{"id":927,"date":"2022-06-07T22:05:41","date_gmt":"2022-06-07T13:05:41","guid":{"rendered":"https:\/\/www-user.yokohama-cu.ac.jp\/~membrane\/?p=927"},"modified":"2023-04-18T22:06:05","modified_gmt":"2023-04-18T13:06:05","slug":"rbat-b0at","status":"publish","type":"post","link":"https:\/\/www-user.yokohama-cu.ac.jp\/~membrane\/index.php\/2022\/06\/07\/rbat-b0at\/","title":{"rendered":"\u30b7\u30b9\u30c1\u30f3\u5c3f\u75c7\u306e\u539f\u56e0\u3068\u306a\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u751f\u5408\u6210\u7570\u5e38\u306e\u3057\u304f\u307f\u3092\u89e3\u660e"},"content":{"rendered":"\n<p>\u674e\u52c7\u71e6\u52a9\u6559\u3068\u6771\u4eac\u6148\u6075\u4f1a\u533b\u79d1\u5927\u5b66 \u6c38\u68ee\u6536\u5fd7\u51c6\u6559\u6388\u3001Pattama Wiriyasermkul\u52a9\u6559\u3089\u306b\u3088\u308b\u56fd\u969b\u5171\u540c\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u306f\u3001\u30b7\u30b9\u30c1\u30f3\u5c3f\u75c7\u306b\u95a2\u308f\u308b\u30a2\u30df\u30ce\u9178\u8f38\u9001\u4f53\u3067\u3042\u308brBAT-b<sup>0<\/sup>,<sup>+<\/sup>AT\u306e\u751f\u5408\u6210\u306b\u304a\u3051\u308b\u91cd\u8981\u306a\u30d7\u30ed\u30bb\u30b9\u3092\u767a\u898b\u3057\u307e\u3057\u305f\u3002&nbsp;<\/p>\n\n\n\n<p>\u4eca\u56de\u306e\u7814\u7a76\u306b\u3088\u308a\u3001\u9577\u5e74\u8b0e\u3068\u3055\u308c\u3066\u304d\u305f\u3044\u304f\u3064\u304b\u306e\u30b7\u30b9\u30c1\u30f3\u5c3f\u75c7\u306e\u75c5\u614b\u5909\u7570\u304c\u8aac\u660e\u3055\u308c\u3001\u5206\u5b50\u30fb\u539f\u5b50\u30ec\u30d9\u30eb\u3067\u306e\u65b0\u305f\u306a\u6cbb\u7642\u6cd5\u306e\u53ef\u80fd\u6027\u304c\u793a\u3055\u308c\u307e\u3059\u3002&nbsp;<\/p>\n\n\n\n<p>\u672c\u7814\u7a76\u6210\u679c\u306f\u300cNature 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class=\"wp-block-heading\">\u7814\u7a76\u80cc\u666f<\/h2>\n\n\n\n<p>\u30b7\u30b9\u30c1\u30f3\u5c3f\u75c7\u306f\u3001\u4e16\u754c\u5404\u5730\u3067\u898b\u3089\u308c\u308b\u814e\u81d3\u306e\u907a\u4f1d\u6027\u75be\u60a3\u306e\u4e00\u7a2e\u3067\u30017,000\u4eba\u306b\uff11\u4eba\uff08\u672c\u90a6\u3067\u306f2\u4e07\u4eba\u306b1\u4eba\uff09\u306e\u983b\u5ea6\u3067\u767a\u75c7\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u8840\u5c3f\u3001\u8179\u75db\u3001\u8170\u80cc\u90e8\u75db\u3001\u5c3f\u8def\u611f\u67d3\u75c7\u72b6\u309210\u301c30\u6b73\u3067\u767a\u75c7\u3059\u308b\u4e8b\u304c\u591a\u304f\u3001\u814e\u4e0d\u5168\u3092\u6765\u3059\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u30b7\u30b9\u30c1\u30f3\u5c3f\u75c7\u306f\u3001\u30b7\u30b9\u30c1\u30f3\u3068\u4e8c\u5869\u57fa\u6027\u30a2\u30df\u30ce\u9178\u306e\u30c8\u30e9\u30f3\u30b9\u30dd\u30fc\u30bf\u30fc\u3067\u3042\u308brBAT-b<sup>0<\/sup>,<sup>+<\/sup>AT\u306e\u5909\u7570\u306b\u3088\u3063\u3066\u5f15\u304d\u8d77\u3053\u3055\u308c\u3001\u518d\u767a\u6027\u306e\u5c3f\u8def\u7d50\u77f3\uff08\u30b7\u30b9\u30c1\u30f3\u7d50\u77f3\uff09\u3092\u5f15\u304d\u8d77\u3053\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u814e\u81d3\u3067\u306e\u30b7\u30b9\u30c1\u30f3\u306e\u518d\u5438\u53ce\u306f\u3001\u8fd1\u4f4d\u5c3f\u7d30\u7ba1\u306e\u5404\u30bb\u30b0\u30e1\u30f3\u30c8\u306b\u304a\u3044\u3066\u30012\u7a2e\u985e\u306e\u8f38\u9001\u7cfb\u306b\u3088\u3063\u3066\u305d\u308c\u305e\u308c\u62c5\u308f\u308c\u3066\u3044\u307e\u3059\uff08\u56f3\uff11\uff09\u3002<\/p>\n\n\n\n<p>\u30bb\u30b0\u30e1\u30f3\u30c81-2\u3067\u306frBAT-b<sup>0<\/sup>,<sup>+<\/sup>AT\u304c\u3001\u30bb\u30b0\u30e1\u30f3\u30c83\u3067\u306frBAT-AGT1\u304c\u306f\u305f\u3089\u304d\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3053\u308c\u3089\u306e\u8f38\u9001\u4f53\u306f\u3001\u30d8\u30c6\u30ed\u4e8c\u91cf\u4f53\u30a2\u30df\u30ce\u9178\u30c8\u30e9\u30f3\u30b9\u30dd\u30fc\u30bf\u30fc\uff08HAT\uff09\u3068\u547c\u3070\u308c\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u30d5\u30a1\u30df\u30ea\u30fc\u306b\u5c5e\u3057\u3001\u5236\u5fa1\u30b5\u30d6\u30e6\u30cb\u30c3\u30c8\u3067\u3042\u308b\u7cd6\u30bf\u30f3\u30d1\u30af\u8cearBAT\u304c\u3001\u89e6\u5a92\u30b5\u30d6\u30e6\u30cb\u30c3\u30c8\u3067\u3042\u308bb<sup>0<\/sup>,<sup>+<\/sup>AT\u3042\u308b\u3044\u306fAGT1\u3068\u4e8c\u91cf\u4f53\u3092\u5f62\u6210\u3059\u308b\u3053\u3068\u3067\u3001\u30b7\u30b9\u30c1\u30f3\u3092\u542b\u3080\u30a2\u30df\u30ce\u9178\u306e\u30c8\u30e9\u30f3\u30b9\u30dd\u30fc\u30bf\u30fc\u3068\u3057\u3066\u6a5f\u80fd\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p>rBAT-b<sup>0<\/sup>,<sup>+<\/sup>AT\u8907\u5408\u4f53\u306b\u95a2\u3057\u3066\u306f\u3001\u9577\u3044\u9593\u7814\u7a76\u304c\u9032\u3081\u3089\u308c\u3001I\u578b\u30b7\u30b9\u30c1\u30f3\u5c3f\u75c7\u306b\u3064\u306a\u304c\u308brBAT\u306e\u5909\u7570\u304c\u591a\u6570\u767a\u898b\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3057\u304b\u3057\u3001\u75c5\u614b\u306e\u610f\u5473\u3059\u308b\u3068\u3053\u308d\u306f\u672a\u3060\u4e0d\u660e\u3067\u3042\u308a\u3001\u8f38\u9001\u306e\u751f\u7406\u7684\u306a\u30e1\u30ab\u30cb\u30ba\u30e0\u3068\u306e\u95a2\u9023\u306f\u4e0d\u660e\u3067\u3057\u305f\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-full is-style-shadow\"><img decoding=\"async\" src=\"https:\/\/www-user.yokohama-cu.ac.jp\/~membrane\/wp-content\/uploads\/image_17.webp\" alt=\"\" class=\"wp-image-559\"\/><figcaption class=\"wp-element-caption\">\uff08\u56f3\uff11\uff09\u814e\u81d3\u8fd1\u4f4d\u5c3f\u7d30\u7ba1\u306e\u5404\u30bb\u30b0\u30e1\u30f3\u30c8\uff08S1\u3001S2\u3001S3\uff09\u3067\u306f\u305f\u3089\u304f\u30b7\u30b9\u30c1\u30f3\u8f38\u9001\u7cfb\u306e\u6982\u5ff5\u56f3<\/figcaption><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\">\u7814\u7a76\u5185\u5bb9<\/h2>\n\n\n\n<p>\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u306f\u3001\u30af\u30e9\u30a4\u30aa\u96fb\u5b50\u9855\u5fae\u93e1\u3092\u7528\u3044\u305f\u6700\u5148\u7aef\u306e\u6280\u8853\u3068\u8907\u6570\u306e\u751f\u5316\u5b66\u30fb\u7d30\u80de\u751f\u7269\u5b66\u7684\u624b\u6cd5\u3092\u7528\u3044\u3066\u3001rBAT-b<sup>0<\/sup>,<sup>+<\/sup>AT\u306e\u751f\u5408\u6210\u3068I\u578b\u30b7\u30b9\u30c1\u30f3\u5c3f\u75c7\u306b\u304a\u3051\u308b\u5c0f\u80de\u4f53\u30ab\u30eb\u30b7\u30a6\u30e0\u306e\u5f79\u5272\u3092\u767a\u898b\u3057\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p>\u30b0\u30eb\u30fc\u30d7\u306f\u3001\u8d85\u4e8c\u91cf\u4f53\u3068\u540d\u4ed8\u3051\u3089\u308c\u305f2\u3064\u306erBAT-b<sup>0<\/sup>,<sup>+<\/sup>AT\u8907\u5408\u4f53\u304c\u4e8c\u91cf\u4f53\u5316\u3057\u3066\u3044\u308b\u69cb\u9020\u306b\u304a\u3044\u3066\u3001rBAT\u306e\u7d30\u80de\u5916\u30c9\u30e1\u30a4\u30f3\u306b\u30ab\u30eb\u30b7\u30a6\u30e0\u30a4\u30aa\u30f3\u304c\u5b58\u5728\u3059\u308b\u3053\u3068\u3092\u7a81\u304d\u6b62\u3081\u307e\u3057\u305f\u3002\uff08\u56f3\uff12\uff09<\/p>\n\n\n\n<p>\u307e\u305f\u3001\u30ab\u30eb\u30b7\u30a6\u30e0\u306e\u7d50\u5408\u306f\u3001\u8907\u5408\u4f53\u3092\u5b89\u5b9a\u5316\u3055\u305b\u3066\u5c0f\u80de\u4f53\u3067\u8d85\u4e8c\u91cf\u4f53\u306e\u751f\u5408\u6210\u3092\u5b8c\u4e86\u3055\u305b\u308b\u3053\u3068\u3067\u3001rBAT-b<sup><sub>0<\/sub><\/sup>,<sup>+<\/sup>AT\u306e\u7d30\u80de\u819c\u3078\u306e\u5c40\u5728\u3068\u8f38\u9001\u6a5f\u80fd\u3092\u4fc3\u9032\u3055\u305b\u308b\u3053\u3068\u3092\u767a\u898b\u3057\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p>\u4e00\u65b9\u3067\u3001\u30ab\u30eb\u30b7\u30a6\u30e0\u304c\u7d50\u5408\u3057\u306a\u3044\u5909\u7570\u3092\u5c0e\u5165\u3059\u308b\u3068\u3001I\u578b\u30b7\u30b9\u30c1\u30f3\u5c3f\u75c7\u5909\u7570\u4f53\u306b\u898b\u3089\u308c\u308b\u3088\u3046\u306b\u3001\u30bf\u30f3\u30d1\u30af\u8cea\u304c\u4e0d\u5b89\u5b9a\u306b\u306a\u308b\u306a\u3069\u3001\u7d30\u80de\u819c\u5c40\u5728\u304c\u963b\u5bb3\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p>\u4f8b\u3048\u3070\u3001\u30e8\u30fc\u30ed\u30c3\u30d1\u3067\u591a\u304f\u898b\u3089\u308c\u308bT216M\u5909\u7570\u3067\u306f\u3001\u767a\u75c7\u3059\u308b\u7406\u7531\u304c\u308f\u304b\u3063\u3066\u3044\u307e\u305b\u3093\u3067\u3057\u305f\u304c\u3001\u5909\u7570\u306b\u3088\u308a\u30ab\u30eb\u30b7\u30a6\u30e0\u7d50\u5408\u3068\u8d85\u4e8c\u91cf\u4f53\u5316\u304c\u963b\u5bb3\u3055\u308c\u3001\u30bf\u30f3\u30d1\u30af\u8cea\u304c\u5c0f\u80de\u4f53\u3067\u6355\u6349\u3055\u308c\u6a5f\u80fd\u4e0d\u5168\u306b\u306a\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u3068\u306a\u308a\u307e\u3057\u305f\uff08\u56f3\uff12\uff09\u3002<\/p>\n\n\n\n<p>\u307e\u305f\u3001\u8d85\u4e8c\u91cf\u4f53\u3092\u5f62\u6210\u3067\u304d\u306a\u3044\u5909\u7570\u4f53\u306b\u5bfe\u3057\u3066\u3001\u3055\u3089\u306a\u308b\u6539\u5909\u3092\u52a0\u3048\u308b\u3068\u3001\u8d85\u4e8c\u91cf\u4f53\u304c\u56de\u5fa9\u3057\u30c8\u30e9\u30f3\u30b9\u30dd\u30fc\u30bf\u30fc\u304c\u6b63\u5e38\u306b\u5c40\u5728\u3067\u304d\u308b\u3088\u3046\u306b\u306a\u308a\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p>\u3053\u306e\u3053\u3068\u306f\u3001\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u5c40\u5728\u7570\u5e38\u306b\u3088\u3063\u3066\u8d77\u3053\u308bI\u578b\u30b7\u30b9\u30c1\u30f3\u5c3f\u75c7\u306e\u6cbb\u7642\u6cd5\u958b\u767a\u306b\u3064\u306a\u304c\u308b\u624b\u304c\u304b\u308a\u3068\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-full is-style-shadow\"><img loading=\"lazy\" decoding=\"async\" width=\"600\" height=\"337\" src=\"https:\/\/www-user.yokohama-cu.ac.jp\/~membrane\/wp-content\/uploads\/image_18.webp\" alt=\"\" class=\"wp-image-594\"\/><figcaption class=\"wp-element-caption\">\uff08\u56f3\uff12\uff09\u30ab\u30eb\u30b7\u30a6\u30e0\u30a4\u30aa\u30f3\u306b\u3088\u3063\u3066\u5b89\u5b9a\u5316\u3055\u308c\u308brBAT-b0,+AT\u8d85\u5206\u5b50\u8907\u5408\u4f53\u306e\u69cb\u9020\u3068\u3001\u30b7\u30b9\u30c1\u30f3\u5c3f\u75c7\u5909\u7570\u306b\u3088\u308b\u305d\u306e\u7570\u5e38<\/figcaption><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\">\u672c\u7814\u7a76\u304c\u793e\u4f1a\u306b\u4e0e\u3048\u308b\u5f71\u97ff<\/h2>\n\n\n\n<p>\u672c\u7814\u7a76\u306f\u3001\u30c8\u30e9\u30f3\u30b9\u30dd\u30fc\u30bf\u30fc\u304c\u6b63\u3057\u304f\u50cd\u304f\u305f\u3081\u306b\u8d85\u5206\u5b50\u8907\u5408\u4f53\u5f62\u6210\u304c\u5fc5\u8981\u3067\u3042\u308b\u3053\u3068\u3092\u793a\u3057\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p>\u3055\u3089\u306b\u3001\u30c8\u30e9\u30f3\u30b9\u30dd\u30fc\u30bf\u30fc\u8907\u5408\u4f53\u306e\u5b89\u5b9a\u5316\u56e0\u5b50\u3068\u3057\u3066\u306e\u30ab\u30eb\u30b7\u30a6\u30e0\u306e\u65b0\u3057\u3044\u5f79\u5272\u3082\u660e\u3089\u304b\u3068\u306a\u308a\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p>\u3053\u308c\u306b\u3088\u308a\u3001\u3053\u308c\u307e\u3067\u9577\u3044\u9593\u8aac\u660e\u306e\u3064\u304b\u306a\u304b\u3063\u305f\u3044\u304f\u3064\u304b\u306e\u30b7\u30b9\u30c1\u30f3\u5c3f\u75c7\u5909\u7570\u306e\u5206\u5b50\u75c5\u614b\u304c\u8aac\u660e\u3055\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3053\u308c\u307e\u3067\u3001\u30b7\u30b9\u30c1\u30f3\u5c3f\u75c7\u306e\u6cbb\u7642\u306f\u6c34\u5206\u306e\u5927\u91cf\u6442\u53d6\u3084\u5c3f\u306e\u30a2\u30eb\u30ab\u30ea\u5316\u3001\u98df\u4e8b\u5236\u9650\u306a\u3069\u306e\u9593\u63a5\u7684\u306a\u65b9\u6cd5\u3067\u884c\u308f\u308c\u3066\u304d\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p>\u672c\u7814\u7a76\u306f\u3001\u539f\u5b50\u30ec\u30d9\u30eb\u3067\u30c8\u30e9\u30f3\u30b9\u30dd\u30fc\u30bf\u30fc\u3092\u76f4\u63a5\u6a19\u7684\u3068\u3059\u308b\u65b0\u305f\u306a\u6cbb\u7642\u6cd5\u3084\u3001\u30c8\u30e9\u30f3\u30b9\u30ec\u30fc\u30b7\u30e7\u30ca\u30eb\u30ea\u30b5\u30fc\u30c1\u306b\u3064\u306a\u304c\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u307e\u305f\u3001\u5c0f\u80de\u4f53\u30ab\u30eb\u30b7\u30a6\u30e0\u306e\u5f79\u5272\u306f\u3001\u819c\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u751f\u5408\u6210\u306b\u304a\u3051\u308b\u666e\u904d\u7684\u306a\u73fe\u8c61\u3068\u3057\u3066\u3001\u4eca\u5f8c\u3001\u3088\u308a\u5e45\u5e83\u3044\u751f\u547d\u73fe\u8c61\u3084\u75be\u60a3\u3068\u306e\u95a2\u9023\u3067\u7814\u7a76\u3055\u308c\u308b\u3053\u3068\u304c\u671f\u5f85\u3055\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u7814\u7a76\u8cbb<\/h3>\n\n\n\n<p>\u672c\u7814\u7a76\u306f\u3001\u79d1\u7814\u8cbb\uff08JP19K07373\u3001JP21H03365\u3001JP21K15031\uff09\u3001AMED\uff08JP21gm0810010\u3001JP21ek0310012\u3001JP21lk0201112\uff09\u3001\u6771\u6d0b\u7d21\u30d0\u30a4\u30aa\u30c6\u30af\u30ce\u30ed\u30b8\u30fc\u8ca1\u56e3\u3001Human Frontier Science Program\u3001\u98a8\u6238\u7814\u7a76\u5968\u52b1\u4f1a\u3001\u6301\u7530\u8a18\u5ff5\u533b\u5b66\u85ac\u5b66\u632f\u8208\u8ca1\u56e3\u306e\u652f\u63f4\u3092\u53d7\u3051\u3066\u5b9f\u65bd\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u8ad6\u6587\u60c5\u5831<\/h3>\n\n\n\n<p>\u30bf\u30a4\u30c8\u30eb\uff1a Ca<sup>2+<\/sup>-mediated higher-order assembly of heterodimers in amino acid transport system b<sup>0<\/sup>,<sup>+<\/sup>biogenesis and cystinuria&nbsp;<br>\u8457\u8005\uff1a Yongchan Lee, Pattama Wiriyasermkul, Pornparn Kongpracha, Satomi Moriyama, Deryck J. Mills, Werner K\u00fchlbrandt &amp; Shushi Nagamori.&nbsp;<br>\u63b2\u8f09\u96d1\u8a8c\uff1a Nature Communications&nbsp;<br>DOI\uff1a&nbsp;<a rel=\"noreferrer noopener\" href=\"https:\/\/doi.org\/10.1038\/s41467-022-30293-9\" target=\"_blank\">10.1038\/s41467-022-30293-9<\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u7528\u8a9e\u8aac\u660e<\/h2>\n\n\n\n<dl class=\"swell-block-dl\">\n<dt class=\"swell-block-dl__dt\">\u30a2\u30df\u30ce\u9178\u8f38\u9001\u4f53\uff08\u30c8\u30e9\u30f3\u30b9\u30dd\u30fc\u30bf\u30fc\uff09<\/dt>\n\n\n\n<dd class=\"swell-block-dl__dd\">\n<p>\u751f\u4f53\u819c\u3092\u4ecb\u3057\u305f\u3001\u30a2\u30df\u30ce\u9178\u306e\u51fa\u5165\u308a\u3092\u62c5\u3046\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u7dcf\u79f0\u300220\u7a2e\u985e\u4ee5\u4e0a\u3042\u308b\u30a2\u30df\u30ce\u9178\u306e\u3046\u3061\u3001\u305d\u308c\u305e\u308c\u306b\u5bfe\u3057\u3066\u7279\u7570\u7684\u306a\u30c8\u30e9\u30f3\u30b9\u30dd\u30fc\u30bf\u30fc\u304c\u5b58\u5728\u3059\u308b\u30021\u7a2e\u985e\u306e\u30a2\u30df\u30ce\u9178\u306b\u5bfe\u3057\u3066\u3001\u8907\u6570\u306e\u30c8\u30e9\u30f3\u30b9\u30dd\u30fc\u30bf\u30fc\u304c\u5272\u308a\u5f53\u3066\u3089\u308c\u3066\u3044\u308b\u5834\u5408\u3082\u3042\u308b\u3002&nbsp;<\/p>\n<\/dd>\n\n\n\n<dt class=\"swell-block-dl__dt\">\u5c0f\u80de\u4f53<\/dt>\n\n\n\n<dd class=\"swell-block-dl__dd\">\n<p>\u7d30\u80de\u5185\u69cb\u9020\u306e\u4e00\u7a2e\u3002\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u751f\u5408\u6210\u3068\u305d\u306e\u54c1\u8cea\u7ba1\u7406\u3001\u30ab\u30eb\u30b7\u30a6\u30e0\u306e\u8caf\u8535\u306a\u3069\u3092\u62c5\u3063\u3066\u3044\u308b\u3002&nbsp;<\/p>\n<\/dd>\n\n\n\n<dt class=\"swell-block-dl__dt\">\u30af\u30e9\u30a4\u30aa\u96fb\u5b50\u9855\u5fae\u93e1<\/dt>\n\n\n\n<dd class=\"swell-block-dl__dd\">\n<p>\u30de\u30a4\u30ca\u30b9180\u5ea6\u7a0b\u5ea6\u306e\u3054\u304f\u51b7\u305f\u3044\u6e29\u5ea6\u3067\u751f\u4f53\u8a66\u6599\u3092\u51cd\u7d50\u3057\u3001\u305d\u306e\u69cb\u9020\u3092\u898b\u308b\u3053\u3068\u306e\u3067\u304d\u308b\u96fb\u5b50\u9855\u5fae\u93e1\u3084\u3001\u305d\u308c\u3092\u7528\u3044\u305f\u6280\u8853\u306e\u7dcf\u79f0\u3002\u4eca\u56de\u306e\u7814\u7a76\u3067\u306f\u3001\u30af\u30e9\u30a4\u30aa\u96fb\u5b50\u9855\u5fae\u93e1\u6280\u8853\u306e\u3046\u3061\u30012017\u5e74\u306b\u30ce\u30fc\u30d9\u30eb\u5316\u5b66\u8cde\u306e\u53d7\u8cde\u5bfe\u8c61\u3068\u306a\u3063\u305f\u5358\u7c92\u5b50\u89e3\u6790\u3068\u3044\u3046\u624b\u6cd5\u3092\u7528\u3044\u3066\u3044\u308b\u3002&nbsp;&nbsp;<\/p>\n<\/dd>\n\n\n\n<dt class=\"swell-block-dl__dt\">I\u578b\u30b7\u30b9\u30c1\u30f3\u5c3f\u75c7\u5909\u7570\u4f53<\/dt>\n\n\n\n<dd class=\"swell-block-dl__dd\">\n<p>\u30b7\u30b9\u30c1\u30f3\u5c3f\u75c7\u306f\u75c5\u6c17\u306e\u539f\u56e0\u3084\u7a0b\u5ea6\u306b\u3088\u308a\u3001I\u578b\uff08\u3042\u308b\u3044\u306fA\u578b\uff09\u3068\u975eI\u578b\uff08\u3042\u308b\u3044\u306fII\u3001III\u578b\u3001\u3082\u3057\u304f\u306fB\u578b\uff09\u306b\u5206\u985e\u3055\u308c\u308b\u3002I\u578b\u306frBAT\u306e\u7570\u5e38\u306b\u3088\u308b\u3082\u306e\u3001\u975eI\u578b\u306fb<sup>0<\/sup>,<sup>+<\/sup>AT\u306e\u7570\u5e38\u306b\u3088\u308b\u3082\u306e\u3067\u3042\u308b\u3068\u3055\u308c\u3066\u3044\u308b\u3002<\/p>\n<\/dd>\n<\/dl>\n\n\n\n<p class=\"has-text-align-center has-border -border01 is-style-bg_grid\"><a href=\"https:\/\/www.yokohama-cu.ac.jp\/news\/2022\/dr3e64000001p4q0-att\/20220516LeeYongchan.pdf\">\u8aad\u8005\u767a\u8868\u8cc7\u6599<\/a>\uff1e\uff1e<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u674e\u52c7\u71e6\u52a9\u6559\u3068\u6771\u4eac\u6148\u6075\u4f1a\u533b\u79d1\u5927\u5b66 \u6c38\u68ee\u6536\u5fd7\u51c6\u6559\u6388\u3001Pattama Wiriyasermkul\u52a9\u6559\u3089\u306b\u3088\u308b\u56fd\u969b\u5171\u540c\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u306f\u3001\u30b7\u30b9\u30c1\u30f3\u5c3f\u75c7\u306b\u95a2\u308f\u308b\u30a2\u30df\u30ce\u9178\u8f38\u9001\u4f53\u3067\u3042\u308brBAT-b0,+AT\u306e\u751f\u5408\u6210\u306b\u304a\u3051\u308b\u91cd\u8981\u306a\u30d7\u30ed\u30bb\u30b9\u3092\u767a\u898b\u3057\u307e\u3057\u305f\u3002&nbsp; \u4eca\u56de\u306e\u7814\u7a76\u306b\u3088\u308a\u3001\u9577\u5e74\u8b0e\u3068\u3055\u308c\u3066\u304d\u305f\u3044\u304f\u3064\u304b\u306e\u30b7\u30b9\u30c1\u30f3\u5c3f\u75c7\u306e\u75c5\u614b\u5909\u7570\u304c\u8aac\u660e\u3055\u308c\u3001\u5206\u5b50\u30fb\u539f\u5b50\u30ec\u30d9\u30eb\u3067\u306e\u65b0\u305f\u306a\u6cbb\u7642\u6cd5\u306e\u53ef\u80fd\u6027\u304c\u793a\u3055\u308c\u307e\u3059\u3002&nbsp; \u672c\u7814\u7a76\u6210\u679c\u306f\u300cNature 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\u8ad6\u6587\u60c5\u5831 \u30bf\u30a4\u30c8\u30eb\uff1a Ca2+-mediated higher-order assembly of heterodimers in amino acid transport system b0,+biogenesis and cystinuria&nbsp;\u8457\u8005\uff1a Yongchan Lee, Pattama Wiriyasermkul, Pornparn Kongpracha, 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