2004年
2. Hoshi, K., Ogata, N., Shimoaka, T., Terauchi, Y., Kadowaki, T., Kenmotsu, S., Chung, U., Ozawa, H., Nakamura, K., and Kawaguchi, H. Deficiency of insulin receptor substrate-1 impairs skeletal growth through early closure of epiphyseal cartilage. J. Bone Miner. Res. 19 : 214-223, 2004.
3. Akune, T., Ohba, S., Kamekura, S., Yamaguchi, M., Chung, U.I., Kubota, N., Terauchi, Y., Harada, Y., Azuma, Y., Kadowaki, T., Nakamura, K., and Kawaguchi, H. PPAR gamma insufficiency enhances osteogenesis from bone marrow progenitors. J. Clin. Invest. 113 : 846-855, 2004.
4. Shimoaka, T., Kamekura, S., Chikuda, H., Hoshi, K., Chung, U.I., Akune, T., Maruyama, Z., Komori, T., Matsumoto, M., Ogawa, W., Terauchi, Y., Kadowaki, T., Nakamura, K., and Kawaguchi, H. Impairment of bone healing by insulin receptor substrate-1 deficiency. J. Biol. Chem. 279 : 15314-15322, 2004.
5. Suzuki, R., Tobe, K., Aoyama, M., Yamauchi, T., Kamon, J., Kubota, N., Terauchi, Y., Yoshimatsu, H., Matsuhisa, M., Nagasaka, S., Ogata, H., Tokuyama, K., Nagai, R., and Kadowaki, T. Both insulin signaling defects in the liver and obesity contribute to insulin resistance and cause diabetes in Irs2-/- mice. J. Biol. Chem. 279 : 25039-25049, 2004.
6. Inoue, M., Sakuraba, Y., Motegi, H., Kubota, N., Toki, H., Matsui, J., Toyoda, Y., Miwa, I., Terauchi, Y., Kadowaki, T., Shigeyama, Y., Kasuga, M., Adachi, T., Fujimoto, N., Matsumoto, R., Tsuchihashi, K., Kagami, T., Inoue, A., Kaneda, H., Ishijima, J., Masuya, H., Suzuki, T., Wakana, S., Gondo, Y., Minowa, O., Shiroishi, T., and Noda, T. A series of maturity onset diabetes of the young, type 2 (MODY2) mouse models generated by a large-scale ENU mutagenesis program. Hum. Mol. Genet. 13 : 1147-1157, 2004.
7. Tsuchida, A., Yamauchi, T., Ito, Y., Hada, Y., Maki, T., Takekawa, S., Kamon, J., Kobayashi, M., Suzuki, R., Hara, K., Kubota, N., Terauchi, Y., Froguel, P., Nakae, J., Kasuga, M., Accili, D., Tobe, K., Ueki, K., Nagai, R., and Kadowaki, T. Insulin/Foxo1 pathway regulates expression levels of adiponectin receptors and adiponectin sensitivity. J. Biol. Chem. 279 : 30817-30822, 2004.
8. Wada, K., Nakajima, A., Takahashi, H., Yoneda, M., Fujisawa, N., Ohsawa, E., Kadowaki, T., Kubota, N., Terauchi, Y., Matsuhashi, N., Saubermann, L.J., Nakajima, N., and Blumberg, R.S. Protective effect of endogenous PPARgamma against acute gastric mucosal lesions associated with ischemia-reperfusion. Am. J. Physiol. Gastrointest. Liver Physiol. 287 : G452-458, 2004.
9. Kubota, N., Terauchi, Y., Tobe, K., Yano, W., Suzuki, R., Ueki, K., Takamoto, I., Satoh, H., Maki, T., Kubota, T., Moroi, M., Okada-Iwabu, M., Ezaki, O., Nagai, R., Ueta, Y., Kadowaki, T., and Noda, T. Insulin receptor substrate 2 plays a crucial role in beta cells and the hypothalamus. J. Clin. Invest. 114 : 917-927, 2004.
10. Matsui, J., Terauchi, Y., Kubota, N., Takamoto, I., Eto, K., Yamashita, T., Komeda, K., Yamauchi, T., Kamon, J., Kita, S., Noda, M., and Kadowaki, T. Pioglitazone reduces islet triglyceride content and restores impaired glucose-stimulated insulin secretion in heterozygous PPAR -deficient mice on a high-fat diet. Diabetes 53 : 2844-2854, 2004.
11. Yoneda, M., Wada, K., Katayama, K., Nakajima, N., Iwasaki, T., Osawa, E., Mukasa, K., Yamada, Y., Blumberg, R.S., Sekihara, H., and Nakajima, A. A novel therapy for acute hepatitis utilizing dehydroepiandrosterone in murine model of hepatitis. Biochem. Pharmacol. 68 : 2283-2289, 2004.
12. Aoki, K., Taniguchi, H., Ito, Y., Satoh, S., Nakamura, S., Muramatsu, K., Yamashita, R., Ito, S., Mori, Y., and Sekihara, H. Dehydroepiandrosterone decreases elevated hepatic glucose production in C57BL/KsJ-db/db mice. Life Sci. 74 : 3075-3084, 2004.
13. Yamashita, R., Kikuchi, T., Mori, Y., Aoki, K., Kaburagi, Y., Yasuda, K., and Sekihara, H. Aldosterone stimulates gene expression of hepatic gluconeogenic enzymes through the glucocorticoid receptor in a manner independent of the protein kinase B cascade. Endocr. J. 51:243-251, 2004.
15. Yamada,Y., Nakajima, A., and Sekihara, H. Supplement. Anti-apoptotic effect of dehydroepiandrosterone and its role in an aging society. Intern. Med. 43 : 158-160, 2004.
2003年
1. Terauchi, Y., Matsui, J., Suzuki, R., Kubota, N., Komeda, K., Aizawa, S., Eto, K., Kimura, S., Nagai, R., Tobe, K., Lienhard, G.E., and Kadowaki, T. Impact of genetic background and ablation of IRS-3 on IRS-2 knockout mice. J. Biol. Chem. 278 : 14284-14290, 2003.
2. Suzuki, H., Matsuda, S., Terauchi, Y., Fujiwara, M., Ohteki, T., Asano, T., Behrens, T.W., Kouro, T., Takatsu, K., Kadowaki, T., and Koyasu, S. PI3K and Btk differentially regulate B cell antigen receptor mediated signal transduction. Nat. Immunol. 4 : 280-286, 2003.
3. Yamauchi, T., Kamon, J., Ito, Y., Tsuchida, A., Yokomizo, T., Kita, S., Sugiyama, T., Miyagishi, M., Hara, K., Tsunoda, M., Murakami, K., Ohteki, T., Uchida, S., Takekawa, S., Waki, H., Tsuno, N.H., Shibata, Y., Terauchi, Y., Froguel, P., Tobe, K., Koyasu, S., Taira, K., Kitamura, T., Shimizu, T., Nagai, R., and Kadowaki, T. Cloning of adiponectin receptors that mediate antidiabetic metabolic effects. Nature 423 : 762-769, 2003.
4. Yamauchi, T., Kamon, J., Waki, H., Imai, Y., Shimozawa, N., Hioki, K., Uchida, S., Ito, Y., Takakuwa, K., Matsui, J., Takata, M., Eto, K., Terauchi, Y., Komeda, K., Tsunoda, M., Murakami, K., Ohnishi, Y., Naitoh, T., Yamamura, K., Ueyama, Y., Froguel, P., Kimura, S., Nagai, R., and Kadowaki, T. Globular adiponectin protected ob/ob mice from diabetes and ApoE-deficient mice from atherosclerosis. J. Biol. Chem. 278: 2461-2468, 2003.
5. Ogura, T., Osawa, H., Tang, Y., Onuma, H., Ochi, M., Nishimiya, T., Kubota, N., Terauchi, Y., Kadowaki, T., and Makino, H. Reduction of phosphodiesterase 3B gene expression in peroxisome proliferator-activated receptor gamma (+/-) mice independent of adipocyte size. FEBS Lett. 542 : 65-68, 2003.
6. Watanabe, N., Nakajima, H., Suzuki, H., Oda, A., Matsubara, Y., Moroi, M., Terauchi, Y., Kadowaki, T.,Suzuki, H., Koyasu, S., Ikeda, Y., and Handa, M. Functional phenotype of phosphoinositide 3-kinase p85alpha null platelets characterized by an impaired response to GPVI stimulation. Blood 102 : 541-548, 2003.
7. Abe, M., Sata, M., Nishimatsu, H., Nagata, D., Suzuki, E., Terauchi, Y., Kadowaki, T., Minamino, N., Kangawa, K., Matsuo, H., Hirata, Y., and Nagai, R. Adrenomedullin augments collateral development in response to acute ischemia. Biochem. Biophys. Res. Commun. 306 : 10-15, 2003.
8. Kubota, T., Kubota, N., Moroi, M., Terauchi, Y., Kobayashi, T., Kamata, K., Suzuki, R., Tobe, K., Namiki, A., Aizawa, S., Nagai, R., Kadowaki, T., and Yamaguchi, T. Lack of insulin receptor substrate-2 causes progressive neointima formation in response to vessel injury. Circulation 107 : 3073-3080, 2003.
9. Suzuki, R., Tobe, K., Terauchi, Y., Komeda, K., Kubota, N., Eto, K., Yamauchi, T., Azuma, K., Kaneto, H., Taguchi, T., Koga, T., German, M.S., Watada, H., Kawamori, R., Wright, C.V., Kajimoto, Y., Kimura, S., Nagai, R., and Kadowaki, T. Pdx1 expression in Irs2 deficient mouse beta-cells is regulated in a strain-dependent manner. J. Biol. Chem. 278 : 43691-43698, 2003.
10. Minami, K., Morita, M., Saraya, A., Yano, H., Terauchi, Y., Miki, T., Kuriyama, T., Kadowaki, T., and Seino, S. ATP-sensitive K+ channel-mediated glucose uptake is independent of IRS-1/ phosphatidylinositol 3-kinase signaling. Am. J. Physiol. Endocrinol. Metab. 285 : E1289-1296, 2003.
11. Inamori, M., Togawa, J., Takahashi, K., Yoneda, M., Fujisawa, N., Iwasaki, T., Ozawa, Y., Kikuchi, T., Muramatsu, K., Chiguchi, G., Matsumoto, S., Kawamura, H., Abe, Y., Kirikoshi, H., Kobayashi, N., Sakaguchi, T., Takamura, T., Nakajima, A., Ueno, N., and Sekihara, H.Comparison of the effect on intragastric pH of a single dose of omeprazole or rabeprazole: which is suitable for on-demand therapy? J. Gastroenterol. Hepatol. 18 : 1034-8, 2003
12. Aoki, K., Nakajima, A., Mukasa, K., Osawa, E., Mori, Y., Sekihara, H. Prevention of diabetes, hepatic injury, and colon cancer with dehydroepiandrosterone. J. Steroid Biochem. Mol. Biol. 85 : 469-472, 2003.
13. Kawasaki, S., Ito, S., Satoh, S., Mori, Y., Saito, T., Fukushima, H., Kato, S., and Sekihara, H. Use of telemedicine in periodic screening of diabetic retinopathy. Telemed. J. E Health 9 : 235-239, 2003.
14. Kaburagi, Y., Satoh, S., Yamamoto-Honda, R., Ito, Y., Akanuma, Y., Sekihara, H., Yasuda, K., Sasazuki, T., Kadowaki, T., and Yazaki, Y. Protection of insulin receptor substrate-3 from staurosporine-induced apoptosis. Biochem. Biophys. Res. Commun. 300 : 371-377, 2003.
15. Fukao, T., Terauchi, Y., Kadowaki, T., and Koyasu, S. Role of phosphoinositide 3-kinase signaling in mast cells: new insights from knockout mouse studies. J. Mol. Med. 81 : 524-535, 2003. (Review)
16. Kadowaki, T., Hara, K., Yamauchi, T., Terauchi, Y., Tobe, K., and Nagai, R. Molecular mechanism of insulin resistance and obesity. Exp. Biol. Med. (Maywood) 228 : 1111-1117, 2003. (Review)
17. Yamauchi, T., Hara, K., Kubota, N., Terauchi, Y., Tobe, K., Froguel, P., Nagai, R., and Kadowaki, T. Dual roles of adiponectin/acrp30 in vivo as an anti-diabetic and anti-atherogenic adipokine. Curr. Drug Targets Immune Endocr. Metabol. Disord. 3 : 243-254, 2003. (Review)
2002年
1. Terauchi, Y., Matsui, J., Suzuki, R., Kubota, N., Komeda, K., Aizawa, S., Eto, K., Kimura, S., Nagai, R., Tobe, K., Lienhard, G.E., and Kadowaki, T. Impact of genetic background and ablation of IRS-3 on IRS-2 knockout mice. J. Biol. Chem. 278 : 14284-14290, 2003.
2. Suzuki, H., Matsuda, S., Terauchi, Y., Fujiwara, M., Ohteki, T., Asano, T., Behrens, T.W., Kouro, T., Takatsu, K., Kadowaki, T., and Koyasu, S. PI3K and Btk differentially regulate B cell antigen receptor mediated signal transduction. Nat. Immunol. 4 : 280-286, 2003.
3. Yamauchi, T., Kamon, J., Ito, Y., Tsuchida, A., Yokomizo, T., Kita, S., Sugiyama, T., Miyagishi, M., Hara, K., Tsunoda, M., Murakami, K., Ohteki, T., Uchida, S., Takekawa, S., Waki, H., Tsuno, N.H., Shibata, Y., Terauchi, Y., Froguel, P., Tobe, K., Koyasu, S., Taira, K., Kitamura, T., Shimizu, T., Nagai, R., and Kadowaki, T. Cloning of adiponectin receptors that mediate antidiabetic metabolic effects. Nature 423 : 762-769, 2003.
4. Yamauchi, T., Kamon, J., Waki, H., Imai, Y., Shimozawa, N., Hioki, K., Uchida, S., Ito, Y., Takakuwa, K., Matsui, J., Takata, M., Eto, K., Terauchi, Y., Komeda, K., Tsunoda, M., Murakami, K., Ohnishi, Y., Naitoh, T., Yamamura, K., Ueyama, Y., Froguel, P., Kimura, S., Nagai, R., and Kadowaki, T. Globular adiponectin protected ob/ob mice from diabetes and ApoE-deficient mice from atherosclerosis. J. Biol. Chem. 278: 2461-2468, 2003.
5. Ogura, T., Osawa, H., Tang, Y., Onuma, H., Ochi, M., Nishimiya, T., Kubota, N., Terauchi, Y., Kadowaki, T., and Makino, H. Reduction of phosphodiesterase 3B gene expression in peroxisome proliferator-activated receptor gamma (+/-) mice independent of adipocyte size. FEBS Lett. 542 : 65-68, 2003.
6. Watanabe, N., Nakajima, H., Suzuki, H., Oda, A., Matsubara, Y., Moroi, M., Terauchi, Y., Kadowaki, T.,Suzuki, H., Koyasu, S., Ikeda, Y., and Handa, M. Functional phenotype of phosphoinositide 3-kinase p85alpha null platelets characterized by an impaired response to GPVI stimulation. Blood 102 : 541-548, 2003.
7. Abe, M., Sata, M., Nishimatsu, H., Nagata, D., Suzuki, E., Terauchi, Y., Kadowaki, T., Minamino, N., Kangawa, K., Matsuo, H., Hirata, Y., and Nagai, R. Adrenomedullin augments collateral development in response to acute ischemia. Biochem. Biophys. Res. Commun. 306 : 10-15, 2003.
8. Kubota, T., Kubota, N., Moroi, M., Terauchi, Y., Kobayashi, T., Kamata, K., Suzuki, R., Tobe, K., Namiki, A., Aizawa, S., Nagai, R., Kadowaki, T., and Yamaguchi, T. Lack of insulin receptor substrate-2 causes progressive neointima formation in response to vessel injury. Circulation 107 : 3073-3080, 2003.
9. Suzuki, R., Tobe, K., Terauchi, Y., Komeda, K., Kubota, N., Eto, K., Yamauchi, T., Azuma, K., Kaneto, H., Taguchi, T., Koga, T., German, M.S., Watada, H., Kawamori, R., Wright, C.V., Kajimoto, Y., Kimura, S., Nagai, R., and Kadowaki, T. Pdx1 expression in Irs2 deficient mouse beta-cells is regulated in a strain-dependent manner. J. Biol. Chem. 278 : 43691-43698, 2003.
10. Minami, K., Morita, M., Saraya, A., Yano, H., Terauchi, Y., Miki, T., Kuriyama, T., Kadowaki, T., and Seino, S. ATP-sensitive K+ channel-mediated glucose uptake is independent of IRS-1/ phosphatidylinositol 3-kinase signaling. Am. J. Physiol. Endocrinol. Metab. 285 : E1289-1296, 2003.
11. Inamori, M., Togawa, J., Takahashi, K., Yoneda, M., Fujisawa, N., Iwasaki, T., Ozawa, Y., Kikuchi, T., Muramatsu, K., Chiguchi, G., Matsumoto, S., Kawamura, H., Abe, Y., Kirikoshi, H., Kobayashi, N., Sakaguchi, T., Takamura, T., Nakajima, A., Ueno, N., and Sekihara, H.Comparison of the effect on intragastric pH of a single dose of omeprazole or rabeprazole: which is suitable for on-demand therapy? J. Gastroenterol. Hepatol. 18 : 1034-8, 2003
12. Aoki, K., Nakajima, A., Mukasa, K., Osawa, E., Mori, Y., Sekihara, H. Prevention of diabetes, hepatic injury, and colon cancer with dehydroepiandrosterone. J. Steroid Biochem. Mol. Biol. 85 : 469-472, 2003.
13. Kawasaki, S., Ito, S., Satoh, S., Mori, Y., Saito, T., Fukushima, H., Kato, S., and Sekihara, H. Use of telemedicine in periodic screening of diabetic retinopathy. Telemed. J. E Health 9 : 235-239, 2003.
14. Kaburagi, Y., Satoh, S., Yamamoto-Honda, R., Ito, Y., Akanuma, Y., Sekihara, H., Yasuda, K., Sasazuki, T., Kadowaki, T., and Yazaki, Y. Protection of insulin receptor substrate-3 from staurosporine-induced apoptosis. Biochem. Biophys. Res. Commun. 300 : 371-377, 2003.
15. Fukao, T., Terauchi, Y., Kadowaki, T., and Koyasu, S. Role of phosphoinositide 3-kinase signaling in mast cells: new insights from knockout mouse studies. J. Mol. Med. 81 : 524-535, 2003. (Review)
16. Kadowaki, T., Hara, K., Yamauchi, T., Terauchi, Y., Tobe, K., and Nagai, R. Molecular mechanism of insulin resistance and obesity. Exp. Biol. Med. (Maywood) 228 : 1111-1117, 2003. (Review)
17. Yamauchi, T., Hara, K., Kubota, N., Terauchi, Y., Tobe, K., Froguel, P., Nagai, R., and Kadowaki, T. Dual roles of adiponectin/acrp30 in vivo as an anti-diabetic and anti-atherogenic adipokine. Curr. Drug Targets Immune Endocr. Metabol. Disord. 3 : 243-254, 2003. (Review)
2001年
1. Yamauchi, T., Kamon, J., Waki, H., Terauchi, Y., Kubota, N., Hara, K., Mori, Y., Ide, T., Murakami, K., Tsuboyama-Kasaoka, N., Ezaki, O., Akanuma, Y., Gavrilova, O., Vinson, C., Reitman, M.L., Kagechika, H., Shudo, K., Yoda, M., Nakano, Y., Tobe, K., Nagai, R., Kimura, S,. Tomita, M., Froguel, P., and Kadowaki, T. The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. Nat. Med. 7 :941-946, 2001.
2. Miki, H., Yamauchi, T., Suzuki, R., Komeda, K., Tsuchida, A., Kubota, N., Terauchi, Y., Kamon, J., Kaburagi, Y., Matsui, J., Akanuma, Y., Nagai, R., Kimura, S., Tobe, K., and Kadowaki, T. Essential role of IRS-1 and IRS-2 in adipocyte differentiation. Mol. Cell. Biol. 21 : 2521-2532, 2001.
3. Tsuji, Y., Kaburagi, Y., Terauchi, Y., Satoh, S., Kubota, N., Tamemoto, H., Kraemer, F.B., Sekihara, H., Aizawa, S., Akanuma, Y., Tobe, K., Kimura, S., and Kadowaki, T. Subcellular localization of IRS family proteins associated with PI 3-kinase activity and alterations in lipolysis in primary mouse adipocytes from IRS-1 null mice. Diabetes 50 : 1-9, 2001.
4. Yamauchi, T., Waki, H., Kamon, J., Murakami, K., Motojima, K., Komeda, K., Miki, H., Kubota, N., Terauchi, Y., Tsuchida, A., Tsuboyama-Kasaoka, N., Yamauchi, N., Ide, T., Hori, W., Kato, S., Fukayama, M., Akanuma, Y., Ezaki, O., Itai, A., Nagai, R., Kimura, S., Tobe, K., Kagechika, H., Shudo, K., and Kadowaki, T. Inhibition of RXR and PPAR ameliorates diet-induced obesity and type 2 diabetes. J. Clin. Invest. 108 : 1001-1013, 2001.
5. Tobe, K., Suzuki, R., Aoyama, M., Yamauchi, T., Kamon, J., Kubota, N., Terauchi, Y., Matsui, J., Akanuma, Y., Kimura, S., Tanaka, J., Abe, M., Ohsumi, J., Nagai, R., and Kadowaki, T. Increased expression of the sterol regulatory element-binding protein-1 gene in insulin receptor substrate-2(-/-) mouse liver. J. Biol. Chem. 276 : 38337-38340, 2001.
6. Yamauchi, T., Kamon, J., Waki, H., Murakami, K., Motojima, K., Komeda, K., Ide, T., Kubota, N., Terauchi, Y., Tobe, K.., Miki, H., Tsuchida, A., Akanuma, Y., Nagai, R., Kimura, S., and Kadowaki, T. The mechanisms by which both heterozygous PPARgamma deficiency and PPARgamma agonist improve insulin resistance. J. Biol. Chem. 276 : 41245-41254, 2001.
7. Setoguchi, K., Misaki, Y., Terauchi, Y., Yamauchi, T., Kawahara, K., Kadowaki, T., and Yamamoto, K. Peroxisome proliferator-activated receptor-gamma haploinsufficiency enhances B cell proliferative responses and exacerbates experimentally induced arthritis. J. Clin. Invest. 108 : 1667-1675, 2001.
8. Nakajima, A., Wada, K., Miki, H., Kubota, N., Nakajima, N., Terauchi, Y., Ohnishi, S., Saubermann, L.J., Kadowaki, T., Blumberg, R.S., Nagai, R., and Matsuhashi, N. Endogenous PPAR gamma mediates anti-inflammatory activity in murine ischemia-reperfusion injury. Gastroenterology 120 : 460-469, 2001.
9. Kaburagi, Y., Satoh, S., Yamamoto-Honda, R., Ito, T., Ueki, K., Akanuma, Y., Sekihara, H., Kimura, S., and Kadowaki, T. Insulin-independent and wortmannin-resistant targeting of IRS-3 to the plasma membrane via its pleckstrin homology domain mediates a different interaction with the insulin receptor from that of IRS-1. Diabetologia 44 : 992-1004, 2001.
10. Aoki, K., Homma, M., Hirano, T., Oka, K., Satoh, S., Mukasa, K., Ito, S., and Sekihara, H. MRNA and enzyme activity of hepatic 11beta-hydroxysteroid dehydrogenase type 1 are elevated in C57BL/KsJ-db/db mice. Life Sci. 69 : 2543-2549, 2001.
11. Yamamoto, R., Kinoshita, T., Momoki, T., Arai, T., Okamura, A., Hirao, K., and Sekihara, H. Postural sway and diabetic peripheral neuropathy. Diabetes Res. Clin. Pract. 52 : 213-221, 2001.
12. Terauchi, Y., and Kadowaki, T. Transgenic approach to insulin signaling. Frontiers in Animal Diabetes Research: Muscle Metabolism: 253-269, 2001. (Book)
2000年
1. Terauchi, Y., Kubota, N., Tamemoto, H., Sakura, H., Nagai, R., Kimura, S., and Kadowaki, T. Insulin effect during embryogenesis determines fetal growth: A possible molecular link between low birth weight and susceptibility to type 2 diabetes. Diabetes 48 : 82-86, 2000.
2. Hara, K., Tobe, K., Uchigata, Y., Nakazono, M., Yasuda, K., Terauchi, Y., Iwamoto, Y., Akanuma, Y., Kimura, S., and Kadowaki, T. Antibody-mediated insulin resistance treated by cessation of insulin administration. Intern. Med. 39 : 143-145, 2000.
3. Ogata, N., Chikazu, D., Kubota, N., Terauchi, Y., Tobe, K., Azuma, Y., Ohta, T., Kadowaki, T., Nakamura, K., and Kawaguchi, H. Insulin receptor substrate-1 in osteoclast is indisdensable for maintaining bone turnover. J. Clin. Invest. 105 : 935-943, 2000.
4 Kubota, N., Tobe, K., Terauchi, Y., Eto, K., Yamauchi, T., Tsubamoto, Y., Komeda, K., Nakano, R., Miki, H., Suzuki, R., Satoh, S., Sekihara, H., Sciacchitano, S., Akanuma, Y., Aizawa, S., Nagai, R., Kimura, S., Taylor, S.I., and Kadowaki, T. Disruption of insulin receptor substrate-2 causes type 2 diabetes due to liver insulin resistance and lack of compensatory beta-cell hyperplasia. Diabetes 49 : 1880-1889, 2000.
5. Andrikopoulos, S., Verchere, C.B., Terauchi, Y., Kadowaki, T., and Kahn, S.E. Beta-cell glucokinase deficiency and hyperglycemia are associated with reduced islet amyloid deposition in a mouse model of type 2 diabetes. Diabetes 49 : 2056-2062, 2000.
6. Aoki, K., Kikuchi, T., Mukasa, K., Ito, S., Nakajima, A., Satoh, S., Okamura, A., and Sekihara, H. Dehydroepiandrosterone suppresses elevated hepatic glucose-6-phosphatase mRNA level in C57BL/KsJ-db/db mice: comparison with troglitazone. Endocr. J. 47 : 799-804, 2000.
7. Saito, T., Satoh, S., Kawasaki, S., Mukasa, K., Itoh, S., Yamakawa, T., and Sekihara, H. Three patients with adrenal tumors having been treated simply for diabetes mellitus. Biomed. Pharmacother. 54 Suppl 1 : 198s-202s, 2000.
8. Ito, S., Nemoto, T., Satoh, S., Sekihara, H., Seyama, Y., and Kubota, S. Human rhabdomyosarcoma cells retain insulin-regulated glucose transport activity through glucose transporter 1. Arch. Biochem. Biophys. 373 : 72-82, 2000.
9. Hara, K., Kubota, N., Tobe, K., Terauchi, Y., Okada, T., Miki, H., Komeda, K., Tamemoto, H., Yamauchi, T., Hagura, R., Ito, C., Akanuma, Y., and Kadowaki, T. The role of PPAR gamma as a thrifty gene in both in mice and humans. Brit. J. Nutr. 84 : 235-239, 2000. (Review)
1999年
1. Terauchi, Y., Tsuji, Y., Satoh, S., Minoura, H., Murakami, K., Okuno, A., Inukai, K., Asano, T., Kaburagi, Y., Ueki, K., Nakajima, H., Hanafusa, T., Matsuzawa, Y., Sekihara, H., Yin, Y., Barrett, J.C., Oda, H., Ishikawa, T., Akanuma, Y., Komuro, I., Suzuki, M., Yamanura, K., Kodama, T., Suzuki, H., Koyasu, S., Aizawa, S., Tobe, K., Fukui, Y., Yazaki, Y., and Kadowaki, T. Increased insulin sensitivity and hypoglycaemia in mice lacking p85 subunit of phosphoinositide 3-kinase. Nat. Genet. 21 : 230-235, 1999.
2. Suzuki, H., Terauchi, Y., Fujiwara, M., Aizawa, S., Yazaki, Y., Kadowaki, T. and Koyasu, S. Xid-like immunodeficiency in mice with disruption of the p85alpha subunit of phosphoinositide 3-kinase. Science 283 : 390-392, 1999.
3. Eto, K., Tsubamoto, Y., Terauchi, Y., Sugiyama, T., Kishimoto, K., Takahashi, N., Yamauchi, N., Kubota, N., Murayama, S., Aizawa, T., Akanuma, Y., Kasai, H., Aizawa, S., Yazaki, Y., and Kadowaki, T. Role of NADH shuttle system in glucose-induced activation of mitochondrial metabolism and insulin secretion. Science 283 : 981-985, 1999.
4. Kubota, N., Terauchi, Y., Miki, H., Tamemoto, H., Yamauchi, T., Komeda, K., Nakano, R., Ishii, C., Sugiyama, T., Eto, K., Tsubamoto, T., Okuno, A., Murakami, K., Ezaki, O., Hasegawa, G., Naito, M., Toyoshima, Y., Tanaka, S., Shiota, K., Aizawa, S., Nagai, R., Tobe, K., Kimura, S., and Kadowaki, T. PPARgamma mediates high-fat diet-induced adipocyte hypertrophy and insulin resistance. Mol. Cell 4 : 597-609, 1999.
5. Eto, K., Suga, S., Wakui, M., Tsubamoto, Y.,Terauchi, Y., Akanuma,Y., Aizawa, S., Noda, M., Kimura, S., Kasai, H., and Kadowaki, T. NADH shuttle system regulates KATP channel-dependent pathway and steps distal to [Ca2+]c elevation in glucose-induced insulin secretion. J. Biol. Chem. 274 : 25386-25392, 1999.
1998年
1. Yin, Y., Terauchi, Y., Solomon, G., Aizawa, S., Yazaki, Y., Kadowaki, T., and Barrett, J.C. Involvement of p85 in p53-dependent apoptotic response to oxidative stress. Nature 391 : 707-710, 1998.
2. Sakura, H., Ashcroft, S.J.H., Terauchi, Y., Kadowaki, T., and Ashcroft, F.M. Glucose modulation of KATP currents in wild-type, homozygous and heterozygous glucokinase knock-out mice. Diabetologia 41 : 654-659, 1998.
3. Hayakawa, T., Noda, M., Yasuda, K., Yorifuji, H., Taniguchi, S., Miwa, I., Sakura, H., Terauchi, Y., Hayashi, J., Sharp, G., Kanazawa, Y., Akanuma, Y., Yazaki, Y., and Kadowaki, T. Ethidium bromide-induced inhibition of mitochondrial gene transcription suppresses glucose-stimulated insulin release in the mouse pancreatic beta-cell line HC9. J. Biol. Chem. 273 : 20300-20307, 1998.
4. Saito, N., Sakai, H., Suzuki, S., Sekihara, H., Yajima, Y. Effect of an alpha-glucosidase inhibitor (voglibose), in combination with sulphonylureas, on glycaemic control in type 2 diabetes patients. J. Int. Med. Res. 26 : 219-232, 1998.
5. Mukasa, K., Kanesiro, M., Aoki, K., Okamura, J., Saito, T., Satoh, S., and Sekihara, H. Dehydroepiandrosterone (DHEA) ameliorates the insulin sensitivity in older rats. J. Steroid Biochem. Mol. Biol. 67 : 355-358, 1998.
6. Yamaguchi, Y., Tanaka, S., Yamakawa, T., Kimura, M., Ukawa, K., Yamada, Y., Ishihara, M., and Sekihara, H. Reduced serum dehydroepiandrosterone levels in diabetic patients with hyperinsulinaemia. Clin. Endocrinol. (Oxf). 49 : 377-383, 1998.
7. Arai, T., Numata, K., Tanaka, K., Kiba, T., Kawasaki, S., Saito, T., Satoh, S., and Sekihara, H. Ocular arterial flow hemodynamics in patients with diabetes mellitus. J. Ultrasound Med. 17 : 675-681, 1998.
8. Saito, T., and Sekihara, H. Errors in sex differentiation. Intern. Med. 37 : 427-428, 1998.
9. Kimura, M., Tanaka, S., Yamada, Y., Kiuchi, Y., Yamakawa, T., and Sekihara, H. Dehydroepiandrosterone decreases serum tumor necrosis factor-alpha and restores insulin sensitivity: independent effect from secondary weight reduction in genetically obese Zucker fatty rats. Endocrinology 139 : 3249-3253, 1998.
10. Kuboi, M., Egawa, M., Udaka, N., Ito, T., Inoue, S., and Sekihara, H. Effects of a 7-day infusion of glucose on insulin secretion in vivo and in vitro in ventromedial hypothalamic-lesioned obese rats. Acta Diabetol. 35 : 26-33, 1998.
11. Kimura, M., Tanaka, S., Isoda, F., Sekigawa, K., Yamakawa, T., and Sekihara, H. T lymphopenia in obese diabetic (db/db) mice is non-selective and thymus independent. Life Sci. 62 : 1243-1250, 1998.
12. Onishi, H., Hanihara, T., Sugiyama, N., Kawanishi, C., Iseki, E., Maruyama, Y., Yamada, Y., Kosaka, K., Yagishita, S., Sekihara, H., and Satoh, S. Pancreatic exocrine dysfunction associated with mitochondrial tRNA(Leu)(UUR) mutation. J. Med. Genet. 35 : 255-257, 1998.
13. Kadowaki, T., Terauchi, Y., Tamemoto, H., Tobe, K., and Yazaki, Y. Approach to the pathogenesis of non-insulin-dependent diabetes mellitus using genetically engineered knockout Animals. Proceedings of 4th Japan-Korea Diabetes Association, 19-29, 1998. (Proceeding)