横浜市立大学　内分泌・糖尿病内科

Yu Togashi

富樫　優

主要論文

2021

  1. Charoensuk C, Thamtarana PJ, Chanprasert C, Tangjittipokin W, Shirakawa J, Togashi Y, Orime K, Songprakhon P, Chaichana C, Abubakar Z, Ouying P, Sujjitjoon J, Doria A, Plengvidhya N, *Yenchitsomanus PT. Autosomal Dominant Diabetes Associated with a Novel ZYG11A Mutation Resulting in Cell Cycle Arrest in Beta-Cells. Mol Cell Endocrinol. 522:111126, 2021. 
  2. Okuyama T, *Shirakawa J, Nakamura T, Murase T, Miyashita D, Inoue R, Kyohara M, Togashi Y, Terauchi Y. Association of the plasma xanthine oxidoreductase activity with the metabolic parameters and vascular complications in patients with type 2 diabetes. Sci Rep. 11(1):3768, 2021. 
  3. Hasebe M, *Shirakawa J, Miyashita D, Kunishita R, Kyohara M, Okuyama T, Togashi Y, Terauchi Y. Asymptomatic meningitis diagnosed by positron emission tomography in a patient with syndrome of inappropriate antidiuretic hormone secretion: a case report. J Med Case Rep. 15(1):390, 2021. 
  4. Terui S, Akamatsu R, Arai M, Inoue R, Okuyama T, Kyohara M, Li J, Tsuno T, Miyashita D, Togashi Y, Terauchi Y, *Shirakawa J. Immediate glucose-lowering effect after the first administration of dulaglutide: a retrospective, single-center, observational study. Diabetes Ther. 12(11):2873-2889, 2021. 
  5. Li J, Inoue R, Togashi Y, Okuyama T, Satoh A, Kyohara M, Nishiyama K, Tsuno T, Miyashita D, Kin T, Shapiro AJM, Chew RSE, Teo AKK, Oyadomari S, Terauchi Y, *Shirakawa J. Imeglimin ameliorates β-cell apoptosis by modulating the endoplasmic reticulum homeostasis pathway. Diabetes. in press, 2021.

2020

  1. *Shirakawa J, Tajima K, Okuyama T, Kyohara M, Togashi Y, De Jesus DF, Basile G, Kin T, Shapiro AMJ, Kulkarni RN, Terauchi Y. Luseogliflozin increases beta cell proliferation through humoral factors that activate an insulin receptor- and IGF-1 receptor-independent pathway. Diabetologia. 63(3):577-587, 2020.
  2. Kyohara M, *Shirakawa J, Okuyama T, Togashi Y, Inoue R, Li J, Miyashita D, Terauchi Y. Soluble EGFR, a hepatokine, and adipsin, an adipokine, are biomarkers correlated with distinct aspects of insulin resistance in type 2 diabetes subjects. Diabetol Metab Syndr. 12:83, 2020. 
  3. Okuyama T, *Shirakawa J, Tajima K, Ino Y, Vethe H, Togashi Y, Kyohara M, Inoue R, Miyashita D, Li J, Goto N, Ichikawa T, Yamasaki S, Ohnuma H, Takayanagi R, Kimura Y, Hirano H, Terauchi Y. Linagliptin Ameliorates Hepatic Steatosis via Non-Canonical Mechanisms in Mice Treated with a Dual Inhibitor of Insulin Receptor and IGF-1 Receptor. Int J Mol Sci. 21(21):E7815, 2020. 

2019

  1. Miyazaki T, Shirakawa J, Nagakura J, Shibuya M, Kyohara M, Okuyama T, Togashi Y, Nakamura A, Kondo Y, Satoh S, Nakajima S, Taguri M, Terauchi Y. Influence of Timing of Insulin Initiation on Long-term Glycemic Control in Japanese Patients with Type 2 Diabetes: A Retrospective Cohort Study. Intern Med. 58(23):3361-3367, 2019.

2018

  1. Inoue H, Shirakawa J, Togashi Y, Tajima K, Okuyama T, Kyohara M, Tanaka Y, Orime K, Saisho Y, Yamada T, Shibue K, Kulkarni RN, Terauchi Y. Signaling between pancreatic β-cells and macrophages via S100 calcium-binding protein A8 exacerbates β-cell apoptosis and islet inflammation. J Biol Chem. 293(16):5934-5946, 2018. 
  2. Konishi H, Shirakawa J, Tajima K, Okuyama T, Togashi Y, Takamine H, Kondo Y, Kunishita R, Terauchi Y. Effects of SGLT2 inhibition on eGFR and glomerular and tubular damage markers in Japanese patients with Type 2 diabetes. J Endocrinol Metab. 8(5):106-112, 2018. 

2017

  1. Okuyama T, Shirakawa J, Yanagisawa H, Kyohara M, Yamazaki S, Tajima K, Togashi Y, Terauchi Y. Identification of the matricellular protein Fibulin-5 as a target molecule of glucokinase-mediated calcineurin/NFAT signaling in pancreatic islets. Sci Rep. 7(1):2364, 2017.
  2.  Tajima K, Shirakawa J, Togashi Y, Yamazaki S, Okuyama T, Kyohara M, Konishi H, Terauchi Y.: Metabolic recovery of lipodystrophy, liver steatosis, and pancreatic β cell proliferation after the withdrawal of OSI-906. Sci Rep. 7(1):4119, 2017.
  3. Tajima K, Shirakawa J, Okuyama T, Kyohara M, Yamazaki S, Togashi Y, Terauchi Y.: Effects of metformin on compensatory pancreatic β-cell hyperplasia in mice fed a high-fat diet. Am J Physiol Endocrinol Metab. 313(3):E367-E380, 2017.
  4. Kyohara M, Shirakawa J, Okuyama T, Kimura A, Togashi Y, Tajima K, Hirano H, Terauchi Y.: Serum quantitative proteomic analysis reveals soluble EGFR to be a marker of insulin resistance in male mice and humans.  Endocrinology. 158(12):4152-4164, 2017.

2016

  1. Togashi Y, Shirakawa J, Okuyama T, Yamazaki S, Kyohara M, Miyazawa A, Suzuki T, Hamada M, Terauchi Y. Evaluation of the appropriateness of using glucometers for measuring the blood glucose levels in mice. Sci Rep. 6:25465, 2016.
  2. Orime K, Shirakawa J, Togashi Y, Tajima K, Inoue H, Nagashima Y, Terauchi Y. Lipid-lowering agents inhibit hepatic steatosis in a non-alcoholic steatohepatitis-derived hepatocellular carcinoma mouse model. Eur J Pharmacol. 5;772:22-32, 2016.

2014

  1. Shirakawa J, Murohashi Y, Okazaki N, Yamazaki S, Tamura T, Okuyama T, Togashi Y, Terauchi Y. Using miglitol at 30 min before meal is effective in hyperinsulinemic hypoglycemia after a total gastrectomy. Endocr J. 61(11):1115-23. 2014.
  2. Shirakawa J, Okuyama T, Yoshida E, Shimizu M, Horigome Y, Tuno T, Hayasaka M, Abe S, Fuse M, Togashi Y, Terauchi Y. Effects of the Antitumor Drug OSI-906, a Dual Inhibitor of IGF-1 Receptor and Insulin Receptor, on the Glycemic Control, β-Cell Functions, and β-Cell Proliferation in Male Mice. Endocrinology. 155(6):2102-11, 2014.
  3. Togashi Y, Shirakawa J, Orime K, Kaji M, Sakamoto E, Tajima K, Inoue H, Nakamura A, Tochino Y, Goshima Y, Shimomura I, Terauchi Y. β -Cell Proliferation After a Partial Pancreatectomy Is Independent of IRS-2 in Mice. Endocrinology. 155(5):1643-52, 2014.

2013

  1. Shirakawa J, Togashi Y, Sakamoto E, Kaji M, Tajima K, Orime K, Inoue H, Kubota N, Kadowaki T, Terauchi Y. Glucokinase activation ameliorates ER stress-induced apoptosis in pancreatic β-cells. Diabetes. 62(10):3448-58, 2013.
  2. Tajima K, Shirakawa J, Togashi Y, Inoue H, Sato K, Orime K, Ito Y, Kaji M, Sakamoto E, Nakamura A, Aoki K, Goshima Y, Atsumi T, Terauchi Y. AMPK is involved in the regulation of incretin receptors expression in pancreatic islets under a low glucose concentration. Plos One. 22(8):e64633, 2013.
  3. Orime K, Shirakawa J, Togashi Y, Tajima K, Inoue H, Ito Y, Sato K, Nakamura A, Aoki K, Goshima Y, Terauchi Y. Trefoil factor 2 promotes cell proliferation in pancreatic β-cells through CXCR-4-mediated ERK1/2 phosphorylation. Endocrinology. 154(1):54-64, 2013.
  4. Tajima K, Nakamura A, Shirakawa J, Togashi Y, Orime K, Sato K, Inoue H, Kaji M, Sakamoto E, Ito Y, Aoki K, Nagashima Y, Atsumi T, Terauchi Y. Metformin prevents liver tumorigenesis induced by high-fat diet in C57Bl/6 Mice. Am J Physiol Endocrinol Metab, 305(8):E987-98, 2013.
  5. Aoki K, Kamiyama H, Masuda K, Togashi Y, Terauchi Y. Mosapride citrate, a 5-HT4 receptor agonist, increased the plasma active and total glucagon-like peptide-1 levels in non-diabetic men. Endocr J,60(4):493-9.2013.

2012

  1. Shirakawa J, Tanami R, Togashi Y, Tajima K, Orime K, Kubota N, Kadowaki T, Goshima Y, Terauchi Y. Effects of Liraglutide on β-Cell-Specific Glucokinase-Deficient Neonatal Mice. Endocrinology. 153(7):3066-75, 2012.
  2. Nakamura A, Togashi Y, Orime K, Sato K, Shirakawa J, Ohsugi M, Kubota N, Kadowaki T, Terauchi Y. Control of beta cell function and proliferation in mice stimulated by small-molecule glucokinase activator under various conditions. Diabetologia. 55(6):1745-54, 2012.
  3. Sato K, Nakamura A, Shirakawa J, Muraoka T, Togashi Y, Shinoda K, Orime K, Kubota N, Kadowaki T, Terauchi Y. Impact of the dipeptidyl peptidase-4 inhibitor vildagliptin on glucose tolerance and β-cell function and mass in insulin receptor substrate-2-knockout mice fed a high-fat diet. Endocrinology. 153(3):1093-102.2012.

2011

  1. Shirakawa J, Amo K, Ohminami H, Orime K, Togashi Y, Ito Y, Tajima K, Koganei M, Sasaki H, Takeda E, Terauchi Y. Protective effects of dipeptidyl peptidase-4 (DPP-4) inhibitor against increased β cell apoptosis induced by dietary sucrose and linoleic acid in mice with diabetes. J Biol Chem. 22;286(29):25467-76, 2011.

2009

  1. Aoki K, Ito Y, Saito K, Shirakawa J, Togashi Y, Satoh K, Muraoka T, Shinoda K, Masuda K, Kimura M, Terauchi Y. Comparison of pre- versus post-meal administration of voglibose in men with or without impaired glucose tolerance. Diabetes Res Clin Pract.83(2):e31-2.2009.

2008

  1. Iwasaki T, Togashi Y, Terauchi Y. Significant association of serum albumin with severity of retinopathy and neuropathy, in addition to that of nephropathy, in Japanese type 2 diabetic patients. Endocr J.55(2):311-6.2008.
  2. Iwasaki T, Togashi Y, Ohshige K, Yoneda M, Fujita K, Nakajima A, Terauchi Y. Neither the presence of metabolic syndrome as defined by the IDF guideline nor an increased waist circumference increased the risk of microvascular or macrovascular complications in Japanese patients with type 2 diabetes. Diabetes Res Clin Pract. 79(3):427-32.2008.

受賞歴

  • 2019年　第47回内分泌代謝研究会　演題特別賞　
  • 2016年　日本糖尿病・肥満動物学会　若手研究奨励賞