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原著論文 / Original papers

Tsurusaki Y, Okamoto N, Ohashi H, Kosho T, Imai Y, Hibi-Ko Y, Kaname T, Naritomi K, Kawame H, Wakui K, Fukushima Y, Homma T, Kato M, Hiraki Y, Yamagata T, Yano S, Mizuno S, Sakazume S, Ishii T, Nagai T, Shiina M, Ogata K, Ohta T, Niikawa N, Miyatake S, Okada I, Mizuguchi T, Doi H, Saitsu H, Miyake N, Matsumoto N: Mutations affecting components of the SWI/SNF complex cause Coffin-Siris syndrome. Nat. Genet., 44(4): 376-378, 2012.

Yoneda Y, Saitsu H, Touyama M, Makita Y, Miyamoto A, Hamada K, Kurotaki N, Tomita H, Nishiyama K, Tsurusaki Y, Doi H, Miyake N, Ogata K, Naritomi K, Matsumoto N: Missense mutations in the DNA-binding/dimerization domain of NFIX cause Sotos-like features. J. Hum. Genet., 57(3): 207-211, 2012.

Saitsu H, Osaka H, Sasaki M, Takanashi J, Hamada K, Yamashita A, Shibayama H, Shiina M, Kondo Y, Nishiyama K, Tsurusaki Y, Miyake N, Doi H, Ogata K, Inoue K, Matsumoto N: Mutations in POLR3A and POLR3B encoding RNA Polymerase III subunits cause an autosomal-recessive hypomyelinating leukoencephalopathy. Am. J. Hum. Genet., 89(5): 644-651, 2011.

Babayeva N D, Wilder P J, Shiina M, Mino K, Desler M, Ogata K, Rizzino A, Tahirov T H: Structural basis of Ets1 cooperative binding to palindromic sequences on stromelysin-1 promoter DNA. Cell Cycle, 9: 3054-3062, 2010.

Saitsu H, Tohyama J, Kumada T, Egawa K, Hamada K, Okada I, Mizuguchi T, Osaka H, Miyata R, Furukawa T, Haginoya K, Hoshino H, Goto T, Hachiya Y, Yamagata T, Saitoh S, Nagai T, Nishiyama K, Nishimura A, Miyake N, Komada M, Hayashi K, Hirai S, Ogata K, Kato M, Fukuda A, Matsumoto N: Dominant-negative mutations in alpha-II spectrin cause West syndrome with severe cerebral hypomyelination, spastic quadriplegia, and developmental delay. Am. J. Hum. Genet., 86(6): 881-891, 2010.

Yamashita K, Suzuki A, Satoh Y, Ide M, Amano Y, Masuda-Hirata M, Hayashi YK, Hamada K, Ogata K, Ohno S: The 8th and 9th tandem spectrin-like repeats of utrophin cooperatively form a functional unit to interact with polarity-regulating kinase PAR-1b. Biochem. Biophys. Res. Commun., 391(1): 812-817, 2010.

Saitsu H, Kato M, Mizuguchi T, Hamada K, Osaka H, Tohyama J, Uruno K, Kumada S, Nishiyama K, Nishimura A, Okada I, Yoshimura Y, Hirai S, Kumada T, Hayasaka K, Fukuda A, Ogata K, Matsumoto N: De novo mutations in the gene encoding STXBP1 (MUNC18-1) cause early infantile epileptic encephalopathy. Nat. Genet., 40(6): 782-788, 2008.

Sekine K, Chen YR, Kojima N, Ogata K, Fukamizu A, Miyajima A: Foxo1 links insulin signaling to C/EBPalpha and regulates gluconeogenesis during liver development. EMBO, 26: 3607-3615, 2007.

Tomoko Morita, Akio Yamashita, Isao Kashima, Kazuhiro Ogata, Shoichi Ishiura, Shigeru Ohno: Distant N-terminal and C-terminal domains are required for intrinsic kinase activity of SMG-1, a critical component of nonsense-mediated mRNA decay. J. Biol. Chem., 16: 7799-7808, 2007.

Nobumoto Watanabe, Harumi Arai, Jun-ichi Iwasaki, Masaaki Shiina, Kazuhiro Ogata, Tony Hunter, Hiroyuki Osada: Cyclin-dependent kinase (CDK) phosphorylation destabilizes somatic Wee1 via multiple pathways. Proc. Natl. Acad. Sci. USA, 102: 11663-11668, 2005.

Ogata K, Sato K, Tahirov TH: Eukaryotic transcriptional regulatory complexes: cooperativity from near and afar. Curr. Opin. Struct. Biol., 13: 40-48, 2003.

Tahirov TH, Sato K, Ichikawa-Iwata E, Sasaki M, Inoue-Bungo T, Shiina M, Kimura K, Takata S, Fujikawa A, Morii H, Kumasaka T, Yamamoto M, Ishii S, Ogata K: Mechanism of c-Myb-C/EBPβ cooperation from separated sites on a promoter. Cell, 108: 57-70, 2002.

Tahirov TH, Sato, K, Inoue-Bungo T, Ichikawa-Iwata E, Sasaki M,Fujikawa A, Shiina M, Takata S, Kimura K, Morii H, Kumasaka T, Yamamoto M, Ishii S, Ogata K: Structural aspects of gene expression by AML1/CBFβ, c-Myb, AMV v-Myb, C/EBPβ and Ets-1. Acta Crystallogr. D Biol. Crystallogr., 58: C20, 2002.

Tahirov TH, Sasaki M, InoueT, Fujikawa A, Sato K, Kumasaka T, Yamamoto M, Ogata K: Crystals of ternary protein-DNA complexes composed of DNA binding domains of c-Myb or v-Myb, C/EBPα or C/EBPβ, and tom-1A promoter fragment. Acta Crystallogr. D Biol. Crystallogr., 57: 1655-1658, 2001.

Lassalle MW, Yamada H, Morii H, Ogata K, Sarai A, Akasaka K: Cavity volume estimation by high pressure NMR. The c-Myb R2 subdomain. Proteins, 45: 96-101, 2001.

Tahirov TH, Inoue T, Sasaki M, Shiina M, Kimura K, Sato K, Kumasaka T, Yamamoto M, Kamiya N, Ogata K: Crystallization and preliminary X-ray analyses of quaternary, ternary and binary protein-DNA complexes with involvement of AML1/Runx-1/CBFα Runt domain, CBFβ and the C/EBPβ bZip region. Acta Crystallogr. D Biol. Crystallogr., 57: 850-853 , 2001.

Tahirov TH, Inoue T, Sasaki M, Fujikawa A, Kimura K, Sato K, Adachi S, Kamiya N, Ogata K: Crystallization and preliminary X-ray analysis of the C/EBPβ C-terminal region in complex with DNA. Acta Crystallogr. D Biol. Crystallogr., 57: 854-856, 2001.

Tahirov TH, Inoue T, Sasaki M, Kimura K, Morii H, Fujikawa A, Shiina M, Sato K, Kumasaka T, Yamamoto M, Ishii S, Ogata K: Structural analyses of DNA recognition by the AML1/Runx-1 Runt domain and its allosteric control by CBFβ. Cell, 104: 755-767, 2001.


総説 / reviews

緒方一博、浜田恵輔:転写制御因子の分子構造と作用機構.転写制御とエピジェネティクス―ゲノムデコードに向けて― 南山堂, : 116-129, 2008.

椎名政昭,浜田恵輔、緒方一博:分子生物学実験シリーズ「図・写真で観るタンパク構造・機能解析実験実践ガイド」タンパク質の立体構造解析を行うために分子構造解析のためのタンパク質試料調整法.メディカル ドゥ, : 18-32, 2005.

緒方一博: 特集 転写制御と疾患 タンパク質の分子構造異常と癌化.Molecular Medicine, 42: 64-75, 2005.

Ogata K, Tahirov TH, Ishii S: c-Myb DNA-binding domain: from molecular structure to functions “Myb Transcription Factors: Their Role in Growth, Differentiation and Disease”, ed. by J. Frampton. Kluwer Academic Publishers B.V., 223-238, 2004.

緒方一博: 特集 ゲノムからプロテオームへヒトプロテオミクスの目指すもの ポストゲノム時代の生化学,構造生物学生体分子の機能発現機構の解明を目指して生化学, 76: 1305-1319, 2004

緒方一博: プロモーターDNA上での転写制御因子会合体の形成と転写調節の分子機構.日本結晶学会誌, 45: 19-25, 2003

緒方一博: 構造解析のための試料調製(総論) タンパク質-DNA複合体を中心として遺伝子医学, 6: 86-95 , 2002.

緒方一博: 分子構造から見たRunxタンパク質によるDNA認識とその制御.細胞工学, 21: 1216-1219, 2002

緒方一博, Tahirov TH 転写因子Runx-1/AML1CBFβによるアロステリック制御.細胞工学, 20: 488-489, 2001