Yokohama City University Graduate School of Medicine, Microbiology Dept. of Microbiology and Molecular Biodefense Research

2021

• Highly specific monoclonal antibodies and epitope identification against SARS-CoV-2 nucleocapsid protein for antigen detection tests.
  Yamaoka Y, Miyakawa K, Jeremiah SS, Funabashi R, Okudela K, Kikuchi S, Katada J, Wada A, Takei T, Nishi M, Shimizu K, Ozawa H, Usuku S, Kawakami C, Tanaka N, Morita T, Hayashi H, Mitsui H, Suzuki K, Aizawa D, Yoshimura Y, Miyazaki T, Yamazaki E, Suzuki T, Kimura H, Shimizu H, Okabe N, Hasegawa H, Ryo A. Cell Rep Med. 2021 May 16:100311.
• Sustained Neutralizing Antibodies 6 Months Following Infection in 376 Japanese COVID-19 Survivors.
  Goto A, Go H, Miyakawa K, Yamaoka Y, Ohtake N, Kubo S, Jeremiah SS, Mihara T, Senuki K, Miyazaki T, Ikeda S, Ogura T, Kato H, Matsuba I, Sanno N, Miyakawa M, Ozaki H, Kikuoka M, Ohashi Y, Ryo A, Yamanaka T. Front Microbiol. 2021 May 7;12:661187.
• Cleavage of TANK-Binding Kinase 1 by HIV-1 Protease Triggers Viral Innate Immune Evasion.
  Jeremiah SS, Miyakawa K, Matsunaga S, Nishi M, Kudoh A, Takaoka A, Sawasaki T, Ryo A. Front Microbiol. 2021 Apr 27;12:643407.

• Carbonic anhydrase 13 suppresses bone metastasis in breast cancer.
  Yogosawa S, Nakayama J, Nishi M, Ryo A, Yoshida K. Cancer Treat Res Commun. 2021 Feb 9;27:100332.

• Severe acute respiratory syndrome coronavirus 2 prevalence in saliva and gastric and intestinal fluid in patients undergoing gastrointestinal endoscopy in coronavirus disease 2019 endemic areas: Prospective cross-sectional study in Japan.
  Miyake S, Ashikari K, Kato S, Takatsu T, Kuwashima H, Kaneko H, Nagai K, Watari I, Sato T, Yamaoka Y, Yamamoto T, Ryo A, Maeda S, Nakajima A, Higurashi T. Dig Endosc. 2021 Feb 6. doi: 10.1111/den.13945. Epub ahead of print. PMID: 33548095.

• Development of an Automated Chemiluminescence Assay System for Quantitative Measurement of Multiple Anti-SARS-CoV-2 Antibodies.
  Kubo S, Ohtake N, Miyakawa K, Jeremiah SS, Yamaoka Y, Murohashi K, Hagiwara E, Mihara T, Goto A, Yamazaki E, Ogura T, Kaneko T, Yamanaka T, Ryo A. Front Microbiol. 2021 Jan 15;11:628281.

• Editorial for the Special Issue: Molecular Epidemiology, Diagnostics and Management of Respiratory Virus Infections.
  Kimura H, Hayashi Y, Sada M, Ishii H, Tsugawa T, Ryo A. Microorganisms. 2020 Dec 20;8(12):2041.
• A longitudinal study on enteric virus contamination in bivalves along the coast of Ibaraki Prefecture, Japan. 
  Motoya T, Nagata N, Kashimura R, Ohashi K, Saito A, Osawa S, Goto K, Iwama S, Yanaoka T, Okayama K, Hirai S, Sugai T, Murakami K, Ishioka T, Ryo A, Katayama K, Kimura H. J Food Prot. 2021 Jan 7. doi: 10.4315/JFP-20-353. Epub ahead of print. PMID: 33411914.

2020

• Point mutation in the stop codon of MAV_RS14660 increases the growth rate of Mycobacterium avium subspecies hominissuis.
  Kawakita T, Mukai T, Yoshida M, Yamada H, Nakayama M, Miyamoto Y, Suzuki M, Nakata N, Takii T, Ryo A, Ohara N, Ato M. Microbiology (Reading). 2020 Dec 23. doi: 10.1099/mic.0.001007. Epub ahead of print. PMID: 33357282.
• Zika virus protease induces caspase-independent pyroptotic cell death by directly cleaving gasdermin D.
  Yamaoka Y, Matsunaga S, Jeremiah SS, Nishi M, Miyakawa K, Morita T, Khatun H, Shimizu H, Okabe N, Kimura H, Hasegawa H, Ryo A. Biochem Biophys Res Commun. 2020 Nov 15:S0006-291X(20)32073-8.
• Treating COVID-19: are we missing out the window of opportunity?
  Sundararaj Stanleyraj J, Sethuraman N, Gupta R, Thiruvoth S, Gupta M, Ryo A. J Antimicrob Chemother. 2020 Oct 25:dkaa442.

• Detailed Molecular Interactions of Favipiravir with SARS-CoV-2, SARS-CoV, MERS-CoV, and Influenza Virus Polymerases In Silico.
  Sada M, Saraya T, Ishii H, Okayama K, Hayashi Y, Tsugawa T, Nishina A, Murakami K, Kuroda M, Ryo A, Kimura H. Microorganisms. 2020 Oct 20;8(10):E1610.

• A hyperactive RelA/p65-hexokinase 2 signaling axis drives primary central nervous system lymphoma.
  Tateishi K, Miyake Y, Kawazu M, Sasaki N, Nakamura T, Sasame J, Yoshii Y, Ueno T, Miyake A, Watanabe J, Matsushita Y, Shiba N, Udaka N, Ohki K, Fink AL, Tummala SS, Natsumeda M, Ikegaya N, Nishi M, Ohtake M, Miyazaki R, Suenaga J, Murata H, Aoki I, Miller JJ, Fujii Y, Ryo A, Yamanaka S, Mano H, Cahill DP, Wakimoto H, Chi AS, Batchelor TT, Nagane M, Ichimura K, Yamamoto T. Cancer Res. 2020 Oct 16:canres.2425.2020.

• Development of Monoclonal Antibodies and Antigen-Capture ELISA for Human Parechovirus Type 3.
  Goto K, Yamaoka Y, Khatun H, Miyakawa K, Nishi M, Nagata N, Yanaoka T, Kimura H, Ryo A. Microorganisms. 2020 Sep 19;8(9):E1437.
• Potent antiviral effect of silver nanoparticles on SARS-CoV-2.
  Jeremiah SS, Miyakawa K, Morita T, Yamaoka Y, Ryo A.Biochem Biophys Res Commun. 2020 Sep 11:S0006-291X(20)31757-5.

• Rapid quantitative screening assay for SARS-CoV-2 neutralizing antibodies using HiBiT-tagged virus-like particles.
  Miyakawa K, Jeremiah SS, Ohtake N, Matsunaga S, Yamaoka Y, Nishi M, Morita T, Saji R, Nishii M, Kimura H, Hasegawa H, Takeuchi I, Ryo A. J Mol Cell Biol. 2020 Sep 15 :mjaa047.

• Molecular pharmacology of ciclesonide against SARS-CoV-2. 
  Kimura H, Kurusu H, Sada M, Kurai D, Murakami K, Kamitani W, Tomita H, Katayama K, Ryo A. J Allergy Clin Immunol. 2020 Jun 13:S0091-6749(20)30749-1.
• Streptococcus pneumoniae promotes its own survival via choline-binding protein CbpC-mediated degradation of ATG14. 
  Shizukuishi S, Ogawa M, Ryo A, Ohnishi M. Autophagy. 2020 Jun 8. Epub ahead of print. PMID: 32508214.
• SIRT1 enhances hepatitis virus B transcription independent of hepatic autophagy.
  Yamai T, Hikita H, Fukuoka M, Fukutomi K, Murai K, Nakabori T, Yamada R, Miyakawa K, Watashi K, Ryo A, Kodama T, Sakamori R, Tatsumi T, Takehara T. Biochem Biophys Res Commun. 2020 Jun 18;527(1):64-70.
• Whole nucleocapsid protein of SARS-CoV-2 may cause false positive results in serological assays.
  Yamaoka Y, Jeremiah SS, Miyakawa K, Saji R, Nishii M, Takeuchi I, Ryo A. Clin Infect Dis. 2020 May 23:ciaa637.
• Molecular evolution of the capsid (VP1) region in human norovirus genogroup II genotype 3.
  Saito M, Tsukagoshi H, Ishigaki H, Aso J, Ishii H, Okayama K, Ryo A, Ishioka T, Kuroda M, Saruki N, Katayama K, Kimura H. Heliyon. 2020
  May 3;6(5):e03835.
• Interpreting Diagnostic Tests for SARS-CoV-2.
  Sethuraman N, Jeremiah SS, Ryo A. JAMA. 2020 May 6.
• Rapid multiplex microfiber-based immunoassay for anti-MERS-CoV antibody detection.
  Hoy CFO, Kushiro K, Yamaoka Y, Ryo A, Takai M. Sens Biosensing Res. 2019 Nov;26:100304.
• Streptococcus pneumoniae hijacks host autophagy by deploying CbpC as a decoy for Atg14 depletion.
  Shizukuishi S, Ogawa M, Matsunaga S, Tomokiyo M, Ikebe T, Fushinobu S, Ryo A, Ohnishi M. EMBO Rep. 2020 May 6;21(5):e49232.
• The multi-step mechanism and biological role of noncanonical autophagy targeting Streptococcus pneumoniae during the early stages of infection.
  Shizukuishi S, Ogawa M, Ryo A, Ohnishi M. Autophagy. 2020 Jun;16(6):1152-1153.
• Engineering Cellular Biosensors with Customizable Antiviral Responses Targeting Hepatitis B Virus. 
  Matsunaga S, Jeremiah SS, Miyakawa K, Kurotaki D, Shizukuishi S, Watashi K, Nishitsuji H, Kimura H, Tamura T, Yamamoto N, Shimotohno K, Wakita T, Ryo A. iScience. 2020 Mar 27;23(3):100867.
• Prolyl Isomerase Pin1 Regulates the Stability of Hepatitis B Virus Core Protein.
  Nishi M, Miyakawa K, Matsunaga S, Khatun H, Yamaoka Y, Watashi K, Sugiyama M, Kimura H, Wakita T, Ryo A. Front Cell Dev Biol. 2020 Jan 31;8:26.
• Molecular Evolution of the Fusion Protein (F) Gene in Human
  Respirovirus 3.
  Aso J, Kimura H, Ishii H, Saraya T, Kurai D, Matsushima Y, Nagasawa K, Ryo A, Takizawa H. Front Microbiol. 2020 Jan 15;10:3054.
• Molecular Evolution of the Protease Region in Norovirus Genogroup II.
  Ozaki K, Matsushima Y, Nagasawa K, Aso J, Saraya T, Yoshihara K, Murakami K, Motoya T, Ryo A, Kuroda M, Katayama K, Kimura H. Front Microbiol. 2020 Jan 14;10:2991.
• Hepatitis C virus infection suppresses hepatitis B virus replication via the RIG-I-like helicase pathway.
  Murai K, Hikita H, Kai Y, Kondo Y, Fukuoka M, Fukutomi K, Doi A, Yamai T, Nakabori T, Fukuda R, Takahashi T, Miyakawa K, Suemizu H, Ryo A, Yamada R, Kodama T, Sakamori R, Tatsumi T, Takehara T. Sci Rep. 2020 Jan 22;10(1):941.
• Streptococcus pneumoniae triggers hierarchical autophagy through reprogramming of LAPosome-like vesicles via NDP52-delocalization.
  Ogawa M, Takada N, Shizukuishi S, Tomokiyo M, Chang B, Yoshida M, Kakuta S, Tanida I, Ryo A, Guan JL, Takeyama H, Ohnishi M. Commun Biol. 2020 Jan 13;3(1):25.

2019

• The machinery for endocytosis of epidermal growth factor receptor coordinates the transport of incoming hepatitis B virus to the endosomal network.
  Iwamoto M, Saso W, Nishioka K, Ohashi H, Sugiyama R, Ryo A, Ohki M, Yun JH, Park SY, Ohshima T, Suzuki R, Aizaki H, Muramatsu M, Matano T, Iwami S, Sureau C, Wakita T, Watashi K.J Biol Chem. 2019 Dec 12. pii: jbc.AC119.010366.
• Molecular evolution of the hemagglutinin-neuraminidase (HN) gene in human respirovirus 3.
  Aso J, Kimura H, Ishii H, Saraya T, Kurai D, Nagasawa K, Matsushima Y, Ryo A, Takizawa H.Virus Res. 2019 Nov 26:197824.
• Non-transmissible MV Vector with Segmented RNA Genome Establishes Different Types of iPSCs from
  Hematopoietic Cells.
  Hiramoto T, Tahara M, Liao J, Soda Y, Miura Y, Kurita R, Hamana H, Inoue K, Kohara H, Miyamoto S, Hijikata Y, Okano S, Yamaguchi Y, Oda Y, Ichiyanagi K, Toh  H, Sasaki H, Kishi H, Ryo A, Muraguchi A, Takeda M, Tani K. Mol Ther. 2019 Sep 12. pii: S1525-0016(19)30410-1.
• Evolutionary Analysis of the VP1 and RNA-Dependent RNA Polymerase Regions of Human Norovirus GII.P17-GII.17 in 2013-2017.
  Matsushima Y, Mizukoshi F, Sakon N, Doan YH, Ueki Y, Ogawa Y, Motoya T, Tsukagoshi H, Nakamura N, Shigemoto N, Yoshitomi H, Okamoto-Nakagawa R, Suzuki R, Tsutsui R, Terasoma F, Takahashi T, Sadamasu K, Shimizu H, Okabe N, Nagasawa K, Aso J, Ishii H, Kuroda M, Ryo A, Katayama K, Kimura H. Front Microbiol. 2019 Sep 27;10:2189.
• Aseptic meningitis caused by torque teno virus in an infant: a case report.
  Ikuta Y, Oba K, Nai E, Katori T, Hashino M, Inamine Y, Matsunaga S, Yamaoka Y, Sekizuka T, Ryo A, Kuroda M. J Med Case Rep. 2019 Sep 24;13(1):302.
• Bardoxolone methyl as a novel potent antiviral agent against hepatitis B and C viruses in human hepatocyte cell culture systems.
  Nio Y, Sasai M, Akahori Y, Okamura H, Hasegawa H, Oshima M, Watashi K, Wakita T, Ryo A, Tanaka Y, Hijikata M. Antiviral Res. 2019 Jun 14;169:104537.

• Allosteric regulation of HIV-1 capsid structure for Gag assembly, virion production, and viral infectivity by a disordered interdomain linker.
  Koma T, Kotani O, Miyakawa K, Ryo A, Yokoyama M, Doi N, Adachi A, Sato H, Nomaguchi M. J Virol. 2019 Jun 12. pii: JVI.00381-19.

• Variation of human norovirus GII genotypes detected in Ibaraki, Japan, during 2012-2018.
  Motoya T, Umezawa M, Saito A, Goto K, Doi I, Fukaya S, Nagata N, Ikeda Y, Okayama K, Aso J, Matsushima Y, Ishioka T, Ryo A, Sasaki N, Katayama K, Kimura H. Gut Pathog. 2019 May 24;11:26.

• PIM kinases facilitate lentiviral evasion from SAMHD1 restriction via Vpx phosphorylation.
  Miyakawa K, Matsunaga S, Yokoyama M, Nomaguchi M, Kimura Y, Nishi M, Kimura H, Sato H, Hirano H, Tamura T, Akari H, Miura T, Adachi A, Sawasaki T, Yamamoto N, Ryo A. Nat Commun. 2019 Apr 23;10(1):1844.
• PI3K/AKT/mTOR pathway alterations promote malignant progression and xenograft formation in oligodendroglial tumors.
  Tateishi K, Nakamura T, Juratli TA, Williams EA, Matsushita Y, Miyake S, Nishi M, Miller JJ, Tummala SS, Fink AL, Lelic N, Koerner MVA, Miyake Y, Sasame J, Fujimoto K, Tanaka T, Minamimoto R, Matsunaga S, Mukaihara S, Shuto T, Taguchi H, Udaka N, Murata H, Ryo A, Yamanaka S, Curry WT, Dias-Santagata D, Yamamoto T, Ichimura K, Batchelor T, Chi AS, Iafrate AJ, Wakimoto H, Cahill DP. Clin Cancer Res. 2019 Apr 11. pii: clincanres.4144.2018.
• Epidermal growth factor receptor is a host-entry cofactor triggering hepatitis B virus internalization.
  Iwamoto M, Saso W, Sugiyama R, Ishii K, Ohki M, Nagamori S, Suzuki R, Aizaki H, Ryo A, Yun JH, Park SY, Ohtani N, Muramatsu M, Iwami S, Tanaka Y, Sureau C, Wakita T, Watashi K.Proc Natl Acad Sci U S A. 2019 Apr 5. pii: 201811064.
• Prolyl Isomerase Pin1 Suppresses Thermogenic Programs in Adipocytes by Promoting Degradation of Transcriptional Co-activator PRDM16.
  Nakatsu Y, Matsunaga Y, Yamamotoya T, Ueda K, Inoue MK, Mizuno Y, Nakanishi M, Sano T, Yamawaki Y, Kushiyama A, Sakoda H, Fujishiro M, Ryo A, Ono H, Minamino T, Takahashi SI, Ohno H, Yoneda M, Takahashi K, Ishihara H, Katagiri H, Nishimura F, Kanematsu T, Yamada T, Asano T.Cell Rep. 2019 Mar 19;26(12):3221-3230.e3.
• A novel inhibitor of tumorspheres reveals the activation of the serine biosynthetic pathway upon mitochondrial inhibition.
  Subedi A, Muroi M, Futamura Y, Kawamura T, Aono H, Nishi M, Ryo A, Watanabe N, Osada H. FEBS Lett. 2019 Mar 15.
• The Association Between Documentation of Koplik Spots and Laboratory Diagnosis of Measles and Other Rash Diseases in a National Measles Surveillance Program in Japan.
  Kimura H, Shirabe K, Takeda M, Kobayashi M, Tsukagoshi H, Okayama K, Ryo A, Nagasawa K, Okabe N, Minagawa H, Kozawa K. Front Microbiol. 2019 Feb 1;10:269.

2018

• Recapitulation of hepatitis B virus-host interactions in liver organoids from human induced pluripotent stem cells.
  Nie YZ, Zheng YW, Miyakawa K, Murata S, Zhang RR, Sekine K, Ueno Y, Takebe T, Wakita T, Ryo A, Taniguchi H. EBioMedicine. 2018 Sep;35:114-123.
  
• Production and characterization of monoclonal antibodies specific for major capsid VP1 protein of trichodysplasia spinulosa-associated polyomavirus.
  Khatun H, Yamaoka Y, Matsushima Y, Matsunaga S, Kimura H, Ho J, Shuda M, Ryo A. Microbiol Immunol. 2018 Dec;62(12):763-773.
  
• Molecular Evolutionary Analyses of the RNA-Dependent RNA Polymerase Region in Norovirus Genogroup II.
  Ozaki K, Matsushima Y, Nagasawa K, Motoya T, Ryo A, Kuroda M, Katayama K, Kimura H. Front Microbiol. 2018 Dec 18;9:3070.
• Development of a cell-based assay to identify hepatitis B virus entry inhibitors targeting the sodium taurocholate cotransporting polypeptide.
  Miyakawa K, Matsunaga S, Yamaoka Y, Dairaku M, Fukano K, Kimura H, Chimuro T, Nishitsuji H, Watashi K, Shimotohno K, Wakita T, Ryo A. Oncotarget. 2018 May 4;9(34):23681-23694. doi: 10.18632/oncotarget.25348.
• A new strategy to identify hepatitis B virus entry inhibitors by AlphaScreen technology targeting the envelope-receptor interaction.
  Saso W, Tsukuda S, Ohashi H, Fukano K, Morishita R, Matsunaga S, Ohki M, Ryo A, Park SY, Suzuki R, Aizaki H, Muramatsu M, Sureau C, Wakita T, Matano T, Watashi K. Biochem Biophys Res Commun. 2018 Jun 22;501(2):374-379. doi: 10.1016/j.bbrc.2018.04.187.
• Lnc RNA H19 is associated with poor prognosis in breast cancer patients and promotes cancer stemness.
  Shima H, Kida K, Adachi S, Yamada A, Sugae S, Narui K, Miyagi Y, Nishi M, Ryo A, Murata S, Taniguchi H, Ichikawa Y, Ishikawa T, Endo I. Breast Cancer Res Treat. 2018 Aug;170(3):507-516. doi: 10.1111/cmi.12846.
• Molecular mechanisms of Streptococcus pneumoniae-targeted autophagy via pneumolysin, Golgi-resident Rab41, and Nedd4-1-mediated K63-linked ubiquitination.
  Ogawa M, Matsuda R, Takada N, Tomokiyo M, Yamamoto S, Shizukusihi S, Yamaji T, Yoshikawa Y, Yoshida M, Tanida I, Koike M, Murai M, Morita H, Takeyama H, Ryo A, Guan JL, Yamamoto M, Inoue JI, Yanagawa T, Fukuda M, Kawabe H, Ohnishi M. Cell Microbiol. 2018 Mar 26:e12846. doi: 10.1111/cmi.12846.
• Chemical array system, a platform to identify novel hepatitis B virus entry inhibitors targeting sodium taurocholate cotransporting polypeptide.
  Kaneko M, Futamura Y, Tsukuda S, Kondoh Y, Sekine T, Hirano H, Fukano K, Ohashi H, Saso W, Morishita R, Matsunaga S, Kawai F, Ryo A, Park SY, Suzuki R, Aizaki H, Ohtani N, Sureau C, Wakita T, Osada H, Watashi K. Sci Rep. 2018 Feb 9;8(1):2769. doi: 10.1038/s41598-018-20987-w.
• Detailed genetic analyses of the HN gene in human respirovirus 3 detected in children with acute respiratory illness in the Iwate Prefecture, Japan.
  Takahashi M, Nagasawa K, Saito K, Maisawa SI, Fujita K, Murakami K, Kuroda M, Ryo A, Kimura H. Infect Genet Evol. 2018 Apr;59:155-162. doi: 10.1016/j.meegid.2018.01.021.
• Genetic Analysis of Human Norovirus Strains in Japan in 2016-2017.
  Nagasawa K, Matsushima Y, Motoya T, Mizukoshi F, Ueki Y, Sakon N, Murakami K, Shimizu T, Okabe N, Nagata N, Shirabe K, Shinomiya H, Suzuki W, Kuroda M, Sekizuka T, Suzuki Y, Ryo A, Fujita K, Oishi K, Katayama K, Kimura H. Front Microbiol. 2018 Jan 18;9:1. doi: 10.3389/fmicb.2018.00001..
• Phylogeny and Immunoreactivity of Norovirus GII.P16-GII.2, Japan, Winter 2016-17.
  Nagasawa K, Matsushima Y, Motoya T, Mizukoshi F, Ueki Y, Sakon N, Murakami K, Shimizu T, Okabe N, Nagata N, Shirabe K, Shinomiya H, Suzuki W, Kuroda M, Sekizuka T, Ryo A, Fujita K, Oishi K, Katayama K, Kimura H. Emerg Infect Dis. 2018 Jan;24(1):144-148. doi: 10.3201/eid2401.170284.

2017

• A detection method for the rash and fever illness-associated viruses using multiplex RT-PCR.
  Matsushima Y, Shimizu T, Doi I, Mizukoshi F, Nagasawa K, Ryo A, Shimizu H, Kobayashi M, Funatogawa K, Nagata N, Ishikawa M, Komane A, Okabe N, Mori Y, Takeda M, Kimura H. Microbiol Immunol. 2017 Jul 15. doi: 10.1111/1348-0421.12502.
• Differences in Three-Dimensional Geometric Recognition by Non-Cancerous and Cancerous Epithelial Cells on Microgroove-Based Topography.
  Kushiro K, Yaginuma T, Ryo A, Takai M. Sci Rep. 2017 Jun 26;7(1):4244. doi: 10.1038/s41598-017-03779-6.
• Editorial: Perspectives for the Next Generation of Virus Research: Spearheading the Use of Innovative Technologies and Methodologies.
  Yamamoto T, Honda A, Sato T, Ryo A. Editorial: Front Microbiol. 2017 May 11;8:758. doi:10.3389/fmicb.2017.00758.
• Molecular Evolution of the RNA-Dependent RNA Polymerase and Capsid Genes of Human Norovirus Genotype GII.2 in Japan during 2004-2015.
  Mizukoshi F, Nagasawa K, Doan YH, Haga K, Yoshizumi S, Ueki Y, Shinohara M, Ishikawa M, Sakon N, Shigemoto N, Okamoto-Nakagawa R, Ochi A, Murakami K, Ryo A, Suzuki Y, Katayama K, Kimura H. Front Microbiol. 2017 Apr 25;8:705. doi: 10.3389/fmicb.2017.00705.
• Molecular evolution of the fusion protein (F) gene in human respiratory syncytial virus subgroup B.
  Kimura H, Nagasawa K, Kimura R, Tsukagoshi H, Matsushima Y, Fujita K, Hirano E, Ishiwada N, Misaki T, Oishi K, Kuroda M, Ryo A. Infect Genet Evol. 2017 Apr 14;52:1-9. doi: 10.1016/j.meegid.2017.04.015.
• Mutations in genes encoding polycomb repressive complex 2 subunits cause Weaver syndrome.
  Imagawa E, Higashimoto K, Sakai Y, Numakura C, Okamoto N, Matsunaga S, Ryo A, Sato Y, Sanefuji M, Ihara K, Takada Y, Nishimura G, Saitsu H, Mizuguchi T, Miyatake S, Nakashima M, Miyake N, Soejima H, Matsumoto N. Hum Mutat. 2017 Jun;38(6):637-648. doi: 10.1002/humu.23200.
• The tumour suppressor APC promotes HIV-1 assembly via interaction with Gag precursor protein.
  Miyakawa K, Nishi M, Matsunaga S, Okayama A, Anraku M, Kudoh A, Hirano H, Kimura H, Morikawa Y, Yamamoto N, Ono A, Ryo A. Nat Commun. 2017 Jan 30;8:14259. doi: 10.1038/ncomms14259.
• Genetic analyses of the fusion protein genes in human parainfluenza virus types 1 and 3 among patients with acute respiratory infections in Eastern Japan from 2011 to 2015.
  Tsutsui R, Tsukagoshi H, Nagasawa K, Takahashi M, Matsushima Y, Ryo A, Kuroda M, Takami H, Kimura H. J Med Microbiol. 2017 Feb;66(2):160-168. doi: 10.1099/jmm.0.000431.

2016

• Complete Genome Sequence of a Recombinant GII.P16-GII.4 Norovirus Detected in Kawasaki City, Japan, in 2016.
  Matsushima Y, Shimizu T, Ishikawa M, Komane A, Okabe N, Ryo A, Kimura H, Katayama K, Shimizu H. Genome Announc. 2016 Oct 6;4(5). pii: e01099-16. doi: 10.1128/genomeA.01099-16.
• Lyn Kinase Suppresses the Transcriptional Activity of IRF5 in the TLR-MyD88 Pathway to Restrain the Development of Autoimmunity.
  Ban T, Sato GR, Nishiyama A, Akiyama A, Takasuna M, Umehara M, Suzuki S, Ichino M, Matsunaga S, Kimura A, Kimura Y, Yanai H, Miyashita S, Kuromitsu J, Tsukahara K, Yoshimatsu K, Endo I, Yamamoto T, Hirano H, Ryo A, Taniguchi T, Tamura T. Immunity. 2016 Aug 16;45(2):319-32. doi: 10.1016/j.immuni.2016.07.015.
• Inhibitory effect of CDK9 inhibitor FIT-039 on hepatitis B virus propagation.
  Tanaka T, Okuyama-Dobashi K, Murakami S, Chen W, Okamoto T, Ueda K, Hosoya T, Matsuura Y, Ryo A, Tanaka Y, Hagiwara M, Moriishi K. Antiviral Res. 2016 Aug 8;133:156-164. doi: 10.1016/j.antiviral.2016.08.008.
• High-throughput screening identifies artesunate as selective inhibitor of cancer stemness: Involvement of mitochondrial metabolism.
  Subedi A, Futamura Y, Nishi M, Ryo A, Watanabe N, Osada H. Biochem Biophys Res Commun. 2016 Sep 2;477(4):737-42. doi: 10.1016/j.bbrc.2016.06.128.
• Molecular evolution of the fusion protein gene in human respiratory syncytial virus subgroup A.
  Kimura H, Nagasawa K, Tsukagoshi H, Matsushima Y, Fujita K, Yoshida LM, Tanaka R, Ishii H, Shimojo N, Kuroda M, Ryo A. Infect Genet Evol. 2016 Sep;43:398-406. doi: 10.1016/j.meegid.2016.06.019.
• Pathogen profiles and molecular epidemiology of respiratory viruses in Japanese inpatients with community-acquired pneumonia.
  Kurai D, Sasaki Y, Saraya T, Ishii H, Tsukagoshi H, Kozawa K, Ryo A, Ishioka T, Kuroda M, Oishi K, Takizawa H, Kimura H. Respir Investig. 2016 Jul;54(4):255-63. doi:10.1016/j.resinv.2016.01.001.
• Molecular evolution of the capsid gene in human norovirus genogroup II.
  Kobayashi M, Matsushima Y, Motoya T, Sakon N, Shigemoto N, Okamoto-Nakagawa R, Nishimura K, Yamashita Y, Kuroda M, Saruki N, Ryo A, Saraya T, Morita Y, Shirabe K, Ishikawa M, Takahashi T, Shinomiya H, Okabe N, Nagasawa K, Suzuki Y, Katayama K, Kimura H. Sci Rep. 2016 Jul 7;6:29400. doi: 10.1038/srep29400.
• Discovery of novel selenium derivatives as Pin1 inhibitors by high-throughput screening.
  Subedi A, Shimizu T, Ryo A, Sanada E, Watanabe N, Osada H. Biochem Biophys Res Commun. 2016 Jun 3;474(3):528-33. doi: 10.1016/j.bbrc.2016.04.124.
• Survey for human polyomaviruses in cancer.
  Toptan T, Yousem SA, Ho J, Matsushima Y, Stabile LP, Fernández-Figueras MT, Bhargava R, Ryo A, Moore PS, Chang Y. JCI Insight. 2016 Feb;1(2). pii: e85562.
• H11/HSPB8 Restricts HIV-2 Vpx to Restore the Anti-Viral Activity of SAMHD1.
  Kudoh A, Miyakawa K, Matsunaga S, Matsushima Y, Kosugi I, Kimura H, Hayakawa S, Sawasaki T, Ryo A. Front Microbiol. 2016 Jun 13;7:883. doi:10.3389/fmicb.2016.00883.
• Development of Monoclonal Antibody and Diagnostic Test for Middle East Respiratory Syndrome Coronavirus Using Cell-Free Synthesized Nucleocapsid Antigen.
  Yamaoka Y, Matsuyama S, Fukushi S, Matsunaga S, Matsushima Y, Kuroyama H, Kimura H, Takeda M, Chimuro T, Ryo A. Front Microbiol. 2016 Apr 20;7:509. doi:10.3389/fmicb.2016.00509.
• Relationship between phosphorylation of sperm-specific antigen and prognosis of lung adenocarcinoma.
  Okayama A, Kimura Y, Miyagi Y, Oshima T, Oshita F, Ito H, Nakayama H, Nagashima T, Rino Y, Masuda M, Ryo A, Hirano H. J Proteomics. 2016 Apr 29;139:60-6. doi: 10.1016/j.jprot.2016.03.005.
• MIP-1α level in nasopharyngeal aspirates at the first wheezing episode predicts recurrent wheezing.
  Sugai K, Kimura H, Miyaji Y, Tsukagoshi H, Yoshizumi M, Sasaki-Sakamoto T, Matsunaga S, Yamada Y, Kashiwakura JI, Noda M, Ikeda M, Kozawa K, Ryo A, Yoshihara S, Ogata H, Okayama Y. J Allergy Clin Immunol. 2016 Mar;137(3):774-81. doi: 10.1016/j.jaci.2015.08.032.
• Eucommicin A, a β-truxinate lignan from Eucommia ulmoides, is a selective inhibitor of cancer stem cells.
  Fujiwara A, Nishi M, Yoshida S, Hasegawa M, Yasuma C, Ryo A, Suzuki Y. Phytochemistry. 2016 Feb;122:139-45. doi: 10.1016/j.phytochem.2015.11.017.

2015

• The Hepatitis B Virus Genotype Affects the Persistence of Viral Replication in Immunodeficient NOG Mice.
  Yokoyama Y, Miyagi T, Hikita H, Yoshioka T, Mukai K, Nawa T, Sakamori R, Ohkawa K, Hiramatsu N, Takahashi T, Suemizu H, Ryo A, Tatsumi T, Takehara T. PLoS One. 2015 Dec 14;10(12):e0144775. doi: 10.1371/journal.pone.0144775.
• Hepatitis B virus efficiently infects non-adherent hepatoma cells via human sodium taurocholate cotransporting polypeptide.
  Okuyama-Dobashi K, Kasai H, Tanaka T, Yamashita A, Yasumoto J, Chen W, Okamoto T, Maekawa S, Watashi K, Wakita T, Ryo A, Suzuki T, Matsuura Y, Enomoto N, Moriishi K. Sci Rep. 2015 Nov 23;5:17047. doi: 10.1038/srep17047.
• Biallelic Mutations in Nuclear Pore Complex Subunit NUP107 Cause Early-Childhood-Onset Steroid-Resistant Nephrotic Syndrome.
  Miyake N, Tsukaguchi H, Koshimizu E, Shono A, Matsunaga S, Shiina M, Mimura Y, Imamura S, Hirose T, Okudela K, Nozu K, Akioka Y, Hattori M, Yoshikawa N, Kitamura A, Cheong HI, Kagami S, Yamashita M, Fujita A, Miyatake S, Tsurusaki Y, Nakashima M, Saitsu H, Ohashi K, Imamoto N, Ryo A, Ogata K, Iijima K, Matsumoto N. Am J Hum Genet. 2015 Oct 1;97(4):555-66. doi: 10.1016/j.ajhg.2015.08.013.
• Molecular evolution of the hypervariable region of the attachment glycoprotein gene in human respiratory syncytial virus subgroup B genotypes BA9 and BA10.
  Nagasawa K, Hirano E, Kobayashi M, Ryo A, Oishi K, Obuchi M, Ishiwada N, Noda M, Kuroda M, Shimojo N, Kimura H. Infect Genet Evol. 2015 Dec;36:217-23. doi: 10.1016/j.meegid.2015.09.020.
• A cell-free enzymatic activity assay for the evaluation of HIV-1 drug resistance to protease inhibitors.
  Matsunaga S, Masaoka T, Sawasaki T, Morishita R, Iwatani Y, Tatsumi M, Endo Y, Yamamoto N, Sugiura W, Ryo A. Front Microbiol. 2015 Oct 31;6:1220. doi: 10.3389/fmicb.2015.01220.
• Molecular Evolution of the Capsid Gene in Norovirus Genogroup I.
  Kobayashi M, Yoshizumi S, Kogawa S, Takahashi T, Ueki Y, Shinohara M, Mizukoshi F, Tsukagoshi H, Sasaki Y, Suzuki R, Shimizu H, Iwakiri A, Okabe N, Shirabe K, Shinomiya H, Kozawa K, Kusunoki H, Ryo A, Kuroda M, Katayama K, Kimura H. Sci Rep. 2015 Sep 4;5:13806. doi: 10.1038/srep13806.
• Molecular dissection of HBV evasion from restriction factor tetherin: A new perspective for antiviral cell therapy.
  Miyakawa K, Matsunaga S, Watashi K, Sugiyama M, Kimura H, Yamamoto N, Mizokami M, Wakita T, Ryo A. Oncotarget. 2015 Aug 27.
• Understanding of tolerance in TRAIL-induced apoptosis and cancelation of its machinery by α-mangostin, a xanthone derivative.
  Kumazaki M, Shinohara H, Taniguchi K, Ueda H, Nishi M, Ryo A, Akao Y. Oncotarget. 2015 Jul 16.
• Identification of Tyrosine-Phosphorylated Proteins Upregulated during Epithelial-Mesenchymal Transition Induced with TGF-β.
  Okayama A, Miyagi Y, Oshita F, Ito H, Nakayama H, Nishi M, Kurata Y, Kimura Y, Ryo A, Hirano H. J Proteome Res. 2015 Aug 28.
• Antibody against early driver of neurodegeneration cis P-tau blocks brain injury and tauopathy.
  Kondo A, Shahpasand K, Mannix R, Qiu J, Moncaster J, Chen CH, Yao Y, Lin YM, Driver JA, Sun Y, Wei S, Luo ML, Albayram O, Huang P, Rotenberg A, Ryo A, Goldstein LE, Pascual-Leone A, McKee AC, Meehan W, Zhou XZ, Lu KP. Nature. 2015 Jul 23;523(7561):431-6. doi: 10.1038/nature14658. Epub 2015 Jul 15.
• Genetic analyses of GII.17 norovirus strains in diarrheal disease outbreaks from December 2014 to March 2015 in Japan reveal a novel polymerase sequence and amino acid substitutions in the capsid region.
  Matsushima Y, Ishikawa M, Shimizu T, Komane A, Kasuo S, Shinohara M, Nagasawa K, Kimura H, Ryo A, Okabe N, Haga K, Doan YH, Katayama K, Shimizu H. Euro Surveill. 2015 Jul 2;20(26). pii: 21173. No abstract available.
• Molecular evolution of haemagglutinin (H) gene in measles virus.
  Kimura H, Saitoh M, Kobayashi M, Ishii H, Saraya T, Kurai D, Tsukagoshi H, Shirabe K, Nishina A, Kozawa K, Kuroda M, Takeuchi F, Sekizuka T, Minakami H, Ryo A, Takeda M. Sci Rep. 2015 Jul 1;5:11648. doi: 10.1038/srep11648.
• ASK1 restores the antiviral activity of APOBEC3G by disrupting HIV-1 Vif-mediated counteraction.
  Miyakawa K, Matsunaga S, Kanou K, Matsuzawa A, Morishita R, Kudoh A, Shindo K, Yokoyama M, Sato H, Kimura H, Tamura T, Yamamoto N, Ichijo H, Takaori-Kondo A, Ryo A. Nat. Commun. 2015 Apr 22;6:6945. doi: 10.1038/ncomms7945.
• Molecular evolution of the VP1, VP2, and VP3 genes in human rhinovirus species C.
  Kuroda M, Niwa S, Sekizuka T, Tsukagoshi H, Yokoyama M, Ryo A, Sato H, Kiyota N, Noda M, Kozawa K, Shirabe K, Kusaka T, Shimojo N, Hasegawa S, Sugai K, Obuchi M, Tashiro M, Oishi K, Ishii H, Kimura H. Sci Rep. 2015 Feb 2;5:8185.

2014

• Pathophysiology and epidemiology of virus-induced asthma.
  Kimura H, Ryo A. Front Microbiol. 2014 Oct 22;5:562.
• Molecular evolution of human respiratory syncytial virus attachment glycoprotein (G) gene of new genotype ON1 and ancestor NA1.
  Hirano E, Kobayashi M, Tsukagoshi H, Yoshida LM, Kuroda M, Noda M, Ishioka T, Kozawa K, Ishii H, Yoshida A, Oishi K, Ryo A, Kimura H. Infect Genet Evol. 2014 Dec;28:183-91.
• IRF8 inhibits C/EBPα activity to restrain mononuclear phagocyte progenitors from differentiating into neutrophils
  Kurotaki D, Yamamoto M, Nishiyama A, Uno K, Ban T, Ichino M, Sasaki H, Matsunaga S, Yoshinari M, Ryo A, Nakazawa M, Ozato K, Tamura T. . Nat Commun. 2014 Sep 19;5:4978.
• Development of an induced cancer stem cell model for drug discovery.
  Mayuko Nishi, Akihide Ryo. Cancer Cell Microenv.1(6), 2014.
• Induced cancer stem-like cells as a model for biological screening and discovery of agents targeting phenotypic traits of cancer stem cell.
  Nishi M, Akutsu H , Kudoh A , Kimura H , Yamamoto N, Umezawa A , Lee SW, RyoA.Oncotarget August 17, 2014
• Combination of vaccine-strain measles and mumps virus synergistically kills a wide range of human hematological cancer cells: special focus on acute myeloid leukemia.
  Zhang L, Tan DQ, Jeyasekharan AD, Hsieh WS, Ho AS, Ichiyama K, Ye M, Pang B, Ohba K, Liu X, de Mel S, Cuong BK, Chng WJ, Ryo A, Suzuki Y, Yeoh KG, Toan NL, Yamamoto N. Cancer Lett. 2014 Sep 1. pii: S0304-3835
• An outbreak of acute respiratory infections due to human respiratory syncytial virus in a nursing home for the elderly in Ibaraki, Japan, 2014.
  Doi I, Nagata N, Tsukagoshi H, Komori H, Motoya T, Watanabe M, Keta T, Kawakami M, Tsukano T, Honda M, Ishioka T, Takeda M, Ryo A, Kuroda M, Oishi K, Kimura H. Jpn J Infect Dis. 2014;67(4):326-8.
• Proteomic Analysis of Proteins Related to Prognosis of Lung Adenocarcinoma.
  Okayama A, Miyagi Y, Oshita F, Nishi M, Nakamura Y, Nagashima Y, Akimoto K, Ryo A, Hirano H. J Proteome Res. 2014 Jul 8.
• Wheat germ cell-free system-based production of hemagglutinin-neuraminidase glycoprotein of human parainfluenza virus type 3 for generation and characterization of monoclonal antibody.
  Matsunaga S, Kawakami S, Matsuo I, Okayama A, Tsukagoshi H, Kudoh A, Matsushima Y, Shimizu H, Okabe N, Hirano H, Yamamoto N, Kimura H, Ryo A. Front Microbiol. 2014 May 13;5:208.
• Profiling of autoantibodies in sera of pancreatic cancer patients.
  Nagayoshi Y, Nakamura M, Matsuoka K, Ohtsuka T, Mori Y, Kono H, Aso T, Ideno N, Takahata S, Ryo A, Takeda H, Ito T, Oda Y, Endo Y, Sawasaki T, Tanaka M.Ann Surg Oncol. 2014 Jun;21 Suppl 3:459-65.
• Quantitative analysis of location- and sequence-dependent deamination by APOBEC3G using real-time NMR spectroscopy.
  Furukawa A, Sugase K, Morishita R, Nagata T, Kodaki T, Takaori-Kondo A, Ryo A, Katahira M.Angew Chem Int Ed Engl. 2014 Feb 24;53(9):2349-52.
• The phosphorylation of HIV-1 Gag by atypical protein kinase C facilitates viral infectivity by promoting Vpr incorporation into virions.
  Kudoh A, Takahama S, Sawasaki T, Ode H, Yokoyama M, Okayama A, Ishikawa A, Miyakawa K, Matsunaga S, Kimura H, Sugiura W, Sato H, Hirano H, Ohno S, Yamamoto N, Ryo A.
  Retrovirology. 2014 Jan 22;11:9.
• Cyclosporin A and its analogs inhibit hepatitis B virus entry into cultured hepatocytes through targeting a membrane transporter, sodium taurocholate cotransporting polypeptide (NTCP).
  Watashi K, Sluder A, Daito T, Matsunaga S, Ryo A, Nagamori S, Iwamoto M, Nakajima S, Tsukuda S, Borroto-Esoda K, Sugiyama M, Tanaka Y, Kanai Y, Kusuhara H, Mizokami M, Wakita T.Hepatology. 2014 May;59(5):1726-37.
• Genetic analysis of human rhinovirus species A to C detected in patients with acute respiratory infection in Kumamoto prefecture, Japan 2011-2012.
  Kiyota N, Kobayashi M, Tsukagoshi H, Ryo A, Harada S, Kusaka T, Obuchi M, Shimojo N, Noda M, Kimura H. Infect Genet Evol. 2014 Jan;21:90-102
• Induction of cells with cancer stem cell properties from nontumorigenic human mammary epithelial cells by defined reprogramming factors.
  Nishi M, Sakai Y, Akutsu H, Nagashima Y, Quinn G, Masui S, Kimura H, Perrem K, Umezawa A, Yamamoto N, Lee SW, Ryo A.
  Oncogene. 2014 Jan 30;33(5):643-52.

2013

• Development of oligomannose-coated liposome-based nasal vaccine against human parainfluenza virus type 3.
  Senchi K, Matsunaga S, Hasegawa H, Kimura H, Ryo A.Front Microbiol. 2013 Nov 26;4:346.
• Generation of rhesus macaque-tropic HIV-1 clones that are resistant to major anti-HIV-1 restriction factors.
  Nomaguchi M, Yokoyama M, Kono K, Nakayama EE, Shioda T, Doi N, Fujiwara S, Saito A, Akari H, Miyakawa K, Ryo A, Ode H, Iwatani Y, Miura T, Igarashi T, Sato H, Adachi A.J Virol. 2013 Nov;87(21):11447-61.
• Molecular evolution of attachment glycoprotein (G) gene in human respiratory syncytial virus detected in Japan 2008-2011.
  Kushibuchi I, Kobayashi M, Kusaka T, Tsukagoshi H, Ryo A, Yoshida A, Ishii H, Saraya T, Kurai D, Yamamoto N, Kanou K, Saitoh M, Noda M, Kuroda M, Morita Y, Kozawa K, Oishi K, Tashiro M, Kimura H. Infect Genet Evol. 2013 Aug;18:168-73.
• Anti-interleukin-5 and multiple autoantibodies are associated with human atherosclerotic diseases and serum interleukin-5 levels.
  Ishigami T, Abe K, Aoki I, Minegishi S, Ryo A, Matsunaga S, Matsuoka K, Takeda H, Sawasaki T, Umemura S, Endo Y. FASEB J. 2013 Sep;27(9):3437-45.
• Sulfated polysaccharide, curdlan sulfate, efficiently prevents entry/fusion and restricts antibody-dependent enhancement of dengue virus infection in vitro: a possible candidate for clinical application.
  Ichiyama K, Gopala Reddy SB, Zhang LF, Chin WX, Muschin T, Heinig L, Suzuki Y, Nanjundappa H, Yoshinaka Y, Ryo A, Nomura N, Ooi EE, Vasudevan SG, Yoshida T, Yamamoto N. PLoS Negl Trop Dis. 2013 Apr 25;7(4):e2188.
• Cytokine profiles, signalling pathways and effects of fluticasone propionate in respiratory syncytial virus-infected human foetal lung fibroblasts.
  Seki E, Yoshizumi M, Tanaka R, Ryo A, Ishioka T, Tsukagoshi H, Kozawa K, Okayama Y, Okabe-Kado J, Goya T, Kimura H.Cell Biol Int. 2013 Jan 22.
• Genetic analysis of the VP4/VP2 coding region in human rhinovirus species C in patients with acute respiratory infection in Japan.
  Kiyota N, Kushibuchi I, Kobayashi M, Tsukagoshi H, Ryo A, Nishimura K, Hirata-Saito A, Harada S, Arakawa M, Kozawa K, Noda M, Kimura H. J Med Microbiol. 2013 Apr;62(Pt 4):610-7.
• Cytomegalovirus retinitis during maintenance therapy for T-cell acute lymphoblastic leukemia.
  Wakai K, Sano H, Shimada A, Shiozawa Y, Park MJ, Sotomatsu M, Yanagisawa R, Koike K, Kozawa K, Ryo A, Tsukagoshi H, Kimura H, Hayashi Y. J Pediatr Hematol Oncol. 2013 Mar;35(2):162-3.
• Pin1 interacts with the Epstein-Barr virus DNA polymerase catalytic subunit and regulates viral DNA replication.
  Narita Y, Murata T, Ryo A, Kawashima D, Sugimoto A, Kanda T, Kimura H, Tsurumi T. Virol. 2013 Feb;87(4):2120-7.
• Molecular evolution of hemagglutinin (H) gene in measles virus genotypes D3, D5, D9, and H1.
  Saitoh M, Takeda M, Gotoh K, Takeuchi F, Sekizuka T, Kuroda M, Mizuta K, Ryo A, Tanaka R, Ishii H, Takada H, Kozawa K, Yoshida A, Noda M, Okabe N, Kimura H. PLoS One. 2012;7(11):e50660.
• Genetic analysis of non-hydrogen sulfide-producing Salmonella enterica serovar typhimurium and S. enterica serovar infantis isolates in Japan.
  Sakano C, Kuroda M, Sekizuka T, Ishioka T, Morita Y, Ryo A, Tsukagoshi H, Kawai Y, Inoue N, Takada H, Ogaswara Y, Nishina A, Shimoda MA, Kozawa K, Oishi K, Kimura H. J Clin Microbiol. 2013 Jan;51(1):328-30
• Seroepidemiology of Saffold cardiovirus (SAFV) genotype 3 in Japan.
  Kobayashi M, Tsukagoshi H, Ishioka T, Mizuta K, Noda M, Morita Y, Ryo A, Kozawa K, Kimura H. J Infect. 2013 Feb;66(2):191-3.

2012

• Cytomegalovirus Retinitis During Maintenance Therapy for T-Cell Acute Lymphoblastic Leukemia.
  Wakai K, Sano H, Shimada A, Shiozawa Y, Park MJ, Sotomatsu M, Yanagisawa R, Koike K, Kozawa K, Ryo A, Tsukagoshi H, Kimura H, Hayashi Y.
  J Pediatr Hematol Oncol. 2012 Dec 13.
• Pin1 interacts with the Epstein-Barr virus DNA polymerase catalytic subunit and regulates viral DNA replication.
  Narita Y, Murata T, Ryo A, Kawashima D, Sugimoto A, Kanda T, Kimura H, Tsurumi T.
  J Virol. 2012 Dec 5.
• Molecular evolution of hemagglutinin (h) gene in measles virus genotypes d3, d5, d9, and h1.
  Saitoh M, Takeda M, Gotoh K, Takeuchi F, Sekizuka T, Kuroda M, Mizuta K, Ryo A, Tanaka R, Ishii H, Takada H, Kozawa K, Yoshida A, Noda M, Okabe N, Kimura H.
  PLoS One. 2012;7(11):e50660. doi: 10.
• Genetic analysis of non-hydrogen sulfide-producing Salmonella enterica serovar Typhimurium and Infantis isolates in Japan.
  Sakano C, Kuroda M, Sekizuka T, Ishioka T, Morita Y, Ryo A, Tsukagoshi H, Kawai Y, Inoue N, Takada H, Ogaswara Y, Nishina A, Shimoda MA, Kozawa K, Oishi K, Kimura H.
  J Clin Microbiol. 2012 Nov 7.
• Seroepidemiology of Saffold cardiovirus (SAFV) genotype 3 in Japan.
  Kobayashi M, Tsukagoshi H, Ishioka T, Mizuta K, Noda M, Morita Y, Ryo A, Kozawa K, Kimura H.
  J Infect. 2012 Oct 26. doi:pii: S0163-4453(12)
• Establishment of a robust dengue virus NS3-NS5 binding assay for identification of protein-protein interaction inhibitors.
  Takahashi H, Takahashi C, Moreland NJ, Chang YT, Sawasaki T, Ryo A, Vasudevan SG, Suzuki Y, Yamamoto N.
  Antiviral Res. 2012 Oct 13. pii: S0166-3542(12)00230-6.
• Interferon-Induced SCYL2 Limits Release of HIV-1 by Triggering PP2A-Mediated Dephosphorylation of the Viral Protein Vpu.
  Miyakawa K, Sawasaki T, Matsunaga S, Tokarev A, Quinn G, Kimura H, Nomaguchi M, Adachi A, Yamamoto N, Guatelli J, Ryo A.
  Sci Signal. 2012 Oct 9;5(245):ra73.
• NMR study of xenotropic murine leukemia virus-related virus protease in a complex with amprenavir.
  Furukawa A, Okamura H, Morishita R, Matsunaga S, Kobayashi N, Ikegami T, Kodaki T, Takaori-Kondo A, Ryo A, Nagata T, Katahira M.
  Biochem Biophys Res Commun. 2012 Aug 24;425(2):284-9.
• Molecular and enzymatic characterization of XMRV protease by a cell-free proteolytic analysis.
  Matsunaga S, Sawasaki T, Ode H, Morishita R, Furukawa A, Sakuma R, Sugiura W, Sato H, Katahira M, Takaori-Kondo A, Yamamoto N, Ryo A.
  J Proteomics. 2012 Aug 3;75(15):4863-73.
• Prolyl Isomerase Pin1 Regulates Neuronal Differentiation via β-Catenin.
  Nakamura K, Kosugi I, Lee DY, Hafner A, Sinclair DA, Ryo A, Lu KP.
  Mol Cell Biol. 2012 Aug;32(15):2966-78. .
• Molecular epidemiology of the attachment glycoprotein (G) gene in respiratory syncytial virus in children with acute respiratory infection in Japan in 2009/2010.
  Yoshida A, Kiyota N, Kobayashi M, Nishimura K, Tsutsui R, Tsukagoshi H, Hirano E, Yamamoto N, Ryo A, Saitoh M, Harada S, Inoue O, Kozawa K, Tanaka R, Noda M, Okabe N, Tashiro M, Mizuta K, Kimura H.
  J Med Microbiol. 2012 Jun;61(Pt 6):820-9.
• Effects of DNA binding of the zinc finger and linkers for domain fusion on the catalytic activity of sequence-specific chimeric recombinases determined by a facile fluorescent system.
  Nomura W, Masuda A, Ohba K, Urabe A, Ito N, Ryo A, Yamamoto N, Tamamura H.
  Biochemistry. 2012 Feb 21;51(7):1510-7.

2011

• Identification of phosphorylated proteins involved in the oncogenesis of prostate cancer via Pin1-proteomic analysis.
  Endoh K, Nishi M, Ishiguro H, Uemura H, Miyagi Y, Aoki I, Hirano H, Kubota Y, Ryo A. Prostate. 2011 Aug 1. doi: 10
• A distinct role for Pin1 in the induction and maintenance of pluripotency.
  Nishi M, Akutsu H, Masui S, Kondo A, Nagashima Y, Kimura H, Perrem K, Shigeri Y, Toyoda M, Okayama A, Hirano H, Umezawa A, Yamamoto N, Lee SW, Ryo A. J Biol Chem. 2011 Apr 1;286(13):11593-603.
• Heat shock protein 70 inhibits HIV-1 Vif-mediated ubiquitination and degradation of APOBEC3G.
  Sugiyama R, Nishitsuji H, Furukawa A, Katahira M, Habu Y, Takeuchi H, Ryo A, Takaku H. J Biol Chem. 2011 Mar 25;286(12):10051-7.
• The impact of Saffold cardiovirus in patients with acute respiratory infections in Yamagata, Japan.
  Tsukagoshi H, Mizuta K, Abiko C, Itagaki T, Yoshizumi M, Kobayashi M, Kuroda M, Kozawa K, Noda M, Ryo A, Kimura H. Scand J Infect Dis. 2011 Mar 24.
• . Vaccination with human induced pluripotent stem cells creates an antigen-specific immune response against HIV-1 gp160.
  Yoshizaki S, Nishi M, Kondo A, Kojima Y, Yamamoto N,Ryo A. Frontiers in Microbiology, 2011 Feb 22;2:27.

2010

• Modulation of intracellular signaling using protein-transduction technology.
  Kobiyama K, Jounai N, Ishii KJ, Horii T, Suzuki K, Ryo A, Takeshita F. Crit Rev Immunol. 2010;30(5):395-421.
• A structural constraint for functional interaction between N-terminal and C-terminal domains in simian immunodeficiency virus capsid proteins.
  Inagaki N, Takeuchi H, Yokoyama M, Sato H, Ryo A, Yamamoto H, Kawada M, Matano T. Retrovirology. 2010 Oct 18;7:90.
• Sequencing and phylogenetic analyses of Saffold cardiovirus (SAFV) genotype 3 isolates from children with upper respiratory infection in Gunma, Japan.
  Tsukagoshi H, Masuda Y, Mizutani T, Mizuta K, Saitoh M, Morita Y, Nishina A, Kozawa K, Noda M, Ryo A, Kimura H. Jpn J Infect Dis. 2010 Sep;63(5):378-80.
• Pinning down viral proteins: A new prototype for virus-host cell interaction.
  Kojima Y, Ryo A. Frontiers in MICROBIOLOGY. 2010 Sep 9;1:107
• Thymic alterations in GM2 gangliosidoses model mice.
  Kanzaki S, Yamaguchi A, Yamaguchi K, Kojima Y, Suzuki K, Koumitsu N, Nagashima Y, Nagahama K, Ehara M, Hirayasu Y, Ryo A, Aoki I, Yamanaka S. PLoS One. 2010 Aug 10;5(8).
• DNA vaccine expressing HIV-1 gp120/immunoglobulin fusion protein enhances cellular immunity.
  Shimada M, Yoshizaki S, Jounai N, Kondo A, Ichino M, Ryo A, Okuda K. Vaccine. 2010 Jul 12;28(31):4920-7.
• Endoscopic therapy using an endoscopic variceal ligation for minute cancer of the esophagogastric junction complicated with esophageal varices: a case report.
  Akiyama T, Abe Y, Iida H, Endo H, Hosono K, Yoneda K, Takahashi H, Inamori M, Ryo A, Yamanaka S, Inayama Y, Nakajima A. J Med Case Reports. 2010 May 23;4:149.
• Co-administration of viral vector-based vaccines suppresses antigen-specific effector CD8 T cells.
  Yashima S, Yoshizaki S, Shinoda K, Yoshida A, Kondo A, Mizuguchi H, Ryo A, Okuda K, Shimada M. Vaccine. 2010 Apr 19;28(18):3257-64. Epub 2010 .
• Elevated PIN1 expression by C/EBPalpha-p30 blocks C/EBPalpha-induced granulocytic differentiation through c-Jun in AML.
  Pulikkan JA, Dengler V, Peer Zada AA, Kawasaki A, Geletu M, Pasalic Z, Bohlander SK, Ryo A, Tenen DG, Behre G. Leukemia. 2010 Apr 8.
• Pin1 promotes transforming growth factor-beta-induced migration and invasion.
  Matsuura I, Chiang KN, Lai CY, He D, Wang G, Ramkumar R, Uchida T, Ryo A, Lu K, Liu F. J Biol Chem. 2010 Jan 15;285(3):1754-64.

2009

• BCA2/Rabring7 promotes tetherin-dependent HIV-1 restriction.
  Miyakawa K, Ryo A, Murakami T, Ohba K, Yamaoka S, Fukuda M, Guatelli J, Yamamoto N. PLoS Pathog. 2009 Dec;5(12):e1000700.
• Pin1 catalyzes conformational changes of Thr187 in p27Kip1 and mediates its stability through a poly-ubiquitination process.
  Zhou W, Yang Q, Low CB, Karthik BC, Wang Y, Ryo A, Yao SQ, Yang D, Liou YC. J Biol Chem. 2009 Jul 7.
• Follicular dendritic cells activate HIV-1 replication in monocytes/macrophages through a juxtacrine mechanism mediated by P-selectin glycoprotein ligand 1.
  Ohba K, Ryo A, Dewan MZ, Nishi M, Naito T, Qi X, Inagaki Y, Nagashima Y, Tanaka Y, Okamoto T, Terashima K, Yamamoto N. J Immunol. 2009 Jul 1;183(1):524-32.
• Requirement for microtubule integrity in the SOCS1-mediated intracellular dynamics of HIV-1 Gag.
  Nishi M, Ryo A, Tsurutani N, Ohba K, Sawasaki T, Morishita R, Perrem K, Aoki I, Morikawa Y, Yamamoto N. FEBS Lett. 2009 Apr 17;583(8):1243-50.
• The prolyl isomerase Pin1 stabilizes the human T-cell leukemia virus type 1 (HTLV-1) Tax oncoprotein and promotes malignant transformation.
  Jeong SJ, Ryo A, Yamamoto N. Biochem Biophys Res Commun. 2009 Apr 3;381(2):294-9.
• Pinning down HER2-ER crosstalk in SMRT regulation.
  Ryo A, Wulf G, Lee TH, Lu KP. Trends Biochem Sci. 2009 Apr;34(4):162-5.

2008

• Low-intensity pulsed ultrasound activates the phosphatidylinositol 3 kinase/Akt pathway and stimulates the growth of chondrocytes in three-dimensional cultures: a basic science study.
  Takeuchi R, Ryo A, Komitsu N, Mikuni-Takagaki Y, Fukui A, Takagi Y, Shiraishi T, Morishita S, Yamazaki Y, Kumagai K, Aoki I, Saito T. Arthritis Res Ther. 2008;10(4):R77.
• The wheat germ cell-free based screening of protein substrates of calcium/calmodulin-dependent protein kinase II delta.
  Masaoka T, Nishi M, Ryo A, Endo Y, Sawasaki T. FEBS Lett. 2008 Jun 11;582(13):1795-801.
• SOCS1 is an inducible host factor during HIV-1 infection and regulates the intracellular trafficking and stability of HIV-1 Gag.
  Ryo A, Tsurutani N, Ohba K, Kimura R, Komano J, Nishi M, Soeda H, Hattori S, Perrem K, Yamamoto M, Chiba J, Mimaya J, Yoshimura K, Matsushita S, Honda M, Yoshimura A, Sawasaki T, Aoki I, Morikawa Y, Yamamoto N. Proc Natl Acad Sci U S A. 2008 Jan 8;105(1):294-9.

2007

• A suppressive role of the prolyl isomerase Pin1 in cellular apoptosis mediated by the death-associated protein Daxx.
  Ryo A, Hirai A, Nishi M, Liou YC, Perrem K, Lin SC, Hirano H, Lee SW, Aoki I. J Biol Chem. 2007 Dec 14;282(50):36671-81.

2006

• Negative regulation of interferon-regulatory factor 3-dependent innate antiviral response by the prolyl isomerase Pin1.
  Saitoh T, Tun-Kyi A, Ryo A, Yamamoto M, Finn G, Fujita T, Akira S, Yamamoto N, Lu KP, Yamaoka S. Nat Immunol. 2006 Jun;7(6):598-605.
• An immunohistochemical scoring system of prolyl isomerase Pin1 for predicting relapse of prostate carcinoma after radical prostatectomy.
  Sasaki T, Ryo A, Uemura H, Ishiguro H, Inayama Y, Yamanaka S, Kubota Y, Nagashima Y, Harada M, Aoki I. Pathol Res Pract. 2006;202(5):357-64.
• Pin1 regulates centrosome duplication, and its overexpression induces centrosome amplification, chromosome instability, and oncogenesis.
  Suizu F, Ryo A, Wulf G, Lim J, Lu KP. Mol Cell Biol. 2006 Feb;26(4):1463-79.
• Prolyl-isomerase Pin1 accumulates in lewy bodies of parkinson disease and facilitates formation of alpha-synuclein inclusions.
  Ryo A, Togo T, Nakai T, Hirai A, Nishi M, Yamaguchi A, Suzuki K, Hirayasu Y, Kobayashi H, Perrem K, Liou YC, Aoki I. J Biol Chem. 2006 Feb 17;281(7):4117-25.

2005

• Stable suppression of tumorigenicity by Pin1-targeted RNA interference in prostate cancer.
  Ryo A, Uemura H, Ishiguro H, Saitoh T, Yamaguchi A, Perrem K, Kubota Y, Lu KP, Aoki I. Clin Cancer Res. 2005 Oct 15;11(20):7523-31.

2003

• Regulation of NF-kappaB signaling by Pin1-dependent prolyl isomerization and ubiquitin-mediated proteolysis of p65/RelA.
  Ryo A, Suizu F, Yoshida Y, Perrem K, Liou YC, Wulf G, Rottapel R, Yamaoka S, Lu KP. Mol Cell. 2003 Dec;12(6):1413-26.
• Activation of Galectin-1 gene in human hepatocellular carcinoma involves methylation-sensitive complex formations at the transcriptional upstream and downstream elements.
  Kondoh N, Hada A, Ryo A, Shuda M, Arai M, Matsubara O, Kimura F, Wakatsuki T, Yamamoto M. Int J Oncol. 2003 Dec;23(6):1575-83.
• Identification of epilepsy-related genes by gene expression profiling in the hippocampus of genetically epileptic rat.
  Arai M, Amano S, Ryo A, Hada A, Wakatsuki T, Shuda M, Kondoh N, Yamamoto M. Brain Res Mol Brain Res. 2003 Oct 21;118(1-2):147-51.
• Role of the prolyl isomerase Pin1 in protecting against age-dependent neurodegeneration.
  Liou YC, Sun A, Ryo A, Zhou XZ, Yu ZX, Huang HK, Uchida T, Bronson R, Bing G, Li X, Hunter T, Lu KP. Nature. 2003 Jul 31;424(6948):556-61.
• Modulation of p53 and p73 levels by cyclin G: implication of a negative feedback regulation.
  Ohtsuka T, Ryu H, Minamishima YA, Ryo A, Lee SW. Oncogene. 2003 Mar 20;22(11):1678-87.
• The prolyl isomerase Pin1 in breast development and cancer.
  Wulf G, Ryo A, Liou YC, Lu KP. Breast Cancer Res. 2003;5(2):76-82.
• Prolyl isomerase Pin1: a catalyst for oncogenesis and a potential therapeutic target in cancer.
  Ryo A, Liou YC, Lu KP, Wulf G. J Cell Sci. 2003 Mar 1;116(Pt 5):773-83.

2002

• Role of Pin1 in the regulation of p53 stability and p21 transactivation, and cell cycle checkpoints in response to DNA damage.
  Wulf GM, Liou YC, Ryo A, Lee SW, Lu KP. J Biol Chem. 2002 Dec 13;277(50):47976-9.
• PIN1 is an E2F target gene essential for Neu/Ras-induced transformation of mammary epithelial cells.
  Ryo A, Liou YC, Wulf G, Nakamura M, Lee SW, Lu KP. Mol Cell Biol. 2002 Aug;22(15):5281-95.
• Identification of PGC7, a new gene expressed specifically in preimplantation embryos and germ cells.
  Sato M, Kimura T, Kurokawa K, Fujita Y, Abe K, Masuhara M, Yasunaga T, Ryo A, Yamamoto M, Nakano T. Mech Dev. 2002 Apr;113(1):91-4.
• Loss of Pin1 function in the mouse causes phenotypes resembling cyclin D1-null phenotypes.
  Liou YC, Ryo A, Huang HK, Lu PJ, Bronson R, Fujimori F, Uchida T, Hunter T, Lu KP. Proc Natl Acad Sci U S A. 2002 Feb 5;99(3):1335-40.
• Pin1 regulates turnover and subcellular localization of beta-catenin by inhibiting its interaction with APC.
  Ryo A, Nakamura M, Wulf G, Liou YC, Lu KP. Nat Cell Biol. 2001 Sep;3(9):793-801.

2002

• Pin1 is overexpressed in breast cancer and cooperates with Ras signaling in increasing the transcriptional activity of c-Jun towards cyclin D1.
  Wulf GM, Ryo A, Wulf GG, Lee SW, Niu T, Petkova V, Lu KP. EMBO J. 2001 Jul 2;20(13):3459-72.
• Enhanced expression of mRNAs of antisecretory factor-1, gp96, DAD1 and CDC34 in human hepatocellular carcinomas.
  Tanaka K, Kondoh N, Shuda M, Matsubara O, Imazeki N, Ryo A, Wakatsuki T, Hada A, Goseki N, Igari T, Hatsuse K, Aihara T, Horiuchi S, Yamamoto N, Yamamoto M. Biochim Biophys Acta. 2001 Apr 30;1536(1):1-12.
• Use of serial analysis of gene expression (SAGE) technology.
  Yamamoto M, Wakatsuki T, Hada A, Ryo A. J Immunol Methods. 2001 Apr;250(1-2):45-66. Review.

2001

• Pin1 is overexpressed in breast cancer and cooperates with Ras signaling in increasing the transcriptional activity of c-Jun towards cyclin D1.
  Wulf GM, Ryo A, Wulf GG, Lee SW, Niu T, Petkova V, Lu KP. EMBO J. 2001 Jul 2;20(13):3459-72.
• Enhanced expression of mRNAs of antisecretory factor-1, gp96, DAD1 and CDC34 in human hepatocellular carcinomas.
  Tanaka K, Kondoh N, Shuda M, Matsubara O, Imazeki N, Ryo A, Wakatsuki T, Hada A, Goseki N, Igari T, Hatsuse K, Aihara T, Horiuchi S, Yamamoto N, Yamamoto M. Biochim Biophys Acta. 2001 Apr 30;1536(1):1-12.
• Use of serial analysis of gene expression (SAGE) technology.
  Yamamoto M, Wakatsuki T, Hada A, Ryo A. J Immunol Methods. 2001 Apr;250(1-2):45-66. Review.

2000

• Enhanced expression of translation factor mRNAs in hepatocellular carcinoma.
  Shuda M, Kondoh N, Tanaka K, Ryo A, Wakatsuki T, Hada A, Goseki N, Igari T, Hatsuse K, Aihara T, Horiuchi S, Shichita M, Yamamoto N, Yamamoto M. Anticancer Res. 2000 Jul-Aug;20(4):2489-94.
• Identification and characterization of differentially expressed mRNAs in HIV type 1-infected human T cells.
  Ryo A, Suzuki Y, Arai M, Kondoh N, Wakatsuki T, Hada A, Shuda M, Tanaka K, Sato C, Yamamoto M, Yamamoto N. AIDS Res Hum Retroviruses. 2000 Jul 1;16(10):995-1005
• A modified serial analysis of gene expression that generates longer sequence tags by nonpalindromic cohesive linker ligation.
  Ryo A, Kondoh N, Wakatsuki T, Hada A, Yamamoto N, Yamamoto M. Anal Biochem. 2000 Jan 1;277(1):160-2.

1999

• Serial analysis of gene expression in HIV-1-infected T cell lines.
  Ryo A, Suzuki Y, Ichiyama K, Wakatsuki T, Kondoh N, Hada A, Yamamoto M, Yamamoto N. FEBS Lett. 1999 Nov 26;462(1-2):182-6.
• Identification and characterization of genes associated with human hepatocellular carcinogenesis.
  Kondoh N, Wakatsuki T, Ryo A, Hada A, Aihara T, Horiuchi S, Goseki N, Matsubara O, Takenaka K, Shichita M, Tanaka K, Shuda M, Yamamoto M. Cancer Res. 1999 Oct 1;59(19):4990-6.
• Serial analysis of gene expression in a microglial cell line.
  Inoue H, Sawada M, Ryo A, Tanahashi H, Wakatsuki T, Hada A, Kondoh N, Nakagaki K, Takahashi K, Suzumura A, Yamamoto M, Tabira T. Glia. 1999 Dec;28(3):265-71.
• A method to isolate differentially expressed genes by displaying specific inner portion of cDNA fragments.
  Kondoh N, Wakatsuki T, Ryo A, Tanaka K, Hada A, Shichita M, Yamamoto M. Anal Biochem. 1999 May 1;269(2):427-30.
• A method for analyzing the qualitative and quantitative aspects of gene expression: a transcriptional profile revealed for HeLa cells.
  Ryo A, Kondoh N, Wakatsuki T, Hada A, Yamamoto N, Yamamoto M. Nucleic Acids Res. 1998 Jun 1;26(11):2586-92.