{"id":18,"date":"2020-04-01T17:52:11","date_gmt":"2020-04-01T08:52:11","guid":{"rendered":"http:\/\/www-user.yokohama-cu.ac.jp\/~immunol\/wp\/?page_id=18"},"modified":"2026-04-03T14:40:48","modified_gmt":"2026-04-03T05:40:48","slug":"publication","status":"publish","type":"page","link":"https:\/\/www-user.yokohama-cu.ac.jp\/~immunol\/publication\/","title":{"rendered":"Publication"},"content":{"rendered":"<p><img loading=\"lazy\" decoding=\"async\" style=\"margin-top: 30px;\" src=\"http:\/\/www-user.yokohama-cu.ac.jp\/~immunol\/wp\/wp-content\/uploads\/2020\/04\/sign4.png\" alt=\"\" width=\"800\" height=\"100\" class=\"aligncenter size-full wp-image-195\" srcset=\"https:\/\/www-user.yokohama-cu.ac.jp\/~immunol\/wp\/wp-content\/uploads\/2020\/04\/sign4.png 800w, https:\/\/www-user.yokohama-cu.ac.jp\/~immunol\/wp\/wp-content\/uploads\/2020\/04\/sign4-300x38.png 300w, https:\/\/www-user.yokohama-cu.ac.jp\/~immunol\/wp\/wp-content\/uploads\/2020\/04\/sign4-768x96.png 768w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><\/p>\n<h2>\u767a\u8868\u8ad6\u6587<\/h2>\n<h4 id=\"1\">2026\u5e74<\/h4>\n<div id=\"list\">\n<ul>\n<li>\nKirino Y, Maeda A, Higashitani K, Horita N, Asano T, Migita K, Motomura Y, Rokutanda R, Kobayashi D, Tamura M, Kanazawa N, Furuhashi K, Kondo Y, Nagahata K, Takahashi H, Kobayashi H, Yao S, Yamagami K, Uchino K, Hidaka Y, Ida H, Kishida D, Sato T, Ichinose K, Miyamae T, Tsujimoto K, Inoue Y, Fujieda Y, Mishima K, Tsuji T, Tanaka K, Noda H, Isogai S, Miyoshi Y, Yokogawa N, Ota S, Sakuraba H, Nishi J, Inoue T, Muraoka S, Nanki T, Shimizu T, Koga T, Inaba Y, Matsubara M, Yoshimoto K, Hasegawa A, Ikeda K, Motohashi R, Takeuchi Y, Shiratsuchi M, Moriyama M, Noda K, Saito S, Hagiyama H, Honda T, Kageyama R, Nakatani N, Goto T, Kishimoto M, Watanabe T, Yamaguchi Y, Nishikomori R, Ohara O, Ban T, Tamura T, Nakajima H: Peripheral blood <em>UBA1<\/em> variant burden predicts poor outcomes in VEXAS syndrome: a nationwide prospective study. <strong><em>Ann Rheum Dis <\/em><\/strong>2026 Apr 1:S0003-4967(26)00148-2. doi: 10.1016\/j.ard.2026.03.003. Epub ahead of print.  (<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41927375\/\">PubMed<\/a>)(<a href=\"https:\/\/www.yokohama-cu.ac.jp\/res-portal\/news\/2026\/20260402kirino.html\">\u30d7\u30ec\u30b9\u30ea\u30ea\u30fc\u30b9<\/a>)\n<\/li>\n<li>\nKanayama Y, Ban T, Sato GR, Arinuma Y, Matsueda Y, Yamaoka K, Tamura T: Predictive value of interferon regulatory factor 5 nuclear translocation in B cells for disease activity and flare in systemic lupus erythematosus: a prospective observational cohort study. <strong><em>Mod Rheumatol <\/em><\/strong> 2026 Mar 13:roag024. doi: 10.1093\/mr\/roag024. Epub ahead of print.  (<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41823707\/\">PubMed<\/a>)\n<\/li>\n<li>\nNegishi H, Wada Y, Shirasaki Y, Hayashi T, Kubota Y, Iwasaki T, Kurosawa M, Ban T, Muto D, Suenaga Y, Kojima T, Matsuda Y, Irish SL, Dodo K, Suzuki T, Yamagishi M, Temizoz B, Yoshimori A, Kanai C, Nagasaki Y, Ohmuraya M, Tamura T, Iwama A, Inada T, Kuroda E, Kobiyama K, Toyama-Sorimachi N, Takekawa M, Coban C, Ishii KJ:  cGAS-IFN-I responses by extracting nuclear DNA from dying cells via nucleocytosis. <strong><em>Nat Commun <\/em><\/strong>17: 1658, 2026 (<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41708603\/\">PubMed<\/a>)\n<\/li>\n<li>\nVerwaerde S, Hastir JF, Schetters STT, Smole U, Seys L, Baptista AP, English K, Schuijs MJ, Aegerter H, Van Damme KFA, Bugler-Lamb A, Gerebtsov N, Toussaint W, Ban T, Tamura T, Ginhoux F, Liu Z, Saelens W, Hammad H, Guilliams M, Lambrecht BN: Innate type 2 lymphocytes trigger an inflammatory switch in alveolar macrophages. <strong><em> Immunity <\/em><\/strong> 59(1): 60-78, 2026 (<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41386231\/\">PubMed<\/a>)\n<\/li>\n<li>\nIchikawa J, Okuda H, Kawano K, Kato S, Sato S, Kuroishikawa R, Kurotaki D, Kawase W, Yoshida H, Hiroshima Y, Endo I, Maeda S, Tamura T: A Combinatorial effect of immune checkpoint inhibitors and CD40 agonistic antibody in murine pancreatic cancer model.<strong><em> Cancer Sci <\/em><\/strong> 117(1): 8-18, 2026 (<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41213887\/\">PubMed<\/a>)\n<\/li>\n<\/ul>\n<\/div>\n<h4 id=\"2\">2025\u5e74<\/h4>\n<div id=\"list\">\n<ul>\n<li>\n\u5965\u7530\u535a\u53f2, \u897f\u5c71\u6643, \u7530\u6751\u667a\u5f66: \u6a39\u72b6\u7d30\u80de\u5206\u5316\u306b\u304a\u3051\u308bIRF8\u306e\u5f79\u5272. <strong><em>\u81e8\u5e8a\u514d\u75ab\u30fb\u30a2\u30ec\u30eb\u30ae\u30fc\u79d1 <\/em><\/strong> 84(5): 440-447, 2025\n<\/li>\n<li>\nShirakawa J, De Jesus DF, Tsuno T, Basile G, Inoue R, Takatani T, Nishiyama A, Okawa ER, Tamura T, Terauchi Y, Kulkarni RN: Regulatory roles of IGF2R in insulin secretion and adaptive \u03b2-cell proliferation. <strong><em> Diabetes <\/em><\/strong> 74(12): 2351-2364, 2025 (<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41042627\/\">PubMed<\/a>)\n<\/li>\n<li>\nNishiyama A, Tamura T: <em>Cis<\/em>&#8211; and <em>trans<\/em>-regulation of <em>Irf8<\/em> enhancers during dendritic cell development. <strong><em> Exp Hematol <\/em><\/strong> 150: 104858, 2025 (<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40680811\/\">PubMed<\/a>)\n<\/li>\n<li>\nYabe SG, Nishida J, Fukuda S, Kin T, Nishiyama A, Tamura T, Takeda F, Tamura-Nakano M, Shirakawa J, Okochi H: High glucose burden disrupts the glucose responsiveness of human pancreatic beta cells encapsulated in alginate fibers during Long-Term culture. <strong><em> Gene <\/em><\/strong> 964: 149639, 2025 (<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40544971\/\">PubMed<\/a>)\n<\/li>\n<li>\nTsuno T, Li J, Nishiyama K, Kawasawa YI, Inoue R, Ong Yajima E, Nishiyama A, Yabe SG, Kin T, Okochi H, Tamura T, Shapiro AMJ, Oyadomari S, Kitamura T, Terauchi Y, Shirakawa J: Imeglimin suppresses glucagon secretion and induces a loss of \u03b1 cell identity. <strong><em> Cell Rep Med <\/em><\/strong> 6(8): 102254, 2025 (<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40713970\/\">PubMed<\/a>)\n<\/li>\n<li>\nIkeda J, Kunimoto H, Saito Y, Tsujimoto SI, Takeuchi M, Miura A, Kurosawa T, Murakami K, Kato I, Funakoshi-Tago M, Yokoyama A, Shiba N, Adachi S, Tomizawa D, Tamura T, Ito S, Nakajima H: Metabolic reprogramming by PRDM16 drives cytarabine resistance in acute myeloid leukemia.<strong><em> Haematologica <\/em><\/strong>  110(11): 2647-2660, 2025 (<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40501394\/\">PubMed<\/a>)\n<\/li>\n<li>\nKoide S, Oshima M, Kamiya T, Zheng Z, Liu Z, Rizq O, Nishiyama A, Murakami K, Yamada Y, Nakajima-Takagi Y, Rahmutulla B, Kaneda A, Yokoyama K, Yusa N, Imoto S, Miura F, Ito T, Tamura T, Nerlov C, Yamashita M, Iwama A: Tracking clusterin expression in hematopoietic stem cells reveals their heterogeneous composition across the lifespan.<strong><em> Blood <\/em><\/strong> 146(1): 62-75, 2025 (<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40132120\/\">PubMed<\/a>)\n<\/li>\n<li>\nNishizawa H, Funasaki S, Ma W, Kubota Y, Watanabe K, Arima Y, Kuroda S, Ito T, Furuya M, Motoshima T, Nishiyama A, Mehanna S, Satou Y, Hasumi H, Jikuya R, Makiyama K, Tamura T, Oike Y, Tanaka Y, Suda T, Schmidt LS, Linehan WM, Baba M, Kamba T: HIF1\u03b1 Plays a Crucial Role in the Development of TFE3-Rearranged Renal Cell Carcinoma by Orchestrating a Metabolic Shift Toward Fatty Acid Synthesis. <strong><em> Genes Cells <\/em><\/strong> 30(1): e13195, 2025 (<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39807625\/\">PubMed<\/a>)\n<\/li>\n<\/ul>\n<\/div>\n<h4 id=\"3\">2024\u5e74<\/h4>\n<div id=\"list\">\n<ul>\n<li>\nXiang H, Kasajima R, Azuma K, Tagami T, Hagiwara A, Nakahara Y, Saito H, Igarashi Y, Wei F, Ban T, Yoshihara M, Nakamura Y, Sato S, Koizume S, Tamura T, Sasada T, Miyagi Y:  Multi-omics analysis-based clinical and functional significance of a novel prognostic and immunotherapeutic gene signature derived from amino acid metabolism pathways in lung adenocarcinoma.  <strong><em>Front Immunol  <\/em><\/strong> 15: 1361992, 2024 (<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39735553\/\">PubMed<\/a>)\n<\/li>\n<li>\nMitome T, Wakui H, Azushima K, Uehara T, Jikuya R, Ohtake S, Noguchi G, Kawaura S, Iribe Y, Aomori K, Tatenuma T, Ito H, Kawahara T, Komeya M, Ito Y, Muraoka K, Furuya M, Kato I, Fujii S, Nagahama K, Nishiyama A, Tamura T, Kimura Y, Kawagoe T, Mizuki N, Huang G, Uemura H, Yao M, Makiyama K, Tamura K, Hasumi H:  SETD2 regulates SLC family transporter-mediated sodium and glucose reabsorptions in renal tubule  <strong><em>Biochem Biophys Res Commun <\/em><\/strong> 734: 150730, 2024 (<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39366177\/\">PubMed<\/a>)\n<\/li>\n<li>\nTsuji M, Kondo M, Nishiyama A, Tamura T, Nakamura-Ishizu A, Koizumi M, Honda H, Tagaya E:  STING\/RANTES pathway in airway epithelium enhances Der p1-induced airway inflammation. <strong><em>Allergy <\/em><\/strong> 79(7): 2008-2011, 2024 (<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38837714\/\">PubMed<\/a>)\n<\/li>\n<li>\nIwata A, Maruyama J, Natsuki S, Nishiyama A, Tamura T, Tanaka M, Shichino S, Seki T, Komai T, Okamura T, Fujio K, Tanaka M, Asano K: Egr2 drives the differentiation of Ly6C<sup>hi<\/sup> monocytes into fibrosis-promoting macrophages in metabolic dysfunction-associated steatohepatitis in mice. <strong><em>Commun Biol <\/em><\/strong> 7(1): 681, 2024 (<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38831027\/\">PubMed<\/a>)\n<\/li>\n<li>\nYamasaki T*, Nishiyama A*, Kurogi N, Nishimura K, Nishida S, Kurotaki D, Ban T, Ramilowski JA, Ozato K, Toyoda A, Tamura T: Physical and functional interaction among Irf8 enhancers during dendritic cell differentiation.<br \/>\n<strong><em>Cell Rep<\/em><\/strong> 43(4): 114107, 2024 (*Co-1st authors)(<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38613785\/\">PubMed<\/a>)(<a href=\"https:\/\/www.yokohama-cu.ac.jp\/res-portal\/news\/2024\/20240424tamura_yamasaki.html\">\u30d7\u30ec\u30b9\u30ea\u30ea\u30fc\u30b9<\/a>)\n<\/li>\n<li>\nWatanuki S, Kobayashi H, Sugiura Y, Yamamoto M, Karigane D, Shiroshita K, Sorimachi Y, Fujita S, Morikawa T, Koide S, Oshima M, Nishiyama A, Murakami K, Haraguchi M, Tamaki S, Yamamoto T, Yabushita T, Tanaka Y, Nagamatsu G, Honda H, Okamoto S, Goda N, Tamura T, Nakamura-Ishizu A, Suematsu M, Iwama A, Suda T, Takubo K: Context-dependent modification of PFKFB3 in hematopoietic stem cells promotes anaerobic glycolysis and ensures stress hematopoiesis.<strong><em>eLife <\/em><\/strong> 12: RP87674, 2024 (<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38573813\/\">PubMed<\/a>)\n<\/li>\n<li>\nKubara K, Yamazaki K, Miyazaki T, Kondo K, Kurotaki D, Tamura T, Suzuki Y: Lymph node macrophages drive innate immune responses to enhance the anti-tumor efficacy of mRNA vaccines.<strong><em> Mol Ther <\/em><\/strong> 32(3): 61-73, 2024 (<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38243602\/\">PubMed<\/a>)\n<\/li>\n<\/ul>\n<\/div>\n<h4 id=\"4\">2023\u5e74<\/h4>\n<div id=\"list\">\n<ul>\n<li>\nTsukamoto S, Suzuki T, Wakui H, Uehara T, Ichikawa J, Okuda H, Haruhara K, Azushima K, Abe E, Tanaka S, Taguchi S, Hirota K, Kinguchi S, Yamashita A, Tamura T, Tamura K: Angiotensin II type 1 receptor-associated protein in immune cells: a possible key factor in the pathogenesis of visceral obesity.<strong><em> Metabolism <\/em><\/strong>  149: 155706, 2023 (<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/37856903\/\">PubMed<\/a>)\n<\/li>\n<li>\nWei F, Azuma K, Nakahara Y, Saito H, Matsuo N, Tagami T, Kouro T, Igarashi Y, Tokito T, Kato T, Kondo T, Murakami S, Usui R, Himuro H, Horaguchi S, Tsuji K, Murotani K, Ban T, Tamura T, Miyagi Y, Sasada T: Machine learning for prediction of immunotherapeutic outcome in non-small-cell lung cancer based on circulating cytokine signatures. <strong><em>J Immunother Cancer <\/em><\/strong>  11(7): e006788, 2023 (<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/37433717\/\">PubMed<\/a>)\n<\/li>\n<li>\nJikuya R, Johnson TA, Maejima K, An J, Ju YS, Lee H, Ha K, Song W, Kim Y, Okawa Y, Sasagawa S, Kanazashi Y, Fujita M, Imoto S, Mitome T, Ohtake S, Noguchi G, Kawaura S, Iribe Y, Aomori K, Tatenuma T, Komeya M, Ito H, Ito Y, Muraoka K, Furuya M, Kato I, Fujii S, Hamanoue H, Tamura T, Baba M, Suda T, Kodama T, Makiyama K, Yao M, Shuch BM, Ricketts CJ, Schmidt LS, Linehan WM, Nakagawa H, Hasumi H: Comparative analyses define differences between BHD-associated renal tumour and sporadic chromophobe renal cell carcinoma. <strong><em>EBioMedicine <\/em><\/strong> 92: 104596, 2023 (<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/37182269\/\">PubMed<\/a>)\n<\/li>\n<li>\nYamazaki K, Kubara K, Suzuki Y, Hihara T, Kurotaki D, Tamura T, Ito M, Tsukahara K: Multivalent mannose-conjugated siRNA causes robust gene silencing in pancreatic macrophages in vivo. <strong><em>Eur J Pharm Biopharm <\/em><\/strong> 183: 61-73, 2023 (<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36603692\/\">PubMed<\/a>)\n<\/li>\n<li> Ono G, Kobayakawa K, Saiwai H, Tamaru T, Iura H, Haruta Y, Kitade K, Iida KI, Kawaguchi KI, Matsumoto Y, Tsuda M, Tamura T, Ozato K, Inoue K, Konno DJ, Maeda T, Okada S, Nakashima Y: Macrophages play a leading role in determining the direction of astrocytic migration in spinal cord injury via ADP-P2Y1R axis.<strong><em> Sci Rep <\/em><\/strong> 13(1): 11177, 2023 (<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/37429920\/\">PubMed<\/a>)\n<\/li>\n<li>Ikeda N, Kubota H, Suzuki R, Morita M, Yoshimura A, Osada Y, Kishida K, Kitamura D, Iwata A, Yotsumoto S, Kurotaki D, Nishimura K, Nishiyama A, Tamura T, Kamatani T, Tsunoda T, Murakawa M, Asahina Y, Hayashi Y, Harada H, Harada Y, Yokota A, Hirai H, Seki T, Kuwahara M, Yamashita M, Shichino S, Tanaka M, Asano K: The early neutrophil-committed progenitors aberrantly differentiate into immunoregulatory monocytes during emergency myelopoiesis. <strong><em>Cell Rep<\/em><\/strong> 42(3): 112165, 2023 (<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36862552\/\">PubMed<\/a>)\n<\/li>\n<li>\u85e9\u9f8d\u99ac, \u7530\u6751\u667a\u5f66: \u5168\u8eab\u6027\u30a8\u30ea\u30c6\u30de\u30c8\u30fc\u30c7\u30b9\u306b\u304a\u3051\u308b\u8ee2\u5199\u56e0\u5b50IRF5\u306e\u65b0\u898f\u6cbb\u7642\u6a19\u7684\u3068\u3057\u3066\u306e\u53ef\u80fd\u6027. <strong><em>\u81e8\u5e8a\u514d\u75ab\u30fb\u30a2\u30ec\u30eb\u30ae\u30fc\u79d1<\/em><\/strong> 79(2): 217-222, 2023\n<\/li>\n<li>Ito T, Ohta M, Osada A, Nishiyama A, Ishiguro KI, Tamura T, Sekita Y, Kimura T: Switching defective\/sucrose non-fermenting chromatin remodeling complex coordinates meiotic gene activation via promoter remodeling and Meiosin activation in female germline. <strong><em>Genes Cells<\/em><\/strong> 28(1): 15-28, 2023 (<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36371617\/\">PubMed<\/a>)\n<\/li>\n<\/ul>\n<\/div>\n<h4 id=\"5\">2022\u5e74<\/h4>\n<div id=\"list\">\n<ul>\n<li>Okuda H, Miyamoto R, Takahashi S, Kawamura T, Ichikawa J, Harada I, Tamura T, Yokoyama A: RNA-binding proteins of KHDRBS and IGF2BP families control the oncogenic activity of MLL-AF4. <strong><em>Nat Commun<\/em><\/strong> 13: 6688, 2022 (<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36335100\/\">PubMed<\/a>)(<a href=\"https:\/\/www.yokohama-cu.ac.jp\/amedrc\/news\/202212okuda.html\">\u30d7\u30ec\u30b9\u30ea\u30ea\u30fc\u30b9<\/a>)<\/li>\n<li>\u85e9\u9f8d\u99ac, \u7530\u6751\u667a\u5f66: \u81ea\u5df1\u514d\u75ab\u75be\u60a3\u306e\u6cbb\u7642\u6a19\u7684\u5206\u5b50\u3068\u3057\u3066\u306e\u8ee2\u5199\u56e0\u5b50IRF5. <strong><em>\u5b9f\u9a13\u533b\u5b66 <\/em><\/strong>\u5897\u520a 40(15): 138-143, 2022<\/li>\n<li>Kurotaki D, Kikuchi K, Cui K, Kawase W, Saeki K, Fukumoto J, Nishiyama A, Nagamune K, Zhao K, Ozato K, Rocha PP, Tamura T: Chromatin structure undergoes global and local reorganization during murine dendritic cell development and activation. <strong><em>Proc Natl Acad Sci USA<\/em><\/strong> 119(34): e2207009119, 2022 (<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35969760\/\">PubMed<\/a>)(<a href=\"https:\/\/www.yokohama-cu.ac.jp\/amedrc\/news\/202208tamura.html\">\u30d7\u30ec\u30b9\u30ea\u30ea\u30fc\u30b9<\/a>)<\/li>\n<li>Jikuya R, Murakami K, Nishiyama A, Kato I, Furuya M, Nakabayashi M, Ramilowski JA, Hamanoue H, Maejima K, Fujita M, Mitome T, Ohtake S, Noguchi G, Kawaura S, Odaka H, Kawahara T, Komeya M, Shinoki R, Ueno D, Ito H, Ito Y, Muraoka K, Hayashi N, Kondo K, Nakaigawa N, Hatano K, Baba M, Suda T, Kodama T, Fujii S, Makiyama K, Yao M, Shuch BM, Schmidt LS, Linehan WM, Nakagawa H, Tamura T, Hasumi H: Single-cell transcriptomes underscore genetically distinct tumor characteristics and microenvironment for hereditary kidney cancers. <strong><em>iScience<\/em><\/strong> 25(6): 104463, 2022 (<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35874919\/\">PubMed<\/a>)<\/li>\n<li>Hayashi Y, Kawabata KC, Tanaka Y, Uehara Y, Mabuchi Y, Murakami K, Nishiyama  A, Kiryu S, Yoshioka Y, Ota Y, Sugiyama T, Mikami K, Tamura M, Fukushima T, Asada S, Takeda R, Kunisaki Y, Fukuyama T, Yokoyama K, Uchida T, Hagihara M, Ohno N, Usuki K, Tojo A, Katayama Y, Goyama S, Arai F, Tamura T, Nagasawa T, Ochiya T, Inoue D, Kitamura T: MDS cells impair osteolineage differentiation of MSCs via extracellular vesicles to suppress normal hematopoiesis. <strong><em>Cell Rep<\/em><\/strong> 39(6): 110805, 2022 (<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35545056\/\">PubMed<\/a>)<\/li>\n<li>Haruhara K, Suzuki T, Wakui H, Azushima K, Kurotaki D, Kawase W, Uneda K, Kobayashi R, Ohki K, Kinguchi S, Yamaji T, Kato I, Ohashi K, Yamashita A, Tamura T, Tsuboi N, Yokoo T, Tamura K: Deficiency of the kidney tubular angiotensin II type1 receptor-binding molecule ATRAP exacerbates streptozotocin-induced diabetic glomerular injury via reducing protective macrophage polarization. <strong><em>Kidney Int<\/em><\/strong> 101(5): 912-928, 2022 (<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35240129\/\">PubMed<\/a>)<\/li>\n<\/ul>\n<\/div>\n<h4 id=\"6\">2021\u5e74<\/h4>\n<div id=\"list\">\n<ul>\n<li>Ito T, Osada A, Ohta M, Yokota K, Nishiyama A, Niikura Y, Tamura T, Sekita Y, Kimura T: SWI\/SNF chromatin remodeling complex is required for initiation of sex-dependent differentiation in mouse germline. <strong><em>Sci Rep<\/em><\/strong> 11(1): 24074, 2021 (<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34912016\/\">PubMed<\/a>)<\/li>\n<li>Kimura Y, Nakai Y, Shin J, Hara M, Takeda Y, Kubo S, Jeremiah SS, Ino Y, Akiyama T, Moriyama K, Sakai K, Saji R, Nishii M, Kitamura H, Murohashi K, Yamamoto K, Kaneko T, Takeuchi I, Hagiwara E, Ogura T, Hasegawa H, Tamura T, Yamanaka  T, Ryo A: Identification of serum prognostic biomarkers of severe COVID-19 using a quantitative proteomic approach. <strong><em>Sci Rep<\/em><\/strong> 11(1): 20638, 2021 (<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34667241\/\">PubMed<\/a>)<\/li>\n<li>\u897f\u5c71\u6643, \u7530\u6751\u667a\u5f66: \u8ee2\u5199\u56e0\u5b50IRF8\u306b\u3088\u308b\u6a39\u72b6\u7d30\u80de\u306e\u5206\u5316\u5236\u5fa1. <strong><em>\u81e8\u5e8a\u514d\u75ab\u30fb\u30a2\u30ec\u30eb\u30ae\u30fc\u79d1<\/em><\/strong> 76(5): 549-554, 2021<\/li>\n<li>Saji R, Nishii M, Sakai K, Miyakawa K, Yamaoka Y, Ban T, Abe T, Ohyama Y, Nakajima K, Hiromi T, Matsumura R, Suzuki N, Taniguchi H, Otsuka T, Oi Y, Ogawa F, Uchiyama M, Takahashi K, Iwashita M, Kimura Y, Fujii S, Furuya R, Tamura T, Ryo A, Takeuchi I: Combining IL-6 and SARS-CoV-2 RNAaemia-based risk stratification for fatal outcomes of COVID-19.  <strong><em>PLoS One<\/em><\/strong> 2021 Aug 11;16(8): e0256022, 2021 (<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34379684\/\">PubMed<\/a>)<\/li>\n<li>Kawase W*, Kurotaki D*, Suzuki Y, Ishihara H, Ban T,  Sato GR, Ichikawa J, Yanai H, Taniguchi T, Tsukahara K, and Tamura T: <em>Irf5<\/em> siRNA-loaded biodegradable lipid nanoparticles ameliorate concanavalin A-induced liver injury.  <strong><em>Mol Ther Nucleic Acids<\/em><\/strong> 25: 708-715, 2021 (*Co-1st authors)(<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34589288\/\">PubMed<\/a>)(<a href=\"https:\/\/www.yokohama-cu.ac.jp\/amedrc\/news\/202109tamura_molther.html\">\u30d7\u30ec\u30b9\u30ea\u30ea\u30fc\u30b9<\/a>)<\/li>\n<li>Harada I, Sasaki H, Murakami K, Nishiyama A, Nakabayashi J, Ichino M, Miyazaki T, Kumagai K, Matsumoto K, Hagihara M, Kawase W, Tachibana T, Tanaka M, Saito T, Kanamori H, Fujita H, Fujisawa S, Nakajima H, Tamura T: Compromised anti-tumor-immune features of myeloid cell components in chronic myeloid leukemia patients. <strong><em>Sci Rep<\/em><\/strong> 11: 18046, 2021 (<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34508131\/\">PubMed<\/a>)<\/li>\n<li>Ban T*, Kikuchi M*, Sato GR*, Manabe A, Tagata N, Harita K, Nishiyama A, Nishimura K, Yoshimi R, Kirino Y, Yanai H, Matsumoto Y, Suzuki S, Hihara H, Ito M, Tsukahara K, Yoshimatsu K, Yamamoto T, Taniguchi T, Nakajima H, Ito S, Tamura T: Genetic and chemical inhibition of IRF5 suppresses pre-existing mouse lupus-like disease. <strong><em>Nat Commun<\/em><\/strong> 12: 4379, 2021 (*Co-1st authors)(<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34282144\/\">PubMed<\/a>)(<a href=\"https:\/\/www.amed.go.jp\/news\/release_20210720.html\">\u30d7\u30ec\u30b9\u30ea\u30ea\u30fc\u30b9<\/a>)<\/li>\n<li>Kato S, Fushimi K, Yabuki Y, Maru Y, Hasegawa S, Matsuura T, Kurotaki D , Suzuki A, Kobayashi N, Yoneda M, Higurashi T, Enaka M, Tamura T, Hippo Y, Nakajima A: Precision modeling of gall bladder cancer patients in mice based on orthotopic implantation of organoid-derived tumor buds. <strong><em>Oncogenesis<\/em><\/strong> 10: 33, 2021 (<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33866327\/\">PubMed<\/a>)<\/li>\n<li>Ototake Y, Yamaguchi Y, Asami M, Komitsu N, Akita A, Watanabe T, Kanaoka M, Kurotaki D, Tamura T, Aihara M: Downregulated IRF8 in monocytes\/macrophages of systemic sclerosis patients may aggravate the fibrotic phenotype. <strong><em>J Invest Dermatol <\/em><\/strong> 141(8): 1954-1963, 2021 (<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33705797\/\">PubMed<\/a>)<\/li>\n<li>Murakami K*, Sasaki H*, Nishiyama A*, Kurotaki D, Kawase W, Ban T, Nakabayashi J, Kanzaki S, Sekita Y, Nakajima H, Ozato K, Kimura T, Tamura T: A RUNX\u2013CBF\u03b2-driven enhancer directs the <em>Irf8<\/em> dose-dependent lineage choice between DCs and monocytes. <strong><em>Nat Immunol<\/em><\/strong> 22(3): 301-311, 2021 (*Co-1st authors)(<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33603226\/\">PubMed<\/a>)(<a href=\"https:\/\/www.yokohama-cu.ac.jp\/amedrc\/news\/20210219tamura_NatImmun.html\">\u30d7\u30ec\u30b9\u30ea\u30ea\u30fc\u30b9<\/a>)<\/li>\n<li>Murakami K, Kurotaki D, Kawase W, Soma S, Fukuchi Y, Kunimoto H, Yoshimi R, Koide S, Oshima M, Hishiki T, Hayakawa N, Matsuura T, Oda M, Yanagisawa K, Kobayashi H, Haraguchi M, Atobe Y, Funakoshi K, Iwama A, Takubo K, Okamoto S, Tamura T, Nakajima H: OGT Regulates Hematopoietic Stem Cell Maintenance via PINK1-Dependent Mitophagy. <strong><em>Cell Rep<\/em><\/strong> 34: 108579, 2021 (<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33406421\/\">PubMed<\/a>)<\/li>\n<li>Matsuki H, Hiroshima Y, Miyake K, Murakami T, Homma Y, Matsuyama R, Morioka D, Kurotaki D, Tamura T, Endo I: Reduction of gender-associated M2-like tumor-associated macrophages in the tumor microenvironment of patients with pancreatic cancer after neoadjuvant chemoradiotherapy. <strong><em>J Hepatobiliary Pancreat Sci<\/em><\/strong> 28(2): 174-182, 2021\uff08<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33316125\/\">PubMed<\/a>)<\/li>\n<\/ul>\n<\/div>\n<h4 id=\"7\">2020\u5e74<\/h4>\n<div id=\"list\">\n<ul>\n<li>Ochiai K, Yamaoka M, Swaminathan A, Shima H, Hiura H, Matsumoto M, Kurotaki D, Nakabayashi J, Funayama R, Nakayama K, Arima T, Ikawa T, Tamura T, Sciammas R, Bouvet P, Kundu TK, Igarashi K: Chromatin Protein PC4 Orchestrates B Cell Differentiation by Collaborating with IKAROS and IRF4. <strong><em>Cell Rep<\/em><\/strong> 33: 108517, 2020 (<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33357426\/\">PubMed<\/a>)<\/li>\n<li>Konishi H, Okamoto T, Hara Y, Komine O, Tamada H, Maeda M, Osako F, Kobayashi M, Nishiyama A, Kataoka Y, Takai T, Udagawa N, Jung S, Ozato K, Tamura T, Tsuda M, Yamanaka K, Ogi T, Sato K, Kiyama H: Astrocytic phagocytosis is a compensatory mechanism for microglial dysfunction. <strong><em>EMBO J<\/em><\/strong> 39(22): e104464, 2020 (<a target=\"_blank\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32959911\/\" rel=\"noopener noreferrer\">PubMed<\/a>)<\/li>\n<li>Kurotaki D, Yoshida H, Tamura T: Epigenetic and transcriptional regulation of osteoclast differentiation. <strong><em>Bone<\/em><\/strong> 138: 115471, 2020 (<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32526404\/\">PubMed<\/a>)<\/li>\n<li>Hiromi T, Yokoyama U, Kurotaki D, Mamun A, Ishiwata R, Ichikawa Y, Nishihara H, Umemura M, Fujita T, Yasuda S, Minami T, Goda M, Uchida K, Suzuki S, Takeuchi I, Masuda M, Breyer RM, Tamura T, Ishikawa Y: Excessive EP4 signaling in smooth muscle cells induces abdominal aortic aneurysm by amplifying inflammation. <strong><em>Arterioscler Thromb Vasc Biol <\/em><\/strong>40(6): 1559-1573, 2020 (<a target=\"_blank\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32321307\/\" rel=\"noopener\">PubMed<\/a>)<\/li>\n<li>Matsunaga S, Jeremiah SS, Miyakawa K, Kurotaki D, Shizukuishi S, Watashi K, Nishitsuji H, Kimura H, Tamura T, Yamamoto N, Shimotohno K, Wakita T, Ryo A: Engineering Cellular Biosensors with Customizable Antiviral Responses Targeting Hepatitis B Virus. <strong><em>iScience<\/em><\/strong> 23: 100867, 2020 (<a target=\"_blank\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/32105634\" rel=\"noopener noreferrer\">PubMed<\/a>)<\/li>\n<li>\u9ed2\u6edd\u5927\u7ffc, \u7530\u6751\u667a\u5f66: \u8ee2\u5199\u56e0\u5b50IRF8\u306b\u3088\u308b\u6a39\u72b6\u7d30\u80de\u5206\u5316\u306e\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30c3\u30af\u5236\u5fa1. <strong><em>\u8840\u6db2\u5185\u79d1<\/em><\/strong> 80(1): 96-100, 2020<\/li>\n<\/ul>\n<\/div>\n<h4 id=\"8\">2019\u5e74<\/h4>\n<div id=\"list\">\n<ul>\n<li>Guiliams M, Tamura T: Decrypting DC development. <strong><em>Nat Immunol<\/em><\/strong> 20: 1090-1092, 2019 (<a target=\"_blank\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/31406381\" rel=\"noopener noreferrer\">PubMed<\/a>)<\/li>\n<li>\u7530\u6751\u667a\u5f66, \u9ed2\u6edd\u5927\u7ffc: \u9020\u8840\u306b\u304a\u3051\u308b\u30b7\u30f3\u30b0\u30eb\u30bb\u30eb\u89e3\u6790\u306e\u9032\u6b69. <strong><em>\u81e8\u5e8a\u8840\u6db2<\/em><\/strong> 60:1075-1083, 2019 (<a target=\"_blank\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/31597830\" rel=\"noopener noreferrer\">PubMed<\/a>)<\/li>\n<li>\u9ed2\u6edd\u5927\u7ffc, \u4f50\u3005\u6728\u60a0, \u7530\u6751\u667a\u5f66: UP-TO-DATE\u8d64\u813e\u9ac4\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8. <strong><em>\u8840\u6db2\u5185\u79d1<\/em><\/strong>78(6): 751-757, 2019<\/li>\n<li>Kobayakawa K, Ohkawa Y, Yoshizaki S, Tamaru T, Saito T, Kijima K, Yokota K, Hara M, Kubota M, Matsumoto M, Harimaya K, Ozato K, Masuda T, Tsuda M, Tamura T, Inoue K, Edgerton VR, Iwamoto Y, Nakashima Y, Okada S: Macrophage centripetal migration drives spontaneous healing process after spinal cord injury. <strong><em>Sci Adv<\/em><\/strong> 5: eaav5086, 2019 (<a target=\"_blank\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/31106270\" rel=\"noopener noreferrer\">PubMed<\/a>)<\/li>\n<li>Miyakawa K, Matsunaga S, Yokoyama M, Nomaguchi M, Kimura Y, Nishi M, Kimura H, Sato H, Hirano H, Tamura T, Akari H, Miura T, Adachi A, Sawasaki T, Yamamoto N, Ryo A: PIM kinases facilitate lentiviral evasion from SAMHD1 restriction via Vpx phosphorylation. <strong><em>Nat Commun<\/em><\/strong> 10: 1844, 2019 (<a target=\"_blank\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/31015445\" rel=\"noopener noreferrer\">PubMed<\/a>)<\/li>\n<li>Kurotaki D*, Kawase W*, Sasaki H, Nakabayashi J, Nishiyama A, Morse HC III, Ozato K, Suzuki Y, Tamura T: Epigenetic control of early dendritic cell lineage specification by the transcription factor IRF8 in mice. <strong><em>Blood<\/em><\/strong> 133: 1803-1813, 2019(*equal contributors) (<a target=\"_blank\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/30796024\" rel=\"noopener noreferrer\">PubMed<\/a>)(<a target=\"_blank\" href=\"http:\/\/www.bloodjournal.org\/content\/133\/17\/1795\" rel=\"noopener noreferrer\">Commentary<\/a>)(<a target=\"_blank\" href=\"https:\/\/www.yokohama-cu.ac.jp\/amedrc\/news\/201902kurotaki.html\" rel=\"noopener noreferrer\">\u30d7\u30ec\u30b9\u30ea\u30ea\u30fc\u30b9<\/a>)<\/li>\n<li>Bachu M, Tamura T, Chen C, Narain A, Nehru V, Sarai N, Ghosh SB, Ghosh A, Kavarthapu R, Dufau ML, Ozato K: A versatile mouse model of epitope-tagged histone H3.3 to study epigenome dynamics. <strong><em>J Biol Chem<\/em><\/strong> 294: 1904-1914, 2019 (<a target=\"_blank\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/30552116\" rel=\"noopener noreferrer\">PubMed<\/a>)<\/li>\n<li>Izawa N*, Kurotaki D*, Nomura S*, Fujita T, Omata Y, Yasui T, Hirose J, Matsumoto T, Saito T, Kadono Y, Okada H, Miyamoto T, Tamura T, Aburatani H, Tanaka S: Cooperation of PU.1 with IRF8 and NFATc1 defines chromatin landscapes during RANKL-induced osteoclastogenesis. <strong><em>J Bone Miner Res<\/em><\/strong> 34: 1143-1154, 2019 (*equal contributors) (<a target=\"_blank\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/30721543\" rel=\"noopener noreferrer\">PubMed<\/a>)(<a target=\"_blank\" href=\"https:\/\/onlinelibrary.wiley.com\/doi\/abs\/10.1002\/jbmr.3689\" rel=\"noopener noreferrer\">Wiley Online Library<\/a>)<\/li>\n<\/ul>\n<\/div>\n<h4 id=\"9\">2018\u5e74<\/h4>\n<div id=\"list\">\n<ul>\n<li>Kamada R, Yang W, Zhang Y, Patel MC, Yang Y, Ouda R, Dey A, Wakabayashi Y, Sakaguchi K, Fujita T, Tamura T, Zhu J, Ozato K: Interferon stimulation creates chromatin marks and establishes transcriptional memory. <strong><em>Proc Natl Acad Sci USA<\/em><\/strong> 115: E9162\u2013E9171, 2018 (<a target=\"_blank\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/30201712\" rel=\"noopener noreferrer\">PubMed<\/a>)<\/li>\n<li>\u85e9 \u9f8d\u99ac, \u7530\u6751\u667a\u5f66: TLR-MyD88\u7d4c\u8def\u3068\u5168\u8eab\u6027\u30a8\u30ea\u30c6\u30de\u30c8\u30fc\u30c7\u30b9\u306b\u304a\u3051\u308b\u8ee2\u5199\u56e0\u5b50IRF5\u306e\u5236\u5fa1\u3068\u5f79\u5272. <strong><em>\u533b\u5b66\u306e\u3042\u3086\u307f<\/em><\/strong> 265: 1185-1191, 2018<\/li>\n<li>Ban T, Sato GR, Tamura T: Regulation and role of the transcription factor IRF5 in innate immune responses and systemic lupus erythematosus. <strong><em>Int Immunol<\/em><\/strong> 30: 529-536, 2018 (<a target=\"_blank\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29860420\" rel=\"noopener noreferrer\">PubMed<\/a>)(<a target=\"_blank\" href=\"https:\/\/academic.oup.com\/intimm\/advance-article\/doi\/10.1093\/intimm\/dxy032\/5026002\" rel=\"noopener noreferrer\">Oxford University Press<\/a>)<\/li>\n<li>\u85e9 \u9f8d\u99ac: \u5168\u8eab\u6027\u30a8\u30ea\u30c6\u30de\u30c8\u30fc\u30c7\u30b9\u306e\u6cbb\u7642\u6cd5\u958b\u767a\u306b\u5411\u3051\u305f\u81ea\u7136\u514d\u75ab\u5fdc\u7b54\u5236\u5fa1\u6a5f\u69cb\u306e\u89e3\u660e. <strong><em>\u6a2a\u6d5c\u533b\u5b66<\/em><\/strong> 69: 59-65, 2018<\/li>\n<li>Kurotaki D, Nakabayashi J, Nishiyama A, Sasaki H, Kawase W, Kaneko N, Ochiai K, Igarashi K, Ozato K, Suzuki Y, Tamura T: Transcription factor IRF8 governs enhancer landscape dynamics in mononuclear phagocyte progenitors. <strong><em>Cell Rep<\/em><\/strong> 22: 2628\u20132641, 2018 (<a target=\"_blank\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29514092\" rel=\"noopener noreferrer\">PubMed<\/a>)(<a target=\"_blank\" href=\"https:\/\/www.yokohama-cu.ac.jp\/amedrc\/news\/20180307Kurotaki.html\" rel=\"noopener noreferrer\">\u30d7\u30ec\u30b9\u30ea\u30ea\u30fc\u30b9<\/a>)(<a target=\"_blank\" href=\"https:\/\/immunol.med.yokohama-cu.ac.jp\/chromatinatlas\/\" rel=\"noopener noreferrer\">Myeloid Chromatin Atlas<\/a>)<\/li>\n<li>Haruhara K, Wakui H, Azushima K, Kurotaki D, Kawase W, Uneda K, Haku S, Kobayashi R, Ohki K, Kinguchi S, Ohsawa M, Minegishi S, Ishigami T, Matsuda M, Yamashita A, Nakajima H, Tamura T, Tsuboi N, Yokoo T, Tamura K: Angiotensin receptor-binding molecule in leukocytes in association with the systemic and leukocyte inflammatory profile. <strong><em>Atherosclerosis<\/em><\/strong> 269: 236-244, 2018 (<a target=\"_blank\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29407599\" rel=\"noopener noreferrer\">PubMed<\/a>)<\/li>\n<\/ul>\n<\/div>\n<h4 id=\"10\">2017\u5e74<\/h4>\n<div id=\"list\">\n<ul>\n<li>\u9ed2\u6edd\u5927\u7ffc, \u7530\u6751\u667a\u5f66: \u8840\u7403\u7cfb\u7d30\u80de\u306e\u30b7\u30f3\u30b0\u30eb\u30bb\u30eb\u89e3\u6790\u306e\u305f\u3081\u306e\u7d30\u80de\u5206\u53d6. <strong><em>\u5b9f\u9a13\u533b\u5b66 <\/em><\/strong>\u5225\u518a: 80-90, 2017<\/li>\n<li>\u7530\u6751\u667a\u5f66: \u8ee2\u5199\u56e0\u5b50IRF8\u306b\u3088\u308b\u5358\u6838\u8caa\u98df\u7d30\u80de\u306e\u5206\u5316\u5236\u5fa1. <strong><em>\u81e8\u5e8a\u8840\u6db2<\/em><\/strong> 58(7): 798-805, 2017 (<a target=\"_blank\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28781277\" rel=\"noopener noreferrer\">PubMed<\/a>)(<a target=\"_blank\" href=\"https:\/\/www.jstage.jst.go.jp\/article\/rinketsu\/58\/7\/58_798\/_article\/-char\/ja\/\" rel=\"noopener noreferrer\">J-STAGE<\/a>)<\/li>\n<li>Sato GR, Ban T, Tamura T: Phos-tag immunoblot analysis for detecting IRF5 phosphorylation. <strong><em>Bio-protocol<\/em><\/strong> 7(10): e2295, 2017 (<a target=\"_blank\" href=\"http:\/\/www.bio-protocol.org\/e2295\" rel=\"noopener noreferrer\">\u8ad6\u6587\u60c5\u5831<\/a>)<\/li>\n<li>\u85e9\u9f8d\u99ac, \u7530\u6751\u667a\u5f66: \u8ee2\u5199\u56e0\u5b50IRF5\u306e\u6d3b\u6027\u3092\u9078\u629e\u7684\u306b\u963b\u5bb3\u3059\u308b\u5206\u5b50Lyn\u306e\u540c\u5b9a\u3068\u5168\u8eab\u6027\u30a8\u30ea\u30c6\u30de\u30c8\u30fc\u30c7\u30b9. <strong><em>\u81e8\u5e8a\u514d\u75ab\u30fb\u30a2\u30ec\u30eb\u30ae\u30fc\u79d1<\/em><\/strong> 67(5): 532-538, 2017<\/li>\n<li>Kurotaki D, Sasaki H, Tamura T: Transcriptional control of monocyte and macrophage development. <strong><em>Int Immunol<\/em><\/strong> 29(3): 97-107, 2017 (<a target=\"_blank\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28379391\" rel=\"noopener noreferrer\">PubMed<\/a>)(<a target=\"_blank\" href=\"https:\/\/academic.oup.com\/intimm\/article\/29\/3\/97\/3098307\" rel=\"noopener noreferrer\">Oxford University Press<\/a>)<\/li>\n<li>Saito E, Suzuki D, Kurotaki D, Mochizuki A, Manome Y, Suzawa T, Toyoshima Y, Ichikawa T, Funatsu T, Inoue T, Takami M, Tamura T, Inagaki K, Kamijo R: Down-regulation of Irf8 by Lyz2-cre\/loxP accelerates osteoclast differentiation in vitro. <strong><em>Cytotechnology<\/em><\/strong> 69(3): 443-450, 2017 (<a target=\"_blank\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27502007\" rel=\"noopener noreferrer\">Pubmed<\/a>)<\/li>\n<li>\u9ed2\u6edd\u5927\u7ffc, \u4f50\u3005\u6728\u60a0, \u7530\u6751\u667a\u5f66: \u8d64\u813e\u9ac4\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u306e\u5206\u5316\u3068\u6a5f\u80fd. <strong><em>\u7d30\u80de <\/em><\/strong>49(4): 163-166, 2017<\/li>\n<\/ul>\n<\/div>\n<h4 id=\"11\">2016\u5e74<\/h4>\n<div id=\"list\">\n<ul>\n<li>\u7530\u6751\u667a\u5f66, \u897f\u5c71\u6643: \u8ee2\u5199\u56e0\u5b50\u306b\u3088\u308b\u30df\u30a8\u30ed\u30a4\u30c9\u7cfb\u7d30\u80de\u306e\u5206\u5316\u5236\u5fa1. <strong><em>\u65e5\u672c\u81e8\u5e8a<\/em><\/strong> 74(\u5897\u520a\u53f710): 481-486, 2016<\/li>\n<li>Miyake N, Fukui R, Ohba C, Chihara T, Miura M, Shimizu H, Kakita A, Imagawa E, Shiina M, Ogata K, Okuno-Yuguchi J, Fueki N, Ogiso Y, Suzumura H, Watabe Y, Imataka G, Leong HY, Fattal-Valevski A, Kramer U, Miyatake S, Kato M, Okamoto N, Sato Y, Mitsuhashi S, Nishino I, Kaneko N, Nishiyama A, Tamura T, Mizuguchi T, Nakashima M, Tanaka F, Saitsu H, Matsumoto N: Biallelic TBCD Mutations Cause Early-Onset Neurodegenerative Encephalopathy. <strong><em>Am J Hum Genet<\/em><\/strong> 99, 950-961, 2016 (<a target=\"_blank\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27666374\" rel=\"noopener noreferrer\">PubMed<\/a>)<\/li>\n<li>Ban T*, Sato GR*, Nishiyama A, Akiyama A, Takasuna M, Umehara M, Suzuki S, Ichino M, Matsunaga S, Kimura A, Kimura Y, Yanai H, Miyashita S, Kuromitsu J, Tsukahara K, Yoshimatsu K, Endo I, Yamamoto T, Hirano H, Ryo A, Taniguchi T, Tamura T: Lyn Kinase Suppresses the Transcriptional Activity of IRF5 in the TLR-MyD88 Pathway to Restrain the Development of Autoimmunity. <strong><em>Immunity<\/em><\/strong> 45, 319\u2013332, 2016 (*equal contributors)(<a target=\"_blank\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27521268\" rel=\"noopener noreferrer\">PubMed<\/a>)(<a target=\"_blank\" href=\"https:\/\/www.yokohama-cu.ac.jp\/amedrc\/news\/20160810.html\" rel=\"noopener noreferrer\">\u30d7\u30ec\u30b9\u30ea\u30ea\u30fc\u30b9<\/a>)(<a target=\"_blank\" href=\"http:\/\/first.lifesciencedb.jp\/archives\/13227\" rel=\"noopener noreferrer\">\u65b0\u7740\u8ad6\u6587\u30ec\u30d3\u30e5\u30fc<\/a>)<\/li>\n<li>Yamamizu K, Sharov AA, Piao Y, Amano M, Yu H, Nishiyama A, Dudekula DB, Schlessinger D, Ko MS: Generation and gene expression profiling of 48 transcription-factor-inducible mouse embryonic stem cell lines. <strong><em>Sci Rep<\/em><\/strong> 6, 25667, 2016 (<a target=\"_blank\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27150017\" rel=\"noopener noreferrer\">PubMed<\/a>)<\/li>\n<li>Kurotaki D, Tamura T: Transcriptional and epigenetic regulation of innate immune cell development by the transcription factor IRF8. <strong><em>J Interferon Cytokine Res<\/em><\/strong> 36, 433-441, 2016 (<a target=\"_blank\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27379865\" rel=\"noopener noreferrer\">PubMed<\/a>)<\/li>\n<li>Sasaki H, Kurotaki D, Tamura T: Regulation of basophil and mast cell development by transcription factors. <strong><em>Allergol Int<\/em><\/strong> 65, 127-134, 2016 (<a target=\"_blank\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26972050\" rel=\"noopener noreferrer\">PubMed<\/a>)<\/li>\n<\/ul>\n<\/div>\n<h4 id=\"12\">2015\u5e74<\/h4>\n<div id=\"list\">\n<ul>\n<li>Suzuki S, Ichikawa Y, Nakagawa K, Kumamoto T, Mori R, Matsuyama R, Takeda K, Ota M, Tanaka K, Tamura T, Endo I: High infiltration of mast cells positive to tryptase predicts worse outcome following resection of colorectal liver metastases. <strong><em>BMC Cancer<\/em><\/strong> 15: 840, 2015 (<a target=\"_blank\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26530140\" rel=\"noopener noreferrer\">PubMed<\/a>)<\/li>\n<li>\u7530\u6751\u667a\u5f66, \u5c0f\u6cc9\u771f\u4e00, \u9ed2\u6edd\u5927\u7ffc: \u30df\u30a8\u30ed\u30a4\u30c9\u7cfb\u7d30\u80de\u306e\u5206\u5316\u3068\u8ee2\u5199\u56e0\u5b50. <strong><em>\u81e8\u5e8a\u8840\u6db2<\/em><\/strong> 56(10): 1861-1870, 2015 (<a target=\"_blank\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26458423\" rel=\"noopener noreferrer\">PubMed<\/a>)<\/li>\n<li>Kato Y, Yokoyama U, Yanai C, Ishige R, Kurotaki D, Umemura M, Fujita T, Kubota T, Okumura S, Sata M, Tamura T, Ishikawa Y: Epac1 Deficiency Attenuated Vascular Smooth Muscle Cell Migration and Neointimal Formation. <strong><em>Arterioscler<\/em><\/strong> <strong>Thromb Vasc Biol<\/strong> 35, 2617-2625, 2015 (<a target=\"_blank\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26427796\" rel=\"noopener noreferrer\">PubMed<\/a>)<\/li>\n<li>Masuda T, Iwamoto S, Mikuriya S, Tozaki-Saitoh H, Tamura T, Tsuda M, Inoue K: Transcription factor IRF1 is responsible for IRF8-mediated IL-1\u03b2 expression in reactive microglia. <strong><em>J Pharmacol Sci<\/em><\/strong> 128, 216-220, 2015 (<a target=\"_blank\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26318672\" rel=\"noopener noreferrer\">PubMed<\/a>)<\/li>\n<li>\u4f50\u3005\u6728\u60a0, \u9ed2\u6edd\u5927\u7ffc, \u7530\u6751\u667a\u5f66: \u8ee2\u5199\u56e0\u5b50IRF8\u306b\u3088\u308b\u597d\u5869\u57fa\u7403\u3068\u30de\u30b9\u30c8\u7d30\u80de\u306e\u5206\u5316\u5236\u5fa1. <strong><em>\u81e8\u5e8a\u514d\u75ab\u30fb\u30a2\u30ec\u30eb\u30ae\u30fc\u79d1<\/em><\/strong> 63(6): 593-596, 2015<\/li>\n<li>Miyakawa K, Matsunaga S, Kanou K, Matsuzawa A, Morishita R, Kudoh A, Shindo K, Yokoyama M, Sato H, Kimura H, Tamura T, Yamamoto N, Ichijo H, Takaori-Kondo A, Ryo A: ASK1 restores the antiviral activity of APOBEC3G by disrupting HIV-1 Vif-mediated counteraction. <strong><em>Nat Commun<\/em><\/strong> 6, 6945, 2015 (<a target=\"_blank\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25901786\" rel=\"noopener noreferrer\">PubMed<\/a>)<\/li>\n<li>Yamashita N, Jitsuki-Takahashi A, Ogawara M, Ohkubo W, Araki T, Hotta C, Tamura T, Hashimoto SI, Yabuki T, Tsuji T, Sasakura Y, Okumura H, Takaiwa A, Koyama C, Murakami K, Goshima Y: Anti-Semaphorin 3A neutralization monoclonal antibody prevents sepsis development in\u3000lipopolysaccharide-treated mice. <strong><em>Int Immunol<\/em><\/strong> 27, 459-466, 2015 (<a target=\"_blank\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25855660\" rel=\"noopener noreferrer\">PubMed<\/a>)<\/li>\n<li>Tamura T: Guest editorial: Transcriptional control in myeloid cell development and related diseases. <strong><em>Int J Hematol<\/em><\/strong> 101, 317-318, 2015 (<a target=\"_blank\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25753224\" rel=\"noopener noreferrer\">PubMed<\/a>)<\/li>\n<li>Tamura T, Kurotaki D, Koizumi S: Regulation of myelopoiesis by the transcription factor IRF8. <strong><em>Int J Hematol<\/em><\/strong> 101, 342-351, 2015 (<a target=\"_blank\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25749660\" rel=\"noopener noreferrer\">PubMed<\/a>)<\/li>\n<li>Kurotaki D, Uede T, Tamura T: Functions and development of red pulp macrophages. <strong><em>Microbial Immunol<\/em><\/strong> 59, 55-62, 2015 (<a target=\"_blank\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25611090\" rel=\"noopener noreferrer\">PubMed<\/a>)<\/li>\n<li>Sasaki H*, Kurotaki D*, Osato N, Sato H, Sasaki I, Koizumi S, Wang H, Kaneda C, Nishiyama A, Kaisho T, Aburatani H, Morse HC 3rd, Ozato K, Tamura T: Transcription factor IRF8 plays a critical role in the development of murine basophils and mast cells. <strong><em>Blood<\/em><\/strong> 125, 358-369, 2015 (*equal contributors)(<a target=\"_blank\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25398936\" rel=\"noopener noreferrer\">PubMed<\/a>)(<a target=\"_blank\" href=\"https:\/\/www.yokohama-cu.ac.jp\/amedrc\/news\/20141120.html\" rel=\"noopener noreferrer\">\u30d7\u30ec\u30b9\u30ea\u30ea\u30fc\u30b9<\/a>)<\/li>\n<\/ul>\n<\/div>\n<h4 id=\"13\">2014\u5e74<\/h4>\n<div id=\"list\">\n<ul>\n<li>\u5c0f\u6cc9\u771f\u4e00, \u7530\u6751\u667a\u5f66: \u8ee2\u5199\u56e0\u5b50\u306b\u3088\u308b\u6a39\u72b6\u7d30\u80de\u306e\u5206\u5316\u5236\u5fa1. <strong><em>\u81e8\u5e8a\u514d\u75ab\u30fb\u30a2\u30ec\u30eb\u30ae\u30fc\u79d1<\/em><\/strong> 62(5): 510-518, 2014<\/li>\n<li>Akagi T, Matsumura Y, Yasui M, Minami E, Inoue H, Masuda T, Tozaki-Saitoh H, Tamura T, Mizumura K, Tsuda M, Kiyama H, Inoue K: Interferon regulatory factor 8 expressed in microglia contributes to tactile allodynia induced by repeated cold stress in rodents. <strong><em>J Pharmacol Sci<\/em><\/strong> 126, 172-176, 2014 (<a target=\"_blank\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25273233\" rel=\"noopener noreferrer\">PubMed<\/a>)<\/li>\n<li>Kurotaki D*, Yamamoto M*, Nishiyama A, Uno K, Ban T, Ichino M, Sasaki H, Matsunaga S, Yoshinari M, Ryo A, Nakazawa M, Ozato K, Tamura T: IRF8 inhibits C\/EBP\u03b1 activity to restrain mononuclear phagocyte progenitors from differentiating into neutrophils. <strong><em>Nat Commun<\/em><\/strong> 5, 4978, 2014 (*equal contributors)(<a target=\"_blank\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25236377\" rel=\"noopener noreferrer\">PubMed<\/a>)(<a target=\"_blank\" href=\"https:\/\/www.yokohama-cu.ac.jp\/amedrc\/news\/20140919.html\" rel=\"noopener noreferrer\">\u30d7\u30ec\u30b9\u30ea\u30ea\u30fc\u30b9<\/a>)<\/li>\n<li>Chiba S, Ikushima H, Ueki H, Yanai H, Kimura Y, Hangai S, Nishio J, Negishi H, Tamura T, Saijo S, Iwakura Y, Taniguchi T: Recognition of tumor cells by Dectin-1 orchestrates innate immune cells for anti-tumor responses. <strong><em>eLife<\/em><\/strong> 3, e04177, 2014 (<a target=\"_blank\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25149452\" rel=\"noopener noreferrer\">PubMed<\/a>)<\/li>\n<li>Sharov AA, Nishiyama A, Qian Y, Dudekula D, Longo DL, Schlessinger D, Ko MSH: Chromatin properties of regulatory DNA probed by manipulation of transcription factors. <strong><em>J Comput Biol<\/em><\/strong> 21, 569-577, 2014 (<a target=\"_blank\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24918633\" rel=\"noopener noreferrer\">PubMed<\/a>)<\/li>\n<li>Masuda T, Iwamoto S, Yoshinaga R, Tozaki-Saitoh H, Nishiyama A, Mak TW, Tamura T, Tsuda M, Inoue K: Transcription factor IRF5 drives P2X4R(+)-reactive microglia gating neuropathic pain. <strong><em>Nat Commun<\/em><\/strong> 5, 3771, 2014 (<a target=\"_blank\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24818655\" rel=\"noopener noreferrer\">PubMed<\/a>)<\/li>\n<li>Masuda T, Nishimoto N, Tomiyama D, Matsuda T, Tozaki-Saitoh H, Tamura T, Kohsaka S, Tsuda M, Inoue K: IRF8 is a transcriptional determinant for microglial motility. <strong><em>Purinergic Signal<\/em><\/strong> 10, 515-521, 2014 (<a target=\"_blank\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24798612\" rel=\"noopener noreferrer\">PubMed<\/a>)<\/li>\n<li>Ito K, Morimoto J, Kihara A, Matsui Y, Kurotaki D, Kanayama M, Simmons S, Ishii M, Sheppard D, Takaoka A, Uede T: Integrin \u03b19 on lymphatic endothelial cells regulates lymphocyte egress. <strong><em>Proc Natl Acad Sci USA<\/em><\/strong> 111, 3080-3085, 2014 (<a target=\"_blank\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24516133\" rel=\"noopener noreferrer\">PubMed<\/a>)<\/li>\n<\/ul>\n<\/div>\n<h4 id=\"14\">2013\u5e74<\/h4>\n<div id=\"list\">\n<ul>\n<li>Watanabe T*, Hotta C*, Koizumi S, Miyashita K, Nakabayashi J, Kurotaki D, Sato GR, Yamamoto M, Nakazawa M, Fujita H, Sakai R, Fujisawa S, Nishiyama A, Ikezawa Z, Aihara M, Ishigatsubo Y, Tamura T: The transcription factor IRF8 counteracts BCR-ABL to rescue dendritic cell development in chronic myeloid leukemia. <strong><em>Cancer Res<\/em><\/strong> 73, 6642-6653, 2013 (*equal contributors)(<a target=\"_blank\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24242069\" rel=\"noopener noreferrer\">PubMed<\/a>)(<a target=\"_blank\" href=\"PDF\/1310_press_release.pdf\" rel=\"noopener noreferrer\">\u30d7\u30ec\u30b9\u30ea\u30ea\u30fc\u30b9<\/a>)<\/li>\n<li>\u9ed2\u6edd\u5927\u7ffc, \u7530\u6751\u667a\u5f66: IRF8-KLF4\u8ee2\u5199\u56e0\u5b50\u30ab\u30b9\u30b1\u30fc\u30c9\u306b\u3088\u308b\u5358\u7403\u5206\u5316\u5236\u5fa1. <strong><em>\u5b9f\u9a13\u533b\u5b66 <\/em><\/strong> 31(18): 2971-2975, 2013<\/li>\n<li>Sarai N, Nimura K, Tamura T, Kanno T, Patel MC, Heightman TD, Ura K, Ozato K: WHSC1 links transcription elongation to HIRA-mediated histone H3.3 deposition. <strong><em>EMBO J<\/em><\/strong> 32, 2392-2406, 2013 (<a target=\"_blank\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23921552\" rel=\"noopener noreferrer\">PubMed<\/a>)<\/li>\n<li>Patel MC, Debrosse M, Smith M, Dey A, Huynh W, Sarai N, Heightman TD, Tamura T, Ozato K: BRD4 coordinates recruitment of pause-release factor P-TEFb and the pausing complex NELF\/DSIF to regulate transcription elongation of interferon stimulated genes. <strong><em>Mol Cell Biol<\/em><\/strong> 33, 2497-2507, 2013 (<a target=\"_blank\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23589332\" rel=\"noopener noreferrer\">PubMed<\/a>)<\/li>\n<li>Nishiyama A, Sharov AA, Piao Y, Amano M, Amano T, Hoang H, Binder BY, Tapnio R, Bassey U, Malinou J, Correa-Cerro LS, Yu H, Xin L, Meyers E, Zalzman M, Nakatake Y, Stagg C, Sharova L, Qian Y, Dudekula D, Sheer S, Cadet JS, Hirata T, Yang HT, Goldberg I, Evans MK, Longo DL, Schlessinger D, Ko MS: Systematic repression of transcription factors reveals limited patterns of gene expression changes in ES cells. <strong><em>Sci Rep<\/em><\/strong> 3, 1390, 2013 (<a target=\"_blank\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23462645\" rel=\"noopener noreferrer\">PubMed<\/a>)<\/li>\n<li>Iwasaki Y, Fujio K, Okamura T, Yanai A, Sumitomo S, Shoda H, Tamura T, Yoshida H, Charnay P, Yamamoto K: Egr-2 transcription factor is required for Blimp-1 mediated IL-10 production in IL-27 stimulated CD4(+) T cells. <strong><em>Eur J Immunol<\/em><\/strong> 43, 1-11, 2013 (<a target=\"_blank\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23349024\" rel=\"noopener noreferrer\">PubMed<\/a>)<\/li>\n<li>*Kurotaki D, *Osato N, *Nishiyama A, *Yamamoto M, Ban T, Sato H, Nakabayashi J, Umehara M, Miyake N, Matsumoto N, Nakazawa M, Ozato K, Tamura T: Essential role of the IRF8-KLF4 transcription factor cascade in murine monocyte differentiation. <strong><em>Blood<\/em><\/strong> 121, 1839-1849, 2013 (*equal contributors)(<a target=\"_blank\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23319570\" rel=\"noopener noreferrer\">PubMed<\/a>)(<a target=\"_blank\" href=\"PDF\/130115_press_release.pdf\" rel=\"noopener noreferrer\">\u30d7\u30ec\u30b9\u30ea\u30ea\u30fc\u30b9<\/a>)<\/li>\n<\/ul>\n<\/div>\n<h4 id=\"15\">2012\u5e74<\/h4>\n<div id=\"list\">\n<ul>\n<li>Nishiyama A, Dey A, Tamura T, Ko M, Ozato K: Activation of JNK triggers release of Brd4 from mitotic chromosomes and mediates protection from drug-induced mitotic stress. <strong><em>PLoS ONE<\/em><\/strong> 7, e34719, 2012 (<a target=\"_blank\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22567088\" rel=\"noopener noreferrer\">PubMed<\/a>)<\/li>\n<li>Masuda T, Tsuda M, Yoshinaga R, Tozaki-Saitoh H, Ozato K, Tamura T, Inoue K: IRF8 is a critical transcription factor for transforming microglia into a reactive phenotype. <strong><em>Cell Rep<\/em><\/strong> 1, 334-340, 2012 (<a target=\"_blank\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22832225\" rel=\"noopener noreferrer\">PubMed<\/a>)<\/li>\n<li>Danzaki K, Matsui Y, Ikesue M, Ohta D, Ito K, Kanayama M, Kurotaki D, Morimoto J, Iwakura Y, Yagita H, Tsutsui H, Uede T: Interleukin-17A deficiency accelerates unstable atherosclerotic plaque formation in apolipoprotein E-Deficient mice. <strong><em>Arterioscler Thromb Vasc Biol<\/em><\/strong> 32 (2) : 273-280, 2012 (<a target=\"_blank\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22116098\" rel=\"noopener noreferrer\">PubMed<\/a>)<\/li>\n<li>Nakabayashi J: Optimal ratio of scaffold complex to free Fus3 to maximise the accumulation of phosphorylated Fus3 in yeast pheromone signaling pathway. <strong><em>IET Syst Biol<\/em><\/strong> 6 (1) : 9-21, 2012 (<a target=\"_blank\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22360267\" rel=\"noopener noreferrer\">PubMed<\/a>)<\/li>\n<li>Koizumi S, Masuko K, Wakita D, Tanaka S, Mitamura R, Kato Y, Tabata H, Nakahara M, Kitamura H, Nishimura T: Extracts of Larix Leptolepsis effectively augments the generation of tumor antigen-specific cytotoxic T lymphocytes via activation of dendritic cells in TLR-2 and TLR-4-dependent manner. <strong><em>Cell Immunol<\/em><\/strong> 276 (1-2) : 153-161, 2012 (<a target=\"_blank\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22677561\" rel=\"noopener noreferrer\">PubMed<\/a>)<\/li>\n<li>Yoshida T, Katsuya K, Oka T, Koizumi S, Wakita D, Kitamura H, Nishimura T: Effects of AhR ligands on the production of immunoglobulins in purified mouse B cells. <strong><em>Biomed Res<\/em><\/strong> 33 (2) : 67-74, 2012 (<a target=\"_blank\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22572380\" rel=\"noopener noreferrer\">PubMed<\/a>)<\/li>\n<li>Nakabayashi J: A compartmentalization model of hepatitis C virus replication: an appropriate distribution of HCV RNA for the effective replication. <strong><em>J Theor Biol<\/em><\/strong> 300: 110-117, 2012 (<a target=\"_blank\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22286015\" rel=\"noopener noreferrer\">PubMed<\/a>)<\/li>\n<li>Kominami K, Nakabayashi J, Nagai T, Tsujimura Y, Chiba K, Kimura H, Miyawaki A, Sawasaki T, Yokota H, Manabe N, Sakamaki K: The molecular mechanism of apoptosis upon caspase-8 activation: quantitative experimental validation of a mathematical model. <strong><em>Biochim Biophys Acta<\/em><\/strong> 1823 (10) : 1825-1840, 2012 (<a target=\"_blank\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22801217\" rel=\"noopener noreferrer\">PubMed<\/a>)<\/li>\n<li>Kominami K, Nagai T, Sawasaki T, Tsujimura Y, Yashima K, Sunaga Y, Tsuchimochi M, Nishimura J, Chiba K, Nakabayashi J, Koyamada K, Endo Y, Yokota H, Miyawaki A, Manabe N, Sakamaki K: In vivo imaging of hierarchical spatiotemporal activation of caspase-8 during apoptosis. <strong><em>PLoS ONE<\/em><\/strong> 7 (11) : e50218, 2012 (<a target=\"_blank\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23185580\" rel=\"noopener noreferrer\">PubMed<\/a>)<\/li>\n<li>Yanai H, Ban T, Taniguchi T: High-mobility group box family of proteins: ligand and sensor for innate immunity. <strong><em>Trends Immunol<\/em><\/strong> 33 (12) : 633-640, 2012 (<a target=\"_blank\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23116548\" rel=\"noopener noreferrer\">PubMed<\/a>)<\/li>\n<li>\u68ee\u672c\u7d14\u5b50\uff0c\u9ed2\u6edd\u5927\u7ffc\uff0c\u4e0a\u51fa\u5229\u5149\uff1a\u8d64\u813e\u9ac4\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u306b\u3088\u308bT\u7d30\u80de\u306e\u6291\u5236\u3068\u305d\u306e\u6a5f\u5e8f. <strong><em>\u81e8\u5e8a\u514d\u75ab\u30fb\u30a2\u30ec\u30eb\u30ae\u30fc\u79d1<\/em><\/strong> 57 (2) : 203-210, 2012<\/li>\n<li>\u4e2d\u6b66\u60a0\u6a39\uff0c\u897f\u5c71\u6643\uff0c\u6d2a\u5b9f\uff1a\u8ee2\u5199\u8abf\u7bc0\u56e0\u5b50\u3092\u81ea\u5728\u306b\u8a98\u5c0e\u3067\u304d\u308bES\u7d30\u80de\u30d0\u30f3\u30af\u306e\u4f5c\u88fd\u3068\u305d\u306e\u5fdc\u7528. <strong><em>\u5b9f\u9a13\u533b\u5b66 \u5897\u520a<\/em><\/strong> 30 (10) : 1639-1645, 2012<\/li>\n<li>\u4e2d\u6797\u6f64\uff1a\u809d\u708e\u30a6\u30a4\u30eb\u30b9\u306e\u7d30\u80de\u5185\u8907\u88fd\u52d5\u614b\u306e\u6570\u7406\u30e2\u30c7\u30eb. <strong><em>\u5fdc\u7528\u6570\u7406<\/em><\/strong> 22 (3) : 173-182, 2012.<\/li>\n<\/ul>\n<\/div>\n<h4 id=\"16\">2011\u5e74<\/h4>\n<div id=\"list\">\n<ul>\n<li>Yamamoto M, Kato T, Hotta C, Nishiyama A, Kurotaki D, Yoshinari M, Takami M, Ichino M, Nakazawa M, Matsuyama T, Kamijo R, Kitagawa S, Ozato K, Tamura T: Shared and distinct functions of the transcription factors IRF4 and IRF8 in myeloid cell development. <strong><em>PLoS ONE<\/em><\/strong> 6, e25812, 2011 (<a target=\"_blank\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22003407\" rel=\"noopener noreferrer\">PubMed<\/a>)<\/li>\n<li>Sharov AA, Nishiyama A, Piao Y, Correa-Cerro LS, Amano, T, Thomas, M, Mehta S, Ko MSH: Responsiveness of genes to manipulation of transcription factors in ES cells is associated with histone modifications and tissue specificity. <strong><em>BMC Genomics<\/em><\/strong> 12: 102, 2011 (<a target=\"_blank\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21306619\" rel=\"noopener noreferrer\">PubMed<\/a>)<\/li>\n<li>Correa-Cerro LS, Piao Y, Sharov AA, Nishiyama A, Cadet JS, Yu H, Sharova LV, Xin L, Hoang HG, Thomas M, Qian Y, Dudekula DB, Meyers E, Binder BY, Mowrer G, Bassey U, Longo DL, Schlessinger D, Ko MSH: Generation of mouse ES cell lines engineered for the forced induction of transcription factors. <strong><em>Sci Rep<\/em><\/strong> 1: 167, 2011 (<a target=\"_blank\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22355682\" rel=\"noopener noreferrer\">PubMed<\/a>)<\/li>\n<li>Kanayama M, Morimoto J, Matsui Y, Danzaki K, Kurotaki D, Ito K, Yoshida T, Uede T: Alpha9beta1 integrin-mediated signaling serves as an intrinsic regulator of pathogenic Th17 cell generation. <strong><em>J Immunol<\/em><\/strong> 187(11): 5851-5864, 2011 (<a target=\"_blank\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22039306\" rel=\"noopener noreferrer\">PubMed<\/a>)<\/li>\n<li>Ikesue M, Matsui Y, Ohta D, Danzaki K, Ito K, Kanayama M, Kurotaki D, Morimoto J, Kojima T, Tsutsui H, Uede T: Syndecan-4 deficiency limits neointimal formation after vascular injury by regulating vascular smooth muscle cell proliferation and vascular progenitor cell mobilization. <strong><em>Arterioscler Thromb Vasc Biol<\/em><\/strong> 31(5): 1066-1074, 2011 (<a target=\"_blank\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21330609\" rel=\"noopener noreferrer\">PubMed<\/a>)<\/li>\n<li>Kurotaki D, Kon S, Bae K, Ito K, Matsui Y, Nakayama Y, Kanayama M, Kimura C, Narita Y, Nishimura T, Iwabuchi K, Mack M, van Rooijen N, Sakaguchi S, Uede T, Morimoto J: CSF-1 dependent red pulp macrophages regulate CD4 T cell responses. <strong><em>J Immunol<\/em><\/strong> 186(4): 2229-2237, 2011 (<a target=\"_blank\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21239712\" rel=\"noopener noreferrer\">PubMed<\/a>)<\/li>\n<\/ul>\n<\/div>\n<h4 id=\"17\">2010\u5e74<\/h4>\n<div id=\"list\">\n<ul>\n<li>\u5e02\u91ce\u7d20\u82f1, \u5800\u7530\u5343\u7d75, \u7530\u6751\u667a\u5f66: \u201c\u6cbb\u3089\u306a\u3044\u708e\u75c7\u201d\u304c\u5f15\u304d\u8d77\u3053\u3059\u75be\u60a3\u306e\u5206\u5b50\u6a5f\u69cb. <strong><em>\u7d30\u80de\u5de5\u5b66 <\/em><\/strong>29(8), 793-798, 2010<\/li>\n<li>Savitsky DA, Yanai H, Tamura T, Taniguchi T, Honda K: Contribution of IRF5 in B cells to the development of murine SLE-like disease through its transcriptional control of the IgG2a locus. <strong><em>Proc Natl Acad Sci USA<\/em><\/strong> 107, 10154-10159, 2010 (<a target=\"_blank\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20479222\" rel=\"noopener noreferrer\">PubMed<\/a>)<\/li>\n<li>Zalzman M, Falco G, Sharova LV, Nishiyama A, Thomas M, Lee SL, Stagg CA, Hoang HG, Yang HT, Indig FE, Wersto RP, Ko MS: Zscan4 regulates telomere elongation and genomic stability in ES cells. <strong><em>Nature<\/em><\/strong> 464(7290): 858-863, 2010 (<a target=\"_blank\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20336070\" rel=\"noopener noreferrer\">PubMed<\/a>)<\/li>\n<li>Jayaraman P, Sada-Ovalle I, Belladi S, Anderson AC, Dardalhon V, Hotta C, Kuchroo VK, Behar S: Tim3 binding to Galectin-9 stimulates antimicrobial immunity. <strong><em>J Exp Med<\/em><\/strong> 207(11): 2343-2354, 2010 (<a target=\"_blank\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20937702\" rel=\"noopener noreferrer\">PubMed<\/a>)<\/li>\n<li>Wang HB, Kondo A, Yoshida A, Yoshizaki S, Abe S, Bao LL, Mizuki N, Ichino M, Klinman D, Okuda K, Shimada M: Partial protection against SIV challenge by vaccination of adenovirus and MVA vectors in rhesus monkeys. <strong><em>Gene Ther<\/em><\/strong> 17(1): 4-13, 2010 (<a target=\"_blank\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19759567\" rel=\"noopener noreferrer\">PubMed<\/a>)<\/li>\n<li>Shimada M, Yoshizaki S, Jounai N, Kondo A, Ichino M, Ryo A, Okuda K: DNA vaccine expressing HIV-1 gp120\/immunoglobulin fusion protein enhances cellular immunity. <strong><em>Vaccine<\/em><\/strong> 28(31): 4920-4927, 2010 (<a target=\"_blank\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20566393\" rel=\"noopener noreferrer\">PubMed<\/a>)<\/li>\n<li>\u7530\u6751\u667a\u5f66: \u8ee2\u5199\u56e0\u5b50\u30d5\u30a1\u30df\u30ea\u30fcIRF\u306e\u751f\u4f53\u9632\u5fa1\u306b\u304a\u3051\u308b\u5f79\u5272 \u2013\u81ea\u7136\u514d\u75ab\u7d30\u80de\u306e\u5206\u5316\u3084\u6162\u6027\u9aa8\u9ac4\u6027\u767d\u8840\u75c5\u3078\u306e\u95a2\u308f\u308a\u3092\u4e2d\u5fc3\u306b-\uff0e<strong><em>\u795e\u5948\u5ddd\u8840\u6db2\u7814\u7a76\u4f1a\u8a8c<\/em><\/strong> 30: 42-44, 2010<\/li>\n<li>Savitsky D, Tamura T, Yanai H, Taniguchi T: Regulation of immunity and oncogenesis by the IRF transcription factor family. <strong><em>Cancer Immunol Immunother<\/em><\/strong> 59, 489-510, 2010 (<a target=\"_blank\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20049431\" rel=\"noopener noreferrer\">PubMed<\/a>)<\/li>\n<\/ul>\n<\/div>\n<h4 id=\"18\">2009\u5e74<\/h4>\n<div id=\"list\">\n<ul>\n<li>Yanai H, Ban T, Wang Z, Choi MK, Kawamura T, Negishi H, Nakasato M, Lu Y, Hangai S, Koshiba R, Savitsky D, Ronfani R, Akira S, Bianchi ME, Honda K, Tamura T, Kodama T, Taniguchi T: HMGB proteins function as universal sentinels for nucleic acid-mediated innate immune responses. <strong><em>Nature<\/em><\/strong> 462, 99-103, 2009 (<a target=\"_blank\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19890330\" rel=\"noopener noreferrer\">PubMed<\/a>)<\/li>\n<li>Choi MK, Wang Z, Ban T, Yanai H, Lu Y, Koshiba R, Nakaima Y, Hangai S, Savitsky D, Nakasato M, Negishi H, Takeuchi O, Honda K, Akira S, Tamura T Taniguchi T: A selective contribution of the RIG-I-like receptor pathway to type I interferon responses activated by cytosolic DNA. <strong><em>Proc Natl Acad Sci USA<\/em><\/strong> 106, 17870-17875, 2009 (<a target=\"_blank\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19805092\" rel=\"noopener noreferrer\">PubMed<\/a>)<\/li>\n<li>Zhao B, Takami M, Yamada A, Wang X, Koga T, Hu X, Tamura T, Ozato K, Choi Y, Ivashkiv LB, Takayanagi H, Kamijo R: Interferon regulatory factor 8 regulates bone metabolism by suppressing osteoclastogenesis. <strong><em>Nat Med<\/em><\/strong> 15, 1066-1071, 2009 (<a target=\"_blank\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19718038\" rel=\"noopener noreferrer\">PubMed<\/a>)<\/li>\n<li>Nakajima A, Nishimura K, Nakaima Y, Oh T, Noguchi S, Taniguchi T, Tamura T: Cell type-dependent proapoptotic role of Bcl2L12 revealed by a mutation concomitant with the disruption of the juxtaposed <em>Irf3<\/em> gene. <strong><em>Proc Natl Acad Sci USA<\/em><\/strong> 106, 12448-12452, 2009 (<a target=\"_blank\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19617565\" rel=\"noopener noreferrer\">PubMed<\/a>)<\/li>\n<li>Pham W, Kobukai S, Hotta C, Gore JC: Dendritic cells: therapy and imaging. <strong><em>Expert Opin Biol Ther<\/em><\/strong> 9(5): 539-564, 2009 (<a target=\"_blank\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19392575\" rel=\"noopener noreferrer\">PubMed<\/a>)<\/li>\n<li>Yanai H, Savitsky D, Tamura T, Taniguchi T: Regulation of the cytosolic DNA-sensing system in innate immunity; A current view. <strong><em>Curr Opin Immunol<\/em><\/strong> 21, 17-22, 2009 (Review) (<a target=\"_blank\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19362700\" rel=\"noopener noreferrer\">PubMed<\/a>)<\/li>\n<li>Tamura T, Smith M, Kanno T, Dasenbrock H, Nishiyama A Ozato K: Inducible deposition of the histone variant H3.3 in interferon-stimulated genes. <strong><em>J Biol Chem<\/em><\/strong> 284, 12217-12225, 2009 (<a target=\"_blank\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19244243\" rel=\"noopener noreferrer\">PubMed<\/a>)<\/li>\n<\/ul>\n<\/div>\n<h4 id=\"19\">2008-1994\u5e74<\/h4>\n<div id=\"list\">\n<ul>\n<li>Takaoka A, Tamura T, Taniguchi T: Interferon regulatory factor family of transcription factors and regulation of oncogenesis. <strong><em>Cancer Sci<\/em><\/strong> 99, 467-478, 2008 (Review)<\/li>\n<li>Negishi H, Osawa T, Ogami K, Ouyang X, Sakaguchi S, Koshiba R, Yanai H, Seko Y, Shitara H, Bishop K, Yonekawa H, Tamura T, Kaisho Y, Taya C, Taniguchi T, Honda K: A critical link between Toll-like receptor 3 and type II interferon signaling pathways in antiviral innate immunity. <strong><em>Proc Natl Acad Sci USA<\/em><\/strong> 105, 20446-20451, 2008<\/li>\n<li>Wang Z, Choi1 MK, Ban T, Yanai H, Negishi H, Lu Y, Tamura T, Takaoka A, Nishikura K, Taniguchi T: Regulation of innate immune responses by DAI (DLM-1 \/ ZBP1) and other DNA-sensing molecules. <strong><em>Proc Natl Acad Sci USA<\/em><\/strong> 105, 5477-5482, 2008<\/li>\n<li>Mochizuki K, Nishiyama A, Jang MK, Dey A, Ghosh A, Tamura T, Natsume H, Yao H, Ozato K.: The bromodomain protein Brd4 stimulates G1 gene transcription and promotes progression to S phase. <strong><em>J Biol Chem<\/em><\/strong> 283, 9040-9048, 2008<\/li>\n<li>Couzinet A, Tamura K, Chen HM, Nishimura K, Wang Z, Morishita Y, Takeda K, Yagita H, Yanai H, Taniguchi T, Tamura T: A cell type-specific requirement for IRF5 in Fas-induced apoptosis. <strong><em>Proc Natl Acad Sci USA<\/em><\/strong> 105: 2556-2561, 2008<\/li>\n<li>Tamura T, Yanai H, Savitsky D, Taniguchi T: The IRF family transcription factors in immunity and oncogenesis. <strong><em>Annu Rev Immunol<\/em><\/strong> 26, 535-584, 2008 (Review)<\/li>\n<li>Tailor P, Tamura T, Morse HC 3rd, Ozato K: The BXH2 mutation in IRF8 differentially impairs dendritic cell subset development in the mouse. <strong><em>Blood<\/em><\/strong> 111, 1942-1945, 2008<\/li>\n<li>Aomatsu K, Kato T, Fujita H, Hato F, Oshitani N, Kamata N, Tamura T, Arakawa T, Kitagawa S: Toll-like receptor agonists stimulate human neutrophil migration via activation of mitogen-activated protein kinases. <strong><em>Immunology<\/em><\/strong> 23, 171-180, 2008<\/li>\n<li>Tailor P, Tamura T, Kong HJ, Kubota T, Kubota M, Borghi P, Gabriele L, Ozato K: The feedback phase of type I interferon induction in dendritic cells requires interferon regulatory factor 8. <strong><em>Immunity<\/em><\/strong> 27: 228-239, 2007<\/li>\n<li>Kong HJ, Anderson DE, Lee CH, Jang MK, Tamura T, Tailor P, Cho HK, Cheong J, Xiong H, Morse HC 3rd, Ozato K: Cutting Edge: Autoantigen Ro52 is an interferon inducible E3 ligase that ubiquitinates IRF-8 and enhances cytokine expression in macrophages. <strong><em>J Immunol<\/em><\/strong> 179: 26-30, 2007<\/li>\n<li>Yang D, Thangaraju M, Greeneltch K, Browning DD, Schoenlein P, Tamura T, Ozato K, Ganapathy V, Abrams SI, Liu K: Repression of IFN regulatory factor 8 by DNA methylation is a molecular determinant of apoptotic resistance and metastatic phenotype in metastatic tumor cells. <strong><em>Cancer Res<\/em><\/strong> 67: 3301-3309, 2007<\/li>\n<li>Dror N, Rave-Harel N, Burchert A, Azriel A, Tamura T, Tailor P, Neubauer A, Ozato K, Levi BZ: IRF-8 is indispensable for the expression of PML and the formation of nuclear bodies in myeloid cells. <strong><em>J Biol Chem<\/em><\/strong> 282: 5633-5640, 2007<\/li>\n<li>Dror N, Alter-Koltunoff M, Azriel A, Amariglio N, Jacob-Hirsch J, Zeligson S, Morgenstern A, Tamura T, Hauser H, Rechavi G, Ozato K, Levi BZ: Identification of IRF-8 and IRF-1 target genes in activated macrophages. <strong><em>Mol Immunol<\/em><\/strong> 44: 338-346, 2007<\/li>\n<li>Tailor P, Tamura T, Ozato K: IRF family proteins and type I interferon induction in dendritic cells. <strong><em>Cell Res<\/em><\/strong> 16: 134-140, 2006 (Review)<\/li>\n<li>Samarasinghe R, Tailor P, Tamura T, Kaisho T, Akira S, Ozato K: Induction of an anti-inflammatory cytokine IL-10 in dendritic cells after Toll-like receptor signaling. J. Interferon <strong><em>Cytokine Res<\/em><\/strong> 26: 893-900, 2006<\/li>\n<li>Kanno Y, Levi BZ, Tamura T, Ozato K: Immune Cell Specific Amplification of IFN Signaling by the IRF4\/8-PU.1 Complex. <strong><em>J Interferon Cytokine Res<\/em><\/strong>25: 770-779, 2005 (Review)<\/li>\n<li>Laricchia-Robbio L, Tamura T, Karpova T, Sprague BL, McNally JG, Ozato K: Partner-regulated interaction of IFN regulatory factor 8 with chromatin visualized in live macrophages. <strong><em>Proc Natl Acad Sci USA<\/em><\/strong> 102: 14368-14373, 2005<\/li>\n<li>Dey M, Cao C, Dar AC, Tamura T, Ozato K, Sicheri F, Dever TE: Mechanistic link between catalytic domain dimerization, autophosphorylation and eIF2a substrate recognition by the RNA-dependent protein kinase PKR. <strong><em>Cell<\/em><\/strong> 122: 901-913, 2005<\/li>\n<li>Tamura T, Thotakura P, Tanaka TS, Ko MS, Ozato K: Identification of target genes and a unique cis element regulated by IRF-8 in developing macrophages. <strong><em>Blood<\/em><\/strong> 106: 1938-1947, 2005<\/li>\n<li>Ishii KJ, Ito S, Tamura T, Hemmi H, Conover J, Ozato K, Akira S, Klinman DM: CpG-activated Thy1.2+ dendritic cells protect against lethal Listeria monocytogenes infection. <strong><em>Eur J Immunol<\/em><\/strong> 35: 2397-2405, 2005<\/li>\n<li>Tamura T, Tailor P, Yamaoka K, Kong HJ, Tsujimura H, O\u2019Shea JJ, Singh H, Ozato K: IFN regulatory factor-4 and -8 govern dendritic cell subset development and their functional diversity. <strong><em>J Immunol<\/em><\/strong> 174: 2573-2581, 2005<\/li>\n<li>Liu J, Guan X, Tamura T, Ozato K, Ma X: Synergistic activation of interleukin-12 p35 gene transcription by interferon regulatory factor-1 and interferon consensus sequence binding protein. <strong><em>J Biol Chem<\/em><\/strong> 279: 55609-55617, 2004<\/li>\n<li>Tsujimura H, Tamura T, Kong HJ, Nishiyama A, Ishii KJ, Klinman DM, Ozato K: Toll-like receptor 9 signaling activates NF-kappaB through IFN regulatory factor-8\/IFN consensus sequence binding protein in dendritic cells. <strong><em>J Immunol<\/em><\/strong> 172: 6820-6827, 2004<\/li>\n<li>Schmidt M, Bies J, Tamura T, Ozato K, Wolff L: The interferon regulatory factor ICSBP\/IRF-8 in combination with PU.1 Up-regulates p15INK4b tumor suppressor expression in murine myeloid cells. <strong><em>Blood<\/em><\/strong> 103: 4142-4149, 2004<\/li>\n<li>Ozato K, Tsujimura H, Tamura T: Toll-like receptor signaling and regulation of cytokine gene expression in the immune system. <strong><em>Biotechniques<\/em><\/strong>Suppl: 66-68, 70, 72 passim, 2003<\/li>\n<li>Alter-Koltunoff M, Ehrlich S, Dror N, Azriel A, Eilers M, Hauser H, Bowen H, Barton CH, Tamura T, Ozato K, Levi BZ: Nramp1 mediated innate resistance to intraphagosomal pathogens is regulated by IRF-8, PU.1 and Miz-1. <strong><em>J Biol Chem<\/em><\/strong> 278: 44025-44032, 2003<\/li>\n<li>Tamura T, Kong HJ, Tunyaplin C, Tsujimura H, Calame K, Ozato K: ICSBP\/IRF-8 inhibits mitogenic Activity of p210 Bcr\/Abl in differentiating myeloid progenitor cells. <strong><em>Blood<\/em><\/strong> 102: 4547-4554, 2003<\/li>\n<li>Tsujimura H, Tamura T, Ozato K: Cutting edge: IFN consensus sequence binding protein\/IFN regulatory factor 8 drives the development of type I IFN-producing plasmacytoid dendritic cells. <strong><em>J Immunol<\/em><\/strong> 170: 1131-1135, 2003<\/li>\n<li>Tsujimura H, Tamura T, Gongora C, Aliberti J, Reis e Sousa C, Sher A, Ozato K: ICSBP\/IRF-8 retrovirus transduction rescues dendritic cell development in vitro. <strong><em>Blood<\/em><\/strong> 101: 961-969, 2003<\/li>\n<li>Tamura T, Ozato K: ICSBP (IRF-8): its regulatory role in the development of myeloid cells. <strong><em>J Interferon Cytokine Res<\/em><\/strong> 22: 145-152, 2002 (Review)<\/li>\n<li>Maruyama T, Farina A, Dey A, Cheong JH, Bermudez VP, Tamura T, Sciortino S, Shuman J, Hurwitz J, Ozato K: A mammalian bromodomain protein Brd4 interacts with replication factor C and inhibits progression to S phase. <strong><em>Mol Cell Biol<\/em><\/strong> 22: 6509-6520, 2002<\/li>\n<li>Kuwata T, Gongora C, Kanno Y, Sakaguchi K, Tamura T, Basrur V, Martinez R, Appella E, Golub T, Ozato K: Gamma interferon triggers the interaction between ICSBP (IRF-8) and TEL recruiting the histone deacetylase HDAC3 to the interferon responsive element. <strong><em>Mol Cell Biol<\/em><\/strong> 22: 7439-7448, 2002<\/li>\n<li>Tsujimura H, Nagamura-Inoue T, Tamura T, Ozato K: IFN Consensus Sequence Binding Protein\/IFN Regulatory Factor-8 guides bone marrow progenitor cells towards the macrophage Lineage. <strong><em>J Immunol<\/em><\/strong> 169: 1261-1269, 2002<\/li>\n<li>Nagamura-Inoue T, Tamura T, Ozato K: Transcription factors that regulate growth and differentiation of myeloid cells. <strong><em>Int Rev Immunol<\/em><\/strong> 20: 83-105, 2001 (Review)<\/li>\n<li>Tamura T, Nagamura-Inoue T, Shmeltzer Z, Kuwata T, Ozato K: ICSBP directs bipotential myeloid progenitor cells to differentiate into mature macrophages. <strong><em>Immunity<\/em><\/strong> 13: 155-165, 2000<\/li>\n<li>Yamauchi T, Yamauchi J, Kuwata T, Tamura T, Yamashita T, Bae N, Westphal H, Ozato K, Nakatani Y: Distinct but overlapping roles of histone acetylase PCAF and of the closely related PCAF-B\/GCN5 in mouse embryogenesis. <strong><em>Proc Natl Acad Sci USA<\/em><\/strong> 97: 11303-11306, 2000<\/li>\n<li>Kuwata T, Wang IM, Tamura T, Ponnamperuma RM, Levine R, Holmes KL, Morse HC, De Luca LM, Ozato K: Vitamin A deficiency in mice causes a systemic expansion of myeloid cells. <strong><em>Blood<\/em><\/strong> 95, 3349-3356, 2000<\/li>\n<li>Kanamori H, Maruta A, Sasaki S, Yamazaki E, Ueda S, Katoh K, Tamura T, Otsuka-Aoba M, Taguchi J, Harano H, Ogawa K, Mohri H, Okubo T, Matsuzaki M, Watanabe S, Koharazawa H, Fujita, H, Kodama F: Diagnostic value of hemostatic parameters in bone marrow transplant-associated thrombotic microangiopathy. <strong><em>Bone Marrow Transplant<\/em><\/strong> 21: 705-709, 1998<\/li>\n<li>Ueda S, Kanamori H, Sasaki S, Yamazaki E, Tamura T, Matsuzaki M, Motomura S, Mohri H, Okubo T: Isolated extramedullary relapse in knee joint after allogeneic bone marrow transplantation for Ph ALL. <strong><em>Bone Marrow Transplant<\/em><\/strong> 21: 319-321, 1998<\/li>\n<li>Tamura T, Matsuzaki M, Harada H, Ogawa K, Mohri H, Okubo T: Up-regulation of interferon-\u03b1 receptor expression in hydroxyurea-treated leukemia cell lines. <strong><em>J Invest Med<\/em><\/strong>45: 160-167, 1997<\/li>\n<li>Kato K, Mohri H, Tamura T, Okubo T: A synthetic peptide, FN-C\/H-V, from the C-terminal heparin-binding domain of fibronectin promotes adhesion of PMA stimulated U937 cells. <strong><em>Biochem Biophys Res Commun<\/em><\/strong> 239: 205-211, 1997<\/li>\n<li>Kanamori H, Sasaki S, Yamazaki E, Ueda S, Hattori M, Fukawa H, Tamura T, Harano H, Matsuzaki M, Ogawa K, Mohri H, Okubo T: Eradication of minimal residual disease during graft-versus-host reaction induced by abrupt 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