-Cerro LS, Amano, T, Thomas, M, Mehta S, Ko MSH: Responsiveness of genes to manipulation of transcription factors in ES cells is associated with histone modifications and tissue specificity. BMC Genomics 12: 102, 2011 (PubMed)
  • Correa-Cerro LS, Piao Y, Sharov AA, Nishiyama A, Cadet JS, Yu H, Sharova LV, Xin L, Hoang HG, Thomas M, Qian Y, Dudekula DB, Meyers E, Binder BY, Mowrer G, Bassey U, Longo DL, Schlessinger D, Ko MSH: Generation of mouse ES cell lines engineered for the forced induction of transcription factors. Sci Rep 1: 167, 2011 (PubMed)
  • Kanayama M, Morimoto J, Matsui Y, Danzaki K, Kurotaki D, Ito K, Yoshida T, Uede T: Alpha9beta1 integrin-mediated signaling serves as an intrinsic regulator of pathogenic Th17 cell generation. J Immunol 187(11): 5851-5864, 2011 (PubMed)
  • Ikesue M, Matsui Y, Ohta D, Danzaki K, Ito K, Kanayama M, Kurotaki D, Morimoto J, Kojima T, Tsutsui H, Uede T: Syndecan-4 deficiency limits neointimal formation after vascular injury by regulating vascular smooth muscle cell proliferation and vascular progenitor cell mobilization. Arterioscler Thromb Vasc Biol 31(5): 1066-1074, 2011 (PubMed)
  • Kurotaki D, Kon S, Bae K, Ito K, Matsui Y, Nakayama Y, Kanayama M, Kimura C, Narita Y, Nishimura T, Iwabuchi K, Mack M, van Rooijen N, Sakaguchi S, Uede T, Morimoto J: CSF-1 dependent red pulp macrophages regulate CD4 T cell responses. J Immunol 186(4): 2229-2237, 2011 (PubMed)

2010年

  • 市野素英, 堀田千絵, 田村智彦: “治らない炎症”が引き起こす疾患の分子機構. 細胞工学 29(8), 793-798, 2010
  • Savitsky DA, Yanai H, Tamura T, Taniguchi T, Honda K: Contribution of IRF5 in B cells to the development of murine SLE-like disease through its transcriptional control of the IgG2a locus. Proc Natl Acad Sci USA 107, 10154-10159, 2010 (PubMed)
  • Zalzman M, Falco G, Sharova LV, Nishiyama A, Thomas M, Lee SL, Stagg CA, Hoang HG, Yang HT, Indig FE, Wersto RP, Ko MS: Zscan4 regulates telomere elongation and genomic stability in ES cells. Nature 464(7290): 858-863, 2010 (PubMed)
  • Jayaraman P, Sada-Ovalle I, Belladi S, Anderson AC, Dardalhon V, Hotta C, Kuchroo VK, Behar S: Tim3 binding to Galectin-9 stimulates antimicrobial immunity. J Exp Med 207(11): 2343-2354, 2010 (PubMed)
  • Wang HB, Kondo A, Yoshida A, Yoshizaki S, Abe S, Bao LL, Mizuki N, Ichino M, Klinman D, Okuda K, Shimada M: Partial protection against SIV challenge by vaccination of adenovirus and MVA vectors in rhesus monkeys. Gene Ther 17(1): 4-13, 2010 (PubMed)
  • Shimada M, Yoshizaki S, Jounai N, Kondo A, Ichino M, Ryo A, Okuda K: DNA vaccine expressing HIV-1 gp120/immunoglobulin fusion protein enhances cellular immunity. Vaccine 28(31): 4920-4927, 2010 (PubMed)
  • 田村智彦: 転写因子ファミリーIRFの生体防御における役割 –自然免疫細胞の分化や慢性骨髄性白血病への関わりを中心に-．神奈川血液研究会誌 30: 42-44, 2010
  • Savitsky D, Tamura T, Yanai H, Taniguchi T: Regulation of immunity and oncogenesis by the IRF transcription factor family. Cancer Immunol Immunother 59, 489-510, 2010 (PubMed)

2009年

  • Yanai H, Ban T, Wang Z, Choi MK, Kawamura T, Negishi H, Nakasato M, Lu Y, Hangai S, Koshiba R, Savitsky D, Ronfani R, Akira S, Bianchi ME, Honda K, Tamura T, Kodama T, Taniguchi T: HMGB proteins function as universal sentinels for nucleic acid-mediated innate immune responses. Nature 462, 99-103, 2009 (PubMed)
  • Choi MK, Wang Z, Ban T, Yanai H, Lu Y, Koshiba R, Nakaima Y, Hangai S, Savitsky D, Nakasato M, Negishi H, Takeuchi O, Honda K, Akira S, Tamura T Taniguchi T: A selective contribution of the RIG-I-like receptor pathway to type I interferon responses activated by cytosolic DNA. Proc Natl Acad Sci USA 106, 17870-17875, 2009 (PubMed)
  • Zhao B, Takami M, Yamada A, Wang X, Koga T, Hu X, Tamura T, Ozato K, Choi Y, Ivashkiv LB, Takayanagi H, Kamijo R: Interferon regulatory factor 8 regulates bone metabolism by suppressing osteoclastogenesis. Nat Med 15, 1066-1071, 2009 (PubMed)
  • Nakajima A, Nishimura K, Nakaima Y, Oh T, Noguchi S, Taniguchi T, Tamura T: Cell type-dependent proapoptotic role of Bcl2L12 revealed by a mutation concomitant with the disruption of the juxtaposed Irf3 gene. Proc Natl Acad Sci USA 106, 12448-12452, 2009 (PubMed)
  • Pham W, Kobukai S, Hotta C, Gore JC: Dendritic cells: therapy and imaging. Expert Opin Biol Ther 9(5): 539-564, 2009 (PubMed)
  • Yanai H, Savitsky D, Tamura T, Taniguchi T: Regulation of the cytosolic DNA-sensing system in innate immunity; A current view. Curr Opin Immunol 21, 17-22, 2009 (Review) (PubMed)
  • Tamura T, Smith M, Kanno T, Dasenbrock H, Nishiyama A Ozato K: Inducible deposition of the histone variant H3.3 in interferon-stimulated genes. J Biol Chem 284, 12217-12225, 2009 (PubMed)

2008-1994年

  • Takaoka A, Tamura T, Taniguchi T: Interferon regulatory factor family of transcription factors and regulation of oncogenesis. Cancer Sci 99, 467-478, 2008 (Review)
  • Negishi H, Osawa T, Ogami K, Ouyang X, Sakaguchi S, Koshiba R, Yanai H, Seko Y, Shitara H, Bishop K, Yonekawa H, Tamura T, Kaisho Y, Taya C, Taniguchi T, Honda K: A critical link between Toll-like receptor 3 and type II interferon signaling pathways in antiviral innate immunity. Proc Natl Acad Sci USA 105, 20446-20451, 2008
  • Wang Z, Choi1 MK, Ban T, Yanai H, Negishi H, Lu Y, Tamura T, Takaoka A, Nishikura K, Taniguchi T: Regulation of innate immune responses by DAI (DLM-1 / ZBP1) and other DNA-sensing molecules. Proc Natl Acad Sci USA 105, 5477-5482, 2008
  • Mochizuki K, Nishiyama A, Jang MK, Dey A, Ghosh A, Tamura T, Natsume H, Yao H, Ozato K.: The bromodomain protein Brd4 stimulates G1 gene transcription and promotes progression to S phase. J Biol Chem 283, 9040-9048, 2008
  • Couzinet A, Tamura K, Chen HM, Nishimura K, Wang Z, Morishita Y, Takeda K, Yagita H, Yanai H, Taniguchi T, Tamura T: A cell type-specific requirement for IRF5 in Fas-induced apoptosis. Proc Natl Acad Sci USA 105: 2556-2561, 2008
  • Tamura T, Yanai H, Savitsky D, Taniguchi T: The IRF family transcription factors in immunity and oncogenesis. Annu Rev Immunol 26, 535-584, 2008 (Review)
  • Tailor P, Tamura T, Morse HC 3rd, Ozato K: The BXH2 mutation in IRF8 differentially impairs dendritic cell subset development in the mouse. Blood 111, 1942-1945, 2008
  • Aomatsu K, Kato T, Fujita H, Hato F, Oshitani N, Kamata N, Tamura T, Arakawa T, Kitagawa S: Toll-like receptor agonists stimulate human neutrophil migration via activation of mitogen-activated protein kinases. Immunology 23, 171-180, 2008
  • Tailor P, Tamura T, Kong HJ, Kubota T, Kubota M, Borghi P, Gabriele L, Ozato K: The feedback phase of type I interferon induction in dendritic cells requires interferon regulatory factor 8. Immunity 27: 228-239, 2007
  • Kong HJ, Anderson DE, Lee CH, Jang MK, Tamura T, Tailor P, Cho HK, Cheong J, Xiong H, Morse HC 3rd, Ozato K: Cutting Edge: Autoantigen Ro52 is an interferon inducible E3 ligase that ubiquitinates IRF-8 and enhances cytokine expression in macrophages. J Immunol 179: 26-30, 2007
  • Yang D, Thangaraju M, Greeneltch K, Browning DD, Schoenlein P, Tamura T, Ozato K, Ganapathy V, Abrams SI, Liu K: Repression of IFN regulatory factor 8 by DNA methylation is a molecular determinant of apoptotic resistance and metastatic phenotype in metastatic tumor cells. Cancer Res 67: 3301-3309, 2007
  • Dror N, Rave-Harel N, Burchert A, Azriel A, Tamura T, Tailor P, Neubauer A, Ozato K, Levi BZ: IRF-8 is indispensable for the expression of PML and the formation of nuclear bodies in myeloid cells. J Biol Chem 282: 5633-5640, 2007
  • Dror N, Alter-Koltunoff M, Azriel A, Amariglio N, Jacob-Hirsch J, Zeligson S, Morgenstern A, Tamura T, Hauser H, Rechavi G, Ozato K, Levi BZ: Identification of IRF-8 and IRF-1 target genes in activated macrophages. Mol Immunol 44: 338-346, 2007
  • Tailor P, Tamura T, Ozato K: IRF family proteins and type I interferon induction in dendritic cells. Cell Res 16: 134-140, 2006 (Review)
  • Samarasinghe R, Tailor P, Tamura T, Kaisho T, Akira S, Ozato K: Induction of an anti-inflammatory cytokine IL-10 in dendritic cells after Toll-like receptor signaling. J. Interferon Cytokine Res 26: 893-900, 2006
  • Kanno Y, Levi BZ, Tamura T, Ozato K: Immune Cell Specific Amplification of IFN Signaling by the IRF4/8-PU.1 Complex. J Interferon Cytokine Res25: 770-779, 2005 (Review)
  • Laricchia-Robbio L, Tamura T, Karpova T, Sprague BL, McNally JG, Ozato K: Partner-regulated interaction of IFN regulatory factor 8 with chromatin visualized in live macrophages. Proc Natl Acad Sci USA 102: 14368-14373, 2005
  • Dey M, Cao C, Dar AC, Tamura T, Ozato K, Sicheri F, Dever TE: Mechanistic link between catalytic domain dimerization, autophosphorylation and eIF2a substrate recognition by the RNA-dependent protein kinase PKR. Cell 122: 901-913, 2005
  • Tamura T, Thotakura P, Tanaka TS, Ko MS, Ozato K: Identification of target genes and a unique cis element regulated by IRF-8 in developing macrophages. Blood 106: 1938-1947, 2005
  • Ishii KJ, Ito S, Tamura T, Hemmi H, Conover J, Ozato K, Akira S, Klinman DM: CpG-activated Thy1.2+ dendritic cells protect against lethal Listeria monocytogenes infection. Eur J Immunol 35: 2397-2405, 2005
  • Tamura T, Tailor P, Yamaoka K, Kong HJ, Tsujimura H, O’Shea JJ, Singh H, Ozato K: IFN regulatory factor-4 and -8 govern dendritic cell subset development and their functional diversity. J Immunol 174: 2573-2581, 2005
  • Liu J, Guan X, Tamura T, Ozato K, Ma X: Synergistic activation of interleukin-12 p35 gene transcription by interferon regulatory factor-1 and interferon consensus sequence binding protein. J Biol Chem 279: 55609-55617, 2004
  • Tsujimura H, Tamura T, Kong HJ, Nishiyama A, Ishii KJ, Klinman DM, Ozato K: Toll-like receptor 9 signaling activates NF-kappaB through IFN regulatory factor-8/IFN consensus sequence binding protein in dendritic cells. J Immunol 172: 6820-6827, 2004
  • Schmidt M, Bies J, Tamura T, Ozato K, Wolff L: The interferon regulatory factor ICSBP/IRF-8 in combination with PU.1 Up-regulates p15INK4b tumor suppressor expression in murine myeloid cells. Blood 103: 4142-4149, 2004
  • Ozato K, Tsujimura H, Tamura T: Toll-like receptor signaling and regulation of cytokine gene expression in the immune system. BiotechniquesSuppl: 66-68, 70, 72 passim, 2003
  • Alter-Koltunoff M, Ehrlich S, Dror N, Azriel A, Eilers M, Hauser H, Bowen H, Barton CH, Tamura T, Ozato K, Levi BZ: Nramp1 mediated innate resistance to intraphagosomal pathogens is regulated by IRF-8, PU.1 and Miz-1. J Biol Chem 278: 44025-44032, 2003
  • Tamura T, Kong HJ, Tunyaplin C, Tsujimura H, Calame K, Ozato K: ICSBP/IRF-8 inhibits mitogenic Activity of p210 Bcr/Abl in differentiating myeloid progenitor cells. Blood 102: 4547-4554, 2003
  • Tsujimura H, Tamura T, Ozato K: Cutting edge: IFN consensus sequence binding protein/IFN regulatory factor 8 drives the development of type I IFN-producing plasmacytoid dendritic cells. J Immunol 170: 1131-1135, 2003
  • Tsujimura H, Tamura T, Gongora C, Aliberti J, Reis e Sousa C, Sher A, Ozato K: ICSBP/IRF-8 retrovirus transduction rescues dendritic cell development in vitro. Blood 101: 961-969, 2003
  • Tamura T, Ozato K: ICSBP (IRF-8): its regulatory role in the development of myeloid cells. J Interferon Cytokine Res 22: 145-152, 2002 (Review)
  • Maruyama T, Farina A, Dey A, Cheong JH, Bermudez VP, Tamura T, Sciortino S, Shuman J, Hurwitz J, Ozato K: A mammalian bromodomain protein Brd4 interacts with replication factor C and inhibits progression to S phase. Mol Cell Biol 22: 6509-6520, 2002
  • Kuwata T, Gongora C, Kanno Y, Sakaguchi K, Tamura T, Basrur V, Martinez R, Appella E, Golub T, Ozato K: Gamma interferon triggers the interaction between ICSBP (IRF-8) and TEL recruiting the histone deacetylase HDAC3 to the interferon responsive element. Mol Cell Biol 22: 7439-7448, 2002
  • Tsujimura H, Nagamura-Inoue T, Tamura T, Ozato K: IFN Consensus Sequence Binding Protein/IFN Regulatory Factor-8 guides bone marrow progenitor cells towards the macrophage Lineage. J Immunol 169: 1261-1269, 2002
  • Nagamura-Inoue T, Tamura T, Ozato K: Transcription factors that regulate growth and differentiation of myeloid cells. Int Rev Immunol 20: 83-105, 2001 (Review)
  • Tamura T, Nagamura-Inoue T, Shmeltzer Z, Kuwata T, Ozato K: ICSBP directs bipotential myeloid progenitor cells to differentiate into mature macrophages. Immunity 13: 155-165, 2000
  • Yamauchi T, Yamauchi J, Kuwata T, Tamura T, Yamashita T, Bae N, Westphal H, Ozato K, Nakatani Y: Distinct but overlapping roles of histone acetylase PCAF and of the closely related PCAF-B/GCN5 in mouse embryogenesis. Proc Natl Acad Sci USA 97: 11303-11306, 2000
  • Kuwata T, Wang IM, Tamura T, Ponnamperuma RM, Levine R, Holmes KL, Morse HC, De Luca LM, Ozato K: Vitamin A deficiency in mice causes a systemic expansion of myeloid cells. Blood 95, 3349-3356, 2000
  • Kanamori H, Maruta A, Sasaki S, Yamazaki E, Ueda S, Katoh K, Tamura T, Otsuka-Aoba M, Taguchi J, Harano H, Ogawa K, Mohri H, Okubo T, Matsuzaki M, Watanabe S, Koharazawa H, Fujita, H, Kodama F: Diagnostic value of hemostatic parameters in bone marrow transplant-associated thrombotic microangiopathy. Bone Marrow Transplant 21: 705-709, 1998
  • Ueda S, Kanamori H, Sasaki S, Yamazaki E, Tamura T, Matsuzaki M, Motomura S, Mohri H, Okubo T: Isolated extramedullary relapse in knee joint after allogeneic bone marrow transplantation for Ph ALL. Bone Marrow Transplant 21: 319-321, 1998
  • Tamura T, Matsuzaki M, Harada H, Ogawa K, Mohri H, Okubo T: Up-regulation of interferon-α receptor expression in hydroxyurea-treated leukemia cell lines. J Invest Med45: 160-167, 1997
  • Kato K, Mohri H, Tamura T, Okubo T: A synthetic peptide, FN-C/H-V, from the C-terminal heparin-binding domain of fibronectin promotes adhesion of PMA stimulated U937 cells. Biochem Biophys Res Commun 239: 205-211, 1997
  • Kanamori H, Sasaki S, Yamazaki E, Ueda S, Hattori M, Fukawa H, Tamura T, Harano H, Matsuzaki M, Ogawa K, Mohri H, Okubo T: Eradication of minimal residual disease during graft-versus-host reaction induced by abrupt discontinuation of immunosuppression following bone marrow transplantation in a patient with Ph1-ALL. Transplant Int 10: 328-330, 1997
  • Tamura T, Ueda S, Yoshida M, Matsuzaki M, Mohri H, Okubo T: Interferon-γ induces Ice gene expression and enhances cellular susceptibility to apoptosis in the U937 leukemia cell line. Biochem Biophys Res Commun 229: 21-26, 1996
  • Tamura T, Ishihara M, Lamphier MS, Tanaka N, Oishi I, Aizawa S, Matsuyama T, Mak TW, Taki S, Taniguchi T: An IRF-1-dependent pathway of DNA damage-induced apoptosis in mitogen-activated T lymphocytes. Nature 376: 596-599, 1995
  • Harada H, Kondo T, Ogawa S, Tamura T, Kitagawa M, Tanaka N, Lamphier MS, Hirai H, Taniguchi T: Accelerated exon skipping of IRF-1 in human myelodysplasia/leukemia; a possible mechanism of tumor suppressor inactivation. Oncogene 9: 3313-3320, 1994
  • Tamura T, Kanamori H, Yamazaki E, Ohtsuka M, Hataoka, K Maeda K, Okamoto R, Tanabe J, Fujita H, Hashimoto Y, Harano H, Matsuzaki M, Watanabe S, Mohri H, Chiba N, Okubo T: Cold agglutinin disease following allogeneic bone marrow transplantation. Bone Marrow Transplant 13: 321-323, 1994
Copyright © Yokohama City University Graduate School of Medicine, Immunology. All Rights Reserved.
トップへ戻るボタン