{"id":41,"date":"2024-02-09T11:10:14","date_gmt":"2024-02-09T02:10:14","guid":{"rendered":"https:\/\/www-user.yokohama-cu.ac.jp\/~canbiol\/?page_id=41"},"modified":"2025-12-24T17:24:39","modified_gmt":"2025-12-24T08:24:39","slug":"publications-en","status":"publish","type":"page","link":"https:\/\/www-user.yokohama-cu.ac.jp\/~canbiol\/publications-en\/","title":{"rendered":"Publications"},"content":{"rendered":"\n

Publications<\/h2>\n\n\n\n

Original Articles<\/h3>\n\n\n\n

2025<\/h4>\n\n\n\n
    \n
  1. Kim HD, Jung S, Bang YH, Kim J, Kim HJ, Lee HY, Hyung J, Yoo C, Kim WT,Yoon MJ, Lee H, Ryou JH, Jeon H, Yanai H, Lee JS, Lee G, Ryu MH.
    Blood TCTP as a Potential Biomarker Associated with Immunosuppressive<\/strong>
    J. Immunother. Cancer.<\/em> 13: e010455 (2025). doi: 10.1136\/jitc-2024-010455<\/a><\/li>\n\n\n\n
  2. Ito R, Sumitomo R, Iizawa M, Yanai H, Ono R.
    Inhibitory effect of streamer discharge on the local recurrence of B16F10 melanoma tumor in mice<\/strong>
    J. Phys. D: Appl. Phys.<\/em> 58: 135202 (2025). doi:     10.1088\/1361-6463\/ada98c<\/a><\/li>\n<\/ol>\n\n\n\n

    2023<\/h4>\n\n\n\n
      \n
    1. Kato M, Maeda K, Nakahara R, Hirose H, Kondo A, Aki S, Sugaya M, Hibino S, Nishida M, Hasegawa M, Morita H, Ando R, Tsuchida R, Yoshida M, Kodama T, Yanai H, Shimamura T, Osawa T.
      Acidic extracellular pH drives accumulation of N1-acetylspermidine and recruitment of protumor neutrophils<\/strong>
      PNAS Nexus.<\/em> 2: pgad306 (2023). doi:       10.1093\/pnasnexus\/pgad306<\/a><\/li>\n\n\n\n
    2. Nakahara R, Aki S, Sugaya M, Hirose H, Kato M, Maeda K, Sakamoto D, Kojima Y, Nishida M, Ando R, Muramatsu M, Pan M, Tsuchida R, Matsumura Y, Yanai H, Takano H, Yao R, Sando S, Shibuya M, Sakai J, Kodama T, Kidoya H, Shimamura T, Osawa T.
      Hypoxia activates SREBP2 through Golgi disassembly in bone marrow-derived monocytes for enhanced tumor growth<\/strong>
      EMBO J.<\/em> 42: e114032 (2023). doi:       10.15252\/embj.2023114032<\/a><\/li>\n\n\n\n
    3. Hibino S, Eto S, Hangai S, Endo K, Ashitani S, Sugaya M, Osawa T, Soga T, Taniguchi T, Yanai H.
      Tumor cell-derived spermidine is an oncometabolite that suppresses TCR clustering for intratumoral CD8+<\/sup> T cell activation<\/strong>
      Proc. Natl. Acad. Sci. USA.<\/em> 120: e2305245120 (2023). doi:       10.1073\/pnas.2305245120<\/a><\/li>\n<\/ol>\n\n\n\n

      2022<\/h4>\n\n\n\n
        \n
      1. Inoue A, Chiba S, Eto S, Taniguchi T, Yanai H.
        Potential of HMGB-inhibitory oligodeoxynucleotide ISM ODN to neutrophil recruitment in mouse model of hepatitis<\/strong>
        Genes Cells<\/em>. 28: 202-210 (2022). doi:         10.1111\/gtc.13002<\/a><\/li>\n\n\n\n
      2. Jinno R, Komuro A, Yanai H, Ono R.
        Antitumor abscopal effects in mice induced by normal tissue irradiation using pulsed streamer discharge plasma<\/strong>
        J. Phys. D: Appl. Phys<\/em>. 55: 17LT01 (2022). doi:         10.1088\/1361-6463\/ac4c23<\/a><\/li>\n<\/ol>\n\n\n\n

        2021<\/h4>\n\n\n\n
          \n
        1. Nishio J, Negishi H, Yasui-Kato M, Miki S, Miyanaga K, Aoki K, Mizusawa T, Ueno M, Ainai A, Muratani M, Hangai S, Yanai H, Hasegawa H, Ishii Y, Tanji Y, Taniguchi T.
          Identification and characterization of a novel Enterococcus bacteriophage with potential to ameliorate murine colitis<\/strong>
          Sci. Rep.<\/em> 11: 20231 (2021). doi:           10.1038\/s41598-021-99602-4<\/a><\/li>\n\n\n\n
        2. Kawase W, Kurotaki D, Suzuki Y, Ishihara H, Ban T, Sato G, Ichikawa J, Yanai H, Taniguchi T, Tsukahara K, Tamura T.
          Irf5<\/em> siRNA-loaded biodegradable lipid nanoparticles ameliorate concanavalin A-induced liver injury<\/strong>
          Mol. Ther. Nucleic Acids<\/em> 25: 708-715 (2021). doi:           10.1016\/j.omtn.2021.08.023<\/a><\/li>\n\n\n\n
        3. Ban T, Kikuchi M, Sato G, Manabe A, Tagata N, Harita K, Nishiyama A, Nishimura K, Yoshimi R, Kirino Y, Yanai H, Matsumoto Y, Suzuki S, Hihara H, Ito M, Tsukahara K, Yoshimatsu K, Yamamoto T, Taniguchi T, Nakajima H, Ito S, Tamura T.
          Genetic and chemical inhibition of IRF5 suppresses pre-existing mouse lupus-like disease<\/strong>
          Nat. Commun.<\/em> 12:<\/strong> 4379 (2021). doi:           10.1038\/s41467-021-24609-4<\/a><\/li>\n\n\n\n
        4. Hangai S, Kawamura T, Kimura Y, C-T Chang, Hibino S, Yamamoto D, Nakai Y, Tateishi R, Oshima M, Oshima H, Kodama T, Moriya K, Koike K, Yanai H, aniguchi T.
          Orchestration of myeloid-derived suppressor cells in the tumor microenvironment by ubiquitous cellular protein TCTP released by tumor cells<\/strong>
          Nat. Immunol. <\/em>22: 947-957 (2021). doi:           10.1038\/s41590-021-00967-5<\/a><\/li>\n\n\n\n
        5. Eto S, Yanai H, Hangai S, Kato D, Nishimura R, Nakagawa T.
          The impact of damage-associated molecules released from canine tumor cells on gene expression in macrophages<\/strong>
          Sci. Rep. <\/em>11, 8525 (2021). doi:           https:\/\/doi.org\/10.1038\/s41598-021-87979-1<\/a><\/li>\n\n\n\n
        6. Senda N, Yanai H, Hibino S, Li L, Mizushima Y, Miyagaki T, Mai Saeki, Kishi Y, Hangai S, Nishio J, Sugaya M, Taniguchi T, Sato S.
          HMGB1-mediated chromatin remodeling attenuates Il24<\/em> gene expression for the protection from allergic contact dermatitis<\/strong>
          Proc. Natl. Acad. Sci. USA.<\/em>118: e2022343118 (2021). doi:           10.1073\/pnas.2022343118<\/a><\/li>\n\n\n\n
        7. Negishi H, Endo N, Nakajima Y, Nishiyama T, Tabunoki Y, Nishio J, Koshiba R, Matsuda A, Matsuki K, Okamura T, Negishi-Koga T, Ichinohe T, Takemura S, Ishiwata H, Iemura SI, Natsume T, Abe T, Kiyonari H, Doi T, Hangai S, Yanai H, Fujio K, Yamamoto K, Taniguchi T.
          Identification of U11snRNA as an Endogenous Agonist of TLR7-mediated Immune Pathogenesis<\/strong>
          Proc. Natl. Acad. Sci. USA.<\/em>116: 23653-23661 (2021). doi:           10.1073\/pnas.1915326116<\/a><\/li>\n<\/ol>\n\n\n\n

          2018<\/h4>\n\n\n\n
            \n
          1. Kimura Y, Negishi H, Matsuda A, Endo N, Hangai S, Inoue A, Nishio J, Taniguchi T, Yanai H.
            Novel chemical compound SINCRO with dual function in STING-type I interferon and tumor cell death pathways.<\/strong>
            Cancer Sci. <\/em>109: 2687-2696 (2018). doi:             10.1111\/cas.13726<\/a><\/li>\n\n\n\n
          2. Yanai H, Chiba S, Hangai S, Kometani K, Inoue A, Kimura Y, Abe T, Kiyonari H, Nishio J, Taguchi-Atarashi N, Mizushima Y, Negishi H, Grosschedl R, Taniguchi T.
            Revisiting the role of IRF3 in inflammation and immunity by conditional and specifically targeted gene ablation in mice<\/strong>
            Proc. Natl. Acad. Sci. USA. <\/em>115: 5253-5258 (2018). doi:             10.1073\/pnas.1803936115<\/a><\/li>\n<\/ol>\n\n\n\n

            2017<\/h4>\n\n\n\n
              \n
            1. Sarashina-Kida H, Negishi H, Nishio J, Suda W, Nakajima Y, Yasui-Kato M, Iwaisako K, Kang S, Endo N, Yanai H, Asagiri N, Kida H, Hattori M, Kumanogo A, Taniguchi T.
              Gallbladder-derived surfactant protein D regulates gut commensal bacteria for maintaining intestinal homeostasis<\/strong>
              Proc. Natl. Acad. Sci. USA. <\/em>114: 10178-10183 (2017). doi:               10.1073\/pnas.1712837114<\/a><\/li>\n\n\n\n
            2. Iwamura T, Narumi H, Suzuki T, Yanai H, Mori K, Yamashita K, Tsushima Y, Asano T, Izawa A, Momen S, Nishimura K, Tsuchiyama H, Uchida M, Yamashita Y, Okano K, Taniguchi T.
              A novel pegylated IFN-b as strong suppressor of the malignant ascites in a peritoneal metastasis model of human cancer<\/strong>
              Cancer Science,108:<\/em> 581-589 (2017). doi:               10.1111\/cas.13176<\/a><\/li>\n<\/ol>\n\n\n\n

              2016<\/h4>\n\n\n\n
                \n
              1. Kimura Y, Inoue A, Hangai S, Saijo S, Negishi H, Nishio J, Yamasaki S, Iwakura Y, Yanai H, Taniguchi T.
                The innate immune receptor Dectin-2 mediates the phagocytosis of cancer cells by Kupffer cells for the suppression of liver metastasis<\/strong>
                Proc. Natl. Acad. Sci. USA. <\/em>113: 14097-14102 (2016). doi:                 10.1073\/pnas.1617903113<\/a><\/li>\n\n\n\n
              2. Ban T, Sato GR, Nishiyama A, Akiyama A, Takasuna M, Umehara M, Suzuki S, Ichino M, Matsunaga S, Kimura A, Kimura Y, Yanai H, Miyashita S, Kuromitsu J, Tsukahara K, Yoshimatsu K, Endo I, Yamamoto T, Hirano H, Ryo A, Taniguchi T, Tamura T.
                Lyn Kinase Suppresses the Transcriptional Activity of IRF5 in the TLR-MyD88 Pathway to Restrain the Development of Autoimmunity<\/strong>
                Immunity. <\/em>2: 319-232 (2016). doi:                 10.1016\/j.immuni.2016.07.015<\/a><\/li>\n\n\n\n
              3. Hangai S, Ao T, Kimura Y, Matsuki K, Kawamura T, Negishi H, Nishio J, Kodama T, Taniguchi T, Yanai H.
                PGE2 induced in and released by dying cells functions as an inhibitory DAMP<\/strong>
                Proc. Natl. Acad. Sci. USA. <\/em>113: 3844-3849 (2016). doi:                 10.1073\/pnas.1602023113<\/a><\/li>\n<\/ol>\n\n\n\n

                2015<\/h4>\n\n\n\n
                  \n
                1. Nishio J, Baba M, Atarashi K, Tanoue T, Negishi H, Yanai H, Habu S, Hori S, Honda K, Taniguchi T.
                  Requirement of full TCR repertoire for regulatory T cells to maintain intestinal homeostasis<\/strong>
                  Proc. Natl. Acad. Sci. USA. <\/em>112: 12770-12775 (2015). doi:                   10.1073\/pnas.1516617112<\/a><\/li>\n\n\n\n
                2. Okazaki T, Higuchi M, Takeda K, Iwatsuki-Horimoto K, Kiso M, Miyagishi M, Yanai H, Kato A, Yoneyama M, Fujita T, Taniguchi T, Kawaoka Y, Ichijo H, Gotoh Y.
                  The ASK family kinases differentially mediate induction of type I interferon and apoptosis during the antiviral response<\/strong>
                  Science Signaling.<\/em> 8: ra78 (2015). doi:                   10.1126\/scisignal.aab1883<\/a><\/li>\n<\/ol>\n\n\n\n

                  2014<\/h4>\n\n\n\n
                    \n
                  1. Chiba S, Ikushima H, Ueki H, Yanai H, Kimura Y, Hangai S, Nishio J, Negishi H, Tamura T, Saijo S, Iwakura Y, Taniguchi T.
                    Recognition of tumor cells by Dectin-1 orchestrates innate immune cells for anti-tumor responses<\/strong>
                    eLife.<\/em> 3: e04177 (2014). doi:                     10.7554\/eLife.04177<\/a><\/li>\n<\/ol>\n\n\n\n

                    2013<\/h4>\n\n\n\n
                      \n
                    1. Yanai H, Matsuda A, An J, Koshiba R, Nishio J, Negishi H, Ikushima H, Onoe T, Ohdan H, Yoshida N, Taniguchi T.
                      Conditional ablation of HMGB1 in mice reveals its protective function against endotoxemia and bacterial infection<\/strong>
                      Proc. Natl. Acad. Sci. USA. <\/em>110: 20699-20704 (2013). doi:                       10.1073\/pnas.1320808110<\/a><\/li>\n\n\n\n
                    2. Negishi H, Matsuki K, Endo N, Sarashina H, Miki S, Matsuda A, Fukazawa K , Taguchi-Atarashi N, Ikushima H, Yanai H, Nishio J, Honda K, Fujioka Y, Ohba Y, Noda T, Taniguchi S, Nishida E, Zhang Y, Chi H, Flavell RA, Taniguchi T.
                      Beneficial innate signaling interference for anti-bacterial responses by a TLR-mediated enhancement of the MKP-IRF3 axis<\/strong>
                      Proc. Natl. Acad. Sci. USA. <\/em>110: 19884-19889 (2013). doi:                       10.1073\/pnas.1320145110<\/a><\/li>\n\n\n\n
                    3. Negishi H, Matsuki K, Endo N, Sarashina H, Miki S, Matsuda A, Fukazawa K , Taguchi-Atarashi N, Ikushima H, Yanai H, Nishio J, Honda K, Fujioka Y, Ohba Y, Noda T, Taniguchi S, Nishida E, Zhang Y, Chi H, Flavell RA, Taniguchi T.
                      Beneficial innate signaling interference for anti-bacterial responses by a TLR-mediated enhancement of the MKP-IRF3 axis<\/strong>
                      Proc. Natl. Acad. Sci. USA. <\/em>110: 19884-19889 (2013). doi:                       10.1073\/pnas.1320145110<\/a><\/li>\n\n\n\n
                    4. Koshiba R, Yanai H, Matsuda A, Goto A, Nakajima A, Negishi H, Nishio J, Smale ST, Taniguchi T.
                      Regulation of cooperative function of the Il12b<\/em> enhancer and promoter by the interferon regulatory factors 3 and 5<\/strong>
                      Biochem. Biophys. Res. Commun. <\/em>430: 95-100 (2013). doi:                       10.1016\/j.bbrc.2012.11.006<\/a><\/li>\n<\/ol>\n\n\n\n

                      2012<\/h4>\n\n\n\n
                        \n
                      1. Negishi H, Miki S, Sarashina H, Taguchi-Atarashi N, Nakajima A, Matsuki K, Endo N, Yanai H, Nishio J, Honda K, Taniguchi T.
                        Essential contribution of IRF3 to intestinal homeostasis and microbiota-mediated Tslp<\/em> gene induction<\/strong>
                        Proc. Natl. Acad. Sci. USA. <\/em>109: 21016-21021 (2012). doi:                         10.1073\/pnas.1219482110<\/a><\/li>\n\n\n\n
                      2. Negishi H, Yanai H, Nakajima A, Koshiba R, Atarashi K, Matsuda A, Matsuki K, Miki S, Doi T, Aderem A, Nishio J, Smale ST, Honda K, Taniguchi T.
                        Cross-interference of RLR and TLR signaling pathways modulates antibacterial T cell responses<\/strong>
                        Nat. Immunol.<\/em> 13: 659-666 (2012). doi:                         10.1038\/ni.2307<\/a><\/li>\n<\/ol>\n\n\n\n

                        2011<\/h4>\n\n\n\n
                          \n
                        1. Matsuda A, Ogawa M, Yanai H, Naka D, Goto A, Ao T, Tanno Y, Takeda K, Watanabe Y, Honda K, Taniguchi T.
                          Generation of mice deficient in RNA-binding motif protein 3 (RBM3) and characterization of its role in innate immune responses and cell growth<\/strong>
                          Biochem. Biophys. Res. Commun. <\/em>411: 7-13 (2011). doi:                           10.1016\/j.bbrc.2011.06.038<\/a><\/li>\n\n\n\n
                        2. Yanai H, Chiba S, Ban T, Nakaima Y, Onoe T, Honda K, Ohdan H, Taniguchi T.
                          Suppression of immune responses by nonimmunogenic oligodeoxynucleotides with high affinity for high-mobility group box proteins (HMGBs)<\/strong>
                          Proc. Natl. Acad. Sci. USA. <\/em>108: 11542-11547 (2011). doi:                           10.1073\/pnas.1108535108<\/a><\/li>\n\n\n\n
                        3. Tsushima K, Osawa T, Yanai H, Nakajima A, Takaoka A, Manabe I, Ohba Y, Imai Y, Taniguchi T, Nagai R.
                          IRF3 regulates cardiac fibrosis but not hypertrophy in mice during angiotensin II-induced hypertension<\/strong>
                          FASEB J. <\/em>25: 1531-1543 (2011). doi:                           10.1096\/fj.10-174615<\/a><\/li>\n<\/ol>\n\n\n\n

                          2010<\/h4>\n\n\n\n
                            \n
                          1. Savitsky D, Yanai H, Tamura T, Taniguchi T and Honda K.
                            Contribution of IRF5 in B cells to the development of murine SLE-like disease through its transcriptional control of the IgG2a<\/em> locus<\/strong>
                            Proc. Natl. Acad. Sci. USA. <\/em>107: 10154-10159 (2010). doi:                             10.1073\/pnas.1005599107<\/a><\/li>\n<\/ol>\n\n\n\n

                            2009<\/h4>\n\n\n\n
                              \n
                            1. Yanai H, Ban T, Wang Z, Choi MK, Kawamura T, Negishi H, Nakasato M, Lu Y, Hangai S, Koshiba R, Savitsky D, Ronfani R, Akira S, Bianchi ME, Honda K, Tamura T, Kodama T, and Taniguchi T.
                              HMGB proteins function as universal sentinels for nucleic acid-mediated innate immune responses<\/strong>
                              Nature <\/em>462: 99-103 (2009). doi:                               10.1038\/nature08512<\/a><\/li>\n\n\n\n
                            2. Choi MK, Wang Z, Ban T, Yanai H, Lu Y, Koshiba R, Nakaima Y, Hangai S, Savitsky D, Nakasato M, Negishi H, Takeuchi O, Honda K, Akira S, Tamura T, and Taniguchi T.
                              A selective contribution of the RIG-I-like receptor pathway to type I interferon responses activated by cytosolic DNA<\/strong>
                              Proc. Natl. Acad. Sci. USA. <\/em>106: 17870-17875 (2009). doi:                               10.1073\/pnas.0909545106<\/a><\/li>\n\n\n\n
                            3. Chen HM, Tanaka N, Mitani Y, Oda E, Nozawa H, Chen JZ, Yanai H, Negishi H, Choi MK, Iwasaki T, Yamamoto H, Taniguchi T, Takaoka A.
                              Critical role for constitutive type I interferon signaling in the prevention of cellular transformation<\/strong>
                              Cancer Sci. <\/em>100: 449-456 (2009). doi:                               10.1111\/j.1349-7006.2008.01051.x<\/a><\/li>\n<\/ol>\n\n\n\n

                              2008<\/h4>\n\n\n\n
                                \n
                              1. Negishi H, Osawa T, Ogami K, Ouyang X, Sakaguchi S, Koshiba R, Yanai H, Seko Y, Shitara H, Bishop K, Yonekawa H, Tamura T, Kaisho T, Taya C, Taniguchi T, Honda K.
                                A critical link between Toll-like receptor 3 and type II interferon signaling pathways in antiviral innate immunity<\/strong>
                                Proc. Natl. Acad. Sci. USA. <\/em>105: 20446-20451 (2008). doi:                                 10.1073\/pnas.0810372105<\/a><\/li>\n\n\n\n
                              2. Wang Z, Choi MK, Ban T, Yanai H, Negishi H, Lu Y, Tamura T, Takaoka A, Nishikura K, Taniguchi T.
                                Regulation of innate immune responses by DAI (DLM-1\/ZBP1) and other DNA-sensing molecules<\/strong>
                                Proc. Natl. Acad. Sci. USA. <\/em>105: 5477-5482 (2008). doi:                                 10.1073\/pnas.0801295105<\/a><\/li>\n\n\n\n
                              3. Couzinet A, Tamura K, Chen HM, Nishimura K, Wang Z, Morishita Y, Takeda K, Yagita H, Yanai H, Taniguchi T, Tamura T.
                                A cell-type-specific requirement for IFN regulatory factor 5 (IRF5) in Fas-induced apoptosis<\/strong>
                                Proc. Natl. Acad. Sci. USA. <\/em>105: 2556-2561 (2008). doi:                                 10.1073\/pnas.0712295105<\/a><\/li>\n<\/ol>\n\n\n\n

                                2007<\/h4>\n\n\n\n
                                  \n
                                1. S Kojima, A Iwahara, Y Hisano, H Yanai.
                                  Effects of hydrophobic amino acid substitution in Pleurotus ostreatus<\/em> proteinase A inhibitor 1 on its structure and functions as protease inhibitor and intramolecular chaperone<\/strong>
                                  Protein Eng. Des. Sel. <\/em>20: 211-217 (2007). doi:                                   10.1093\/protein\/gzm013<\/a><\/li>\n\n\n\n
                                2. Takaoka A, Wang Z, Choi MK, Yanai H, Negishi H, Ban T, Lu Y, Miyagishi M, Kodama T, Honda K, Ohba Y, Taniguchi T.
                                  DAI (DLM-1\/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response<\/strong>
                                  Nature <\/em>448: 501-505 (2007). doi:                                   10.1038\/nature06013<\/a><\/li>\n\n\n\n
                                3. Yanai H, Chen H, Inuzuka T, Kondo S, Mak WT, Takaoka A, Honda K, Taniguchi T.
                                  Role of IFN regulatory factor 5 transcription factor in antiviral immunity and tumor suppression<\/strong>
                                  Proc. Natl. Acad. Sci. USA. <\/em>104: 3402-3407 (2007). doi:                                   10.1073\/pnas.0611559104<\/a><\/li>\n<\/ol>\n\n\n\n

                                  2006<\/h4>\n\n\n\n
                                    \n
                                  1. Negishi H, Fujita Y, Yanai H, Sakaguchi S, Ouyang X, Shinohara M, Takayanagi H, Ohba Y, Taniguchi T, Honda K.
                                    Evidence for licensing of IFN-g-induced IFN regulatory factor 1 transcription factor by MyD88 in Toll-like receptor-dependent gene induction program<\/strong>
                                    Proc. Natl. Acad. Sci. USA. <\/em>103: 15136-15141 (2006). doi:                                     10.1073\/pnas.0607181103<\/a><\/li>\n<\/ol>\n\n\n\n

                                    2005<\/h4>\n\n\n\n
                                      \n
                                    1. Negishi H, Ohba Y, Yanai H, Takaoka A, Honma K, Yui K, Matsuyama T, Taniguchi T, Honda K.
                                      Negative regulation of Toll-like-receptor signaling by IRF-4<\/strong>
                                      Proc. Natl. Acad. Sci. USA. <\/em>102: 15989-15994 (2005). doi:                                       10.1073\/pnas.0508327102<\/a><\/li>\n\n\n\n
                                    2. Honda K, Ohba Y, Yanai H, Negishi H, Mizutani T, Takaoka A, Taya C, Taniguchi T.
                                      Spatiotemporal regulation of MyD88-IRF-7 signalling for robust type I interferon induction<\/strong>
                                      Nature <\/em>434: 1035-1040 (2005). doi:                                       10.1038\/nature03547<\/a><\/li>\n\n\n\n
                                    3. Honda K, Yanai H, Negishi H, Asagiri M, Sato M, Mizutani T, Shimada N, Ohba Y, Takaoka A, Yoshida N, Taniguchi T.
                                      IRF-7 is the master regulator of type-I interferon-dependent immune responses<\/strong>
                                      Nature <\/em>434: 772-777 (2005). doi:                                       10.1038\/nature03464<\/a><\/li>\n\n\n\n
                                    4. Takaoka A, Yanai H, Kondo S, Duncan G, Negishi H, Mizutani T, Kano S, Honda K, Ohba Y, Mak TM, Taniguchi T.
                                      Integral role of IRF-5 in the gene induction programme activated by Toll-like receptors<\/strong>
                                      Nature <\/em>434: 243-249 (2005). doi:                                       10.1038\/nature03308<\/a><\/li>\n\n\n\n
                                    5. S Kojima, A Iwahara, H Yanai.
                                      Inhibitor-assisted refolding of protease: a protease inhibitor as an intramolecular chaperone<\/strong>
                                      FEBS Lett. <\/em>579: 4430-4436 (2005). doi:                                       10.1016\/j.febslet.2005.06.083<\/a><\/li>\n<\/ol>\n\n\n\n

                                      2004<\/h4>\n\n\n\n
                                        \n
                                      1. Honda K, Yanai H, Mizutani T, Negishi H, Shimada N, Suzuki N, Ohba Y, Takaoka A, WC Yeh, Taniguchi T.
                                        Role of a transductional-transcriptional processor complex involving MyD88 and IRF-7 in Toll-like receptor signaling<\/strong>
                                        Proc. Natl. Acad. Sci. USA. <\/em>101: 15416-15421 (2004). doi:                                         10.1073\/pnas.0406933101<\/a><\/li>\n<\/ol>\n\n\n\n

                                        2003<\/h4>\n\n\n\n
                                          \n
                                        1. Honda K, Sakaguchi S, Nakajima C, Watanabe A, Yanai H, Matsumoto M, Ohteki T, Kaisho T, Takaoka A, Akira S, Seya T, Taniguchi T.
                                          Selective contribution of IFN-a\/b signaling to the maturation of dendritic cells induced by double-stranded RNA or viral infection<\/strong>
                                          Proc. Natl. Acad. Sci. USA. <\/em>100: 10872-10877 (2003). doi:                                           10.1073\/pnas.1934678100<\/a><\/li>\n\n\n\n
                                        2. Takaoka A, Hayakawa K, Yanai H, Stoiber D, Negishi H, Kikuchi H, Shibue T, Honda K, Taniguchi T.
                                          Integration of IFN-a\/b signalling to p53 responses in tumor suppression and antiviral defense<\/strong>
                                          Nature <\/em>424: 516-523 (2003). doi:                                           10.1038\/nature01850<\/a><\/li>\n<\/ol>\n\n\n\n

                                          2001<\/h4>\n\n\n\n
                                            \n
                                          1. Kojima S, Yanai H, Miura K.
                                            Accelerated refolding of subtilisin BPN’ by tertiary-structure-forming mutants of its propeptide<\/strong>
                                            J. Biochem. <\/em>130: 471-474 (2001). doi:                                             10.1093\/oxfordjournals.jbchem.a003008<\/a><\/li>\n<\/ol>\n\n\n\n

                                            Review Articles<\/h3>\n\n\n\n
                                              \n
                                            1. \u67f3\u4e95\u79c0\u5143, \u885b\u85e4\u7fd4\u592a\u90ce
                                              \u816b\u760d\u6b7b\u7d30\u80de\u7531\u6765\u5206\u5b50\u306b\u3088\u308b\u514d\u75ab\u5236\u5fa1\u6a5f\u69cb<\/strong>
                                              \u533b\u5b66\u306e\u3042\u3086\u307f, 292: 241-246, 2025<\/li>\n\n\n\n
                                            2. \u885b\u85e4\u7fd4\u592a\u90ce, \u67f3\u4e95\u79c0\u5143
                                              \u7d30\u80de\u969c\u5bb3\u95a2\u9023\u5206\u5b50\uff08DAMPs\uff09\u3068\u708e\u75c7\u8001\u5316<\/strong>}
                                              \u5b9f\u9a13\u533b\u5b66, 41: 749-753, 2023<\/li>\n\n\n\n
                                            3. \u67f3\u4e95\u79c0\u5143, \u65e5\u6bd4\u91ce\u6c99\u5948, \u885b\u85e4\u7fd4\u592a\u90ce, \u534a\u8c37\u5320
                                              \u5f8c\u5929\u6027\u514d\u75ab\u4e0d\u5168\u62c5\u304c\u3093\u72b6\u614b\u306b\u304a\u3051\u308b\u514d\u75ab\u6291\u5236<\/strong>
                                              \u79d1\u5b66\u8a55\u8ad6\u793e\uff08\u81e8\u5e8a\u514d\u75ab\u30fb\u30a2\u30ec\u30eb\u30ae\u30fc\u79d1\uff09, 79: 601-606, 2023<\/li>\n\n\n\n
                                            4. \u534a\u8c37\u5320, \u67f3\u4e95\u79c0\u5143
                                              \u6b7b\u7d30\u80de\u7531\u6765\u5206\u5b50\u7fa4\u306b\u3088\u308b\u816b\u760d\u514d\u75ab\u5fae\u5c0f\u74b0\u5883\u8abf\u7bc0\u6a5f\u69cb<\/strong>
                                              \u751f\u5316\u5b66, 94: 749-753, 2022<\/li>\n\n\n\n
                                            5. \u534a\u8c37\u5320, \u67f3\u4e95\u79c0\u5143
                                              \u304c\u3093\u6b7b\u7d30\u80de\u7531\u6765\u5206\u5b50\u306b\u3088\u308b\u514d\u75ab\u7cfb\u306e\u8abf\u7bc0\u6a5f\u69cb<\/strong>
                                              \u81e8\u5e8a\u514d\u75ab\u30fb\u30a2\u30ec\u30eb\u30ae\u30fc\u79d1, 77: 352-358, 2022<\/li>\n\n\n\n
                                            6. Yanai H, Hangai S, Taniguchi T.
                                              Damage-associated molecular patterns and Toll-like receptors in the tumor immune microenvironment<\/strong>
                                              Int. Immunol.<\/em> 33: 841-846 (2021). doi:                                               10.1093\/intimm\/dxab050<\/a><\/li>\n\n\n\n
                                            7. Hangai S, Kimura Y, Taniguchi T, Yanai H.
                                              Signal-transducing innate receptors in tumor immunity<\/strong>
                                              Cancer Sci.<\/em> 112: 2578-2591 (2021). doi:                                               10.1111\/cas.14848<\/a><\/li>\n\n\n\n
                                            8. \u67f3\u4e95\u79c0\u5143, \u534a\u8c37\u5320
                                              \u7d30\u80de\u969c\u5bb3\u95a2\u9023\u5206\u5b50\uff08DAMPs\uff09\u306b\u3088\u308b\u81ea\u7136\u514d\u75ab\u5fdc\u7b54\u5236\u5fa1<\/strong>
                                              \u533b\u5b66\u306e\u3042\u3086\u307f, 265: 1192-1197, 2018<\/li>\n\n\n\n
                                            9. Negishi H, Taniguchi T, Yanai H.
                                              The Interferon (IFN) Class of Cytokines and the IFN Regulatory Factor (IRF) Transcription Factor Family<\/strong>
                                              Cold Spring Harb Perspect Biol.<\/em> 10: a028423 (2018). doi:                                               10.1101\/cshperspect.a028423<\/a><\/li>\n\n\n\n
                                            10. Yanai H, Taniguchi T.
                                              Fine-tuning type I IFN signaling: A new chapter in the IFN saga<\/strong>
                                              Cell Res. <\/em>27: 1407-1408 (2017). doi:                                               10.1038\/cr.2017.118<\/a><\/li>\n\n\n\n
                                            11. \u67f3\u4e95\u79c0\u5143, \u677e\u6728\u5eb7\u7950, \u8c37\u53e3\u7dad\u7d39
                                              HMGB1\uff08High-mobility group box protein 1\uff09\u306b\u3088\u308b\u708e\u75c7\u5236\u5fa1<\/strong>
                                              \u708e\u75c7\u3068\u514d\u75ab, 24: 17-23, 2016<\/li>\n\n\n\n
                                            12. Yanai H, Taniguchi T.
                                              Nucleic acid sensing and beyond: virtues and vices of HMGB1<\/strong>
                                              J. Intern. Med. <\/em>276:444-453 (2014). doi:                                               10.1111\/joim.12285<\/a><\/li>\n\n\n\n
                                            13. Yanai H, Negishi H, Taniguchi T.
                                              The IRF family of transcription factors: Inception, impact and implications in oncogenesis<\/strong>
                                              Oncoimmunol. <\/em>1: 1376-1386 (2012). doi:                                               10.4161\/onci.22475<\/a><\/li>\n\n\n\n
                                            14. Yanai H, Ban T, Taniguchi T.
                                              High-mobility group box family of proteins: ligand and sensor for innate immunity<\/strong>
                                              Trends. Immunol.<\/em> 33: 633-640 (2012). doi:                                               10.1016\/j.it.2012.10.005<\/a><\/li>\n\n\n\n
                                            15. Yanai H, Ban T, Taniguchi T.
                                              Essential role of high-mobility group box proteins in nucleic acid-mediated innate immune responses<\/strong>
                                              J. Intern. Med. <\/em>270: 301-308 (2011). doi:                                               10.1111\/j.1365-2796.2011.02433.x<\/a><\/li>\n\n\n\n
                                            16. \u67f3\u4e95\u79c0\u5143
                                              \u6838\u9178\u30a2\u30ca\u30ed\u30b0\u306b\u3088\u308b\u81ea\u7136\u514d\u75ab\u5fdc\u7b54\u306e\u8abf\u7bc0<\/strong>
                                              \u30a6\u30a4\u30eb\u30b9, 61: 141-152, 2011<\/li>\n\n\n\n
                                            17. Savitsky D, Tamura T, Yanai H, and Taniguchi T.
                                              Regulation of immunity and oncogenesis by the IRF transcription factor family<\/strong>
                                              Cancer Immunol. Immunother. <\/em>59: 489-510 (2010). doi:                                               10.1007\/s00262-009-0804-6<\/a><\/li>\n\n\n\n
                                            18. Yanai H, Savitsky D, Tamura T, Taniguchi T.
                                              Regulation of the cytosolic DNA-sensing system in innate immunity: a current view<\/strong>
                                              Curr. Opin. Immunol. <\/em>1: 17-22 (2009). doi:                                               10.1016\/j.coi.2009.01.005<\/a><\/li>\n\n\n\n
                                            19. \u67f3\u4e95\u79c0\u5143
                                              \u6838\u9178\u8a8d\u8b58\u306b\u304a\u3051\u308bHMGB\u30bf\u30f3\u30d1\u30af\u306e\u5f79\u5272<\/strong>
                                              \u7d30\u80de\u5de5\u5b66, 29: 1014-1019, 2009<\/li>\n\n\n\n
                                            20. \u67f3\u4e95\u79c0\u5143, \u8c37\u53e3\u7dad\u7d39
                                              IRF\u30d5\u30a1\u30df\u30ea\u30fc\u8ee2\u5199\u56e0\u5b50\u3068\u751f\u4f53\u9632\u5fa1\u30b7\u30b0\u30ca\u30eb<\/strong>
                                              \u86cb\u767d\u8cea\u6838\u9178\u9175\u7d20, 53: 1231-1238, 2008<\/li>\n\n\n\n
                                            21. Tamura T, Yanai H, Savitsky D, Taniguchi T.
                                              The IRF Family Transcription Factors in Immunity and Oncogenesis<\/strong>
                                              Annu. Rev. Immunol. <\/em>26: 535-584 (2008). doi:                                               10.1146\/annurev.immunol.26.021607.090400<\/a><\/li>\n\n\n\n
                                            22. \u9ad9\u5ca1\u6643\u6559, \u67f3\u4e95\u79c0\u5143, \u672c\u7530 \u8ce2\u4e5f, \u5927\u5834 \u96c4\u4ecb, \u8c37\u53e3\u7dad\u7d39
                                              IRF\u30d5\u30a1\u30df\u30ea\u30fc\u8ee2\u5199\u56e0\u5b50\u3068\u751f\u4f53\u9632\u5fa1\u6a5f\u69cb<\/strong>
                                              \u300c\u514d\u75ab2006\u300dMolecular Medicine, 42: 308-317, 2006<\/li>\n\n\n\n
                                            23. \u9ad9\u5ca1\u6643\u6559, \u67f3\u4e95\u79c0\u5143
                                              IFN-IRF\u30b7\u30b9\u30c6\u30e0\u3068\u81ea\u5df1\u514d\u75ab\u75be\u60a3\u306e\u3064\u306a\u304c\u308a<\/strong>
                                              \u5b9f\u9a13\u533b\u5b66, 24: 1525-1534, 2006<\/li>\n\n\n\n
                                            24. Yanai H, Mizutani T, Inuzuka T, Honda K, Takaoka A, Taniguchi T.
                                              IRF family transcription factors in type I interferon induction<\/strong>
                                              Int. Congress Series <\/em>1285<\/strong>: 104-113 (2005). doi:                                               10.1016\/j.ics.2005.09.010<\/a><\/li>\n\n\n\n
                                            25. Honda K, Yanai H, Takaoka A, Taniguchi T.
                                              Regulation of the type I IFN induction: a current view<\/strong>
                                              Int. Immunol. <\/em>17: 1367-1378 (2005). doi:                                               10.1093\/intimm\/dxh318<\/a><\/li>\n\n\n\n
                                            26. \u9ad9\u5ca1\u6643\u6559, \u67f3\u4e95\u79c0\u5143
                                              Class II cytokine receptors and their ligands<\/strong>
                                              \u65e5\u672c\u81e8\u5e8a, 63: 193-201, 2005<\/li>\n<\/ol>\n\n\n\n

                                              Conference Presentations<\/h3>\n\n\n\n
                                                \n
                                              • Yanai H
                                                Suppression of anti-tumor immune responses by dead cell-derived molecules
                                                The 17th Annual Meeting of Chinese Society for Immunology (CSI), (2025\/11\/6). Chongqing China<\/li>\n\n\n\n
                                              • \u67f3\u4e95\u79c0\u5143
                                                \u7d44\u7e54\u7279\u7570\u7684\u306a\u816b\u760d\u514d\u75ab\u5fae\u5c0f\u74b0\u5883\u5f62\u6210\u6a5f\u69cb\u306e\u89e3\u660e
                                                \u7b2c47\u56de\u65e5\u672c\u5206\u5b50\u751f\u7269\u5b66\u4f1a\u5e74\u4f1a (2024\/11\/27). \u798f\u5ca1<\/li>\n\n\n\n
                                              • Yanai H
                                                Modulation of tumor immune responses by dead cell-derived molecules
                                                2nd International Congress of Asian Oncology Society (AOS), (2022\/6\/16). Seoul Korea<\/li>\n<\/ul>\n\n\n\n

                                                Books<\/h3>\n\n\n\n
                                                  \n
                                                • \u5343\u8449\u5fd7\u7a42, \u67f3\u4e95\u79c0\u5143
                                                  \u30aa\u30ea\u30b4\u6838\u9178\u6295\u4e0e\u306b\u3088\u308b\u6557\u8840\u75c7\u75c5\u614b\u306e\u6291\u5236\u3068\u305d\u306e\u6a19\u7684\u5206\u5b50\uff08\u6557\u8840\u75c7\u306e\u8a3a\u65ad\uff0f\u6cbb\u7642\u306e\u5b9f\u72b6\u3068\u75c5\u614b\u30fb\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u3075\u307e\u3048\u305f\u958b\u767a\u6226\u7565\uff09\u5b89\u4fdd\u516c\u4ecb\u7de8<\/strong>
                                                  \u6280\u8853\u60c5\u5831\u5354\u4f1a\u3001 56-60, 2013<\/li>\n<\/ul>\n\n\n\n

                                                  Awards<\/h3>\n\n\n\n
                                                    \n
                                                  • 2013\u5e74 \u65e5\u672c\u514d\u75ab\u5b66\u4f1a \u7814\u7a76\u5968\u52b1\u8cde \u53d7\u8cde<\/li>\n\n\n\n
                                                  • 2019\u5e74 \u65e5\u672c\u30a4\u30f3\u30bf\u30fc\u30d5\u30a7\u30ed\u30f3\u30fb\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u5b66\u4f1a \u7814\u7a76\u5968\u52b1\u8cde \u53d7\u8cde<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"

                                                    Publications Original Articles 2025 2023 2022 2021 2018 2017 2016 2015 2014 2013 … <\/p>\n","protected":false},"author":4,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-41","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/www-user.yokohama-cu.ac.jp\/~canbiol\/wp-json\/wp\/v2\/pages\/41","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www-user.yokohama-cu.ac.jp\/~canbiol\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www-user.yokohama-cu.ac.jp\/~canbiol\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www-user.yokohama-cu.ac.jp\/~canbiol\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/www-user.yokohama-cu.ac.jp\/~canbiol\/wp-json\/wp\/v2\/comments?post=41"}],"version-history":[{"count":4,"href":"https:\/\/www-user.yokohama-cu.ac.jp\/~canbiol\/wp-json\/wp\/v2\/pages\/41\/revisions"}],"predecessor-version":[{"id":143,"href":"https:\/\/www-user.yokohama-cu.ac.jp\/~canbiol\/wp-json\/wp\/v2\/pages\/41\/revisions\/143"}],"wp:attachment":[{"href":"https:\/\/www-user.yokohama-cu.ac.jp\/~canbiol\/wp-json\/wp\/v2\/media?parent=41"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}