研究業績

原著論文

2025

53. Kim HD, Jung S, Bang YH, Kim J, Kim HJ, Lee HY, Hyung J, Yoo C, Kim WT,Yoon MJ, Lee H, Ryou JH, Jeon H, Yanai H, Lee JS, Lee G, Ryu MH.
    Blood TCTP as a Potential Biomarker Associated with Immunosuppressive
    J. Immunother. Cancer. 13: e010455 (2025). doi: 10.1136/jitc-2024-010455
54. Ito R, Sumitomo R, Iizawa M, Yanai H, Ono R.
    Inhibitory effect of streamer discharge on the local recurrence of B16F10 melanoma tumor in mice
    J. Phys. D: Appl. Phys. 58: 135202 (2025). doi: 10.1088/1361-6463/ada98c

2023

51. Kato M, Maeda K, Nakahara R, Hirose H, Kondo A, Aki S, Sugaya M, Hibino S, Nishida M, Hasegawa M, Morita H, Ando R, Tsuchida R, Yoshida M, Kodama T, Yanai H, Shimamura T, Osawa T.
    Acidic extracellular pH drives accumulation of N1-acetylspermidine and recruitment of protumor neutrophils
    PNAS Nexus. 2: pgad306 (2023). doi: 10.1093/pnasnexus/pgad306
52. Nakahara R, Aki S, Sugaya M, Hirose H, Kato M, Maeda K, Sakamoto D, Kojima Y, Nishida M, Ando R, Muramatsu M, Pan M, Tsuchida R, Matsumura Y, Yanai H, Takano H, Yao R, Sando S, Shibuya M, Sakai J, Kodama T, Kidoya H, Shimamura T, Osawa T.
    Hypoxia activates SREBP2 through Golgi disassembly in bone marrow-derived monocytes for enhanced tumor growth
    EMBO J. 42: e114032 (2023). doi: 10.15252/embj.2023114032
53. Hibino S, Eto S, Hangai S, Endo K, Ashitani S, Sugaya M, Osawa T, Soga T, Taniguchi T, Yanai H.
    Tumor cell-derived spermidine is an oncometabolite that suppresses TCR clustering for intratumoral CD8⁺ T cell activation
    Proc. Natl. Acad. Sci. USA. 120: e2305245120 (2023). doi: 10.1073/pnas.2305245120

2022

48. Inoue A, Chiba S, Eto S, Taniguchi T, Yanai H.
    Potential of HMGB-inhibitory oligodeoxynucleotide ISM ODN to neutrophil recruitment in mouse model of hepatitis
    Genes Cells. 28: 202-210 (2022). doi: 10.1111/gtc.13002
49. Jinno R, Komuro A, Yanai H, Ono R.
    Antitumor abscopal effects in mice induced by normal tissue irradiation using pulsed streamer discharge plasma
    J. Phys. D: Appl. Phys. 55: 17LT01 (2022). doi: 10.1088/1361-6463/ac4c23

2021

46. Nishio J, Negishi H, Yasui-Kato M, Miki S, Miyanaga K, Aoki K, Mizusawa T, Ueno M, Ainai A, Muratani M, Hangai S, Yanai H, Hasegawa H, Ishii Y, Tanji Y, Taniguchi T.
    Identification and characterization of a novel Enterococcus bacteriophage with potential to ameliorate murine colitis
    Sci. Rep. 11: 20231 (2021). doi: 10.1038/s41598-021-99602-4
47. Kawase W, Kurotaki D, Suzuki Y, Ishihara H, Ban T, Sato G, Ichikawa J, Yanai H, Taniguchi T, Tsukahara K, Tamura T.
    Irf5 siRNA-loaded biodegradable lipid nanoparticles ameliorate concanavalin A-induced liver injury
    Mol. Ther. Nucleic Acids 25: 708-715 (2021). doi: 10.1016/j.omtn.2021.08.023
48. Ban T, Kikuchi M, Sato G, Manabe A, Tagata N, Harita K, Nishiyama A, Nishimura K, Yoshimi R, Kirino Y, Yanai H, Matsumoto Y, Suzuki S, Hihara H, Ito M, Tsukahara K, Yoshimatsu K, Yamamoto T, Taniguchi T, Nakajima H, Ito S, Tamura T.
    Genetic and chemical inhibition of IRF5 suppresses pre-existing mouse lupus-like disease
    Nat. Commun. 12: 4379 (2021). doi: 10.1038/s41467-021-24609-4
49. Hangai S, Kawamura T, Kimura Y, C-T Chang, Hibino S, Yamamoto D, Nakai Y, Tateishi R, Oshima M, Oshima H, Kodama T, Moriya K, Koike K, Yanai H, aniguchi T.
    Orchestration of myeloid-derived suppressor cells in the tumor microenvironment by ubiquitous cellular protein TCTP released by tumor cells
    Nat. Immunol. 22: 947-957 (2021). doi: 10.1038/s41590-021-00967-5
50. Eto S, Yanai H, Hangai S, Kato D, Nishimura R, Nakagawa T.
    The impact of damage-associated molecules released from canine tumor cells on gene expression in macrophages
    Sci. Rep. 11, 8525 (2021). doi: https://doi.org/10.1038/s41598-021-87979-1
51. Senda N, Yanai H, Hibino S, Li L, Mizushima Y, Miyagaki T, Mai Saeki, Kishi Y, Hangai S, Nishio J, Sugaya M, Taniguchi T, Sato S.
    HMGB1-mediated chromatin remodeling attenuates Il24 gene expression for the protection from allergic contact dermatitis
    Proc. Natl. Acad. Sci. USA.118: e2022343118 (2021). doi: 10.1073/pnas.2022343118
52. Negishi H, Endo N, Nakajima Y, Nishiyama T, Tabunoki Y, Nishio J, Koshiba R, Matsuda A, Matsuki K, Okamura T, Negishi-Koga T, Ichinohe T, Takemura S, Ishiwata H, Iemura SI, Natsume T, Abe T, Kiyonari H, Doi T, Hangai S, Yanai H, Fujio K, Yamamoto K, Taniguchi T.
    Identification of U11snRNA as an Endogenous Agonist of TLR7-mediated Immune Pathogenesis
    Proc. Natl. Acad. Sci. USA.116: 23653-23661 (2021). doi: 10.1073/pnas.1915326116

2018

39. Kimura Y, Negishi H, Matsuda A, Endo N, Hangai S, Inoue A, Nishio J, Taniguchi T, Yanai H.
    Novel chemical compound SINCRO with dual function in STING-type I interferon and tumor cell death pathways.
    Cancer Sci. 109: 2687-2696 (2018). doi: 10.1111/cas.13726
40. Yanai H, Chiba S, Hangai S, Kometani K, Inoue A, Kimura Y, Abe T, Kiyonari H, Nishio J, Taguchi-Atarashi N, Mizushima Y, Negishi H, Grosschedl R, Taniguchi T.
    Revisiting the role of IRF3 in inflammation and immunity by conditional and specifically targeted gene ablation in mice
    Proc. Natl. Acad. Sci. USA. 115: 5253-5258 (2018). doi: 10.1073/pnas.1803936115

2017

37. Sarashina-Kida H, Negishi H, Nishio J, Suda W, Nakajima Y, Yasui-Kato M, Iwaisako K, Kang S, Endo N, Yanai H, Asagiri N, Kida H, Hattori M, Kumanogo A, Taniguchi T.
    Gallbladder-derived surfactant protein D regulates gut commensal bacteria for maintaining intestinal homeostasis
    Proc. Natl. Acad. Sci. USA. 114: 10178-10183 (2017). doi: 10.1073/pnas.1712837114
38. Iwamura T, Narumi H, Suzuki T, Yanai H, Mori K, Yamashita K, Tsushima Y, Asano T, Izawa A, Momen S, Nishimura K, Tsuchiyama H, Uchida M, Yamashita Y, Okano K, Taniguchi T.
    A novel pegylated IFN-b as strong suppressor of the malignant ascites in a peritoneal metastasis model of human cancer
    Cancer Science,108: 581-589 (2017). doi: 10.1111/cas.13176

2016

35. Kimura Y, Inoue A, Hangai S, Saijo S, Negishi H, Nishio J, Yamasaki S, Iwakura Y, Yanai H, Taniguchi T.
    The innate immune receptor Dectin-2 mediates the phagocytosis of cancer cells by Kupffer cells for the suppression of liver metastasis
    Proc. Natl. Acad. Sci. USA. 113: 14097-14102 (2016). doi: 10.1073/pnas.1617903113
36. Ban T, Sato GR, Nishiyama A, Akiyama A, Takasuna M, Umehara M, Suzuki S, Ichino M, Matsunaga S, Kimura A, Kimura Y, Yanai H, Miyashita S, Kuromitsu J, Tsukahara K, Yoshimatsu K, Endo I, Yamamoto T, Hirano H, Ryo A, Taniguchi T, Tamura T.
    Lyn Kinase Suppresses the Transcriptional Activity of IRF5 in the TLR-MyD88 Pathway to Restrain the Development of Autoimmunity
    Immunity. 2: 319-232 (2016). doi: 10.1016/j.immuni.2016.07.015
37. Hangai S, Ao T, Kimura Y, Matsuki K, Kawamura T, Negishi H, Nishio J, Kodama T, Taniguchi T, Yanai H.
    PGE2 induced in and released by dying cells functions as an inhibitory DAMP
    Proc. Natl. Acad. Sci. USA. 113: 3844-3849 (2016). doi: 10.1073/pnas.1602023113

2015

32. Nishio J, Baba M, Atarashi K, Tanoue T, Negishi H, Yanai H, Habu S, Hori S, Honda K, Taniguchi T.
    Requirement of full TCR repertoire for regulatory T cells to maintain intestinal homeostasis
    Proc. Natl. Acad. Sci. USA. 112: 12770-12775 (2015). doi: 10.1073/pnas.1516617112
33. Okazaki T, Higuchi M, Takeda K, Iwatsuki-Horimoto K, Kiso M, Miyagishi M, Yanai H, Kato A, Yoneyama M, Fujita T, Taniguchi T, Kawaoka Y, Ichijo H, Gotoh Y.
    The ASK family kinases differentially mediate induction of type I interferon and apoptosis during the antiviral response
    Science Signaling. 8: ra78 (2015). doi: 10.1126/scisignal.aab1883

2014

30. Chiba S, Ikushima H, Ueki H, Yanai H, Kimura Y, Hangai S, Nishio J, Negishi H, Tamura T, Saijo S, Iwakura Y, Taniguchi T.
    Recognition of tumor cells by Dectin-1 orchestrates innate immune cells for anti-tumor responses
    eLife. 3: e04177 (2014). doi: 10.7554/eLife.04177

2013

29. Yanai H, Matsuda A, An J, Koshiba R, Nishio J, Negishi H, Ikushima H, Onoe T, Ohdan H, Yoshida N, Taniguchi T.
    Conditional ablation of HMGB1 in mice reveals its protective function against endotoxemia and bacterial infection
    Proc. Natl. Acad. Sci. USA. 110: 20699-20704 (2013). doi: 10.1073/pnas.1320808110
30. Negishi H, Matsuki K, Endo N, Sarashina H, Miki S, Matsuda A, Fukazawa K , Taguchi-Atarashi N, Ikushima H, Yanai H, Nishio J, Honda K, Fujioka Y, Ohba Y, Noda T, Taniguchi S, Nishida E, Zhang Y, Chi H, Flavell RA, Taniguchi T.
    Beneficial innate signaling interference for anti-bacterial responses by a TLR-mediated enhancement of the MKP-IRF3 axis
    Proc. Natl. Acad. Sci. USA. 110: 19884-19889 (2013). doi: 10.1073/pnas.1320145110
31. Negishi H, Matsuki K, Endo N, Sarashina H, Miki S, Matsuda A, Fukazawa K , Taguchi-Atarashi N, Ikushima H, Yanai H, Nishio J, Honda K, Fujioka Y, Ohba Y, Noda T, Taniguchi S, Nishida E, Zhang Y, Chi H, Flavell RA, Taniguchi T.
    Beneficial innate signaling interference for anti-bacterial responses by a TLR-mediated enhancement of the MKP-IRF3 axis
    Proc. Natl. Acad. Sci. USA. 110: 19884-19889 (2013). doi: 10.1073/pnas.1320145110
32. Koshiba R, Yanai H, Matsuda A, Goto A, Nakajima A, Negishi H, Nishio J, Smale ST, Taniguchi T.
    Regulation of cooperative function of the Il12b enhancer and promoter by the interferon regulatory factors 3 and 5
    Biochem. Biophys. Res. Commun. 430: 95-100 (2013). doi: 10.1016/j.bbrc.2012.11.006

2012

25. Negishi H, Miki S, Sarashina H, Taguchi-Atarashi N, Nakajima A, Matsuki K, Endo N, Yanai H, Nishio J, Honda K, Taniguchi T.
    Essential contribution of IRF3 to intestinal homeostasis and microbiota-mediated Tslp gene induction
    Proc. Natl. Acad. Sci. USA. 109: 21016-21021 (2012). doi: 10.1073/pnas.1219482110
26. Negishi H, Yanai H, Nakajima A, Koshiba R, Atarashi K, Matsuda A, Matsuki K, Miki S, Doi T, Aderem A, Nishio J, Smale ST, Honda K, Taniguchi T.
    Cross-interference of RLR and TLR signaling pathways modulates antibacterial T cell responses
    Nat. Immunol. 13: 659-666 (2012). doi: 10.1038/ni.2307

2011

23. Matsuda A, Ogawa M, Yanai H, Naka D, Goto A, Ao T, Tanno Y, Takeda K, Watanabe Y, Honda K, Taniguchi T.
    Generation of mice deficient in RNA-binding motif protein 3 (RBM3) and characterization of its role in innate immune responses and cell growth
    Biochem. Biophys. Res. Commun. 411: 7-13 (2011). doi: 10.1016/j.bbrc.2011.06.038
24. Yanai H, Chiba S, Ban T, Nakaima Y, Onoe T, Honda K, Ohdan H, Taniguchi T.
    Suppression of immune responses by nonimmunogenic oligodeoxynucleotides with high affinity for high-mobility group box proteins (HMGBs)
    Proc. Natl. Acad. Sci. USA. 108: 11542-11547 (2011). doi: 10.1073/pnas.1108535108
25. Tsushima K, Osawa T, Yanai H, Nakajima A, Takaoka A, Manabe I, Ohba Y, Imai Y, Taniguchi T, Nagai R.
    IRF3 regulates cardiac fibrosis but not hypertrophy in mice during angiotensin II-induced hypertension
    FASEB J. 25: 1531-1543 (2011). doi: 10.1096/fj.10-174615

2010

20. Savitsky D, Yanai H, Tamura T, Taniguchi T and Honda K.
    Contribution of IRF5 in B cells to the development of murine SLE-like disease through its transcriptional control of the IgG2a locus
    Proc. Natl. Acad. Sci. USA. 107: 10154-10159 (2010). doi: 10.1073/pnas.1005599107

2009

19. Yanai H, Ban T, Wang Z, Choi MK, Kawamura T, Negishi H, Nakasato M, Lu Y, Hangai S, Koshiba R, Savitsky D, Ronfani R, Akira S, Bianchi ME, Honda K, Tamura T, Kodama T, and Taniguchi T.
    HMGB proteins function as universal sentinels for nucleic acid-mediated innate immune responses
    Nature 462: 99-103 (2009). doi: 10.1038/nature08512
20. Choi MK, Wang Z, Ban T, Yanai H, Lu Y, Koshiba R, Nakaima Y, Hangai S, Savitsky D, Nakasato M, Negishi H, Takeuchi O, Honda K, Akira S, Tamura T, and Taniguchi T.
    A selective contribution of the RIG-I-like receptor pathway to type I interferon responses activated by cytosolic DNA
    Proc. Natl. Acad. Sci. USA. 106: 17870-17875 (2009). doi: 10.1073/pnas.0909545106
21. Chen HM, Tanaka N, Mitani Y, Oda E, Nozawa H, Chen JZ, Yanai H, Negishi H, Choi MK, Iwasaki T, Yamamoto H, Taniguchi T, Takaoka A.
    Critical role for constitutive type I interferon signaling in the prevention of cellular transformation
    Cancer Sci. 100: 449-456 (2009). doi: 10.1111/j.1349-7006.2008.01051.x

2008

16. Negishi H, Osawa T, Ogami K, Ouyang X, Sakaguchi S, Koshiba R, Yanai H, Seko Y, Shitara H, Bishop K, Yonekawa H, Tamura T, Kaisho T, Taya C, Taniguchi T, Honda K.
    A critical link between Toll-like receptor 3 and type II interferon signaling pathways in antiviral innate immunity
    Proc. Natl. Acad. Sci. USA. 105: 20446-20451 (2008). doi: 10.1073/pnas.0810372105
17. Wang Z, Choi MK, Ban T, Yanai H, Negishi H, Lu Y, Tamura T, Takaoka A, Nishikura K, Taniguchi T.
    Regulation of innate immune responses by DAI (DLM-1/ZBP1) and other DNA-sensing molecules
    Proc. Natl. Acad. Sci. USA. 105: 5477-5482 (2008). doi: 10.1073/pnas.0801295105
18. Couzinet A, Tamura K, Chen HM, Nishimura K, Wang Z, Morishita Y, Takeda K, Yagita H, Yanai H, Taniguchi T, Tamura T.
    A cell-type-specific requirement for IFN regulatory factor 5 (IRF5) in Fas-induced apoptosis
    Proc. Natl. Acad. Sci. USA. 105: 2556-2561 (2008). doi: 10.1073/pnas.0712295105

2007

13. S Kojima, A Iwahara, Y Hisano, H Yanai.
    Effects of hydrophobic amino acid substitution in Pleurotus ostreatus proteinase A inhibitor 1 on its structure and functions as protease inhibitor and intramolecular chaperone
    Protein Eng. Des. Sel. 20: 211-217 (2007). doi: 10.1093/protein/gzm013
14. Takaoka A, Wang Z, Choi MK, Yanai H, Negishi H, Ban T, Lu Y, Miyagishi M, Kodama T, Honda K, Ohba Y, Taniguchi T.
    DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response
    Nature 448: 501-505 (2007). doi: 10.1038/nature06013
15. Yanai H, Chen H, Inuzuka T, Kondo S, Mak WT, Takaoka A, Honda K, Taniguchi T.
    Role of IFN regulatory factor 5 transcription factor in antiviral immunity and tumor suppression
    Proc. Natl. Acad. Sci. USA. 104: 3402-3407 (2007). doi: 10.1073/pnas.0611559104

2006

10. Negishi H, Fujita Y, Yanai H, Sakaguchi S, Ouyang X, Shinohara M, Takayanagi H, Ohba Y, Taniguchi T, Honda K.
    Evidence for licensing of IFN-g-induced IFN regulatory factor 1 transcription factor by MyD88 in Toll-like receptor-dependent gene induction program
    Proc. Natl. Acad. Sci. USA. 103: 15136-15141 (2006). doi: 10.1073/pnas.0607181103

2005

9. Negishi H, Ohba Y, Yanai H, Takaoka A, Honma K, Yui K, Matsuyama T, Taniguchi T, Honda K.
   Negative regulation of Toll-like-receptor signaling by IRF-4
   Proc. Natl. Acad. Sci. USA. 102: 15989-15994 (2005). doi: 10.1073/pnas.0508327102
10. Honda K, Ohba Y, Yanai H, Negishi H, Mizutani T, Takaoka A, Taya C, Taniguchi T.
    Spatiotemporal regulation of MyD88-IRF-7 signalling for robust type I interferon induction
    Nature 434: 1035-1040 (2005). doi: 10.1038/nature03547
11. Honda K, Yanai H, Negishi H, Asagiri M, Sato M, Mizutani T, Shimada N, Ohba Y, Takaoka A, Yoshida N, Taniguchi T.
    IRF-7 is the master regulator of type-I interferon-dependent immune responses
    Nature 434: 772-777 (2005). doi: 10.1038/nature03464
12. Takaoka A, Yanai H, Kondo S, Duncan G, Negishi H, Mizutani T, Kano S, Honda K, Ohba Y, Mak TM, Taniguchi T.
    Integral role of IRF-5 in the gene induction programme activated by Toll-like receptors
    Nature 434: 243-249 (2005). doi: 10.1038/nature03308
13. S Kojima, A Iwahara, H Yanai.
    Inhibitor-assisted refolding of protease: a protease inhibitor as an intramolecular chaperone
    FEBS Lett. 579: 4430-4436 (2005). doi: 10.1016/j.febslet.2005.06.083

2004

4. Honda K, Yanai H, Mizutani T, Negishi H, Shimada N, Suzuki N, Ohba Y, Takaoka A, WC Yeh, Taniguchi T.
   Role of a transductional-transcriptional processor complex involving MyD88 and IRF-7 in Toll-like receptor signaling
   Proc. Natl. Acad. Sci. USA. 101: 15416-15421 (2004). doi: 10.1073/pnas.0406933101

2003

3. Honda K, Sakaguchi S, Nakajima C, Watanabe A, Yanai H, Matsumoto M, Ohteki T, Kaisho T, Takaoka A, Akira S, Seya T, Taniguchi T.
   Selective contribution of IFN-a/b signaling to the maturation of dendritic cells induced by double-stranded RNA or viral infection
   Proc. Natl. Acad. Sci. USA. 100: 10872-10877 (2003). doi: 10.1073/pnas.1934678100
4. Takaoka A, Hayakawa K, Yanai H, Stoiber D, Negishi H, Kikuchi H, Shibue T, Honda K, Taniguchi T.
   Integration of IFN-a/b signalling to p53 responses in tumor suppression and antiviral defense
   Nature 424: 516-523 (2003). doi: 10.1038/nature01850

2001

1. Kojima S, Yanai H, Miura K.
   Accelerated refolding of subtilisin BPN’ by tertiary-structure-forming mutants of its propeptide
   J. Biochem. 130: 471-474 (2001). doi: 10.1093/oxfordjournals.jbchem.a003008

総説

1. 柳井秀元, 衛藤翔太郎
   腫瘍死細胞由来分子による免疫制御機構
   医学のあゆみ, 292: 241-246, 2025
2. 衛藤翔太郎, 柳井秀元
   細胞障害関連分子（DAMPs）と炎症老化}
   実験医学, 41: 749-753, 2023
3. 柳井秀元, 日比野沙奈, 衛藤翔太郎, 半谷匠
   後天性免疫不全担がん状態における免疫抑制
   科学評論社（臨床免疫・アレルギー科）, 79: 601-606, 2023
4. 半谷匠, 柳井秀元
   死細胞由来分子群による腫瘍免疫微小環境調節機構
   生化学, 94: 749-753, 2022
5. 半谷匠, 柳井秀元
   がん死細胞由来分子による免疫系の調節機構
   臨床免疫・アレルギー科, 77: 352-358, 2022
6. Yanai H, Hangai S, Taniguchi T.
   Damage-associated molecular patterns and Toll-like receptors in the tumor immune microenvironment
   Int. Immunol. 33: 841-846 (2021). doi: 10.1093/intimm/dxab050
7. Hangai S, Kimura Y, Taniguchi T, Yanai H.
   Signal-transducing innate receptors in tumor immunity
   Cancer Sci. 112: 2578-2591 (2021). doi: 10.1111/cas.14848
8. 柳井秀元, 半谷匠
   細胞障害関連分子（DAMPs）による自然免疫応答制御
   医学のあゆみ, 265: 1192-1197, 2018
9. Negishi H, Taniguchi T, Yanai H.
   The Interferon (IFN) Class of Cytokines and the IFN Regulatory Factor (IRF) Transcription Factor Family
   Cold Spring Harb Perspect Biol. 10: a028423 (2018). doi: 10.1101/cshperspect.a028423
10. Yanai H, Taniguchi T.
    Fine-tuning type I IFN signaling: A new chapter in the IFN saga
    Cell Res. 27: 1407-1408 (2017). doi: 10.1038/cr.2017.118
11. 柳井秀元, 松木康祐, 谷口維紹
    HMGB1（High-mobility group box protein 1）による炎症制御
    炎症と免疫, 24: 17-23, 2016
12. Yanai H, Taniguchi T.
    Nucleic acid sensing and beyond: virtues and vices of HMGB1
    J. Intern. Med. 276:444-453 (2014). doi: 10.1111/joim.12285
13. Yanai H, Negishi H, Taniguchi T.
    The IRF family of transcription factors: Inception, impact and implications in oncogenesis
    Oncoimmunol. 1: 1376-1386 (2012). doi: 10.4161/onci.22475
14. Yanai H, Ban T, Taniguchi T.
    High-mobility group box family of proteins: ligand and sensor for innate immunity
    Trends. Immunol. 33: 633-640 (2012). doi: 10.1016/j.it.2012.10.005
15. Yanai H, Ban T, Taniguchi T.
    Essential role of high-mobility group box proteins in nucleic acid-mediated innate immune responses
    J. Intern. Med. 270: 301-308 (2011). doi: 10.1111/j.1365-2796.2011.02433.x
16. 柳井秀元
    核酸アナログによる自然免疫応答の調節
    ウイルス, 61: 141-152, 2011
17. Savitsky D, Tamura T, Yanai H, and Taniguchi T.
    Regulation of immunity and oncogenesis by the IRF transcription factor family
    Cancer Immunol. Immunother. 59: 489-510 (2010). doi: 10.1007/s00262-009-0804-6
18. Yanai H, Savitsky D, Tamura T, Taniguchi T.
    Regulation of the cytosolic DNA-sensing system in innate immunity: a current view
    Curr. Opin. Immunol. 1: 17-22 (2009). doi: 10.1016/j.coi.2009.01.005
19. 柳井秀元
    核酸認識におけるHMGBタンパクの役割
    細胞工学, 29: 1014-1019, 2009
20. 柳井秀元, 谷口維紹
    IRFファミリー転写因子と生体防御シグナル
    蛋白質核酸酵素, 53: 1231-1238, 2008
21. Tamura T, Yanai H, Savitsky D, Taniguchi T.
    The IRF Family Transcription Factors in Immunity and Oncogenesis
    Annu. Rev. Immunol. 26: 535-584 (2008). doi: 10.1146/annurev.immunol.26.021607.090400
22. 髙岡晃教, 柳井秀元, 本田 賢也, 大場 雄介, 谷口維紹
    IRFファミリー転写因子と生体防御機構
    「免疫2006」Molecular Medicine, 42: 308-317, 2006
23. 髙岡晃教, 柳井秀元
    IFN-IRFシステムと自己免疫疾患のつながり
    実験医学, 24: 1525-1534, 2006
24. Yanai H, Mizutani T, Inuzuka T, Honda K, Takaoka A, Taniguchi T.
    IRF family transcription factors in type I interferon induction
    Int. Congress Series 1285: 104-113 (2005). doi: 10.1016/j.ics.2005.09.010
25. Honda K, Yanai H, Takaoka A, Taniguchi T.
    Regulation of the type I IFN induction: a current view
    Int. Immunol. 17: 1367-1378 (2005). doi: 10.1093/intimm/dxh318
26. 髙岡晃教, 柳井秀元
    Class II cytokine receptors and their ligands
    日本臨床, 63: 193-201, 2005

学会発表

• Yanai H
  Suppression of anti-tumor immune responses by dead cell-derived molecules
  The 17th Annual Meeting of Chinese Society for Immunology (CSI), (2025/11/6). Chongqing China
• 柳井秀元
  組織特異的な腫瘍免疫微小環境形成機構の解明
  第47回日本分子生物学会年会 (2024/11/27). 福岡
• Yanai H
  Modulation of tumor immune responses by dead cell-derived molecules
  2nd International Congress of Asian Oncology Society (AOS), (2022/6/16). Seoul Korea

著書

• 千葉志穂, 柳井秀元
  オリゴ核酸投与による敗血症病態の抑制とその標的分子（敗血症の診断／治療の実状と病態・メカニズムをふまえた開発戦略）安保公介編
  技術情報協会、 56-60, 2013

受賞

• 2013年 日本免疫学会 研究奨励賞 受賞
• 2019年 日本インターフェロン・サイトカイン学会 研究奨励賞 受賞