PAR-細胞極性病：がん-分子細胞生物学大野研究室

細胞極性病：がん

TOP ＞研究の概要＞細胞極性病：がん

上皮細胞の極性とは何か？

細胞と細胞の接着、細胞と基質との接着が上皮細胞の極性を決めている。
上皮細胞をモデルとして、その分子機構の解析を進めている。

Kishikawa M, Suzuki A, Shigeo Ohno. aPKC plays an essential role in the development of zonula adherens of epithelial cells by antagonizing centripetal contraction of the circumferential actomyosin cables. J Cell Science, in press.
Takahama S, Hirose T, Ohno S.aPKC restricts the basolateral determinant PtdIns(3,4,5)P3 to the basal region.Biochem Biophys Res Commun. 368(2):249-255, 2008. (2008 Apr 4)
Yamanaka T, Horikoshi Y, Izumi N, Suzuki A, Mizuno K, and Ohno S. Lgl mediates apical domain disassembly by suppressing PAR-3/aPKC/PAR-6 complex to orient apical membrane polarity. J. Cell Science, 119, 2107-2118, 2006.(PubMed)
紹介記事, IN THIS ISSUE, Lgl polarizes the (t)issueJ Cell Sci 2006 119: e1004. First published online on May 10, 2006
Yoshii T, Mizuno K, Hirose T, Nakajima A, Sekihara H, Ohno S. sPAR-3, a splicing variant of PAR-3, shows cellular localization and expression pattern different from that of PAR-3 during enterocyte polarization. Am J Physiol Gastrointest Liver Physiol. 2004 Sep 9 PMID: 15358599
Suzuki A, HirataM, Kamimura K, Maniwa R, Yamanaka T, Mizuno K, Kishikawa M, Hirose H, Amano Y, Izumi N, Miwa Y, Ohno, S. aPKC acts upstream of PAR-1b both in the establishment and maintenance of mammalian epithelial polarity. Current Biology, Aug 24;14(16):1425-35, 2004. PMID: 15324659
Keiko Mizuno, Atsushi Suzuki, Tomonori Hirose, Koichi Kitamura, Yoshikazu Kutsuzawa, Masaaki Futaki, Yoshiko Amano, and Shigeo Ohno. Self-association of PAR-3 mediated by the conserved N-terminal domain contributes to the development of epithelial tight junctions. J. Biol. Chem, 10.1074/jbc.M303593200 (PubMed)
Tomoyuki Yamanaka, Yosuke Horikoshi, Yuki Sugiyama, Chikako Ishiyama, Atsushi Suzuki, Tomonori Hirose, Akihiro IwamatsuY, Azusa Shinohara and Shigeo Ohno. Mammalian Lgl forms a protein complex with PAR-6 and aPKC independently of PAR-3 to regulate epithelial cell polarity. Current Biology, Apr 29;13(9):734-43, 2003.(PubMed)
Y. Nagai-Tamai, K. Mizuno, T. Hirose, A. Suzuki, and S. Ohno. Regulated protein-protein interaction between aPKC and PAR-3 plays an essential role in the polarization of epithelial cells. Genes to Cells, Nov;7(11):1161-71, 2002. (PubMed)
Suzuki, A, Ishiyama, C, Hashiba, K, Shimizu, M, Ebnet, K, Takai, Y, Ohno, S.: aPKC kinase activity is required for the asymmetric differentiation of the premature junctional complex during epithelial cell polarizatioin. J Cell Science, Sep 15;115(Pt 18):3565-73 , 2002. (PubMed)
Mishima A, Suzuki A, Enaka M, Hirose T, Mizuno K, Ohnishi T, Mohri H, Ishigatsubo Y, Ohno S. Over-expression of PAR-3 suppresses contact-mediated inhibition of cell migration in MDCK cells. Genes to Cells. 2002 Jun;7(6):581-96.(PubMed)
Hirose T, Izumi Y, Nagashima Y, Tamai-Nagai Y, Kurihara H, Sakai T, Suzuki Y, Yamanaka T, Suzuki A, Mizuno K, Ohno S. Involvement of ASIP/PAR-3 in the promotion of epithelial tight junction formation. J Cell Science. 2002 Jun 15;115(Pt 12):2485-2495. (PubMed)
Tomoyuki Yamanaka, Yosuke Horikoshi, Atsushi Suzuki, Yuki Sugiyama, Koichi Kitamura, Rika Maniwa, Yoko Nagai, Akio Yamashita, Tomonori Hirose, Hiroko Ishikawa, and Shigeo Ohno. PAR-6 regulates aPKC activity in a novel way and mediates cell-cell contact-induced formation of the epithelial junctional complex. Genes to Cells, 6, 721-31., 2001. (PubMed)
Klaus Ebnet, Atsushi Suzuki, Yosuke Horikoshi, Tomonori Hirose, Maria-Katharina Meyer zu Brickwedde, Shigeo Ohno, and Dietmar Vestweber. The cell polarity protein ASIP/PAR-3 directly associates with Junctional Adhesion Molecule (JAM) EMBO J, 20, 3738-48., 2001. (PubMed)
Suzuki, A., Yamanaka, T., Hashiba, K., Hirose, T., Izumi, Y., Ohnishi, T., and Ohno, S. : Atypical PKC is involved in the establishment of epithelial polarity in mammalian cells. J. Cell Biol. , 152, 1183-1196, 2001.(PubMed)

大野研究室 分子細胞生物学 Cell Signaling TOP

細胞極性病：がん

上皮細胞の極性とは何か？

大野研究室
分子細胞生物学
Cell Signaling
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