Department of Microbiology and Molecular  Biodefense Research
 
                            
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Publications

 Akihide Ryo M.D.Ph.D.  
 Last Updated: Sept. 2014  
       
     
2014
 
   

Induced cancer stem-like cells as a model for biological screening and discovery of agents targeting phenotypic traits of cancer stem cell. Nishi M, Akutsu H, Kudoh A, Kimura H, Yamamoto N, Umezawa A, Lee SW, RyoA.Oncotarget August 17, 2014

 
 
   

Combination of vaccine-strain measles and mumps virus synergistically kills a wide range of human hematological cancer cells: special focus on acute myeloid leukemia. Zhang L, Tan DQ, Jeyasekharan AD, Hsieh WS, Ho AS, Ichiyama K, Ye M, Pang B, Ohba K, Liu X, de Mel S, Cuong BK, Chng WJ, Ryo A, Suzuki Y, Yeoh KG, Toan NL, Yamamoto N. Cancer Lett. 2014 Sep 1. pii: S0304-3835 

 
   



An outbreak of acute respiratory infections due to human respiratory syncytial virus in a nursing home for the elderly in Ibaraki, Japan, 2014.
Doi I, Nagata N, Tsukagoshi H, Komori H, Motoya T, Watanabe M, Keta T, Kawakami M, Tsukano T, Honda M, Ishioka T, Takeda M, Ryo A, Kuroda M, Oishi K, Kimura H. Jpn J Infect Dis. 2014;67(4):326-8. 

 
   

Proteomic Analysis of Proteins Related to Prognosis of Lung Adenocarcinoma.Okayama A, Miyagi Y, Oshita F, Nishi M, Nakamura Y, Nagashima Y, Akimoto K, Ryo A, Hirano H. J Proteome Res. 2014 Jul 8.

 
   



Wheat germ cell-free system-based production of hemagglutinin-neuraminidase glycoprotein of human parainfluenza virus type 3 for generation and characterization of monoclonal antibody.
Matsunaga S, Kawakami S, Matsuo I, Okayama A, Tsukagoshi H, Kudoh A, Matsushima Y, Shimizu H, Okabe N, Hirano H, Yamamoto N, Kimura H, Ryo A. Front Microbiol. 2014 May 13;5:208.

 
     

Profiling of autoantibodies in sera of pancreatic cancer patients.Nagayoshi Y, Nakamura M, Matsuoka K, Ohtsuka T, Mori Y, Kono H, Aso T, Ideno N, Takahata S, Ryo A, Takeda H, Ito T, Oda Y, Endo Y, Sawasaki T, Tanaka M.Ann Surg Oncol. 2014 Jun;21 Suppl 3:459-65.

 
     

Quantitative analysis of location- and sequence-dependent deamination by APOBEC3G using real-time NMR spectroscopy.Furukawa A, Sugase K, Morishita R, Nagata T, Kodaki T, Takaori-Kondo A, Ryo A, Katahira M.Angew Chem Int Ed Engl. 2014 Feb 24;53(9):2349-52.

 
     

The phosphorylation of HIV-1 Gag by atypical protein kinase C facilitates viral infectivity by promoting Vpr incorporation into virions. Kudoh A, Takahama S, Sawasaki T, Ode H, Yokoyama M, Okayama A, Ishikawa A, Miyakawa K, Matsunaga S, Kimura H, Sugiura W, Sato H, Hirano H, Ohno S, Yamamoto N, Ryo A.
Retrovirology
. 2014 Jan 22;11:9.

 
     

Cyclosporin A and its analogs inhibit hepatitis B virus entry into cultured hepatocytes through targeting a membrane transporter, sodium taurocholate cotransporting polypeptide (NTCP).Watashi K, Sluder A, Daito T, Matsunaga S, Ryo A, Nagamori S, Iwamoto M, Nakajima S, Tsukuda S, Borroto-Esoda K, Sugiyama M, Tanaka Y, Kanai Y, Kusuhara H, Mizokami M, Wakita T.Hepatology. 2014 May;59(5):1726-37.

 
     

Genetic analysis of human rhinovirus species A to C detected in patients with acute respiratory infection in Kumamoto prefecture, Japan 2011-2012.Kiyota N, Kobayashi M, Tsukagoshi H, Ryo A, Harada S, Kusaka T, Obuchi M, Shimojo N, Noda M, Kimura H. Infect Genet Evol. 2014 Jan;21:90-102

 
     

Induction of cells with cancer stem cell properties from nontumorigenic human mammary epithelial cells by defined reprogramming factors.Nishi M, Sakai Y, Akutsu H, Nagashima Y, Quinn G, Masui S, Kimura H, Perrem K, Umezawa A, Yamamoto N, Lee SW, Ryo A.
Oncogene. 2014 Jan 30;33(5):643-52.

 
     
2013

 
     

Development of oligomannose-coated liposome-based nasal vaccine against human parainfluenza virus type 3.Senchi K, Matsunaga S, Hasegawa H, Kimura H, Ryo A.Front Microbiol. 2013 Nov 26;4:346.

 
     

Generation of rhesus macaque-tropic HIV-1 clones that are resistant to major anti-HIV-1 restriction factors.Nomaguchi M, Yokoyama M, Kono K, Nakayama EE, Shioda T, Doi N, Fujiwara S, Saito A, Akari H, Miyakawa K, Ryo A, Ode H, Iwatani Y, Miura T, Igarashi T, Sato H, Adachi A.J Virol. 2013 Nov;87(21):11447-61.

 
     

Molecular evolution of attachment glycoprotein (G) gene in human respiratory syncytial virus detected in Japan 2008-2011. Kushibuchi I, Kobayashi M, Kusaka T, Tsukagoshi H, Ryo A, Yoshida A, Ishii H, Saraya T, Kurai D, Yamamoto N, Kanou K, Saitoh M, Noda M, Kuroda M, Morita Y, Kozawa K, Oishi K, Tashiro M, Kimura H. Infect Genet Evol. 2013 Aug;18:168-73.

 
     

Anti-interleukin-5 and multiple autoantibodies are associated with human atherosclerotic diseases and serum interleukin-5 levels. Ishigami T, Abe K, Aoki I, Minegishi S, Ryo A, Matsunaga S, Matsuoka K, Takeda H, Sawasaki T, Umemura S, Endo Y. FASEB J. 2013 Sep;27(9):3437-45.

 
     

Sulfated polysaccharide, curdlan sulfate, efficiently prevents entry/fusion and restricts antibody-dependent enhancement of dengue virus infection in vitro: a possible candidate for clinical application. Ichiyama K, Gopala Reddy SB, Zhang LF, Chin WX, Muschin T, Heinig L, Suzuki Y, Nanjundappa H, Yoshinaka Y, Ryo A, Nomura N, Ooi EE, Vasudevan SG, Yoshida T, Yamamoto N. PLoS Negl Trop Dis. 2013 Apr 25;7(4):e2188.

 
     

Cytokine profiles, signalling pathways and effects of fluticasone propionate in respiratory syncytial virus-infected human foetal lung fibroblasts.Seki E, Yoshizumi M, Tanaka R, Ryo A, Ishioka T, Tsukagoshi H, Kozawa K, Okayama Y, Okabe-Kado J, Goya T, Kimura H.Cell Biol Int. 2013 Jan 22.

 
     

Genetic analysis of the VP4/VP2 coding region in human rhinovirus species C in patients with acute respiratory infection in Japan. Kiyota N, Kushibuchi I, Kobayashi M, Tsukagoshi H, Ryo A, Nishimura K, Hirata-Saito A, Harada S, Arakawa M, Kozawa K, Noda M, Kimura H. J Med Microbiol. 2013 Apr;62(Pt 4):610-7.

 
     

Cytomegalovirus retinitis during maintenance therapy for T-cell acute lymphoblastic leukemia. Wakai K, Sano H, Shimada A, Shiozawa Y, Park MJ, Sotomatsu M, Yanagisawa R, Koike K, Kozawa K, Ryo A, Tsukagoshi H, Kimura H, Hayashi Y. J Pediatr Hematol Oncol. 2013 Mar;35(2):162-3.

 
     

Pin1 interacts with the Epstein-Barr virus DNA polymerase catalytic subunit and regulates viral DNA replication.Narita Y, Murata T, Ryo A, Kawashima D, Sugimoto A, Kanda T, Kimura H, Tsurumi T. Virol. 2013 Feb;87(4):2120-7.

 
     

Molecular evolution of hemagglutinin (H) gene in measles virus genotypes D3, D5, D9, and H1. Saitoh M, Takeda M, Gotoh K, Takeuchi F, Sekizuka T, Kuroda M, Mizuta K, Ryo A, Tanaka R, Ishii H, Takada H, Kozawa K, Yoshida A, Noda M, Okabe N, Kimura H. PLoS One. 2012;7(11):e50660.

 
     

Genetic analysis of non-hydrogen sulfide-producing Salmonella enterica serovar typhimurium and S. enterica serovar infantis isolates in Japan. Sakano C, Kuroda M, Sekizuka T, Ishioka T, Morita Y, Ryo A, Tsukagoshi H, Kawai Y, Inoue N, Takada H, Ogaswara Y, Nishina A, Shimoda MA, Kozawa K, Oishi K, Kimura H. J Clin Microbiol. 2013 Jan;51(1):328-30

 
     

Seroepidemiology of Saffold cardiovirus (SAFV) genotype 3 in Japan.Kobayashi M, Tsukagoshi H, Ishioka T, Mizuta K, Noda M, Morita Y, Ryo A, Kozawa K, Kimura H. J Infect. 2013 Feb;66(2):191-3.

 
   
 2012
 
     
Cytomegalovirus Retinitis During Maintenance Therapy for T-Cell Acute Lymphoblastic Leukemia.Wakai K, Sano H, Shimada A, Shiozawa Y, Park MJ, Sotomatsu M, Yanagisawa R, Koike K, Kozawa K, Ryo A, Tsukagoshi H, Kimura H, Hayashi Y.
J Pediatr Hematol Oncol. 2012 Dec 13.
 
     
Pin1 interacts with the Epstein-Barr virus DNA polymerase catalytic subunit and regulates viral DNA replication.
Narita Y, Murata T, Ryo A, Kawashima D, Sugimoto A, Kanda T, Kimura H, Tsurumi T.
J Virol. 2012 Dec 5.
 
     
Molecular evolution of hemagglutinin (h) gene in measles virus genotypes d3, d5, d9, and h1. Saitoh M, Takeda M, Gotoh K, Takeuchi F, Sekizuka T, Kuroda M, Mizuta K, Ryo A, Tanaka R, Ishii H, Takada H, Kozawa K, Yoshida A, Noda M, Okabe N, Kimura H.
PLoS One. 2012;7(11):e50660. doi: 10.
 
     
Genetic analysis of non-hydrogen sulfide-producing Salmonella enterica serovar Typhimurium and Infantis isolates in Japan. Sakano C, Kuroda M, Sekizuka T, Ishioka T, Morita Y, Ryo A, Tsukagoshi H, Kawai Y, Inoue N, Takada H, Ogaswara Y, Nishina A, Shimoda MA, Kozawa K, Oishi K, Kimura H.
J Clin Microbiol. 2012 Nov 7.
 
   


Seroepidemiology of Saffold cardiovirus (SAFV) genotype 3 in Japan.
Kobayashi M, Tsukagoshi H, Ishioka T, Mizuta K, Noda M, Morita Y, Ryo A, Kozawa K, Kimura H.
J Infect. 2012 Oct 26. doi:pii: S0163-4453(12)

 
   


Establishment of a robust dengue virus NS3-NS5 binding assay for identification of protein-protein interaction inhibitors.
Takahashi H, Takahashi C, Moreland NJ, Chang YT, Sawasaki T, Ryo A, Vasudevan SG, Suzuki Y, Yamamoto N.
Antiviral Res
. 2012 Oct 13. pii: S0166-3542(12)00230-6.

 
   


Interferon-Induced SCYL2 Limits Release of HIV-1 by Triggering PP2A-Mediated Dephosphorylation of the Viral Protein Vpu. Miyakawa K, Sawasaki T, Matsunaga S, Tokarev A, Quinn G, Kimura H, Nomaguchi M, Adachi A, Yamamoto N, Guatelli J, Ryo A.
Sci Signal. 2012 Oct 9;5(245):ra73.

 
   
NMR study of xenotropic murine leukemia virus-related virus protease in a complex with amprenavir.
Furukawa A, Okamura H, Morishita R, Matsunaga S, Kobayashi N, Ikegami T, Kodaki T, Takaori-Kondo A, Ryo A, Nagata T, Katahira M.
Biochem Biophys Res Commun
. 2012 Aug 24;425(2):284-9.
 
   

Molecular and enzymatic characterization of XMRV protease by a cell-free proteolytic analysis.
Matsunaga S, Sawasaki T, Ode H, Morishita R, Furukawa A, Sakuma R, Sugiura W, Sato H, Katahira M, Takaori-Kondo A, Yamamoto N, Ryo A.
J Proteomics. 2012 Aug 3;75(15):4863-73.
 
     
Prolyl Isomerase Pin1 Regulates Neuronal Differentiation via β-Catenin. Nakamura K, Kosugi I, Lee DY, Hafner A, Sinclair DA, Ryo A, Lu KP.
Mol Cell Biol. 2012 Aug;32(15):2966-78. .
 
     
Molecular epidemiology of the attachment glycoprotein (G) gene in respiratory syncytial virus in children with acute respiratory infection in Japan in 2009/2010.
Yoshida A, Kiyota N, Kobayashi M, Nishimura K, Tsutsui R, Tsukagoshi H, Hirano E, Yamamoto N, Ryo A, Saitoh M, Harada S, Inoue O, Kozawa K, Tanaka R, Noda M, Okabe N, Tashiro M, Mizuta K, Kimura H.
J Med Microbio
l
. 2012 Jun;61(Pt 6):820-9.
 
       
     2011

 
   

Identification of phosphorylated proteins involved in the oncogenesis of prostate cancer via Pin1-proteomic analysis.
Endoh K, Nishi M, Ishiguro H, Uemura H, Miyagi Y, Aoki I, Hirano H, Kubota Y, Ryo A.
Prostate
.
2011 Aug 1. doi: 10

 
   
A distinct role for Pin1 in the induction and maintenance of pluripotency.
Nishi M, Akutsu H, Masui S, Kondo A, Nagashima Y, Kimura H, Perrem K, Shigeri Y, Toyoda M, Okayama A, Hirano H, Umezawa A, Yamamoto N, Lee SW, Ryo A.
J Biol Chem
. 2011 Apr 1;286(13):11593-603.
 
   
Heat shock protein 70 inhibits HIV-1 Vif-mediated ubiquitination and degradation of APOBEC3G.
Sugiyama R, Nishitsuji H, Furukawa A, Katahira M, Habu Y, Takeuchi H, Ryo A, Takaku H.
J Biol Chem
. 2011 Mar 25;286(12):10051-7.
 
     
The impact of Saffold cardiovirus in patients with acute respiratory infections in Yamagata, Japan.
Tsukagoshi H, Mizuta K, Abiko C, Itagaki T, Yoshizumi M, Kobayashi M, Kuroda M, Kozawa K, Noda M, Ryo A, Kimura H. Scand J Infect Dis. 2011 Mar 24.
 
     
.Vaccination with human induced pluripotent stem cells creates an antigen-specific immune response against HIV-1 gp160. Yoshizaki S, Nishi M, Kondo A, Kojima Y, Yamamoto N,Ryo A.
Frontiers in Microbiology, 2011 Feb 22;2:27.

 
     2010
 
     

Modulation of intracellular signaling using protein-transduction technology. Kobiyama K, Jounai N, Ishii KJ, Horii T, Suzuki K, Ryo A, Takeshita F.
Crit Rev Immunol
. 2010;30(5):395-421.

 
     

A structural constraint for functional interaction between N-terminal and C-terminal domains in simian immunodeficiency virus capsid proteins. Inagaki N, Takeuchi H, Yokoyama M, Sato H, Ryo A, Yamamoto H, Kawada M, Matano T.
Retrovirology
. 2010 Oct
18;7:90.

 
     

Sequencing and phylogenetic analyses of Saffold cardiovirus (SAFV) genotype 3 isolates from children with upper respiratory infection in Gunma, Japan. Tsukagoshi H, Masuda Y, Mizutani T, Mizuta K, Saitoh M, Morita Y, Nishina A, Kozawa K, Noda M, Ryo A, Kimura H.
Jpn J Infect Dis
. 2010 Sep;63(5):378-80.

 
     
Pinning down viral proteins: A new prototype for virus-host cell interaction. Kojima Y, Ryo A.
Frontiers in MICROBIOLOGY. 2010 Sep 9;1:10
7
 
   
Thymic alterations in GM2 gangliosidoses model mice. Kanzaki S, Yamaguchi A, Yamaguchi K, Kojima Y, Suzuki K, Koumitsu N, Nagashima Y, Nagahama K, Ehara M, Hirayasu Y, Ryo A, Aoki I, Yamanaka S.
PLoS One
. 2010 Aug 10;5(8).
 
     

DNA vaccine expressing HIV-1 gp120/immunoglobulin fusion protein enhances cellular immunity.
Shimada M, Yoshizaki S, Jounai N, Kondo A, Ichino M, Ryo A, Okuda K.
Vaccine
. 2010 Jul 12;28(31):4920-7
.

 
     

Endoscopic therapy using an endoscopic variceal ligation for minute cancer of the esophagogastric junction complicated with esophageal varices: a case report.
Akiyama T, Abe Y, Iida H, Endo H, Hosono K, Yoneda K, Takahashi H, Inamori M, Ryo A, Yamanaka S, Inayama Y, Nakajima A.
J Med Case Reports
. 2010 May 23;4:149
.

 
     

Co-administration of viral vector-based vaccines suppresses antigen-specific effector CD8 T cells. Yashima S, Yoshizaki S, Shinoda K, Yoshida A, Kondo A, Mizuguchi H, Ryo A, Okuda K, Shimada M.
Vaccine
. 2010 Apr 19;28(18):3257-64. Epub 2010 .


 
     Elevated PIN1 expression by C/EBPalpha-p30 blocks C/EBPalpha-induced granulocytic differentiation through c-Jun in AML.Pulikkan JA, Dengler V, Peer Zada AA, Kawasaki A, Geletu M, Pasalic Z, Bohlander SK, Ryo A, Tenen DG, Behre G. Leukemia. 2010 Apr 8.

 
 

Pin1 promotes transforming growth factor-beta-induced migration and invasion. Matsuura I, Chiang KN, Lai CY, He D, Wang G, Ramkumar R, Uchida T, Ryo A, Lu K, Liu F.
J Biol Chem. 2010 Jan 15;285(3):1754-64.

 
     2009
 
     BCA2/Rabring7 promotes tetherin-dependent HIV-1 restriction. Miyakawa K, Ryo A, Murakami T, Ohba K, Yamaoka S, Fukuda M, Guatelli J, Yamamoto N.
PLoS Pathog. 2009 Dec;5(12):e1000700.

 
     Pin1 catalyzes conformational changes of Thr187 in p27Kip1 and mediates its stability through a poly-ubiquitination process. Zhou W, Yang Q, Low CB, Karthik BC, Wang Y, Ryo A, Yao SQ, Yang D, Liou YC.
J Biol Chem. 2009 Jul 7.

 
   

Follicular dendritic cells activate HIV-1 replication in monocytes/macrophages through a juxtacrine mechanism mediated by P-selectin glycoprotein ligand 1. Ohba K, Ryo A, Dewan MZ, Nishi M, Naito T, Qi X, Inagaki Y, Nagashima Y, Tanaka Y, Okamoto T, Terashima K, Yamamoto N.
J Immunol
. 2009 Jul 1;183(1):524-32
.

 
   Requirement for microtubule integrity in the SOCS1-mediated intracellular dynamics of HIV-1 Gag. Nishi M, Ryo A, Tsurutani N, Ohba K, Sawasaki T, Morishita R, Perrem K, Aoki I, Morikawa Y, Yamamoto N.
FEBS Lett. 2009 Apr 17;583(8):1243-50.

 
     The prolyl isomerase Pin1 stabilizes the human T-cell leukemia virus type 1 (HTLV-1) Tax oncoprotein and promotes malignant transformation.Jeong SJ, Ryo A, Yamamoto N.
Biochem Biophys Res Commun. 2009 Apr 3;381(2):294-9.

 

   Pinning down HER2-ER crosstalk in SMRT regulation. Ryo A, Wulf G, Lee TH, Lu KP.
Trends
Biochem Sci. 2009 Apr;34(4):162-5
.

 
     2008
 

   Low-intensity pulsed ultrasound activates the phosphatidylinositol 3 kinase/Akt pathway and stimulates the growth of chondrocytes in three-dimensional cultures: a basic science study. Takeuchi R, Ryo A, Komitsu N, Mikuni-Takagaki Y, Fukui A, Takagi Y, Shiraishi T, Morishita S, Yamazaki Y, Kumagai K, Aoki I, Saito T.
Arthritis Res Ther. 2008;10(4):R77.

 

   The wheat germ cell-free based screening of protein substrates of calcium/calmodulin-dependent protein kinase II delta. Masaoka T, Nishi M, Ryo A, Endo Y, Sawasaki T.
FEBS Lett. 2008 Jun 11;582(13):1795-801.

 
   SOCS1 is an inducible host factor during HIV-1 infection and regulates the intracellular trafficking and stability of HIV-1 Gag.
Ryo A, Tsurutani N, Ohba K, Kimura R, Komano J, Nishi M, Soeda H, Hattori S, Perrem K, Yamamoto M, Chiba J, Mimaya J, Yoshimura K, Matsushita S, Honda M, Yoshimura A, Sawasaki T, Aoki I, Morikawa Y, Yamamoto N.
Proc Natl Acad Sci U S A. 2008 Jan 8;105(1):294-9.

 
     2007
 
   A suppressive role of the prolyl isomerase Pin1 in cellular apoptosis mediated by the death-associated protein Daxx. Ryo A, Hirai A, Nishi M, Liou YC, Perrem K, Lin SC, Hirano H, Lee SW, Aoki I.
J Biol Chem
. 2007 Dec 14;282(50):36671-81
.

 
     2006
 
   Negative regulation of interferon-regulatory factor 3-dependent innate antiviral response by the prolyl isomerase Pin1. Saitoh T, Tun-Kyi A, Ryo A, Yamamoto M, Finn G, Fujita T, Akira S, Yamamoto N, Lu KP, Yamaoka S.
Nat Immunol
. 2006 Jun;7(6):598-605.


 
   An immunohistochemical scoring system of prolyl isomerase Pin1 for predicting relapse of prostate carcinoma after radical prostatectomy. Sasaki T, Ryo A, Uemura H, Ishiguro H, Inayama Y, Yamanaka S, Kubota Y, Nagashima Y, Harada M, Aoki I.
Pathol Res Pract
. 2006;202(5):357-64
.

 
   Pin1 regulates centrosome duplication, and its overexpression induces centrosome amplification, chromosome instability, and oncogenesis. Suizu F, Ryo A, Wulf G, Lim J, Lu KP.
Mol Cell Biol. 2006 Feb;26(4):1463-79.

 
   Prolyl-isomerase Pin1 accumulates in lewy bodies of parkinson disease and facilitates formation of alpha-synuclein inclusions. Ryo A, Togo T, Nakai T, Hirai A, Nishi M, Yamaguchi A, Suzuki K, Hirayasu Y, Kobayashi H, Perrem K, Liou YC, Aoki I.
J Biol Chem. 2006 Feb 17;281(7):4117-25.

 
     2005
 
   Stable suppression of tumorigenicity by Pin1-targeted RNA interference in prostate cancer. Ryo A, Uemura H, Ishiguro H, Saitoh T, Yamaguchi A, Perrem K, Kubota Y, Lu KP, Aoki I.
Clin Cancer Res. 2005 Oct 15;11(20):7523-31.

 
     2003
 
   Regulation of NF-kappaB signaling by Pin1-dependent prolyl isomerization and ubiquitin-mediated proteolysis of p65/RelA. Ryo A, Suizu F, Yoshida Y, Perrem K, Liou YC, Wulf G, Rottapel R, Yamaoka S, Lu KP.
Mol Cell. 2003 Dec;12(6):1413-26.

 
   Activation of Galectin-1 gene in human hepatocellular carcinoma involves methylation-sensitive complex formations at the transcriptional upstream and downstream elements. Kondoh N, Hada A, Ryo A, Shuda M, Arai M, Matsubara O, Kimura F, Wakatsuki T, Yamamoto M.
Int J Oncol. 2003 Dec;23(6):1575-83.

 
   Identification of epilepsy-related genes by gene expression profiling in the hippocampus of genetically epileptic rat. Arai M, Amano S, Ryo A, Hada A, Wakatsuki T, Shuda M, Kondoh N, Yamamoto M.
Brain Res Mol Brain Res. 2003 Oct 21;118(1-2):147-51.

 
   Role of the prolyl isomerase Pin1 in protecting against age-dependent neurodegeneration.
Liou YC, Sun A, Ryo A, Zhou XZ, Yu ZX, Huang HK, Uchida T, Bronson R, Bing G, Li X, Hunter T, Lu KP.
Nature. 2003 Jul 31;424(6948):556-61.

 
   Modulation of p53 and p73 levels by cyclin G: implication of a negative feedback regulation. Ohtsuka T, Ryu H, Minamishima YA, Ryo A, Lee SW.
Oncogene. 2003 Mar 20;22(11):1678-87.

 
   The prolyl isomerase Pin1 in breast development and cancer. Wulf G, Ryo A, Liou YC, Lu KP.
Breast Cancer Res. 2003;5(2):76-82.

 
   Prolyl isomerase Pin1: a catalyst for oncogenesis and a potential therapeutic target in cancer. Ryo A, Liou YC, Lu KP, Wulf G.
J Cell Sci. 2003 Mar 1;116(Pt 5):773-83.

 
     2002
 

   Role of Pin1 in the regulation of p53 stability and p21 transactivation, and cell cycle checkpoints in response to DNA damage. Wulf GM, Liou YC, Ryo A, Lee SW, Lu KP.
J Biol Chem. 2002 Dec 13;277(50):47976-9.

 
     PIN1 is an E2F target gene essential for Neu/Ras-induced transformation of mammary epithelial cells. Ryo A, Liou YC, Wulf G, Nakamura M, Lee SW, Lu KP.
Mol Cell Biol. 2002 Aug;22(15):5281-95.

 
   Identification of PGC7, a new gene expressed specifically in preimplantation embryos and germ cells. Sato M, Kimura T, Kurokawa K, Fujita Y, Abe K, Masuhara M, Yasunaga T, Ryo A, Yamamoto M, Nakano T.
Mech Dev. 2002 Apr;113(1):91-4.

 
   Loss of Pin1 function in the mouse causes phenotypes resembling cyclin D1-null phenotypes. Liou YC, Ryo A, Huang HK, Lu PJ, Bronson R, Fujimori F, Uchida T, Hunter T, Lu KP.
Proc Natl Acad Sci U S A. 2002 Feb 5;99(3):1335-40.

 
   Pin1 regulates turnover and subcellular localization of beta-catenin by inhibiting its interaction with APC. Ryo A, Nakamura M, Wulf G, Liou YC, Lu KP.
Nat Cell Biol. 2001 Sep;3(9):793-801.

 
     2001
 
     Pin1 is overexpressed in breast cancer and cooperates with Ras signaling in increasing the transcriptional activity of c-Jun towards cyclin D1. Wulf GM, Ryo A, Wulf GG, Lee SW, Niu T, Petkova V, Lu KP.
EMBO J. 2001 Jul 2;20(13):3459-72.

 
 

Enhanced expression of mRNAs of antisecretory factor-1, gp96, DAD1 and CDC34 in human hepatocellular carcinomas. Tanaka K, Kondoh N, Shuda M, Matsubara O, Imazeki N, Ryo A, Wakatsuki T, Hada A, Goseki N, Igari T, Hatsuse K, Aihara T, Horiuchi S, Yamamoto N, Yamamoto M.
Biochim Biophys Acta. 2001 Apr 30;1536(1):1-12.

 
   Use of serial analysis of gene expression (SAGE) technology. Yamamoto M, Wakatsuki T, Hada A, Ryo A.
J Immunol Methods. 2001 Apr;250(1-2):45-66. Review.

 
     2000
 
   Enhanced expression of translation factor mRNAs in hepatocellular carcinoma. Shuda M, Kondoh N, Tanaka K, Ryo A, Wakatsuki T, Hada A, Goseki N, Igari T, Hatsuse K, Aihara T, Horiuchi S, Shichita M, Yamamoto N, Yamamoto M.
Anticancer Res. 2000 Jul-Aug;20(4):2489-94.

 

   Identification and characterization of differentially expressed mRNAs in HIV type 1-infected human T cells.Ryo A, Suzuki Y, Arai M, Kondoh N, Wakatsuki T, Hada A, Shuda M, Tanaka K, Sato C, Yamamoto M, Yamamoto N.
AIDS Res Hum Retroviruses. 2000 Jul 1;16(10):995-1005

 

   A modified serial analysis of gene expression that generates longer sequence tags by nonpalindromic cohesive linker ligation. Ryo A, Kondoh N, Wakatsuki T, Hada A, Yamamoto N, Yamamoto M.
Anal Biochem. 2000 Jan 1;277(1):160-2.

 
     1999
 

 
   Serial analysis of gene expression in HIV-1-infected T cell lines. Ryo A, Suzuki Y, Ichiyama K, Wakatsuki T, Kondoh N, Hada A, Yamamoto M, Yamamoto N.
FEBS Lett. 1999 Nov 26;462(1-2):182-6.

 

   Identification and characterization of genes associated with human hepatocellular carcinogenesis. Kondoh N, Wakatsuki T, Ryo A, Hada A, Aihara T, Horiuchi S, Goseki N, Matsubara O, Takenaka K, Shichita M, Tanaka K, Shuda M, Yamamoto M.
Cancer Res. 1999 Oct 1;59(19):4990-6.

 

   Serial analysis of gene expression in a microglial cell line. Inoue H, Sawada M, Ryo A, Tanahashi H, Wakatsuki T, Hada A, Kondoh N, Nakagaki K, Takahashi K, Suzumura A, Yamamoto M, Tabira T.
Glia. 1999 Dec;28(3):265-71.

 

   A method to isolate differentially expressed genes by displaying specific inner portion of cDNA fragments. Kondoh N, Wakatsuki T, Ryo A, Tanaka K, Hada A, Shichita M, Yamamoto M.
Anal Biochem. 1999 May 1;269(2):427-30.

 


   A method for analyzing the qualitative and quantitative aspects of gene expression: a transcriptional profile revealed for HeLa cells. Ryo A, Kondoh N, Wakatsuki T, Hada A, Yamamoto N, Yamamoto M.
Nucleic Acids Res. 1998 Jun 1;26(11):2586-92.

 
       
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