{"id":928,"date":"2025-11-27T04:30:32","date_gmt":"2025-11-27T04:30:32","guid":{"rendered":"https:\/\/www-user.yokohama-cu.ac.jp\/~aritak7225\/?p=928"},"modified":"2026-01-29T03:08:33","modified_gmt":"2026-01-29T03:08:33","slug":"journal-of-biological-chemistry%e8%aa%8c%e3%81%ab%e6%8e%b2%e8%bc%89%ef%bc%9auhrf1%e3%81%a8%e3%83%8c%e3%82%af%e3%83%ac%e3%82%aa%e3%82%bd%e3%83%bc%e3%83%a0%e3%81%ae%e6%96%b0%e3%81%97%e3%81%84%e7%9b%b8","status":"publish","type":"post","link":"https:\/\/www-user.yokohama-cu.ac.jp\/~aritak7225\/journal-of-biological-chemistry%e8%aa%8c%e3%81%ab%e6%8e%b2%e8%bc%89%ef%bc%9auhrf1%e3%81%a8%e3%83%8c%e3%82%af%e3%83%ac%e3%82%aa%e3%82%bd%e3%83%bc%e3%83%a0%e3%81%ae%e6%96%b0%e3%81%97%e3%81%84%e7%9b%b8\/","title":{"rendered":"Journal of Biological Chemistry\u8a8c\u306b\u63b2\u8f09\uff1aUHRF1\u3068\u30cc\u30af\u30ec\u30aa\u30bd\u30fc\u30e0\u306e\u65b0\u3057\u3044\u76f8\u4e92\u4f5c\u7528\u3092\u767a\u898b\uff01"},"content":{"rendered":"\n<p class=\"is-style-big_icon_point\">2023\u5e74\u5ea6\u5352\u696d\u751f\u306e\u6577\u753a\u601c\u611b\u306b\u3088\u308b\u3001\u30af\u30e9\u30a4\u30aa\u96fb\u5b50\u9855\u5fae\u93e1\u3092\u7528\u3044\u305fUHRF1\u3068\u30cc\u30af\u30ec\u30aa\u30bd\u30fc\u30e0\u306e\u8907\u5408\u4f53\u69cb\u9020\u89e3\u6790\u306b\u95a2\u3059\u308b\u7814\u7a76\u6210\u679c\u304c\u3001\u56fd\u969b\u5b66\u8853\u8a8c\u300eJournal of Biological Chemistry\u300f\u306b\u63b2\u8f09\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p>UHRF1\u306fDNA\u30e1\u30c1\u30eb\u5316\u7dad\u6301\u306b\u5fc5\u9808\u306e\u56e0\u5b50\u3067\u3042\u308a\u3001\u305d\u306e\u904e\u7a0b\u3067\u306f\u30cc\u30af\u30ec\u30aa\u30bd\u30fc\u30e0\u4e2d\u306e\u30d2\u30b9\u30c8\u30f3H3\u3092\u30de\u30eb\u30c1\u30d7\u30eb\u30e2\u30ce\u30e6\u30d3\u30ad\u30c1\u30f3\u5316\u3057\u307e\u3059\u3002\u672c\u7814\u7a76\u3067\u306f\u3001UHRF1\u3068\u30d8\u30df\u30e1\u30c1\u30eb\u5316\u30b5\u30a4\u30c8\u3068H3K9me3\u306e\u4fee\u98fe\u3092\u5c0e\u5165\u3057\u305f\u30cc\u30af\u30ec\u30aa\u30bd\u30fc\u30e0\u306e\u8907\u5408\u4f53\u69cb\u9020\u3092\u30af\u30e9\u30a4\u30aa\u96fb\u5b50\u9855\u5fae\u93e1\u5358\u7c92\u5b50\u89e3\u6790\u306b\u3088\u3063\u3066\u6c7a\u5b9a\u3057\u307e\u3057\u305f\u3002UHRF1\u306eTTD\u30c9\u30e1\u30a4\u30f3\u4e2d\u306b\u3042\u308bArginine anchor\u304c\u3001\u30cc\u30af\u30ec\u30aa\u30bd\u30fc\u30e0\u306eacidic patch\u306b\u76f8\u4e92\u4f5c\u7528\u3059\u308b\u3053\u3068\u3092\u767a\u898b\u3057\u3001\u3053\u306e\u65b0\u898f\u306e\u76f8\u4e92\u4f5c\u7528\u304cUHRF1\u306b\u3088\u308b\u52b9\u7387\u7684\u306a\u30d2\u30b9\u30c8\u30f3H3\u306e\u30e6\u30d3\u30ad\u30c1\u30f3\u5316\u306b\u91cd\u8981\u3067\u3042\u308b\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p><strong>Shikimachi R<\/strong>, <strong>Matsuzawa S<\/strong>, <strong>Onoda H<\/strong>, Konuma T, Yamagata A, Shirouzu M, Yamaguchi K, #<strong>Arita K<\/strong>. Structural basis for E3 ubiquitin ligase UHRF1 binding to nucleosome core particle and histone H3 ubiquitination. <strong><em>J Biol Chem<\/em><\/strong>. 2025. doi: 10.1016\/j.jbc.2025.110894.<\/p>\n\n\n\n<p><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0021925825027462?via%3Dihub\" target=\"_blank\" rel=\"noreferrer noopener\">Journal of Biological Chemistry\u8a8c<\/a><\/p>\n\n\n\n<p><a href=\"https:\/\/www.yokohama-cu.ac.jp\/res-portal\/news\/20251202arita.html\" target=\"_blank\" rel=\"noreferrer noopener\">\u30d7\u30ec\u30b9\u30ea\u30ea\u30fc\u30b9<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>2023\u5e74\u5ea6\u5352\u696d\u751f\u306e\u6577\u753a\u601c\u611b\u306b\u3088\u308b\u3001\u30af\u30e9\u30a4\u30aa\u96fb\u5b50\u9855\u5fae\u93e1\u3092\u7528\u3044\u305fUHRF1\u3068\u30cc\u30af\u30ec\u30aa\u30bd\u30fc\u30e0\u306e\u8907\u5408\u4f53\u69cb\u9020\u89e3\u6790\u306b\u95a2\u3059\u308b\u7814\u7a76\u6210\u679c\u304c\u3001\u56fd\u969b\u5b66\u8853\u8a8c\u300eJournal of Biological Chemistry\u300f\u306b\u63b2\u8f09\u3055\u308c\u307e\u3057\u305f\u3002  [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":930,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"swell_btn_cv_data":"","_locale":"ja","_original_post":"https:\/\/www-user.yokohama-cu.ac.jp\/~aritak7225\/?p=928","footnotes":""},"categories":[3,5],"tags":[],"class_list":["post-928","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-member","category-research","ja"],"_links":{"self":[{"href":"https:\/\/www-user.yokohama-cu.ac.jp\/~aritak7225\/wp-json\/wp\/v2\/posts\/928"}],"collection":[{"href":"https:\/\/www-user.yokohama-cu.ac.jp\/~aritak7225\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www-user.yokohama-cu.ac.jp\/~aritak7225\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www-user.yokohama-cu.ac.jp\/~aritak7225\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www-user.yokohama-cu.ac.jp\/~aritak7225\/wp-json\/wp\/v2\/comments?post=928"}],"version-history":[{"count":5,"href":"https:\/\/www-user.yokohama-cu.ac.jp\/~aritak7225\/wp-json\/wp\/v2\/posts\/928\/revisions"}],"predecessor-version":[{"id":950,"href":"https:\/\/www-user.yokohama-cu.ac.jp\/~aritak7225\/wp-json\/wp\/v2\/posts\/928\/revisions\/950"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www-user.yokohama-cu.ac.jp\/~aritak7225\/wp-json\/wp\/v2\/media\/930"}],"wp:attachment":[{"href":"https:\/\/www-user.yokohama-cu.ac.jp\/~aritak7225\/wp-json\/wp\/v2\/media?parent=928"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www-user.yokohama-cu.ac.jp\/~aritak7225\/wp-json\/wp\/v2\/categories?post=928"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www-user.yokohama-cu.ac.jp\/~aritak7225\/wp-json\/wp\/v2\/tags?post=928"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}