{"id":828,"date":"2025-07-11T00:00:42","date_gmt":"2025-07-11T00:00:42","guid":{"rendered":"https:\/\/www-user.yokohama-cu.ac.jp\/~aritak7225\/?p=828"},"modified":"2026-01-29T03:09:33","modified_gmt":"2026-01-29T03:09:33","slug":"structure%e8%aa%8c%e3%81%ab%e6%8e%b2%e8%bc%89%ef%bc%9a%e8%84%b1%e3%83%a6%e3%83%93%e3%82%ad%e3%83%81%e3%83%b3%e5%8c%96%e9%85%b5%e7%b4%a0usp7%e3%81%ae%e6%b4%bb%e6%80%a7%e5%8c%96%e3%81%ab%e4%bc%b4","status":"publish","type":"post","link":"https:\/\/www-user.yokohama-cu.ac.jp\/~aritak7225\/structure%e8%aa%8c%e3%81%ab%e6%8e%b2%e8%bc%89%ef%bc%9a%e8%84%b1%e3%83%a6%e3%83%93%e3%82%ad%e3%83%81%e3%83%b3%e5%8c%96%e9%85%b5%e7%b4%a0usp7%e3%81%ae%e6%b4%bb%e6%80%a7%e5%8c%96%e3%81%ab%e4%bc%b4\/","title":{"rendered":"Structure\u8a8c\u306b\u63b2\u8f09\uff1a\u8131\u30e6\u30d3\u30ad\u30c1\u30f3\u5316\u9175\u7d20USP7\u306e\u6d3b\u6027\u5316\u306b\u4f34\u3046\u69cb\u9020\u5909\u5316\u3092\u30af\u30e9\u30a4\u30aa\u96fb\u9855\u3067\u53ef\u8996\u5316 \uff5e\u4e0d\u6d3b\u6027\u5316\u306e\u6642\u306f\u958b\u304d\u3001\u6d3b\u6027\u5316\u306e\u6642\u306f\u201c\u30b7\u30e5\u30c3\u201d\u3068\u9589\u3058\u308b\uff5e"},"content":{"rendered":"\n<p>\u4e2d\u6751\u83dc\u7dd2\u3055\u3093\uff08\u4fee\u58eb\u8ab2\u7a0b2\u5e74\uff09\u3068\u5409\u898b\u65e9\u6075\u3055\u3093\uff082022\u5e74\u5ea6\u4fee\u58eb\u8ab2\u7a0b\u4fee\u4e86\uff09\u306b\u3088\u308b\u3001\u8131\u30e6\u30d3\u30ad\u30c1\u30f3\u5316\u9175\u7d20USP7\u306e\u69cb\u9020\u751f\u7269\u5b66\u7684\u7814\u7a76\u6210\u679c\u304c\u3001\u56fd\u969b\u5b66\u8853\u8a8c\u300eStructure\u300f\u306b\u63b2\u8f09\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p>USP7\u306f\u3001DNA\u306e\u7dad\u6301\u30e1\u30c1\u30eb\u5316\u904e\u7a0b\u306b\u304a\u3044\u3066\u3001\u30e6\u30d3\u30ad\u30c1\u30f3\u5316\u3055\u308c\u305f\u30d2\u30b9\u30c8\u30f3H3\u304b\u3089\u30e6\u30d3\u30ad\u30c1\u30f3\u3092\u9664\u53bb\u3059\u308b\u5f79\u5272\u3092\u62c5\u3046\u91cd\u8981\u306a\u9175\u7d20\u3067\u3059\u3002\u672c\u7814\u7a76\u3067\u306f\u3001USP7\u306e\u8131\u30e6\u30d3\u30ad\u30c1\u30f3\u5316\u6d3b\u6027\u3092\u8a66\u9a13\u7ba1\u5185\u3067\u8a55\u4fa1\u3059\u308b\u5b9f\u9a13\u7cfb\u3092\u65b0\u305f\u306b\u69cb\u7bc9\u3057\u3001\u305d\u306e\u53cd\u5fdc\u6a5f\u69cb\u3092\u8a73\u7d30\u306b\u89e3\u6790\u3057\u307e\u3057\u305f\u3002\u3055\u3089\u306b\u3001\u30af\u30e9\u30a4\u30aa\u96fb\u5b50\u9855\u5fae\u93e1\u5358\u7c92\u5b50\u89e3\u6790\u306b\u3088\u308a\u3001USP7\u304cDNMT1\u3068\u7d50\u5408\u3057\u305f\u72b6\u614b\u3067\u3001\u4e0d\u6d3b\u6027\u72b6\u614b\u3067\u3042\u308b\u300c\u958b\u3044\u305f\u69cb\u9020\u300d\u3068\u3001\u6d3b\u6027\u72b6\u614b\u3067\u3042\u308b\u300c\u9589\u3058\u305f\u69cb\u9020\u300d\u306e2\u3064\u306e\u7570\u306a\u308b\u7acb\u4f53\u69cb\u9020\u3092\u3068\u308b\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p><strong>Nakamura N<\/strong>, <strong>Yoshimi S<\/strong>, <strong>Kikuchi A<\/strong>, <strong>Onoda H<\/strong>, <strong>Kori S<\/strong>, Nakanishi M, Nishiyama A, #<strong>Arita K<\/strong>. Structures of USP7 in active and inactive states bound to DNMT1 revealed by cryo-EM. <strong><em>Structure<\/em><\/strong> 33 1-9, 2025<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0969212625002217\" target=\"_blank\" rel=\"noreferrer noopener\">Structure\u8a8c<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/www.yokohama-cu.ac.jp\/res-portal\/news\/20250711arita.html\" target=\"_blank\" rel=\"noreferrer noopener\">\u65e5\u672c\u8a9e\u30d7\u30ec\u30b9\u30ea\u30ea\u30fc\u30b9<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/www.yokohama-cu.ac.jp\/news\/2025\/20250714nakamura.html\" target=\"_blank\" rel=\"noreferrer noopener\">\u5b66\u751f\u306e\u6d3b\u8e8d\u3000\u4e2d\u6751\u83dc\u7dd2<\/a><\/li>\n<\/ul>\n\n\n\n\n","protected":false},"excerpt":{"rendered":"<p>\u4e2d\u6751\u83dc\u7dd2\u3055\u3093\uff08\u4fee\u58eb\u8ab2\u7a0b2\u5e74\uff09\u3068\u5409\u898b\u65e9\u6075\u3055\u3093\uff082022\u5e74\u5ea6\u4fee\u58eb\u8ab2\u7a0b\u4fee\u4e86\uff09\u306b\u3088\u308b\u3001\u8131\u30e6\u30d3\u30ad\u30c1\u30f3\u5316\u9175\u7d20USP7\u306e\u69cb\u9020\u751f\u7269\u5b66\u7684\u7814\u7a76\u6210\u679c\u304c\u3001\u56fd\u969b\u5b66\u8853\u8a8c\u300eStructure\u300f\u306b\u63b2\u8f09\u3055\u308c\u307e\u3057\u305f\u3002 USP7\u306f\u3001DNA\u306e\u7dad\u6301\u30e1\u30c1\u30eb\u5316\u904e\u7a0b\u306b [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":840,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"swell_btn_cv_data":"","_locale":"ja","_original_post":"https:\/\/www-user.yokohama-cu.ac.jp\/~aritak7225\/?p=828","footnotes":""},"categories":[3,5],"tags":[],"class_list":["post-828","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-member","category-research","ja"],"_links":{"self":[{"href":"https:\/\/www-user.yokohama-cu.ac.jp\/~aritak7225\/wp-json\/wp\/v2\/posts\/828"}],"collection":[{"href":"https:\/\/www-user.yokohama-cu.ac.jp\/~aritak7225\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www-user.yokohama-cu.ac.jp\/~aritak7225\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www-user.yokohama-cu.ac.jp\/~aritak7225\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www-user.yokohama-cu.ac.jp\/~aritak7225\/wp-json\/wp\/v2\/comments?post=828"}],"version-history":[{"count":9,"href":"https:\/\/www-user.yokohama-cu.ac.jp\/~aritak7225\/wp-json\/wp\/v2\/posts\/828\/revisions"}],"predecessor-version":[{"id":952,"href":"https:\/\/www-user.yokohama-cu.ac.jp\/~aritak7225\/wp-json\/wp\/v2\/posts\/828\/revisions\/952"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www-user.yokohama-cu.ac.jp\/~aritak7225\/wp-json\/wp\/v2\/media\/840"}],"wp:attachment":[{"href":"https:\/\/www-user.yokohama-cu.ac.jp\/~aritak7225\/wp-json\/wp\/v2\/media?parent=828"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www-user.yokohama-cu.ac.jp\/~aritak7225\/wp-json\/wp\/v2\/categories?post=828"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www-user.yokohama-cu.ac.jp\/~aritak7225\/wp-json\/wp\/v2\/tags?post=828"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}