生殖再生医学・in vitro精子形成・小川毅彦研究室

発表論文 (2009年以前)

最新の発表論文へ
Watanabe T, Hayashi H, Kita K, Kubota Y, Ogawa T. Ectopic porcine spermatogenesis in murine subcutis: tissue grafting versus cell-injection methods. Asian Journal of Andrology 11: 317-323 (2009).

Kita K, Watanabe T, Ohsaka K, Hayashi H, Kubota Y, Nagashima Y, Aoki I, Taniguchi H, Noce T, Inoue K, Miki H, Ogonuki N, Tanaka H, Ogura A, Ogawa T. Production of Functional Spermatids from Mouse Germline Stem Cells in Ectopically Reconstituted Seminiferous Tubules. Biology of Reproduction76: 211-217 (2007).

Udagawa K, Ogawa T, Watanabe T, Tamura Y, Kita K, Kubota Y. Testosterone administration promotes regeneration of chemically impaired spermatogenesis in rats. International Journal of Urology 13, 1103-1108 (2006).

Nakamura T, Yao R, Ogawa T, Suzuki T, Ito C, Tsunekawa N, Ajima R, Miyasaka T, Yoshida Y, Toshimori K, Noce T, Yamamoto T, Noda T. Oligo-astheno-teratozoospermia in mice lacking Cnot7, a regulator of retinoid X receptor beta. Nature Genetics 36, 528-533 (2004). 

Ogawa T, Ohmura M, Tamura Y, Kita K, Ohbo K, Suda T, Kubota Y. Derivation and Morphological Characterization of Mouse Spermatogonial Stem Cell Lines. Arch. Histol. Cytol., 67, 297-306 (2004).

Ogawa T, Ito C, Nakamura T, Tamura Y, Yamamoto T, Noda T, Kubota Y, Toshimori K. Abnormal sperm morphology caused by defects in Sertoli cells of Cnot7 knockout mice. Arch. Histol. Cytol., 67, 307-314 (2004).

Ogawa T, Ohmura M, Yumura Y, Sawada H, Kubota Y. Expansion of murine spermatogonial stem cells through serial transplantation. Biology of Reproduction68, 316-322 (2003).

Ohmura M, Ogawa T, Ono M, Dezawa M, Hosaka M, Kubota Y, Sawada H. Increment of Murine Spermatogonial Cell Number by Gonadotropin- Releasing Hormone Analogue Is Independent of Stem Cell Factor - c-kit signal. Biology of Reproduction 68, 2304-2313 (2003).

Udagawa K, Ogawa T, Watanabe T, Yumura Y, Takeda M, Hosaka M; GnRH analogue, leuprorelin acetate, promotes regeneration of rat spermatogenesis after severe chemical damage. International Journal of Urology 8, 615-622 (2001).

Udagawa K, Takeda M, Hosaka M, Kubota Y, Ogawa T. Recovery of spermatogenesis by high dose gonadotropin-releasing hormone analogue treatment in rat cryptorchid testis after orchiopexy. Journal of Urology 168, 1279-1283 (2002).

Ogawa T, Dobrinski I, Avarbock MR, Brinster RL. Transplantation of male germ line stem cells restores fertility in infertile mice. Nature Medicine 6, 29-34 (2000). 

Ogawa T, Dobrinski I, Brinster RL; Recipient preparation is critical for spermatogonial transplantation in the rat. Tissue Cell 31, 461-472 (1999).

Ogawa T, Dobrinski I, Avorbock MR, Brinster RL. Xenogeneic spermatogenesis following transplantation of hamster germ cells to mouse testes. Biology of Reproduction 60, 515-521 (1999)

Ogawa T, Dobrinski I, Avarbock MR, Brinster RL; Leuprolide, a gonadotropin-
releasing hormone agonist, enhances colonization after spermatogonial transplantation into mouse testes. Tissue Cell 30, 583-588 (1998)

Ogawa T, Poncelet DA, Kinoshita Y, Noce T, Takeda M, Kawamoto K, Udagawa K, Lecocq PJ, Marine JC, Martial JA, Hosaka M: Enhanced expression in seminoma of human zinc finger genes located on chromosome 19. Cancer Genet Cytogenet  100, 36-42 (1998).

Ogawa T, Arechaga JM, Avarbock MR, Brinster RL. Transplantation of testis germinal cells into mouse seminiferous tubules. International Journal of Developmental Biology 41, 111-122 (1997).

著作・総説・解説文

小川毅彦:「精子系細胞の体外分化と成熟」〈特集〉精子をめぐる最近の進歩 産婦人科治療 vol. 90, No. 4, 345-351 (2008).

Ogawa T. Reproductive stem cell research and its application to urology. International Journal of Urology 15, 121-127 (2008). (Review)

小川毅彦:「生殖幹細胞(精子幹細胞と多能性幹細胞)」幹細胞技術の現状と展望 No.8, 蛋白質 核酸 酵素 Vol.52(4): 356-363 (2007)

小川毅彦:「精細胞培養の最前線」特集:男性不妊症 Modern Physician 第27巻12号 1672-1677 (2007).

小川毅彦;「精細管内移植」第17章、新編 精子学 [編] 森沢正昭・星 和彦・岡部 勝 東京大学出版会 pp351-362, 2006年

Ogawa T, Ohmura M, Ohbo K. The Niche for Spermatogonial Stem Cells in the Mammalian Testis. International Journal of Hematology 82, 381–388 (2005). Review.

Ogawa T. Spermatogonial transplantation: the principle and possible applications. Journal of Molecular Medicine 79, 368-374 (2001)

Ogawa T; Spermatogonial transplantation technique in spermatogenesis research. International Journal of Andrology 23 Suppl 2, 57-59 (2000).

小川毅彦;精原細胞移植 −その原理と臨床応用への可能性− 細胞 32, 503-507 (2000).

小川毅彦;精原細胞移植―男性不妊症への応用― 泌尿器外科 14(Suppl.), 423-425 (2001).

 

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横浜市立大学

新学術領域


配偶子産生制御(平成30〜令和4年)


配偶子産生制御(平成25〜29年)


配偶子幹細胞制御(平成20〜24年)