The brain is made up of precisely wired neuronal circuitry with assemblies of neuronal cells that continually receive information, elaborate and perceive it, and make decisions.  The neuronal cells use chemical substances called neurotransmitters to mediate most of the synaptic transmission in the nervous system.  Synaptic transmission occurs at synapses, where the axon comes in contact with other neurons and passes information on to them.   Hence proper axonal growth to appropriate synaptic targets is essential for the production of a functioning nervous system.  We are interested in understanding the molecular and cellular mechanisms of the interaction between the neurotransmitters and their receptors, and the signal transduction underlying axonal guidance, transport, and synaptic plasticity.

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