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2022-08-12

Structure of the human galanin receptor 2 bound to galanin and Gq reveals the basis of ligand specificity and how binding affects the G-protein interface

Galanin is a neuropeptide expressed in the central and peripheral nervous systems, where it regulates various processes including neuroendocrine release, cognition, and nerve regeneration.

2022-08-05

Structure of SARS-CoV-2 membrane protein essential for virus assembly

The coronavirus membrane protein (M) is the most abundant viral structural protein and plays a central role in virus assembly and morphogenesis. However, the process of M protein-driven virus assembly are largely unknown. Here, we report the cryo-electron microscopy structure of the SARS-CoV-2 M protein in two different conformations.

2022-08-01

An autopsy case of COVID-19-like acute respiratory distress syndrome after mRNA-1273 SARS-CoV-2 vaccination.

Highlights •An old woman developed interstitial pneumonia after mRNA-1273 vaccination. •The patient's symptoms, laboratory findings, and images were similar to those of COVID-19. •Serological and pathological tests were useful in diagnosing vaccine-induced acute respiratory distress syndrome. •Serum level of antibodies against spike protein was extremely high.

2022-07-14

A panel of nanobodies recognizing conserved hidden clefts of all SARS-CoV-2 spike variants including Omicron

We are amid the historic coronavirus infectious disease 2019 (COVID-19) pandemic. Imbalances in the accessibility of vaccines, medicines, and diagnostics among countries, regions, and populations, and those in war crises, have been problematic.