{"id":17,"date":"2023-05-02T09:58:16","date_gmt":"2023-05-02T00:58:16","guid":{"rendered":"https:\/\/www-user.yokohama-cu.ac.jp\/~pharmac\/?page_id=17"},"modified":"2024-09-26T13:29:05","modified_gmt":"2024-09-26T04:29:05","slug":"research","status":"publish","type":"page","link":"https:\/\/www-user.yokohama-cu.ac.jp\/~pharmac\/research\/","title":{"rendered":"\u7814\u7a76\u5185\u5bb9"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\">\u7814\u7a76\u5185\u5bb9<\/h2>\n\n\n\n<p>\u5f53\u6559\u5ba4\u3067\u306f\u3001\u5fc3\u7b4b\u6897\u585e\u3084\u6162\u6027\u5fc3\u4e0d\u5168\u306a\u3069\u306e<strong>\u96e3\u6cbb\u6027\u5fc3\u75be\u60a3<\/strong>\u3001\u305d\u308c\u306b\u5408\u4f75\u3059\u308b\u6291\u3046\u3064\u306a\u3069\u306e<strong>\u7cbe\u795e\u75be\u60a3<\/strong>\u3001<strong>\u304c\u3093<\/strong>\u5fae\u5c0f\u74b0\u5883\u306e\u514d\u75ab\u7d30\u80de\u306e\u5f79\u5272\u3092\u6700\u5148\u7aef\u306e\u6280\u8853\u3092\u7528\u3044\u3066\u89e3\u6790\u30fb\u79d1\u5b66\u3059\u308b\u3053\u3068\u3067\u3001\u81e8\u5e8a\u306b\u9084\u5143\u3059\u308b\u3053\u3068\u3092\u76ee\u6307\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"695\" src=\"https:\/\/www-user.yokohama-cu.ac.jp\/~pharmac\/wp-content\/uploads\/2024\/09\/\u30b9\u30af\u30ea\u30fc\u30f3\u30b7\u30e7\u30c3\u30c8-2024-08-13-22.51.03-1024x695.png\" alt=\"\" class=\"wp-image-365\" style=\"width:560px;height:auto\" srcset=\"https:\/\/www-user.yokohama-cu.ac.jp\/~pharmac\/wp-content\/uploads\/2024\/09\/\u30b9\u30af\u30ea\u30fc\u30f3\u30b7\u30e7\u30c3\u30c8-2024-08-13-22.51.03-1024x695.png 1024w, https:\/\/www-user.yokohama-cu.ac.jp\/~pharmac\/wp-content\/uploads\/2024\/09\/\u30b9\u30af\u30ea\u30fc\u30f3\u30b7\u30e7\u30c3\u30c8-2024-08-13-22.51.03-300x204.png 300w, https:\/\/www-user.yokohama-cu.ac.jp\/~pharmac\/wp-content\/uploads\/2024\/09\/\u30b9\u30af\u30ea\u30fc\u30f3\u30b7\u30e7\u30c3\u30c8-2024-08-13-22.51.03-768x521.png 768w, https:\/\/www-user.yokohama-cu.ac.jp\/~pharmac\/wp-content\/uploads\/2024\/09\/\u30b9\u30af\u30ea\u30fc\u30f3\u30b7\u30e7\u30c3\u30c8-2024-08-13-22.51.03-1536x1042.png 1536w, https:\/\/www-user.yokohama-cu.ac.jp\/~pharmac\/wp-content\/uploads\/2024\/09\/\u30b9\u30af\u30ea\u30fc\u30f3\u30b7\u30e7\u30c3\u30c8-2024-08-13-22.51.03.png 1828w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<h3 class=\"wp-block-heading\">\u30ca\u30c8\u30ea\u30a6\u30e0\u5229\u5c3f\u30da\u30d7\u30c1\u30c9\u306e\u751f\u7406\u30fb\u85ac\u7406\u4f5c\u7528\u89e3\u6790\u306b\u95a2\u3059\u308b\u7814\u7a76<\/h3>\n\n\n\n<p>\u56fd\u7acb\u5faa\u74b0\u5668\u75c5\u7814\u7a76\u30bb\u30f3\u30bf\u30fc\u7814\u7a76\u6240\u306e\u677e\u5c3e\u58fd\u4e4b\u540d\u8a89\u6240\u9577\u3089\u306f\u3001\u5fc3\u81d3\u304b\u3089\u300c\u5fc3\u623f\u6027\u30ca\u30c8\u30ea\u30a6\u30e0\u5229\u5c3f\u30da\u30d7\u30c1\u30c9 (Atrial Natriuretic Peptide; ANP)\u300d\u3084\u300c\u8133\u6027\u30ca\u30c8\u30ea\u30a6\u30e0\u5229\u5c3f\u30da\u30d7\u30c1\u30c9 (Brain Natriuretic Peptide; BNP)\u300d\u304c\u7523\u751f\u30fb\u5206\u6ccc\u3055\u308c\u308b\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057\u3001\u5fc3\u81d3\u304c\u5185\u5206\u6ccc\u81d3\u5668\u3067\u3042\u308b\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057\u307e\u3057\u305f (<em>BBRC<\/em> 1984, <em>Nature<\/em> 1988 )\u3002ANP\u306f\u65e5\u672c\u306b\u304a\u3044\u3066\u6025\u6027\u5fc3\u4e0d\u5168\u6cbb\u7642\u85ac\u3068\u3057\u3066\u3001BNP\u306f\u5fc3\u4e0d\u5168\u8a3a\u65ad\u85ac\u3068\u3057\u3066\u81e8\u5e8a\u5fdc\u7528\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"842\" height=\"250\" src=\"https:\/\/www-user.yokohama-cu.ac.jp\/~pharmac\/wp-content\/uploads\/2023\/06\/r1.png\" alt=\"\" class=\"wp-image-63\" srcset=\"https:\/\/www-user.yokohama-cu.ac.jp\/~pharmac\/wp-content\/uploads\/2023\/06\/r1.png 842w, https:\/\/www-user.yokohama-cu.ac.jp\/~pharmac\/wp-content\/uploads\/2023\/06\/r1-300x89.png 300w, https:\/\/www-user.yokohama-cu.ac.jp\/~pharmac\/wp-content\/uploads\/2023\/06\/r1-768x228.png 768w\" sizes=\"auto, (max-width: 842px) 100vw, 842px\" \/><\/figure>\n\n\n\n<p>\u8fd1\u5e74\u3001ANP\u30fbBNP\u306e\u5206\u89e3\u9175\u7d20\u3092\u963b\u5bb3\u3059\u308b\u85ac\u5264\u304c\u3001\u6162\u6027\u5fc3\u4e0d\u5168\u6cbb\u7642\u85ac\u30fb\u9ad8\u8840\u5727\u6cbb\u7642\u85ac\u3068\u3057\u3066\u81e8\u5e8a\u5fdc\u7528\u3055\u308c\u307e\u3057\u305f\u3002\u6211\u3005\u306fANP\u30fbBNP\u306e\u5171\u901a\u53d7\u5bb9\u4f53\u3067\u3042\u308bNPR1\u306e\u907a\u4f1d\u5b50\u6539\u5909\u30de\u30a6\u30b9\u3092\u72ec\u81ea\u306b\u4f5c\u88fd\u3057\u3001\u305d\u306e\u8868\u73fe\u578b\u89e3\u6790\u3092\u884c\u3046\u3053\u3068\u3067ANP\u30fbBNP\u306e\u751f\u7406\u30fb\u85ac\u7406\u4f5c\u7528\u306e\u5206\u5b50\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u660e\u3089\u304b\u306b\u3057\u3066\u304d\u307e\u3057\u305f\u3002\u4eca\u5f8c\u306fANP\u30fbBNP\u306e\u85ac\u7406\u4f5c\u7528\u3092\u3001\u7279\u306b\u795e\u7d4c\u7cfb\u30fb\u514d\u75ab\u7cfb\u306b\u6ce8\u76ee\u3057\u3066\u6df1\u304f\u6398\u308a\u4e0b\u3052\u3066\u8abf\u3079\u308b\u3068\u3068\u3082\u306b\u3001\u5faa\u74b0\u5668\u9818\u57df\u4ee5\u5916\u306b\u304a\u3051\u308b\u6cbb\u7642\u5fdc\u7528\u306e\u53ef\u80fd\u6027\u3082\u63a2\u3063\u3066\u3044\u304d\u307e\u3059\u3002\u56fd\u5185\u5916\u306e\u7814\u7a76\u8005\u3068\u306e\u5171\u540c\u7814\u7a76\u3082\u7a4d\u6975\u7684\u306b\u884c\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u30b0\u30ec\u30ea\u30f3\u306e\u751f\u7406\u30fb\u85ac\u7406\u4f5c\u7528\u89e3\u6790\u306b\u95a2\u3059\u308b\u7814\u7a76<\/h3>\n\n\n\n<p>\u56fd\u7acb\u5faa\u74b0\u5668\u75c5\u7814\u7a76\u30bb\u30f3\u30bf\u30fc\u7814\u7a76\u6240\u3067\u767a\u898b\u3055\u308c\u305f\u80c3\u304b\u3089\u7523\u751f\u30fb\u5206\u6ccc\u3055\u308c\u308b\u30db\u30eb\u30e2\u30f3\u3067\u3042\u308b\u30b0\u30ec\u30ea\u30f3\u306b\u3064\u3044\u3066\u3082\u3001\u5faa\u74b0\u5668\u75be\u60a3\u306b\u304a\u3051\u308b\u75c5\u614b\u751f\u7406\u7684\u610f\u7fa9\u306b\u3064\u3044\u3066\u7814\u7a76\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u30b0\u30ec\u30ea\u30f3\u306f\u6210\u9577\u30db\u30eb\u30e2\u30f3\u5206\u6ccc\u4fc3\u9032\u30db\u30eb\u30e2\u30f3\u3068\u3057\u3066\u30e9\u30c3\u30c8\u80c3\u304b\u3089\u767a\u898b\u3055\u308c (<em>Nature<\/em>, 1999)\u3001\u305d\u306e\u5f8c\u30b0\u30ec\u30ea\u30f3\u304c\u6442\u98df\u4ea2\u9032\u4f5c\u7528\u3092\u6709\u3059\u308b\u3053\u3068\u3082\u660e\u3089\u304b\u306b\u3055\u308c\u307e\u3057\u305f (<em>Nature<\/em>, 2001) \u3002\u6211\u3005\u306f\u30b0\u30ec\u30ea\u30f3\u304c\u81ea\u5f8b\u795e\u7d4c\u7cfb\u306b\u4f5c\u7528\u3059\u308b\u3053\u3068\u3067\u3001\u5fc3\u7b4b\u6897\u585e\u30e2\u30c7\u30eb\u3084\u5fc3\u4e0d\u5168\u30e2\u30c7\u30eb\u52d5\u7269\u306e\u75c5\u614b\u3092\u6539\u5584\u3059\u308b\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057\u307e\u3057\u305f\u3002\u30b0\u30ec\u30ea\u30f3\u306f\u8996\u5e8a\u4e0b\u90e8\u3067\u3082\u7523\u751f\u3055\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u305d\u306e\u75c5\u614b\u751f\u7406\u7684\u610f\u7fa9\u306b\u306f\u4e0d\u660e\u306a\u70b9\u304c\u6b8b\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u4eca\u5f8c\u306f\u672b\u68a2\u7d44\u7e54\u3067\u7523\u751f\u3055\u308c\u308b\u30b0\u30ec\u30ea\u30f3\u306b\u52a0\u3048\u3066\u3001\u4e2d\u67a2\u795e\u7d4c\u7cfb\u3067\u7523\u751f\u3055\u308c\u308b\u30b0\u30ec\u30ea\u30f3\u306b\u3064\u3044\u3066\u3082\u3001\u305d\u306e\u751f\u7406\u7684\u306a\u610f\u7fa9\u3084\u85ac\u7406\u4f5c\u7528\u3092\u5206\u5b50\u30ec\u30d9\u30eb\u3067\u63a2\u3063\u3066\u3044\u304d\u307e\u3059\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"519\" src=\"https:\/\/www-user.yokohama-cu.ac.jp\/~pharmac\/wp-content\/uploads\/2023\/06\/r2-1024x519.png\" alt=\"\" class=\"wp-image-60\" srcset=\"https:\/\/www-user.yokohama-cu.ac.jp\/~pharmac\/wp-content\/uploads\/2023\/06\/r2-1024x519.png 1024w, https:\/\/www-user.yokohama-cu.ac.jp\/~pharmac\/wp-content\/uploads\/2023\/06\/r2-300x152.png 300w, https:\/\/www-user.yokohama-cu.ac.jp\/~pharmac\/wp-content\/uploads\/2023\/06\/r2-768x389.png 768w, https:\/\/www-user.yokohama-cu.ac.jp\/~pharmac\/wp-content\/uploads\/2023\/06\/r2.png 1176w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<h3 class=\"wp-block-heading\"><\/h3>\n\n\n\n<div><a href=\"#\">\u30da\u30fc\u30b8\u30c8\u30c3\u30d7\u3078\u623b\u308b<\/a><\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u7814\u7a76\u5185\u5bb9 \u5f53\u6559\u5ba4\u3067\u306f\u3001\u5fc3\u7b4b\u6897\u585e\u3084\u6162\u6027\u5fc3\u4e0d\u5168\u306a\u3069\u306e\u96e3\u6cbb\u6027\u5fc3\u75be\u60a3\u3001\u305d\u308c\u306b\u5408\u4f75\u3059\u308b\u6291\u3046\u3064\u306a\u3069\u306e\u7cbe\u795e\u75be\u60a3\u3001\u304c\u3093\u5fae\u5c0f\u74b0\u5883\u306e\u514d\u75ab\u7d30\u80de\u306e\u5f79\u5272\u3092\u6700\u5148\u7aef\u306e\u6280\u8853\u3092\u7528\u3044\u3066\u89e3\u6790\u30fb\u79d1\u5b66\u3059 &#8230; <\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-17","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/www-user.yokohama-cu.ac.jp\/~pharmac\/wp-json\/wp\/v2\/pages\/17","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www-user.yokohama-cu.ac.jp\/~pharmac\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www-user.yokohama-cu.ac.jp\/~pharmac\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www-user.yokohama-cu.ac.jp\/~pharmac\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www-user.yokohama-cu.ac.jp\/~pharmac\/wp-json\/wp\/v2\/comments?post=17"}],"version-history":[{"count":7,"href":"https:\/\/www-user.yokohama-cu.ac.jp\/~pharmac\/wp-json\/wp\/v2\/pages\/17\/revisions"}],"predecessor-version":[{"id":366,"href":"https:\/\/www-user.yokohama-cu.ac.jp\/~pharmac\/wp-json\/wp\/v2\/pages\/17\/revisions\/366"}],"wp:attachment":[{"href":"https:\/\/www-user.yokohama-cu.ac.jp\/~pharmac\/wp-json\/wp\/v2\/media?parent=17"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}