免疫生物学研究室

研究業績

  1. Aratani Y: Myeloperoxidase: Its role for host defense, inflammation, and neutrophil function. Arch. Biochem. Biophys. 640, 47-52 (2018)
  2. Nagai, K., Aratani, Y., Shibuya, A., and Yamagata, K: Involvement of pentraxin-3 in anti-neutrophil cytoplasmic antibody production induced by aluminum salt adjuvant. Clin. Exp. Rheumatol. 35, 735-738 (2017)
  3. Endo, D., Fujimoto, K., Hirose, R., Yamanaka, H., Homme, M., Ishibashi, K., Miura, N., Ohno, N., and Aratani, Y: Genetic phagocyte NADPH-oxidase deficiency enhances nonviable Candida albicans-induced inflammation in mouse lungs. Inflammation, 40, 123-135 (2017)
  4. Fujimoto, K., Motowaki, T., Tamura, N., and Aratani, Y: Myeloperoxidase deficiency enhances zymosan phagocytosis associated with up-regulation of surface expression of CD11b in mouse neutrophils. Free Radic. Res., 50, 1340-1349 (2016)
  5. Suzuki, S., Ogawa, M., Ohta, S., Arima, K., Nunomura, S., Nanri, Y., Mitamura, Y., Yoshihara, T., Nakamura, Y., Yamauchi, K., Chibana, K., Ishii, Y., Lee, J.J., Aratani, Y., Kakuta, S., Kubo, S., Iwakura, Y., Yoshida, H., and Izuhara, K: The potential for repositioning anti-thyroid agents as anti-asthma drugs. J Allergy Clin Immun., 138, 1458-1461 (2016)
  6. Endo, D., Saito, T., Suzuki, K., and Aratani, Y: Myeloperoxidase negatively regulates the expression of proinflammatory cytokines and chemokines by zymosan-induced mouse neutrophils. Inflamm. Res., 65, 151-159 (2016)
  7. Okochi, Y., Aratani, Y., Adissu, H., Miyawaki, N., Sasaki, M., Suzuki, K., and Okamura, Y: The voltage-gated proton channel Hv1/VSOP inhibits neutrophil granule release. J. Leukoc. Biol., 99, 7-19 (2016)
  8. Homme, M., Tateno, N., Miura, N., Ohno, N., and Aratani, Y: Myeloperoxidase deficiency in mice exacerbates lung inflammation induced by nonviable Candida albicans. Inflamm Res, 62, 981-990 (2013)
  9. Tateno, N., Matsumoto, N., Motowaki, T., Suzuki, K., and Aratani, Y: Myeloperoxidase deficiency induces MIP-2 production via ERK activation in zymosan-stimulated mouse neutrophils. Free Radic. Res., 47, 376-385 (2013)
  10. Kubota, K., Saiwai, H., Kumamaru, H., Maeda, T., Ohkawa, Y., Aratani, Y., Nagano, T., Iwamoto, Y., and Okada, S: Myeloperoxidase exacerbates secondary injury by generating highly reactive oxygen species and mediating neutrophil recruitment in experimental spinal cord injury. Spine, 37, 1363-1369 (2012)
  11. Sugamata, R., Dobashi, H., Nagao, T., Yamamoto, K., Nakajima, N., Sato, Y., Aratani, Y., Oshima, M., Sata, T., Kobayashi, K., Kawachi, S., Nakayama, T., and Suzuki, K: The contribution of neutrophil-derived myeloperoxidase in early phase of fulminant acute respiratory distress syndrome induced by influenza virus infection. Microbiol. Immunol., 56, 171-182 (2012)
  12. Takeuchi, K., Umeki, Y., Matsumoto, N., Yamamoto, K., Yoshida, M., Suzuki, K., and Aratani, Y: Severe neutrophil-mediated lung inflammation in myeloperoxidase-deficient mice exposed to zymosan. Inflamm. Res., 61, 197-205 (2012)
  13. Phung, T., Sugamata, R., Uno K. Aratani, Y., Ozato, K., Kawachi, S., Nguyen, L., Nakayama, T., and Suzuki, K: Key role of RANTES (regulated upon activation normal T-cell expressed and secreted), nonstructural protein1 and myeloperoxidase in cytokine storm induced by influenza virus PR-8 (A/H1N1) infection in A549 bronchial epithelial cells. Microbiol. Immunol. 55, 874-884 (2011).
  14. Nagao, T., Suzuki, K., Utsunomiya, K., Matsumura, M., Saiga, K., Wang, P., Minamitani, H., Aratani, Y., Nakayama, T., Suzuki, K: Direct activation of glomerular endothelial cells by anti-moesin activity of anti-myeloperoxidase antibody. Nephrol. Dial. Transplant. 26, 2752-60 (2011)
  15. Tomono S, Miyoshi N, Shiokawa H, Iwabuchi T, Wakao Y, Suzuki A, Aratani Y, Higashi T, Nukaya H, Ohshima H: Formation of cholesterol ozonolysis products in vitro and in vivo through a myeloperoxidase-dependent pathway. J. Lipid Res. 52, 87-97 (2011)
  16. Asahi T, Kondo H, Masuda M, Nishino H, Aratani Y, Naito Y, Yoshikawa T, Hisaka S, Kato Y, Osawa T. Chemical and immunochemical detection of 8-halogenated deoxyguanosines at early stage inflammation. J. Biol. Chem., 285, 9282-9291 (2010).
  17. Haegens A, Heeringa P, van Suylen RJ, Steele C, Aratani Y, O'Donoghue RJ, Mutsaers SE, Mossman BT, Wouters EF, Vernooy JH: Myeloperoxidase deficiency attenuates lipopolysaccharide-induced acute lung inflammation and subsequent cytokine and chemokine production. J. Immunol. 182, 7990-7996 (2009)