{"id":479,"date":"2024-08-05T03:14:03","date_gmt":"2024-08-05T03:14:03","guid":{"rendered":"https:\/\/www-user.yokohama-cu.ac.jp\/~aritak7225\/wp\/?page_id=479"},"modified":"2025-06-23T07:48:25","modified_gmt":"2025-06-23T07:48:25","slug":"%e3%83%88%e3%83%83%e3%83%97%e3%83%9a%e3%83%bc%e3%82%b8","status":"publish","type":"page","link":"https:\/\/www-user.yokohama-cu.ac.jp\/~aritak7225\/","title":{"rendered":"TOP PAGE"},"content":{"rendered":"\n<div class=\"swell-block-fullWide pc-py-0 sp-py-0 alignfull\"><div class=\"swell-block-fullWide__inner\">\n<h2 class=\"wp-block-heading is-style-section_ttl u-mb-ctrl u-mb-0\">&#8211; NEWS &#8211;<\/h2>\n<\/div><\/div>\n\n\n<div class=\"p-postListWrap u-mb-ctrl u-mb-30\"><ul class=\"p-postList -type-card -pc-col3 -sp-col1\"><li class=\"p-postList__item\">\n\t<a href=\"https:\/\/www-user.yokohama-cu.ac.jp\/~aritak7225\/en\/published-in-the-journal-of-biochemistry-discovery-of-a-new-interaction-between-uhrf1-and-the-nucleosome\/\" class=\"p-postList__link\">\n\t\t<div class=\"p-postList__thumb c-postThumb\">\n\t<figure class=\"c-postThumb__figure\">\n\t\t<img decoding=\"async\" width=\"1024\" height=\"1012\"  src=\"https:\/\/www-user.yokohama-cu.ac.jp\/~aritak7225\/wp\/wp-content\/uploads\/2025\/11\/251127_JBC_En-1024x1012.png\" alt=\"\" class=\"c-postThumb__img u-obf-cover\" srcset=\"https:\/\/www-user.yokohama-cu.ac.jp\/~aritak7225\/wp\/wp-content\/uploads\/2025\/11\/251127_JBC_En-1024x1012.png 1024w, https:\/\/www-user.yokohama-cu.ac.jp\/~aritak7225\/wp\/wp-content\/uploads\/2025\/11\/251127_JBC_En-300x297.png 300w, https:\/\/www-user.yokohama-cu.ac.jp\/~aritak7225\/wp\/wp-content\/uploads\/2025\/11\/251127_JBC_En-768x759.png 768w, https:\/\/www-user.yokohama-cu.ac.jp\/~aritak7225\/wp\/wp-content\/uploads\/2025\/11\/251127_JBC_En-1536x1518.png 1536w, https:\/\/www-user.yokohama-cu.ac.jp\/~aritak7225\/wp\/wp-content\/uploads\/2025\/11\/251127_JBC_En-2048x2024.png 2048w\" sizes=\"(min-width: 960px) 400px, 100vw\" loading=\"lazy\" >\t<\/figure>\n\t\t\t<span class=\"c-postThumb__cat icon-folder\" data-cat-id=\"1\">\u672a\u5206\u985e<\/span>\n\t<\/div>\n\t\t\t\t\t<div class=\"p-postList__body\">\n\t\t\t\t<h2 class=\"p-postList__title\">Published in the Journal of Biochemistry: Discovery of a New Interaction Between UHRF1 and the Nucleosome!<\/h2>\t\t\t\t\t\t\t\t<div class=\"p-postList__meta\">\n\t\t\t\t\t<div class=\"p-postList__times c-postTimes u-thin\">\n\t<time class=\"c-postTimes__posted icon-posted\" datetime=\"2025-11-27\" aria-label=\"\u516c\u958b\u65e5\">November 27, 2025<\/time><\/div>\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t<\/a>\n<\/li>\n<li class=\"p-postList__item\">\n\t<a href=\"https:\/\/www-user.yokohama-cu.ac.jp\/~aritak7225\/en\/breakthrough-study-uncovering-the-regulatory-mechanism-of-the-plant-maintenance-dna-methyltransferase-met1-published-in-nature-communications\/\" class=\"p-postList__link\">\n\t\t<div class=\"p-postList__thumb c-postThumb\">\n\t<figure class=\"c-postThumb__figure\">\n\t\t<img decoding=\"async\" width=\"1024\" height=\"699\"  src=\"https:\/\/www-user.yokohama-cu.ac.jp\/~aritak7225\/wp\/wp-content\/uploads\/2025\/09\/250929MET1_English-1024x699.png\" alt=\"\" class=\"c-postThumb__img u-obf-cover\" srcset=\"https:\/\/www-user.yokohama-cu.ac.jp\/~aritak7225\/wp\/wp-content\/uploads\/2025\/09\/250929MET1_English-1024x699.png 1024w, https:\/\/www-user.yokohama-cu.ac.jp\/~aritak7225\/wp\/wp-content\/uploads\/2025\/09\/250929MET1_English-300x205.png 300w, https:\/\/www-user.yokohama-cu.ac.jp\/~aritak7225\/wp\/wp-content\/uploads\/2025\/09\/250929MET1_English-768x525.png 768w, https:\/\/www-user.yokohama-cu.ac.jp\/~aritak7225\/wp\/wp-content\/uploads\/2025\/09\/250929MET1_English-1536x1049.png 1536w, https:\/\/www-user.yokohama-cu.ac.jp\/~aritak7225\/wp\/wp-content\/uploads\/2025\/09\/250929MET1_English-2048x1399.png 2048w\" sizes=\"(min-width: 960px) 400px, 100vw\" loading=\"lazy\" >\t<\/figure>\n\t\t\t<span class=\"c-postThumb__cat icon-folder\" data-cat-id=\"5\">\u7814\u7a76<\/span>\n\t<\/div>\n\t\t\t\t\t<div class=\"p-postList__body\">\n\t\t\t\t<h2 class=\"p-postList__title\">Breakthrough study uncovering the regulatory mechanism of the plant maintenance DNA methyltransferase MET1 published in Nature Communications.<\/h2>\t\t\t\t\t\t\t\t<div class=\"p-postList__meta\">\n\t\t\t\t\t<div class=\"p-postList__times c-postTimes u-thin\">\n\t<time class=\"c-postTimes__posted icon-posted\" datetime=\"2025-09-29\" aria-label=\"\u516c\u958b\u65e5\">September 29, 2025<\/time><\/div>\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t<\/a>\n<\/li>\n<li class=\"p-postList__item\">\n\t<a href=\"https:\/\/www-user.yokohama-cu.ac.jp\/~aritak7225\/en\/usp7-in-action-cryo-em-captures-the-structural-change-of-usp7\/\" class=\"p-postList__link\">\n\t\t<div class=\"p-postList__thumb c-postThumb\">\n\t<figure class=\"c-postThumb__figure\">\n\t\t<img decoding=\"async\" width=\"1024\" height=\"892\"  src=\"https:\/\/www-user.yokohama-cu.ac.jp\/~aritak7225\/wp\/wp-content\/uploads\/2025\/07\/\uff12\uff15\uff10\uff17\uff12\uff11-1024x892.jpg\" alt=\"\" class=\"c-postThumb__img u-obf-cover\" srcset=\"https:\/\/www-user.yokohama-cu.ac.jp\/~aritak7225\/wp\/wp-content\/uploads\/2025\/07\/\uff12\uff15\uff10\uff17\uff12\uff11-1024x892.jpg 1024w, https:\/\/www-user.yokohama-cu.ac.jp\/~aritak7225\/wp\/wp-content\/uploads\/2025\/07\/\uff12\uff15\uff10\uff17\uff12\uff11-300x261.jpg 300w, https:\/\/www-user.yokohama-cu.ac.jp\/~aritak7225\/wp\/wp-content\/uploads\/2025\/07\/\uff12\uff15\uff10\uff17\uff12\uff11-768x669.jpg 768w, https:\/\/www-user.yokohama-cu.ac.jp\/~aritak7225\/wp\/wp-content\/uploads\/2025\/07\/\uff12\uff15\uff10\uff17\uff12\uff11.jpg 1351w\" sizes=\"(min-width: 960px) 400px, 100vw\" loading=\"lazy\" >\t<\/figure>\n\t\t\t<span class=\"c-postThumb__cat icon-folder\" data-cat-id=\"5\">\u7814\u7a76<\/span>\n\t<\/div>\n\t\t\t\t\t<div class=\"p-postList__body\">\n\t\t\t\t<h2 class=\"p-postList__title\">USP7 in Action! Cryo-EM Captures the structural change of USP7.<\/h2>\t\t\t\t\t\t\t\t<div class=\"p-postList__meta\">\n\t\t\t\t\t<div class=\"p-postList__times c-postTimes u-thin\">\n\t<time class=\"c-postTimes__posted icon-posted\" datetime=\"2025-07-11\" aria-label=\"\u516c\u958b\u65e5\">July 11, 2025<\/time><\/div>\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t<\/a>\n<\/li>\n<\/ul><div class=\"is-style-more_btn\"><a href=\"https:\/\/www-user.yokohama-cu.ac.jp\/~aritak7225\/en\/news\/\" class=\"btn_text\">READ MORE<\/a><\/div><\/div>\n\n\n<div class=\"swell-block-fullWide pc-py-0 sp-py-0 alignfull\"><div class=\"swell-block-fullWide__inner\">\n<h2 class=\"wp-block-heading is-style-section_ttl u-mb-ctrl u-mb-0\">&#8211; About &#8211;<\/h2>\n<\/div><\/div>\n\n\n\n<p>Welcome to our web site!<\/p>\n\n\n\n<p>One of the most exciting aspects of structural biology is the opportunity to visualize the beautiful three-dimensional structures of proteins\u2014many of which have never been seen before. Why not enjoy the thrill of discovery and contribute to research that inspires wonder?<br>Our laboratory is home to many enthusiastic students who are actively engaged in their research. We welcome motivated undergraduate, master&#8217;s, and doctoral students who are eager to take on scientific challenges. If you are interested in joining us, please feel free to get in touch.<\/p>\n\n\n\n<p>Our research focuses on the structural biology of the epigenome\u2014the mechanisms by which DNA methylation and histone modifications regulate cellular identity and function. By elucidating the three-dimensional structures of key molecular complexes, we aim to understand how the epigenome is established and maintained. Since epigenomic dysregulation is closely linked to cancer and aging, we are also engaged in structure-based drug discovery targeting these pathways.<\/p>\n\n\n\n<p>If our research interests you, please don\u2019t hesitate to contact us. We look forward to hearing from you!<\/p>\n\n\n\n<h4 class=\"wp-block-heading u-mb-ctrl u-mb-5\">Keywords<\/h4>\n\n\n\n<ul class=\"wp-block-list u-mb-ctrl u-mb-10\">\n<li>Structural biology (X-ray crystallography, cryo-electron microscopy, X-ray solution scattering, high-speed AFM)<\/li>\n\n\n\n<li>Epigenetics (chromatin, DNA methylation, histone modification, ubiquitination)<\/li>\n\n\n\n<li>Reconstitution of complex biomolecular complexes including proteins and DNA<\/li>\n<\/ul>\n\n\n\n<div class=\"swell-block-button is-style-more_btn u-mb-ctrl u-mb-30\"><a href=\"\/~aritak7225\/en\/about\/\" class=\"swell-block-button__link\"><span>Read More about The Research Content<\/span><\/a><\/div>\n\n\n\n<div class=\"swell-block-fullWide pc-py-0 sp-py-0 alignfull\"><div class=\"swell-block-fullWide__inner\">\n<h2 class=\"wp-block-heading is-style-section_ttl u-mb-ctrl u-mb-0\">&#8211; Contact &#8211;<\/h2>\n<\/div><\/div>\n\n\n\n<p>Kyohei Arita \uff08Professor\uff09<br>Structural Biology Laboratory, Graduate School of Medical Life Science, Yokohama City University<\/p>\n\n\n\n<p>address\uff1a1-7-29 Suehiro-cho, Tsurumi-ku, Yokohama \u3012230-0045 JAPAN<br>TEL\uff1a045-508-7225<br>mail\uff1a<a href=\"mailto:aritak@yokohama-cu.ac.jp\">aritak@yokohama-cu.ac.jp<\/a><\/p>\n\n\n\n<h4 class=\"wp-block-heading u-mb-ctrl u-mb-5\">Link<\/h4>\n\n\n\n<div class=\"swell-block-columns\" style=\"--clmn-w--pc:33.33%\" data-valign=\"center\"><div class=\"swell-block-columns__inner\">\n<div class=\"swell-block-column swl-has-mb--s\">\n<figure class=\"wp-block-image size-full is-resized is-style-shadow\"><a href=\"https:\/\/www.yokohama-cu.ac.jp\/\" target=\"_blank\" rel=\"noreferrer noopener\"><img decoding=\"async\" width=\"1000\" height=\"370\" src=\"https:\/\/www-user.yokohama-cu.ac.jp\/~aritak7225\/wp\/wp-content\/uploads\/2024\/07\/ycu.png\" alt=\"\" class=\"wp-image-208\" style=\"object-fit:contain;width:300px;height:80px\" srcset=\"https:\/\/www-user.yokohama-cu.ac.jp\/~aritak7225\/wp\/wp-content\/uploads\/2024\/07\/ycu.png 1000w, https:\/\/www-user.yokohama-cu.ac.jp\/~aritak7225\/wp\/wp-content\/uploads\/2024\/07\/ycu-300x111.png 300w, https:\/\/www-user.yokohama-cu.ac.jp\/~aritak7225\/wp\/wp-content\/uploads\/2024\/07\/ycu-768x284.png 768w\" sizes=\"(max-width: 1000px) 100vw, 1000px\" \/><\/a><\/figure>\n<\/div>\n\n\n\n<div class=\"swell-block-column swl-has-mb--s\">\n<figure class=\"wp-block-image size-full is-resized is-style-shadow\"><a href=\"http:\/\/www-mls.tsurumi.yokohama-cu.ac.jp\/\" target=\"_blank\" rel=\"noreferrer noopener\"><img decoding=\"async\" width=\"679\" height=\"174\" src=\"https:\/\/www-user.yokohama-cu.ac.jp\/~aritak7225\/wp\/wp-content\/uploads\/2024\/07\/gs-mls.png\" alt=\"\" class=\"wp-image-205\" style=\"object-fit:contain;width:300px;height:80px\" srcset=\"https:\/\/www-user.yokohama-cu.ac.jp\/~aritak7225\/wp\/wp-content\/uploads\/2024\/07\/gs-mls.png 679w, https:\/\/www-user.yokohama-cu.ac.jp\/~aritak7225\/wp\/wp-content\/uploads\/2024\/07\/gs-mls-300x77.png 300w\" sizes=\"(max-width: 679px) 100vw, 679px\" \/><\/a><\/figure>\n<\/div>\n<\/div><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Welcome to our web site! One of the most exciting aspects of structural biology is the opportunity to visualize the beautiful three-dimensional structures of proteins\u2014many of which have never been seen before. Why not enjoy the thrill of discovery and contribute to research that inspires wonder?Our laboratory is home to many enthusiastic students who are [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"swell_btn_cv_data":"","_locale":"en_US","_original_post":"https:\/\/www-user.yokohama-cu.ac.jp\/~aritak7225\/wp\/?page_id=7","footnotes":""},"class_list":["post-479","page","type-page","status-publish","hentry","en-US"],"_links":{"self":[{"href":"https:\/\/www-user.yokohama-cu.ac.jp\/~aritak7225\/wp-json\/wp\/v2\/pages\/479"}],"collection":[{"href":"https:\/\/www-user.yokohama-cu.ac.jp\/~aritak7225\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www-user.yokohama-cu.ac.jp\/~aritak7225\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www-user.yokohama-cu.ac.jp\/~aritak7225\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www-user.yokohama-cu.ac.jp\/~aritak7225\/wp-json\/wp\/v2\/comments?post=479"}],"version-history":[{"count":7,"href":"https:\/\/www-user.yokohama-cu.ac.jp\/~aritak7225\/wp-json\/wp\/v2\/pages\/479\/revisions"}],"predecessor-version":[{"id":873,"href":"https:\/\/www-user.yokohama-cu.ac.jp\/~aritak7225\/wp-json\/wp\/v2\/pages\/479\/revisions\/873"}],"wp:attachment":[{"href":"https:\/\/www-user.yokohama-cu.ac.jp\/~aritak7225\/wp-json\/wp\/v2\/media?parent=479"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}