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Welcome to Department of Molecular Pharmacology & Neurobiology

業績

2021年

  • Jitsuki-Takahashi A, Jitsuki S, Yamashita N, Kawamura M, Abe M, Sakimura K, Sano A, Nakamura F, Goshima Y, Takahashi T. Activity-Induced Secretion of Semaphorin 3A Mediates Learning.Eur J Neurosci. doi:10.1111/ejn.15210. Epub ahead of print, 2021.
  • Kawashima T, Jitsuki-Takahashi A, Takizawa K, Jitsuki S, Takahashi T, Ohshima T, Goshima Y, Nakamura F. Phosphorylation of Collapsin Response Mediator Protein1 (CRMP1) at Tyrosine 504 residue regulates Semaphorin 3A-induced cortical dendritic growth. J Neurochem. doi: 10.1111/jnc.15304. Epub ahead of print, 2021.
  • Sugeno A, Piao W, Yamazaki M, Takahashi K, Arikawa K, Matsunaga H, Hosokawa M, Tominaga D, Goshima Y, Takeyama H, Ohshima T. Cortical transcriptome analysis after spinal cord injury reveals the regenerative mechanism of central nervous system in CRMP2 knock-in mice. Neural Regen Res. 16(7):1258-1265. doi: 10.4103/1673-5374.301035, 2021.

2020年

  • Kasahara Y, Masukawa D, Nakamura Y, Murata K, Hashimoto T, Takizawa K, Koga M, Nakamura F, Fukazawa Y, Funakoshi K, Goshima Y. Distribution of mRNA for GPR143, a receptor of 3,4-L-dihydroxyphenylalanine, and of immunoreactivities for nicotinic acetylcholine receptors in the nigrostriatal and mesolimbic regions. Neurosci Res. S0168-0102(20)30423-5. doi: 10.1016/j.neures.2020.08.003. Online ahead of print, 2020.
  • Masukawa D, Nishizawa D, Kanai K, Kitamura S, Kasahara Y, Hashimoto T, Takahagi R, Hasegawa J, Nakayama K, Sato N, Tanioka F, Sugimura H, Ikeda K, Goshima Y. Genetic associations of single nucleotide polymorphisms in the l-DOPA receptor(GPR143) gene with severity of nicotine dependence in Japanese individuals, and attenuation of nicotine reinforcement in Gpr143 gene-deficient mice. J Pharmacol Sci. 144(2):89-93. doi: 10.1016/j.jphs.2020.07.003, 2020.
  • Li W, Goshima Y, Ohshima T. Loss of Collapsin Response Mediator Protein 4 Attenuates 6-Hydroxydopamine-Induced Impairments in a Mouse Model of Parkinson's Disease. Neurochem Res. doi: 10.1007/s11064-020-03086-z. Online ahead of print, 2020.
  • Nakamura F, Ohshima T, Goshima Y. Collapsin Response Mediator Proteins: Their Biological Functions and Pathophysiology in Neuronal Development and Regeneration. Front Cell Neurosci. 14:188. doi: 10.3389/fncel.2020.00188, 2020.
  • Togashi K, Hasegawa M, Nagai J, Kotaka K, Yazawa A, Takahashi M, Masukawa D, Goshima Y, Hensley K, Ohshima T. Lanthionine ketimine ester improves outcome in an MPTP-induced mouse model of Parkinson's disease via suppressions of CRMP2 phosphorylation and microglial activation. J Neurol Sci. 413:116802. doi: 10.1016/j.jns.2020.116802. [Epub ahead of print], 2020.
  • Takabatake M, Goshima Y, Sasaki Y. Semaphorin-3A Promotes Degradation of Fragile X Mental Retardation Protein in Growth Cones via the Ubiquitin-Proteasome Pathway. Front Neural Circuits. 28;14:5. doi: 10.3389/fncir.2020.00005, eCollection 2020.
  • Hamanaka K, Imagawa E, Koshimizu E, Miyatake S, Tohyama J, Yamagata T, Miyauchi A, Ekhilevitch N, Nakamura F, Kawashima T, Goshima Y, Mohamed AR, Ch'ng GS, Fujita A, Azuma Y, Yasuda K, Imamura S, Nakashima M, Saitsu H, Mitsuhashi S, Mizuguchi T, Takata A, Miyake N, Matsumoto N. De Novo Truncating Variants in the Last Exon of SEMA6B Cause Progressive Myoclonic Epilepsy. Am J Hum Genet. pii: S0002-9297(20)30053-7. doi: 10.1016/j.ajhg.2020.02.011. [Epub ahead of print], 2020.
  • Yamazaki Y, Nagai J, Akinaga S, Koga Y, Hasegawa M, Takahashi M, Yamashita N, Kolattukudy P, Goshima Y, Ohshima T. Phosphorylation of CRMP2 is required for migration and positioning of Purkinje cells: Redundant roles of CRMP1 and CRMP4. Brain Res. 1736:146762. doi: 10.1016/j.brainres.2020.146762. [Epub ahead of print] ,2020.
  • Yazawa K, Nakamura F, Masukawa D, Sato S, Hiroshima Y, Yabushita Y, Mori R, Matsuyama R, Kato I, Taniguchi H, Goshima Y, Endo I. Low Incidence of High-Grade Pancreatic Intraepithelial Neoplasia Lesions in a Crmp4 Gene-Deficient Mouse Model of Pancreatic Cancer. Transl Oncol. 13(3):100746. doi:10.1016/j.tranon.2020.100746. [Epub ahead of print], 2020.

2019年

  • Goshima Y, Masukawa D, Kasahara Y, Hashimoto T, Aladeokin AC. L-DOPA and Its Receptor GPR143: Implications for Pathogenesis and Therapy in Parkinson's Disease.Front Pharmacol. 10:1119. doi: 10.3389/fphar.2019.01119. eCollection 2019. Review.
  • Masukawa D, Yamada K, Goshima Y. Overexpression of the gene product of ocular albinism 1 (GPR143/OA1) but not its mutant forms inhibits neurite outgrowth in PC12 cells. J Pharmacol Sci. 141(1):41-48. doi:10.1016/j.jphs.2019.09.002. Epub 2019 Sep 11.
  • Aladeokin AC, Akiyama T, Kimura A, Kimura Y, Takahashi-Jitsuki A, Nakamura H, Makihara H, Masukawa D, Nakabayashi J, Hirano H, Nakamura F, Saito T, Saido T, Goshima Y. Network-guided analysis of hippocampal proteome identifies novel proteins that colocalize with Aβ in a mice model of early-stage Alzheimer's disease. Neurobiol Dis. doi: 10.1016/j.nbd.2019.104603, 2019.
  • アルツハイマー型認知症(AD) モデルマウスの比較的初期の海馬のプロテオーム解析及びパスウェイ解析を行い、ADに関わる可能性のある新規分子の同定に成功した。これらのタンパク質のいくつかはADの成因の一つとされるアミロイドβタンパク質と共局在を示した。

  • Kinoshita Y, Kondo S, Takahashi K, Nagai J, Wakatsuki S, Araki T, Goshima Y, Ohshima T. Genetic inhibition of CRMP2 phosphorylation delays Wallerian degeneration after optic nerve injury. Biochem Biophys Res Commun. 514(4):1037-1039. doi: 10.1016/j.bbrc.2019.05.060, 2019.
  • Kondo S, Takahashi K, Kinoshita Y, Nagai J, Wakatsuki S, Araki T, Goshima Y, Ohshima T. Genetic inhibition of CRMP2 phosphorylation at serine 522 promotes axonal regeneration after optic nerve injury. Sci Rep. 9(1):7188. doi: 10.1038/s41598-019
    -43658-w, 2019.
  • Goshima Y. [Historical background of pharmacology education in medical school in Japan]. Nihon Yakurigaku Zasshi. 153(3):103-106. doi: 10.1254/fpj.153.103. Japanese, 2019.
  • 日本の医学教育の歴史的背景とその特色、今後取り組むべき課題について概説した。

  • Kasahara Y, Igata H, Sasaki T, Ikegaya Y, Koyama R. The pharmacological assessment of GABA A receptor activation in experimental febrile seizures in mice. eNeuro, 6(1). doi: 10.1523/ENEURO.0429-18.2019, 2019.

2018年

  • Goshima Y, Watanabe S, Seki E, Koga M, Masukawa D, Nakamura F, Komori T, Arai
    N. Immunoreactivity of a G protein-coupled l-DOPA receptor GPR143, in Lewy
    bodies. Neurosci Res. pii: S0168-0102(18)30598-4. doi:10.1016/j.neures.2018.12.
    004., 2018.
  • L-ドーパ受容体、GPR143がレビー小体に局在することを発見
    パーキンソン病罹患患者剖検脳組織において、ドーパ受容体であるGPR143がパーキンソン病脳の中脳黒質に見られるレビー小体という構造物に含まれることを見出しました。現在でも、L—ドーパはパーキンソン病の特効薬ですが、その受容体分子がレビー小体に存在するとの今回の知見は、病気そのものの進展や、L-ドーパの薬効、副作用に関わる可能性を示唆します。

    *論文掲載サイト
     https://doi.org/10.1016/j.neures.2018.12.004

  • Togashi K, Hasegawa M, Nagai J, Tonouchi A, Masukawa D, Hensley K, Goshima Y,
    Ohshima T. Genetic suppression of collapsin response mediator protein 2
    phosphorylation improves outcome in methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson's model mice. Genes Cells. 24(1):31-40. doi: 10.1111/gtc.12651. Epub 2018 Nov 18.
  • Pernia CD, Nathan NH, Tobe BTD, Winquist AM, Sidman RL, Goshima Y, Snyder EY.
    Modeling Complex Neurological Diseases with Stem Cells: A Study of Bipolar Disorder. Results Probl Cell Differ. 66:265-282. doi:10.1007/978-3-319-93485-3_12, 2018.
  • Numata-Uematsu Y, Wakatsuki S, Nagano S, Shibata M, Sakai K, Ichinohe N, Mikoshiba K, Ohshima T, Yamashita N, Goshima Y, Araki T. Inhibition of collapsin response mediator protein-2 phosphorylation ameliorates motor phenotype of ALS model mice expressing SOD1G93A. Neurosci Res. pii: S0168-0102(18)30499-1. doi:10.1016/j.neures.2018.08.016, 2018.
  • Watanabe K, Nomoto M, Nakamura F, Hachuda S, Sakata A, Watanabe T, Goshima Y, Baba T. Label-free and spectral-analysis-free detection of neuropsychiatricdisease biomarkers using an ion-sensitive GaInAsP nanolaser biosensor. Biosens Bioelectron. 2;117:161-167. doi: 10.1016/j.bios.2018.05.059, 2018.
  • Nakamura H, Takahashi-Jitsuki A, Makihara H, Asano T, Kimura Y, Nakabayashi J,Yamashita N, Kawamoto Y, Nakamura F, Ohshima T, Hirano H, Tanaka F, Goshima Y.Proteome and behavioral alterations in phosphorylation-deficient mutant CollapsinResponse Mediator Protein2 knock-in mice. Neurochem Int. pii:S0197-0186(17)30576-4. doi: 10.1016/j.neuint.2018.04.009, 2018.
  • Abe H, Jitsuki S, Nakajima W, Murata Y, Jitsuki-Takahashi A, Katsuno Y, TadaH, Sano A, Suyama K, Mochizuki N, Komori T, Masuyama H, Okuda T, Goshima Y, Higo N, Takahashi T. CRMP2-binding compound, edonerpic maleate, accelerates motor function recovery from brain damage. Science, 360(6384):50-57. doi:10.1126/science.aao2300, 2018.
  • Suzuki S, Shino M, Fujikawa T, Itoh Y, Ueda E, Hashimoto T, Kuji T, Kobayashi N, Ohnishi T, Hirawa N, Tamura K, and Toya Y: Plasma Cystine Levels and Cardiovascular and All-Cause Mortality in Hemodialysis Patients. Ther Apher Dial, 22(5): 476-484. doi: 10.1111/ 1744-9987.12669, 2018.
  • Nakamori H, Yoshida S, Ishiguro H, Suzuki S, Yasuzaki H, Hashimoto T, Ishigami T, Hirawa N, Toya Y, Umemura S, Tamura K: Arterial wall hypertrophy is ameliorated by α2-adrenergic receptor antagonist or aliskiren in kidneys of angiotensinogen-knockout mice. Clin Exp Nephrol, 22(4): 773-781. https://doi.org/10.1007/s10157-017-1520-8, 2018.

2017年

  • Tsutiya A, Nakano Y, Hansen-Kiss E, Kelly B, Nishihara M, Goshima Y, Corsmeier D, White P, Herman GE, Ohtani-Kaneko R. Human CRMP4 mutation and disrupted Crmp4 expression in mice are associated with ASD characteristics and sexual dimorphism. Sci Rep, 7(1):16812. doi: 10.1038/s41598-017-16782-8, 2017.
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  • Masukawa D, Koga M, Sezaki A, Nakao Y, Kamikubo Y, Hashimoto T, Okuyama-Oki Y, Aladeokin AC, Nakamura F, Yokoyama U, Wakui H, Ichinose H, Sakurai T, Umemura S, Tamura K, Ishikawa Y, Goshima Y. L-DOPA sensitizes vasomotor tone by modulating the vascular alpha1-adrenergic receptor. JCI Insight 2(18). pii: 90903. doi: 10.1172/jci.insight.90903.
  • 新しい血圧コントロールの仕組みを解明!

     私達は、本学循環器・腎臓・高血圧内科学、循環制御医学教室と共同で、血圧が昼夜で変動する新たな仕組みを明らかにしました。
     血圧は、心臓と血管の働きを通じ、交感神経や副交感神経と呼ばれる自律神経系によってコントロールされることが知られています。我々は、主に交感神経から遊離されるノルアドレナリンという血管収縮物質に対する血管の反応性が、ノルアドレナリンの原料となるドーパというアミノ酸によってコントロールされていることを明らかにしました。
     本成果は、従来の治療法では血圧のコントロールが困難な高血圧症や、それに伴う心疾患、腎疾患の新しい治療法につながることが期待されます。

    なお本研究は、米国科学誌『JCI Insight』に掲載されました。

    *論文掲載サイト
     https://insight.jci.org/articles/view/90903
    *大学HP
     http://www.yokohama-cu.ac.jp/amedrc/news/20170922_goshima.html

      
  • Hirokawa T, Zou Y, Kurihara Y, Jiang Z, Sakakibara Y, Ito H, Funakoshi K, Kawahara N, Goshima Y, Strittmatter SM, Takei K. Regulation of axonal regeneration by the level of function of the endogenous Nogo receptor antagonist LOTUS. Sci Rep. 7(1):12119. doi: 10.1038/s41598-017-12449-6
  •   
  • Niwa S, Nakamura F, Tomabechi Y, Aoki M, Shigematsu H, Matsumoto T, Yamagata A, Fukai S, Hirokawa N, Goshima Y, Shirouzu M, Nitta R. Structural basis for CRMP2-induced axonal microtubule formation. Sci Rep. 7(1):10681. doi: 10.1038/s41598-017-11031-4.
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  • Nakamura F, Okada T, Shishikura M, Uetani N, Taniguchi M, Yagi T, Iwakura Y, Oshima T, Goshima Y, Strittmatter SM. Protein Tyrosine Phosphatase δ Mediates the Sema3A-Induced Cortical Basal Dendritic Arborization through the Activation of Fyn Tyrosine Kinase. J Neurosci. 37(30):7125-7139. doi: 10.1523/JNEUROSCI.2519-16.2017, 2017.
  • 神経樹状突起形成の新たな分子機構を解明!

     神経ガイダンス分子セマフォリン3A (Sema3A) は神経回路形成に重要な分子であることがわかっています。この研究は、Sema3Aの新しい細胞内情報伝達分子として、PTPdelta という分子が、Fynというチロシンリン酸化酵素のリン酸化修飾を介して樹状突起の形成を制御していることを初めて明らかにしました。

     この研究は、神経科学の領域で権威のある米国神経科学会の学会誌ジャーナルオブニューロサイエンス(Journal of Neuroscience) に掲載され、表紙の図にも選ばれました(http://www.jneurosci.org/content/37/30.cover-expansion)。

    *論文掲載サイト
     http://www.jneurosci.org/content/37/30/7125

      
  • Tobe BTD, Crain AM, Winquist AM, Calabrese B, Makihara H, Zhao WN, Lalonde J, Nakamura H, Konopaske G, Sidor M, Pernia CD, Yamashita N, Wada M, Inoue Y, Nakamura F, Sheridan SD, Logan RW, Brandel M, Wu D, Hunsberger J, Dorsett L, Duerr C, Basa RCB, McCarthy MJ, Udeshi ND, Mertins P, Carr SA, Rouleau GA, Mastrangelo L, Li J, Gutierrez GJ, Brill LM, Venizelos N, Chen G, Nye JS, Manji H, Price JH, McClung CA, Akiskal HS, Alda M, Chuang DM, Coyle JT, Liu Y, Teng YD, Ohshima T, Mikoshiba K, Sidman RL, Halpain S, Haggarty SJ, Goshima Y, Snyder EY.
    Probing the lithium-response pathway in hiPSCs implicates the phosphoregulatory set-point for a cytoskeletal modulator in bipolar pathogenesis. Proc Natl Acad Sci U S A. doi: 10.1073/pnas.1700111114, 2017.
  • 双極性気分障害の原因を特定!

     私達は、サンフォード・バーナム・プレビス医学研究所(米国、サンディエゴ)のEvan Snyder博士らと共同で、双極性気分障害の患者さんのiPS細胞の解析から、collapsin response mediator protein 2 (CRMP2) というタンパク質の翻訳後修飾異常を発見しました。
     双極性気分障害とは、気分障害と言われる疾患の中の一つのタイプで、躁と鬱の状態の両方が出現する病態、いわゆる躁鬱病です。この双極性気分障害の患者さんには古くから炭酸リチウムという薬物が使用され、良く効く人とそうでない人がいることが知られていましたが、なぜ効果があるかはよくわかっていませんでした。今回の研究において、疾患特異的iPS細胞を使った実験で、炭酸リチウムが効く双極性気分障害の患者さんの脳では、CRMP2のリン酸化が亢進していること、この亢進は炭酸リチウムで抑えられること、躁病の動物モデルでは、CRMP2 のリン酸化が亢進していること、CRMP2のリン酸化を起こらないようにしたCRMP2S522Aノックインマウスというモデル動物では、躁状態が軽減されること、等を明らかにしました。本研究により、炭酸リチウムが効く双極性障害患者さんではCRMP2のリン酸化修飾異常が病態と相関しており、その異常は炭酸リチウムで抑制されることが分かりました。

    なお本研究は、米国科学雑誌『Proceedings of the National Academy of Sciences』に掲載されました。

    *論文掲載サイト
     http://www.pnas.org/content/early/2017/05/11/1700111114.full

    *横浜市立大学ホームページ 掲載記事
     http://www.yokohama-cu.ac.jp/amedrc/news/20170508_goshima.html

    *共同研究者・Evan Snyder博士の本研究に関する記事
     http://www.sciencealert.com/finally-scientists-think-they-know-how-lithium-treats-bipolar-disorder

      
  • Yamane M, Yamashita N, Hida T, Kamiya Y, Nakamura F, Kolattukudy P, Goshima Y. A functional coupling between CRMP1 and Nav1.7 for retrograde propagation of Semaphorin3A signaling. J Cell Sci. 130(8):1393-1403. doi:10.1242/jcs.199737, 2017.
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  • Abdallah BM, Figeac F, Larsen KH, Ditzel N, Keshari P, Isa A, Jafari A, Andersen TL, Delaisse JM, Goshima Y, Ohshima T, Kassem M. CRMP4 Inhibits Bone Formation by Negatively Regulating BMP and RhoA Signaling. J Bone Miner Res. doi:10.1002/jbmr.3069, 2017.
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  • Goshima Y, Takei K. Micro-CALI to Study Localized Roles of the Semaphorin Signaling Component CRMP in Axon Growth. Methods Mol Biol. 1493:265-275, 2017.

2016年

      
  • Iketani M, Yokoyama T, Kurihara Y, Strittmatter SM, Goshima Y, Kawahara N, Takei K. Axonal branching in lateral olfactory tract is promoted by Nogo signaling. Sci Rep. 6:39586. doi: 10.1038/srep39586, 2016.
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  • Makihara H, Hidaka M, Sakai Y, Horie Y, Mitsui H, Ohashi K, Goshima Y, Akase T. Reduction and fragmentation of elastic fibers in the skin of obese mice isassociated with altered mRNA expression levels of fibrillin-1 and neprilysin. Connect Tissue Res. 1-8. doi: 10.1080/03008207.2016.1255205, 2016.
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  • Takaya R, Nagai J, Piao W, Niisato E, Nakabayashi T, Yamazaki Y, Nakamura F, Yamashita N, Kolattukudy P, Goshima Y, Oshima T. CRMP1 and CRMP4 are required for proper orientation of dendrites of cerebral pyramidal neurons in the developing mouse brain. Brain Res. doi:10.1016/j.brainres.2016.11.003, 2016.
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  • Fujita S, Yokoyama U, Ishiwata R, Aoki R, Nagao K, Masukawa D, Umemura M,Fujita T, Iwasaki S, Nishimaki S, Seki K, Ito S, Goshima Y, Asou T, Masuda M, Ishikawa Y. Glutamate Promotes Contraction of the Rat Ductus Arteriosus. Circ J. 80(11):2388-2396, 2016.
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  • Ueda S, Masukawa D, Koga M, Goshima Y. l-3,4-Dihydroxyphenylalanine induces ptosis through a GPR143-independent mechanism in mice. J Pharmacol Sci. 132(1):109-112. doi: 10.1016/j.jphs.2016.08.005, 2016.
  •   
  • Nakamura H, Yamashita N, Kimura A, Kimura Y, Hirano H, Makihara H, Kawamoto Y, Jitsuki-Takahashi A, Yonezaki K, Takase K, Miyazaki T, Nakamura F, Tanaka F, Goshima Y. Comprehensive behavioral study and proteomic analyses of CRMP2-deficient mice. Genes Cells. 2016 Oct;21(10):1059-1079. doi:10.1111/gtc.12403, 2016.
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  • Makihara H, Nakai S, Ohkubo W, Yamashita N, Nakamura F, Kiyonari H, Shioi G, Jitsuki-Takahashi A, Nakamura H, Tanaka F, Akase T, Kolattukudy P, Goshima Y. CRMP1 and CRMP2 have synergistic but distinct roles in dendritic development. Genes Cells. (9):994-1005. doi: 10.1111/gtc.12399, 2016.
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  • Goshima Y, Yamashita N, Nakamura F, Sasaki Y. Regulation of dendritic development by Semaphorin 3A through novel intracellular remote signaling. Cell Adh Migr. 2016 Jul 8:0.
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  • Makihara H, Koike Y, Ohta M, Horiguchi-Babamoto E, Tsubata M, Kinoshita K, Akase T, Goshima Y, Aburada M, Shimada T. Gallic Acid, the Active Ingredient of Terminalia bellirica, Enhances Adipocyte Differentiation and Adiponectin Secretion. Biol Pharm Bull.39(7):1137-43. doi: 10.1248/bpb.b16-00064, 2016.
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  • Sato S, Nakamura F, Hiroshima Y, Nagashima Y, Kato I, Yamashita N, Goshima Y, Endo I.
    Caerulein-induced pancreatitis augments the expression and phosphorylation of collapsin response mediator protein 4. J Hepatobiliary Pancreat Sci. doi: 10.1002/jhbp.361,2016.
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  • Shishikura M, Nakamura F, Yamashita N, Uetani N, Iwakura Y, Goshima Y. Expression of receptor protein tyrosine phosphatase δ, PTPδ, in mouse central nervous system. Brain Res. doi: 10.1016/j.brainres.2016.
    03.030.
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  • Nagai J, Takaya R, Piao W, Goshima Y, Ohshima T. Deletion of Crmp4 attenuates CSPG-induced inhibition of axonal growth and induces nociceptive recovery after spinal cord injury. Mol Cell Neurosci. 74:42-48. doi: 10.1016/j.mcn.2016.03.006,2016.
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  • Tonouchi A, Nagai J, Togashi K, Goshima Y, Ohshima T. Loss of collapsin response mediator protein 4 suppresses dopaminergic neuron death in an 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced mouse model of Parkinson's disease.J Neurochem. 137(5):795-805. doi: 10.1111/jnc.13617, 2016.
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  • Yamashita N, Yamane M, Suto F, Goshima Y. TrkA mediates retrograde semaphorin 3A signaling through plexin A4 to regulate dendritic branching. J Cell Sci. 129(9):1802-14. doi: 10.1242/jcs.184580, 2016.
    神経軸索の伸長を阻害する作用を持つ反発因子であるセマフォリン3A(Sema3A)が、逆に神経を伸長する効果のある神経栄養因子と共通の TrkA と呼ばれる受容体を使って、樹状突起のパターン形成に関わる情報を伝えていることを明らかにしました。 Journal of Cell Science 誌の注目すべき論文としても取り上げられ、これに関する総説の依頼も相次いでいます。
  • Jin X, Sasamoto K, Nagai J, Yamazaki Y, Saito K, Goshima Y, Inoue T, Ohshima T. Phosphorylation of CRMP2 by Cdk5 Regulates Dendritic Spine Development of Cortical Neuron in the Mouse Hippocampus. Neural Plast, doi: 10.1155/2016/6790743, 2016.
  • Nagai J, Owada K, Kitamura Y, Goshima Y, Ohshima T. Inhibition of CRMP2 phosphorylation repairs CNS by regulating neurotrophic and inhibitory responses. Exp Neurol, doi: 10.1016/j.expneurol, 2016.
  • Tsutiya A, Watanabe H, Nakano Y, Nishihara M, Goshima Y, Ohtani-Kaneko R. Deletion of collapsin response mediator protein 4 results in abnormal layer thickness and elongation of mitral cell apical dendrites in the neonatal olfactory bulb. J Anat, doi: 10.1111/joa.12434, 2016.
  • Yamashita N, Aoki R, Chen S, Jitsuki-Takahashi A, Ohura S, Kamiya H, Goshima Y. Voltage-gated calcium and sodium channels mediate Sema3A retrograde signaling that regulates dendritic development. Brain Res, doi: 10.1016/j.brainres.2015.11.034, 2016.

2015年

  • Nakamura H, Yamashita N, Kanamaru Y, Tachibana T, Sekino Y, Chen S, Gotoh T, Tanaka F, Goshima Y. Quantitative analysis of intraneuronal transport in human iPS neurons. J Pharmacol Sci, doi: 10.1016/j.jphs.2015.06.006, 2015.
  • Tsutiya A, Nishihara M, Goshima Y, Ohtani-Kaneko R. Mouse pups lacking collapsin response mediator protein 4 (CRMP4) manifest impaired olfactory function and hyperactivity in the olfactory bulb. Eur J Neurosci, doi: 10.1111/ejn.12999, 2015.
  • Yamashita N, Jitsuki-Takahashi A, Ogawara M, Ohkubo W, Araki T, Hotta C, Tamura T, Hashimoto SI,
    Yabuki T, Tsuji T, Sasakura Y, Okumura H, Takaiwa A, Koyama C, Murakami K, Goshima Y. Anti-Semaphorin 3A neutralization monoclonal antibody prevents sepsis development in lipopolysaccharide-treated mice. Int Immunol, doi: 10.1093/intimm/dxv014, 2015.
  • 敗血症の新しい治療法を発見!
    私達は、カイオムバイオサイエンス社と共同で、選択的抗セマフォリン3Aモノクローナル抗体の開発に成功しました。セマフォリン3Aは神経回路形成に重要な役割を担う蛋白質であり、神経成長末端に形成される成長円錐を退縮させ、突起の伸長を抑制する作用があります。現在、セマフォリン3Aは神経系のみならず、心血管系、免疫系、骨代謝に関わる重要な分子であることが分っており、がんや免疫疾患との関わりも示唆されています。今回、その作製に成功したセマフォリン3A抗体は、ニワトリ後根神経節細胞の成長円錐を退縮するセマフォリン3Aの効果を阻害する活性を示すことに加え、敗血症モデルマウスの生存率を高める効果を持つことが明らかになりました。この抗体の投与は、敗血症増悪因子の一つである血中のプラスミノーゲンアクチベーター1を抑制します。様々な感染症にともなう敗血症の致死率は依然として高く、有効な治療法も乏しいなか、今回の成果は、敗血症にともなう著しいサイトカイン過剰産生、サイトカインストームを抑制するという全く新しい治療法の開発に繋がるものとして注目されます。 (詳細はこちらをご確認下さい)
  • Tanaka J, Tanaka H, Mizuki N, Nomura E, Ito N, Nomura N, Yamane M, Hida T, Goshima Y, Hatano H, Nakagawa H. Semaphorin 3A controls allergic and inflammatory responses in experimental allegic conjunctivitis. Int J Ophthalmol, 8(1):1-10, 2015.
  • Nagai J, Kitamura Y, Owada K, Yamashita N, Takei K, Goshima Y, Ohshima T. Crmp4 deletion promotes recovery from spinal cord injury by neuroprotection and limites scar formation. Sci Rep, 5:8269, 2015.
  • Fukuda N, Naito S, Masukawa D, Kaneda M, Miyamoto H, Abe T, Yamashita Y, Endo I, Nakamura F, Goshima Y. Expression of ocular albinism 1(OA1), 3, 4-dihydroxy-L-phenylalanine(DOPA) receptor, in both neuronal and non-neuronal organs. Brain Res, 1602:62-74, 2015.

2014年

  • Nakamura F, Kumeta K, Hida T, Isono T, Nakayama Y, Kuramata-Matsuoka E, Yamashita N, Uchida Y, Ogura K, Gengyo-Ando K, Mitani S, Ogino T, Goshima Y.Amino- and carboxyl-terminal domains of Filamin-A interact with CRMP1 to mediate Sema3A signalling. Nat Commun 5:5325. doi: 10.1038/ncomms6325, 2014.
  • 神経ガイド分子セマフォリン3Aの新たな作用メカニズムを解明
  • 神経回路が形成される時に、神経ガイド分子とよばれるタンパク質が神経突起の伸長をコントロールします。神経ガイド分子のうち、神経突起を遠ざける反発因子の一つであるセマフォリン3A (SemaA)は、神経の伸びを阻止します。私たちは、アクチン結合蛋白質の一つであるフィラミンA(Filamin-A)が、CRMP1(細胞内蛋白質の一つ)と結合してアクチン骨格をコントロールしている事実を発見しました。私たちは、このとき、これらの分子複合体の構造が大きく変化していることを原子間顕微鏡を用いて明らかにしました。この成果を得るにあたり、科学研究費基盤研究(C)、文部科学省「イノベーションシステム整備事業」、グローバルCOE「情報通信による医工学融合イノベーション創生」により支援を受けました。ここに謝辞を申し上げます。
  •  (詳細はこちらをご確認下さい)
  • Yamashita N, Usui H, Nakamura F, Chen S, Sasaki Y, Hida T, Suto F, Taniguchi M, Takei K, Goshima Y.
    PlexinA4-dependent Retrograde Semaphorin3A Signalling Regulates the Dendritic Localization of GluA2-Containing AMPA Receptors. Nat Commun, 5:3424. 2014.
    神経回路形成の新しいメカニズムを発見
    グルタミン酸は私達の脳で学習や記憶を司る重要な働きをしています。グルタミン酸が働くためにはそれと結合して脳内の情報を伝達するグルタミン酸受容体が、神経細胞の一定の場所に存在していることが必要です。私達は、神経の伸長方向のコントロールに重要な役割をするセマフォリン3Aというタンパク質が、グルタミン酸受容体の神経細胞の細胞体や樹状突起における場所を、今までにない新しい仕組みで神経突起の末端の遠隔からコントロールするというメカニズムを発見しました。
    (詳細はこちらをご確認下さい) http://www.yokohama-cu.ac.jp/amedrc/res/goshima_2014_3.html
  • Hiroshima Y, Miyamoto H, Nakamura F, Masukawa D, Yamamoto T, Muraoka H, Kamiya M, Yamashita N, Suzuki T, Matsuzaki S, Endo I, Goshima Y. The protein Ocular albinism 1 is the orphan GPCR GPR143 and mediates depressor and bradycardic responses to DOPA in the nucleus tractus solitarii. Br J Pharmacol, 171(2):403-14. 2014.
  • 私達は、ドパミンの前駆体であるドーパが神経伝達物質であることを提起してきました。この論文は、私達が長年検討してきたドーパの作用が、Gpr143、別名OA1 (ocular albinism 1)と呼ばれるG蛋白質連関型受容体を介して発現することを世界に先駆けて明かにすることに成功しました。この発見は、ドーパ神経伝達物質仮説をさらに支持するものであり、今後、全く新たな発見、創薬研究の基礎となるものと考えられます。
  • Hida T, Nakamura F, Usui H, Takeuchi K, Yamashita N, Goshima Y. Semaphorin3A-induced axonal transport mediated through phosphorylation of Axin-1 by GSK3β. Brain Res, 1598: 46-56, 2014.
  • Asakura T, Ogura K, Goshima Y. IRE-1/XBP-1 pathway of the unfolded protein response is required for properly localizing neuronal UNC-6/Netrin for axon guidance in C. elegans. Genes Cells, 20(3): 153-159, 2014.
  • Takahashi K, Kurihara Y, Suzuki Y, Goshima Y, Tanaka F, Takei K. Association of cerebrospinal fluid levels of lateral olfactory tract usher substance (LOTUS) with disease activity in multiple sclerosis. JAMA Neurol, 72(2):176-179, 2014.
  • Masukawa D, Nakamura F, Koga M, Kamiya M, Chen S, Yamashita N, Arai N, Goshima Y. Localization of ocular albinism-1 gene product GPR143 in the rat central nervous system. Neurosci Res.
    pii: S0168-0102(14)00139-4. doi: 10.1016/j.neures.2014.07.008, 2014.
  • Shimada K, Ishikawa T, Nakamura F, Shimizu D, Chishima T, Ichikawa Y, Sasaki T,  Endo I, Nagashima Y, Goshima Y. Collapsin response  mediator protein 2 is involved in regulating breast cancer progression. Breast Cancer, 21(6):725-723, 2014.
  • Kurihara Y, Iketani M, Ito H, Nishiyama K, Sakakibara Y, Goshima Y, Takei K. LOTUS suppresses axon
    growth inhibition by blocking interaction between Nogo receptor-1 and all four types of its ligand.
    Mol Cell Neurosci. 61:211-218.doi: 10.1016/j.mcn.2014.07.001, 2014.
  • Koga M, Mizuno Y, Watanabe I, Kawakami H, Goto T: Role of VPAC2 receptor in monocrotaline-induced pulmonary hypertension in rats. J Appl Physiol, 15;117(4):383-391,2014.
  • Fujiwara A, Hirawa N, Fujita M, Kobayashi Y, Okuyama Y, Yatsu K, Katsumata M, Yamamoto Y, Ichihara N, Saka S, Toya Y, Yasuda G, Goshima Y, Tabara Y, Miki T, Ueshima H, Ishikawa Y, Umemura S. Impaired nitric oxide production and increased blood pressure in systemic heterozygous ATP2B1 null mice. J Hypertens. 32(7):1415-1423, 2014.
  • Togashi Y, Shirakawa J, Orime K, Kaji M, Sakamoto E, Tajima K, Inoue H, Nakamura A, Tochino Y, Goshima Y, Shimomura I, Terauchi Y. β cell proliferation  after a partial pancreatectomy is independent of IRS-2 in mice. Endocrinology, en20131796. 2014.
  • 渡辺 厚彦, 野本 宗孝, 小田原 俊成, 加藤 大慈, 平安 良雄. デイケア家族会の心理教育による家族自身の変化 「生活困難感」や「生活時間の使い方」の調査から. 神奈川県精神医学会誌, 0288-9617 (63): 49-52, 2014.
  • Sasaki Y, Gross C, Xing L, Goshima Y, Bassell GJ. Identification of axon-enriched MicroRNAs localized to growth cones of cortical neurons. Dev Neurobiol, 74(3):397-406. 2014.
  • Goshima Y. Brainstem DOPAergic System. Catecholamine Research in the 21st Century ― Abstracts and Graphical Abstracts, 10th International Catecholamine Symposium, 2012, Edited by Lee E. Eiden, 18,  Academic Press, 2014.
  • Lemmon VP, Ferguson AR, Popovich PG, Xu XM, Snow DM, Igarashi M, Beattie CE, Bixby JL; MIASCI
    Consortium. Minimum information about a spinal cord injury experiment: a proposed reporting standard for spinal cord injury experiments. J Neurotrauma. 31(15):1354-1361.doi: 10.1089/neu.2014.3400, 2014.
  • Goshima Y, Nakamura F, Masukawa D, Chen S, Koga M. The Cardiovascular Actions of DOPA Mediated by the Gene Product of ocular albinism. J Pharmacol Sci 126(1):14-20, 2014.

2013年

  • Niisato E, Nagai J, Yamashita N, Nakamura F, Goshima Y, Ohshima T. Phosphorylation of CRMP2 is involved in proper bifurcation of the apical dendrite of hippocampal CA1 pyramidal neurons. Developmental Neurobiology, 73(2):142-51. 2013.
  • Orime K, Shirakawa J, Togashi Y, Tajima K, Inoue H, Ito Y, Sato K, Nakamura A, Aoki K, Goshima Y, Terauchi Y. Trefoil factor 2 promotes cell proliferation in pancreatic β cells through CXCR-4-mediated ERK1/2 phosphorylation. Endocrinology,  154(1):54-64. 2013.
  • Iwakura T, Sakoh M, Tsutiya A, Yamashita N, Ohtani A, Tsuda MC, Ogawa S, Tsukahara S, Nishihara M, Shiga T, Goshima Y, Kato T, Ohtani-Kaneko R. Collapsin response mediator protein 4 affects the number of tyrosine hydroxylase-immunoreactive neurons in the sexually dimorphic nucleus in female mice. Developmental Neurobiology, 73(7): 502-17. 2013.
  • Isono T, Yamashita N, Obara M, Araki T, Nakamura F, Kamiya Y, Alkam T, Nitta A, Nabeshima T, Mikoshiba K, Ohshima T, Goshima Y. Amyloid-β2 5 – 3 5 induces impairment of cognitive function and long-term potentiation through phosphorylation of collapsin response mediator protein 2. Neuroscience Research, 77(3):180-5. 2013.
  • Yamashita N, Takahashi A, Takao K, Yamamoto T, Kolattukudy P, Miyakawa T, Goshima Y. Mice lacking collapsin response mediator protein 1 manifest hyperactivity, impaired learning and memory, and impaired prepulse inhibition. Frontiers in Behavioral Neuroscience, doi: 10.3389/fnbeh.2013.00216. 2013.
  • Hachuda S, Otsuka S, Kita S, Isono T, Narimatsu M, Watanabe K, Goshima Y, Baba T. Selective detection of sub-atto-molar streptavidin in 1013-fold impure sample using photonic crystal nanolaser sensors. Optics Express, 21: 12815-12812. 2013.
  • Tajima K, Shirakawa J, Togashi Y, Inoue H, Sato K, Orime K, Ito Y, Kaji M, Sakamoto E, Nakamura A, Aoki K, Goshima Y, Atsumi T, Terauchi Y. AMPK  is involved in the regulation of incretin receptors expression in pancreatic islets under a low glucose concentration. PLos One, 22;8(5):e64633. 2013.
  • Shimada K, Ishikawa T, Nakamura F, Shimizu D, Chishima T, Ichikawa Y, Sasaki T, Endo I, Nagashima Y, Goshima Y. Collapsin response mediator protein 2 is involved in regurating breast cancer progression. Breast Cancer,  2013 Feb.5. [ Epub ahead of print]
  • Takagawa S, Nakamura F, Kumagai K, Nagashima Y, Goshima Y, Saito T. Decreased semaphorin3A expression correlates with disease activity and histological features of rheumatoid arthritis. BMC Musculoskelet Disord, 23; 14:40. 2013.
  • Iketani M, Iizuka A, Sengoku K, Kurihara Y, Nakamura F, Sasaki Y, Sato Y, Yamane M, Matsushita M, Nairn AC, Takamatsu K, Goshima Y, Takei K. Regulation of neurite outgrowth mediated by localized phosphorylation of protein translational factor eEF2 in growth cones. Dev Neurobiol., 73(3):230-46. 2013.
  • Hiroshima Y, Nakamura F, Miyamoto H, Mori R, Taniguchi K, Matsuyama R, Akiyama H, Tanaka K, Ichikawa Y, Kato S, Kobayashi N, Kubota K, Nagashima Y, Goshima Y, Endo I. Collapsin response mediator protein 4 expression is associated with liver metastasis and poor survival in pancreatic cancer. Ann Surg Oncol., Suppl 3: S369-78. 2013. 

2012年

  • Hida T, Yamashita N, Usui H, Nakamura F, Sasaki Y, Kikuchi A, Goshima Y. GSK3β/axin-1/β-catenin complex is involved in semaphorin3A signaling. Journal of Neuroscience,32(35):11905-11918. 2012. 
  • Niisato E, Nagai J, Yamashita N, Abe T, Kiyonari H, Goshima Y, Ohshima T. CRMP4 suppresses apical dendrite bifurcation of CA1 pyramidal neurons in the mouse hippocampus. Developmental Neurobiology, 72(11):1447-1457. 2012.
  • Yamashita N, Ohshima T, Nakamura F, Kolattukudy P, Honnorat J, Mikoshiba K, Goshima Y. Phosphorylation of CRMP2 (Collapsin Response Mediator Protein 2) Is Involved in Proper Dendritic Field Organization. Journal of Neuroscience, 32(4):1360-1365. 2012.
  • Kurihara Y, Arie Y, Iketani M, Ito H, Nishiyama K, Sato Y, Nakamura F, Mizuki N, Goshima Y, Takei K. The carboxyl-terminal region of Crtac1B/LOTUS acts as a functional domain in endogenous antagonism to Nogo receptor-1. Biochem. Biophys. Res. Commun., 418(2):390-5. 2012. 
  • Kou K, Nakamura F, Aihara M, Chen H, Seto K, Komori-Yamaguchi J, Kambara T, Nagashima Y, Goshima Y and Ikezawa Z. Decreased Semaphorin-3A Expression in the Lesional Skin of Patients with Psoriasis Vulgaris. Acta Dermato-Venereologica, 92(5):521-528. 2012.
  • Nagai J, Goshima Y, Ohshima T. CRMP4 mediates MAG-induced inhibition of axonal outgrowth and protection against Vincristine-induced axonal degeneration. Neuroscience Letter,519(1):56-61. 2012.
  • Yamane M, Yamashita N, Yamamoto H, Iizuka A, Shouji M, Usui H, Goshima Y. Semaphorin3A facilitates axonal transport through a local calcium signaling and tetrodotoxin-sensitive voltage-gated sodium channels. Biochemical and Biophysical Research Communications,422(2):333-338. 2012.
  • Goshima Y, Hida T, Gotoh T. Computational analysis of axonal transport: a novel assessment of neurotoxicity, neuronal development and functions. International Journal of Molecular Sciences. 13(3):3414-3430. 2012.
  • Higurashi M, Iketani M, Takei K, Yamashita N, Aoki R, Kawahara N, Goshima Y. Localized role of CRMP1 and CRMP2 in neurite outgrowth and growth cone steering. Developmental Neurobiology,72(12):1528-1540. 2012.
  • Shirakawa J, Tanami R, Togashi Y, Tajima K, Orime K, Kubota N, Kadowaki T, Goshima Y, Terauchi Y. Effects of liraglutide on β cell-specific glucokinase-deficient neonatal mice. Endocrinology,  153(7):3066-75. 2012.
  • Shirakawa J, Togashi Y, Tajima K, Orime K, Kikuchi K, Miyazaki T, Sato K, Kimura M, Goshima Y, Terauchi Y. Plasminogen activator inhibitor-1 is associated with renal dysfunction independent of BMI and serum lipid levels in patients with type 2 diabetes. Diabetes Res Clin Pract, 97(1):e7-e10. 2012.
    Kikuchi K, Nezu U, Inazumi K, Miyazaki T, Ono K, Orime K, Shirakawa J, Sato K, Koike H, Wakasugi T, Sato M, Kawakami C, Watanabe S, Yamakawa T, Terauchi Y. Double-blind randomized clinical trial of the effects of ezetimibe on postprandial hyperlipidaemia and hyperglycaemia. J Atheroscler Thromb., 19(12):1093-101. 2012.
  • Sato K, Nakamura A, Shirakawa J, Muraoka T, Togashi Y, Shinoda K, Orime K, Kubota N, Kadowaki T, Terauchi Y. Impact of the dipeptidyl peptidase-4 inhibitor vildagliptin on glucose tolerance, beta cell function and mass in insulin receptor substrate-2-knockout mice fed a high-fat diet. Endocrinology, 153(3):1093-102. 2012.  
  • Nakamura A, Togashi Y, Orime K, Sato K, Shirakawa J, Ohsugi M, Kubota N, Kadowaki T, Terauchi Y. Control of beta cell function and proliferation in mice stimulated by small-molecule glucokinase activator under various conditions. Diabetologia, 55(6):1745-54. 2012.
  • Iwasaki T, Tomeno W, Yoneda M, Inamori M, Shirakawa J, Imajo K, Kawashima K, Terauchi Y, Nakajima A. Nonalcoholic fatty liver disease adversely affects the glycemic control afforded by sitagliptin. Hepatogastroenterology,  59(117):1522-5. 2012.
  • Kobayashi Y, Hirawa N, Tabara Y, Muraoka H, Fujita M, Miyazaki N, Fujiwara A, Ichikawa Y, Yamamoto Y, Ichihara N, Saka S, Wakui H, Yoshida S, Yatsu K, Toya Y, Yasuda G, Kohara K, Kita Y, Takei K, Goshima Y, Ishikawa Y, Ueshima H, Miki T, Umemura S. Mice lacking hypertension candidate gene ATP2B1 in vascular smooth muscle cells show significant blood pressure elevation. Hypertension, 59(4):854-60.2012.
  • Goshima Y, Sasaki Y, Yamashita N, Nakamura F. Class 3 semaphorins as a therapeutic target. Expert Opinion on Therapeutic Targets, 16(9):933-944. 2012.
  • Ogura K, Asakura T, Goshima Y. Localization mechanisms of the axon guidance molecule UNC-6/Netrin and its receptors, UNC-5 and UNC-40, in Caenorhabditis elegans. Dev. Growth Differ. , 54(3):390-397.
    2012.
  • 池谷 真澄,栗原 裕司,佐藤 泰史,五嶋 良郎,竹居 光太郎. 内在性Nogo受容体アンタゴニストLOTUSの嗅索形成における生理的役割.実験医学,vol.30 No.3. 2012.
  • Yamashita N, Goshima Y.  Collapsin Response Mediator Proteins Regulate Neuronal Development and Plasticity by Switching Their Phosphorylation Status. Molecular Neurobiology, 45(2):234-46.2012.
  • 白川純、寺内康夫. グルコキナーゼ活性化薬(GKA),糖尿病治療薬のサイエンス, 189-196. 2012.
  • 白川純、寺内康夫. インスリン分泌低下モデルマウス 「モデル動物利用マニュアル 疾患モデルの作成と利用 糖尿病・肥満・感染症」,130-139. 2012.
  • 白川純、寺内康夫. グルコキナーゼ活性化薬. 日本臨床, 70巻増刊号3:721-727.2012.
  • 佐々木 幸生、五嶋 良郎. 神経軸索における局所翻訳制御と機能調節. 細胞工学, 31 (6): 677-682. 2012.

2011年

  • Yamashita N, Mosinger B, Roy A, Miyazaki M, Ugajin K, Nakamura F, Sasaki Y, Yamaguchi K, Kolattukudy P, Goshima Y. CRMP5 (collapsin response mediator protein 5) regulates dendritic development and synaptic plasticity in the cerebellar Purkinje cells. Journal of Neuroscience, 31(5):1773-1779. 2011.
  • Nishiyama M, Togashi K, von Schimmelmann MJ, Lim CS, Maeda S, Yamashita N, Goshima Y, Ishii S, Hong K. Semaphorin 3A induces CaV2.3 channel-dependent conversion of axons to dendrites. Nature Neuroscience, 13(6):676-685. 2011.
  • Sato Y, Iketani M, Kurihara Y, Yamaguchi M, Yamashita N, Nakamura F, Arie Y, Kawasaki T, Hirata T, Abe T, Kiyonari H, Strittmatter SM, Goshima Y, Takei K. Cartilage acidic protein-1B (LOTUS), an endogenous Nogo receptor antagonist for axon tract formation. Science, 333(6043):769-773. 2011.
  • Sawaki H, Nakamura F, Aihara M, Nagashima Y, Komori-Yamaguchi J, Yamashita N, Nakazawa M, Goshima Y, Ikezawa Z. Intranasal administration of semaphorin-3A alleviates sneezing and nasal rubbing in a murine model of allergic rhinitis. Journal of Pharmacological Sciences, 117(1):34-44. 2011.
  • Nakamura  M, Isono T, Ogino T. Selective deposition of lipid membranes on locally anodic-oxidized silicon surface. e-Journal of Surface Science and Nanotechnology, 9:357-362. 2011.
  • Yamazaki K, Ikeda T, Isono T, Ogino T. Selective adsorption of protein molecules on phase-separated sapphire surfaces. Journal of Colloid and Interface Science, 361:64-70. 2011.
  • Aoki R, Yagami T, Sasakura H, Ogura K, Kajihara Y, Ibi M, Miyamae T, Nakamura F, Asakura T, Kanai Y, Misu Y, Iino Y, Ezcurra M, Schafer WR, Mori I, Goshima Y. A seven-transmembrane receptor that mediates avoidance response to dihydrocaffeic acid, a water-soluble repellent in Caenorhabditis elegans. Journal of Neuroscience, 31(46):16603-16610. 2011.
  • Kato S, Kubota K, Shimamura T, Shinohara Y, Kobayashi N, Watanabe S, Yoneda M, Inamori M, Nakamura F, Ishiguro H, Nakaigawa N, Nagashima Y, Taguri M, Kubota Y, Goshima Y, Morita S, Endo I, Maeda S, Nakajima A, Nakagama H. Semaphorin 4D, a lymphocyte semaphorin, enhances tumor cell motility through binding its receptor, plexinB1, in pancreatic cancer. Cancer Sci,102(11):2029-37. 2011.
  • Morinaka A, Yamada M, Itofusa R, Funato Y, Yoshimura Y, Nakamura F, Yoshimura T, Kaibuchi K, Goshima Y, Hoshino M, Kamiguchi H, Miki H. Thioredoxin mediates oxidation-dependent phosphorylation of CRMP2 and growth cone collapse. Sci Signal, 4 (170):ra26, 2011.
  • Han, L., Wen, Z., Lynn, R. C., Baudet, M. L., Holt, C. E., Sasaki, Y., Bassell, G. J., and Zheng, J. Q.  Regulation of chemotropic guidance of nerve growth cones by microRNA. Mol. Brain, 4:40. 2011.
  • Jitsuki S, Takemoto K, Kawasaki T, Tada H, Takahashi A, Becamel C, Sano A, Yuzaki M, Zukin RS, Ziff EB, Kessels HW, and Takahashi T. Serotonin mediates cross-modal reorganization of cortical circuits. Neuron, 69, 780-792. 2011.
  • Shirakawa J, Fujii H, Ohnuma K, Sato K, Ito Y, Kaji M, Sakamoto E, Koganei M, Sasaki H, Nagashima Y, Amo K, Aoki K, Morimoto C, Takeda E, Terauchi Y. Diet-induced adipose tissue inflammation and liver steatosis are prevented by DPP-4 inhibition in diabetic mice. Diabetes, 60(4):1246-57. 2011.
  • Shirakawa J, Amo K, Ohminami H, Orime K, Togashi Y, Ito Y, Tajima K, Koganei M, Sasaki H, Takeda E, Terauchi Y. Protective effects of a DPP-4 inhibitor against increased beta cell apoptosis induced by dietary sucrose and linoleic acid in mice with diabetes. J Biol Chem, 286(29):25467-76. 2011.
  • Iwasaki T, Yoneda M, Inamori M, Shirakawa J, Higurashi T, Maeda S, Terauchi Y, Nakajima A. Sitagliptin as a novel treatment agent for non-alcoholic fatty liver disease patients with type 2 diabetes mellitus. Hepatogastroenterology, 58(112):2103-5. 2011.
  • 山下 直也: 神経回路網の発達・可塑性・維持におけるCollapsin Response Mediator Proteinの役割. 横浜医学, 62: 545-553. 2011.
  • 白川純、寺内康夫. 炎症性疾患としての肥満と栄養. 栄養-診断と治療, 28(3):218-221.2011. 
  • 白川純、寺内康夫. 糖尿病マウスではDPP-4阻害薬によって食餌誘発性の脂肪組織炎症および肝脂肪症が抑制される. Diabetes strategy, 1(3):34-35. 2011.
  • 白川純、寺内康夫. 「DPP-4阻害薬にnon-responderはいるのか?」 診断と治療. インクレチン療法実践ブラッシュアップ, 134-138. 2011. 
  • 白川純、寺内康夫. ブドウ糖負荷テスト(GH測定). 検査値express,:191, 2011.
  • 福原俊太郎, 丹 愛, 松浦 恵子, 近藤智津恵,尾崎 和子, 青木 昭子, 白井 輝, 五嶋 良郎.大学における危機対応―医学部を有する大学の対応と支援体制について.CAMPUS  HEALTH, 48 (2), 2011.

2010年

  • Hayashi M, Kamiya Y, Itoh H, Higashi T, Miyazaki T, Funakoshi K, Yamashita N, Goshima Y, Andoh T, Yamada Y, Goto T. Intrathecally administered Sema3A protein attenuates neuropathic pain behavior in rats with chronic constriction injury of the sciatic nerve.Neuroscience Research, 69(1):17-24. 2010.
  • Nogi T, Yasui N, Mihara E, Matsunaga Y, Noda M, Yamashita N, Toyofuku T, Uchiyama S, Goshima Y, Kumanogoh A, Takagi J. Structural basis for semaphorin signalling through the plexin receptor. Nature,
    467(7319):1123-7. 2010.
  • Goshima Y, Usui H, Shiozawa T, Hida T, Kuraoka S, Takeshita S, Yamashita N, Ichikawa Y, Kamiya Y, Gotoh T, Gotoh T. Computational analysis of the effects of antineoplastic agents on axonal transport. Journal of Pharmacological Sciences, 114(2):168-79. 2010.
  • Suzuki S, Yokoyama U, Abe T, Kiyonari H, Yamashita N, Kato Y, Kurotani R, Sato M, Okumura S, Ishikawa Y. Differential roles of Epac in regulating cell death in neuronal and myocardial cells. The Journal of Biological Chemistry, 285(31):24248-59. 2010.
  • Sasaki Y, Welshhans K, Wen Z, Yao J, Xu M, Goshima Y, Zheng JQ, Bassell GJ. Phosphorylation of zipcode binding protein is required for BDNF signaling of local β-actin synthesis and growth cone turning. Journal of Neuroscience, 30: 9349-9358. 2010.
  • Asakura T, Waga N, Ogura K, Goshima Y. Genes Required for Cellular UNC-6/Netrin Localization in Caenorhabditis elegans. Genetics, 185(2):573-585. 2010.
  • Fujii M, Shikatani K, Ogura K, Goshima Y, Ayusawa D: Mutation in a mitochondrial ribosomal protein causes increased sensitivity to oxygen with decreased longevity in the nematode Caenorhabditis elegans. Genes Cells,16(1):69-79. 2010.
  • Ogura K, Okada T, Mitani S, Gengyo-Ando K, Baillie DL, Kohara Y, Goshima Y. Protein phosphatase 2A cooperates with the autophagy-related kinase UNC-51 to regulate axon guidance in Caenorhabditis elegans. Development, 137(10):1657-1667. 2010.
  • 五嶋良郎. 喫煙の生理学. 臨床と研究, 1025:743-746. 2010.

2009年

  • Arie Y, Iketani M, Takamatsu K, Mikoshiba K, Goshima Y, Takei K. Developmental changes in the regulation of calcium-dependent neurite outgrowth. Biochem Biopys Res Commun, 379(1):11-15. 2009.
  • Matsushita N, Misu Y, Goshima Y. In vivo antagonism of the behavioral responses to L-3,4-dihydroxyphenylalanine by l-3,4-dihydoroxyphenylalanine cyclohexyl ester in conscious rats. Eur J Pharmacol, 605(1-3):109-113. 2009.
  • Santangelo PJ, Lifland AW, Curt P, Sasaki Y, Bassell GJ, Lindquist ME, Crowe JE Jr. Single molecule-sensitive probes for imaging RNA in live cells. Nat Methods, 6(5):347-349. 2009.
  • Iketani M, Imaizumi C, Nakamura F, Jeromin A, Mikoshiba K, Goshima Y, Takei K. Regulation of neurite outgrowth mediated by neuronal calcium sensor-1 and inositol 1,4,5-trisphosphate receptor in nerve growth cones. Neuroscience, 161(3):743-752. 2009.
  • Fuchikawa T, Nakamura F, Fukuda N, Takei K, Goshima Y. Protein tyrosine phosphatase SHP2 is involved in Semaphorin 4D-induced axon repulsion. Biochem Biophys Res Commun, 385(1):6-10. 2009.
  • Uchida Y, Ohshima T, Yamashita N, Ogawara M, Sasaki Y, Nakamura F, Goshima Y. Semaphorin3A signaling mediated by Fyn-dependent tyrosine phosphorylation of collapsin response mediator protein 2 at tyrosine 32. J Biol Chem, 284(40): 27393-27401. 2009.
  • Nakamura F, Ugajin K, Yamashita N, Okada T, Uchida Y, Taniguchi M, Ohshima T, Goshima Y. Increased proximal bifurcation of CA1 pyramidal apical dendrites in sema3A mutant mice. J Comp Neurol, 516(5):360-375, 2009.
  • 竹居光太郎. 光照射による分子機能阻害法:開発適用の歴史と新たな幕開け. 蛋白質・核酸・酵素, 53(3): 284-291. 2009.
  • 山下直也, 中村史雄, 五嶋良郎. 軸索ガイダンスおよびシナプス形成とCdk5. 蛋白質・核酸・酵素, 54(7): 802-807.2009.

2008年

  • Araki N, Umemura M, Miyagi Y, Yabana M, Miki Y, Tamura K, Uchino K, Aoki R, Goshima Y, Umemura S, Ishigami T. Expression, transcription, and possible antagonistic interaction of the human Nedd4L gene variant: implications for essential hypertension. Hypertension, 51(3):773-777. 2008.
  • Togashi K, von Schimmelmann MJ, Nishiyama M, Lim CS, Yoshida N, Yun B, Molday RS, Goshima Y, Hong K. Cyclic GMP-gated CNG channels function in Sema3A-induced growth cone repulsion. Neuron, 58(5):694-707. 2008.
  • Murota Y, Fujii M, Sugiyama Y, Funabashi T, Yagami T, Takahashi T, Goshima Y. DOPA cyclohexyl ester, a DOPA antagonist, blocks the depressor responses elicited by microinjections of nicotine into the nucleus tractus solitarii of rat. Neurosci Lett, 442(2):114-117. 2008.
  • Yamaguchi J, Nakamura F, Aihara M, Yamashita N, Usui H, Hida T, Takei K, Nagashima Y, Ikezawa Z, Goshima Y. Semaphorin3A alleviates skin lesions and scratching behavior in NC/Nga mice, an atopic dermatitis model. J Invest Dermatol, 128(12): 2842-2849. 2008.
  • Abe TK, Honda T, Takei K, Mikoshiba K, Hoffman-Kim D, Jay DG, Kuwano R. Dynactin is essential for growth cone adovance. Biochem Biophys Res Comm, 372:418-422. 2008.
  • 青木令奈, 矢上達郎, 梶原康宏, 衣斐督和, 宮前丈明, 小倉顕一, 中村史雄, 三須良實, 五嶋良郎. 線虫C. elegans における新規7回膜貫通型受容体は揮発性ベンズアルデヒドに対する忌避応答に関与する. 横浜医学, 59: 117-123. 2008.
  • 2007年

  • Yamashita N, Morita A, Uchida Y, Nakamura F, Usui H, Ohshima T, Taniguchi M, Honnorat J, Thomasset N, Takei K, Takahashi T, Kolattukudy P, Goshima Y. Regulation of spine development by semaphorin3A through cyclin-dependent kinase 5 phosphorylation of collapsin response mediator protein 1. J Neurosci 27(46): 12546-12554. 2007.
  • Asakura T, Ogura K, Goshima Y. UNC-6 expression by the vulval precursor cells of Caenorhabditis elegans is required for the complex axon guidance of the HSN neurons. Dev Biol, 304(2): 800-10. 2007.
  • Watari-Goshima N, Ogura K, Wolf FW, Goshima Y, Garriga G. C. elegans VAB-8 and UNC-73 regulate the SAX-3 receptor to direct cell and growth-cone migrations. Nat Neurosci, 10(2): 169-76. 2007.
    線虫をモデル生物として用い、SAX-3受容体の局在性制御が細胞移動と神経回路形成に重要であることを証明しました。
  • Iizuka A, Sengoku K, Iketani M, Nakamura F, Sato Y, Matsushita M, Nairn AC, Takamatsu K, Goshima Y, Takei K. Calcium-induced synergistic inhibition of a translational factor eEF2 in nerve growth cones. Biochem Biophys Res Commun, 353(2): 244-50. 2007.
    成長円錐局所のeEF2(翻訳制御因子)が細胞内カルシウムイオンによる神経突起伸長制御機構に関わることを示しました。

2006年

  • Morita A, Yamashita N, Sasaki Y, Uchida Y, Nakajima O, Nakamura F, Yagi T, Taniguchi M, Usui H, Katoh-Semba R, Takei K, Goshima Y. Regulation of dendritic branching and spine maturation by semaphorin3A-Fyn signaling. J Neurosci, 26(11): 2971-80. 2006.
    反発性のガイダンス分子Sema3Aがシナプス成熟にも関わることを証明しました。
  • Shimamura M, Shimizu M, Yagami T, Funabashi T, Kimura F, Kuroiwa Y, Misu Y, Goshima Y. L-3, 4 - Dihydroxyphenylalanine-induced c-Fos expression in the CNS under inhibition of central aromatic L-amino acid decarboxylase. Neuropharmacology, 50(8): 909-16. 2006.
    ドーパがドパミンへの変換を介さずに脳内c-FOS発現を誘導することを示しました。
  • Nakajima O, Nakamura F, Yamashita N, Tomita Y, Saito F, Okada T, Iwamatsu A, Kondo E, Fujisawa H, Takei K, Goshima Y. FKBP133:A novel mouse FK-506 binding protein homolog alters growth cone morphology. Biochem Biophys Res Comm, 346(1): 140-149. 2006.
    新規の神経成長円錐制御因子FKBP-133を発見しました。
  • Ogura K, Goshima Y. The autophagy-related kinase UNC-51 and its binding partner UNC-14 regulate the subcellular localization of the Netrin receptor UNC-5 in Caenorhabditis elegans. Development, 133(17): 3441-50. 2006.
    オートファジー関連分子UNC-51がガイダンス分子ネトリンの細胞内局在制御を担うことを証明しました。
  •  
  • Izawa J, Yamanashi K, Asakura T, Misu Y, Goshima Y. Differential effects of methamphetamine and cocaine on behavior and extracellular levels of dopamine and 3,4-dihydroxyphenylalanine in the nucleus accumbens of conscious rats. Eur J Pharmacol, 549(1-3): 84-90. 2006.
  • Kaneko S, Iwanami A, Nakamura M, Kishino A, Kikuchi K, Shibata S, Okano HJ, Ikegami T, Moriya A, Konishi O, Nakayama C, Kumagai K, Kimura T, Sato Y, Goshima Y, Taniguchi M, Ito M, He Z, Toyama Y, Okano H. A selective Sema3A inhibitor enhances regenerative responses and functional recovery of the injured spinal cord. Nat Med, 12(12):1380-9. 2006.
    脊髄損傷モデルラットにおいて、セマフォリン3Aの阻害薬がそのシグナル伝達を阻害し、損傷後の機能回復を促進することを示しました。
  • Charrier E, Mosinger B, Meissirel C, Aguera M, Rogemond V, Reibel S, Salin P, Chounlamountri N, Perrot V, Belin MF, Goshima Y, Honnorat J, Thomasset N, Kolattukudy P. Transient Alterations in granule cell proliferation, apoptosis and migration in post-natal developing cerebellum of CRMP1-/- mice. Genes Cells, 11(12): 1337-52. 2006.
  • Yamashita N, Uchida Y, Ohshima T, Hirai S, Nakamura F, Taniguchi M, Mikoshiba K, Honnorat J, Kolattukudy P, Thomasset N, Takei K, Takahashi T, Goshima Y. Collapsin Response Mediator Protein 1 Mediates Reelin Signaling in Cortical Neuronal Migration. J Neurosci, 26(51) : 13357-62. 2006.
  • 中島央美, 中村史雄, 須藤文和, 岡田貴子, 岩松明彦, 藤澤肇, 竹居光太郎, 五嶋良郎. 新規分子KIAA0674の同定と発現解析. 横浜医学, 57: 85-93. 2006.
  • 中村史雄, 竹居光太郎, 五嶋良郎. 軸索ガイダンス分子による神経成長円錐の細胞骨格制御. 蛋白質核酸酵素, 51(6Suppl): 733-741. 2006. (Review)
  • 五嶋良郎. 神経回路形成と細胞内輸送制御. 日本神経精神薬理学雑誌, 26(3):135-40. 2006(Review)
  • 2005年

  • Uchida Y, Ohshima T, Sasaki Y, Suzuki H, Yanai S, Yamashita N, Nakamura F, Takei K, Ihara Y, Mikoshiba K, Kolattukudy P, Honnorat J, Goshima Y. Semahphorin3A signalling is mediated via sequential Cdk5 and GSK3β phosphorylation of CRMP2: implication of common phosphorylating mechanism underlying axon guidance and Alzheimer’s disease. Genes to Cells, 10:165-179. 2005.
    セマフォリン応答がCdk5およびGSK3betaによるCRMP1およびCRMP2のリン酸化を介することを証明しました。
  • Arimura N, Menager C, Kawano Y, Yoshimura T, Kawabata S, Hattori A, Fukata Y, Amano M, Goshima Y, Inagaki M, Morone N, Usukura J, Kaibuchi K. Phosphorylation by Rho kinase regulates CRMP-2 activity in growth cones. Mol Cell Biol, 25: 9973-84. 2005.
  • Shibakawa YS, Sasaki Y, Goshima Y, Echigo N, Kamiya Y, Kurahashi K, Yamada Y, Andoh T .Effects of ketamine and propofol on inflammatory responses of primary glial cell cultures stimulated with lipopolysaccharide. Br J Anaesth, 95: 803-10. 2005.
  • Yagami T, Ueda K, Sakaeda T, Okamura N, Nakazato H, Kuroda T, Hata S, Sakaguchi G, Itoh N, Hashimoto Y, Fujimoto M. Effects of an endothelin B receptor agonist on secretory phospholipase A2-IIA-induced apoptosis in cortical neurons. Neuropharmacology, 48:291-300. 2005.
  • Yagami T, Ueda K, Hata S, Kuroda T, Itoh N, Sakaguchi G, Okamura N, Sakaeda T, Fujimoto M. Effects of S-2474, A Novel nonsteroidal anti-inflammatory drug, on Group IIA secretory phospholipase A2-induced neuronal cell death. Neuropharmacolgy, 49: 4-184. 2005.
  • 五嶋良郎. 脳の神経細胞は全部機能しているか. Clinical Neurosci, 23: 955. 2005. (Review)
  • 内田穣、五嶋良郎. CRMP2のリン酸化を介した軸索ガイダンスの分子機構. 生化学, 77: 1424-1427. 2005. (Review)
  • 五嶋良郎.神経軸索ガイダンス分子と神経再生. 医学のあゆみ, 215: 847-850. 2005. (Review)

2004年

  • Fukumori R, Nishigori Y, Goshima Y, Kubo T. Contribution of the medial amygdaloid nucleus to the development of hypertension in spontaneously hypertensive rats.
    Neurosci Lett, 365:128-131. 2004.
  • Li C, Sasaki Y, Takei K, Yamamoto H, Shouji M, Sugiyama Y, Kawakami T, Nakamura F, Yagi T, Ohshima T, Goshima Y. Correlation between semaphorin3A-induced facilitation of axonal transport and local activation of a translation initiation factor eukaryotic translation initiation factor 4. E.J Neurosci, 24: 6161-6170. 2004.
    セマフォリンによる軸索輸送の制御作用が局所蛋白合成に関わることを示しました。
  • Ishii T, Fujishiro M, Masuda M, Goshima Y, Kitamura H, Teramoto S, Matsuse T.Effects of p27Kip1 on cell cycle status and viability in A549 lung adenocarcinoma cells. Eur Respir J, 23: 665-670. 2004.
  • Kubo T, Okatani H, Nishigori Y, Hagiwara Y, Fukumori R, Goshima Y. Involvement of the medial amygdaloid nucleus in restraint stress-induced pressor responses in rats. Neurosci Lett, 354 : 84-86. 2004.
  • Yagami T, Ueda K, Sakaeda T, Itoh N, Sakaguchi G, Okamura N, Hori Y, Fujimoto M.
    Protective effects of a selective L-type voltage-sensitive calcium channel blocker, S-312-d, on neuronal cell death. Biochem Pharmacol, 67:1153-65. 2004.
  • Itagaki F, Homma M, Takara K, Ohnishi N, Yokoyama T, Sakaeda T, Yagami T, Kobayashi H, Okamura N, Kohda Y. Effect of rabeprazole on MDR1-mediated transport of Rhodamine 123 in Caco-2 and Hvr100-6 cells. Biol Pharm Bull, 27: 1694-96. 2004.
  • Yagami T, Takahara Y, Ishibashi C, Sakaguchi G, Itoh N, Ueda K, Nakazato H, Okamura N, Hiramatsu Y, Honma T, Arimura A, Sakaeda T, Katsuura G. Amyloid beta protein impairs motor function via thromboxane A2 in the rat striatum. Neurobiol Dis,16: 481-9. 2004.

2003年

  • Kikuchi S, Fujimoto K, Kitagawa N, FuchikawaT, Abe M, Oka K, Takei K, Tomita M.Kinetic simulation of signal transduction system in hippocampal long-term potentiation with dynamic modeling ofprotein phosphatase 2A. Neural Networks, 16: 1-11. 2003.
    神経系におけるシュミレーションモデルを確立しました。
  • Cheng Q, Sasaki Y, Shoji M, Sugiyama Y, Tanaka H, Nakayama T, Mizuki N, Nakamura F, Takei K, Goshima Y. Cdk5/p35 and Rho-kinase mediate ephrin-A5-induced signaling in retinal ganglion cells. Mol Cell Neurosci. (3): 632-45. 2003.
    ガイダンス分子エフリンA5の下流にCdK5とRhoキナーゼ系が共存することを証明しました。
  • Yau DM, Yokoyama N, Goshima Y, Siddiqui ZK, Siddiqui SS, Kozasa T.Identification and molecular characterization of the G alpha12-Rho guanine nucleotide exchange factor pathway in Caenorhabditis elegans. Proc Natl Acad Sci U S A., 100(25):14748-53. 2003.
  • Kanaya T, Okatani H, Hagiwara Y, Fukumori R, Goshima Y, Kubo T. Projections from the caudal part to the rostral part of the lateral septal area mediate blood pressure increase.
    Brain Res Bull, 61(5):505-10. 2003.
  • Nishiyama M, Hoshino A, Tsai L, Henley JR, Goshima Y, Tessier-Lavigne M, Poo MM, Hong K. Cyclic AMP/GMP-dependent modulation of Ca2+ channels sets the polarity of nerve growth-cone turning. Nature, 424(6943):990-5. 2003.
  • Endo M, Ohashi K, Sasaki Y, Goshima Y, Niwa R, Uemura T, Mizuno K.Control of growth cone motility and morphology by LIM kinase and Slingshot via phosphorylation and dephosphorylation of cofilin. J Neurosci, 23(7): 2527-37. 2003.
  • Iwamoto T, Okumura S, Iwatsubo K, Kawabe J, Ohtsu K, Sakai I, Hashimoto Y, Izumitani A, Sango K, Ajiki K, Toya Y, Umemura S, Goshima Y, Arai N, Vatner SF, Ishikawa Y.Motor dysfunction in type 5 adenylyl cyclase-null mice. J Biol Chem, 278(19):16936-40. 2003.
  • Hashimoto M, Miyamae T, Yamamoto I, Goshima Y. DOPA cyclohexyl ester potently inhibits aglycemia-induced release of glutamate in rat striatal slices. Neurosci Res, (3): 335-44. 2003.
  • Suto F, Murakami Y, Nakamura F, Goshima Y, Fujisawa H. Identification and characterization of a novel mouse plexin, plexin-A4. Mech Dev, 120(3): 385-96. 2003.
  • Kubo T, Okatani H, Kanaya T, Hagiwara Y, Fukumori R, Goshima Y. Cholinergic mechanism in the lateral septal area is involved in the stress-induced blood pressure increase in rats. Brain Res Bull, 59(5): 359-64. 2003.
  • Goshima Y. CRMP-2: an intracellular mediator protein for Semaphorin3A signaling.
    Neurosci.Res, 46: Suppl.1,S24. 2003. (Review)
  • Misu Y, Kitahama K, Goshima Y.L-3,4-Dihydroxyphenylalanine as a neurotransmitter candidate in the central nervous system. Pharmacol Ther, 97(2):117-37. 2003. (Review)
  • 五嶋良郎. DOPAと自律神経機能. Clinical Neuroscience, 21(12):1396-1398. 2003. (Review)

2002年

  • Lee S, Kim JH, Lee CS, Kim JH, Kim Y, Heo K, Ihara Y, Goshima Y, Suh PG, Ryu SH.
    Collapsin response mediator protein-2 inhibits neuronal phospholipase D(2) activity by direct interaction. J Biol Chem, 277: 6542-6549. 2002.
  • Mitsui N, Inatome R, Takahashi S, Goshima Y, Yamamura H, Yanagi S. Involvement of Fes/Fps tyrosine kinase in semaphorin3A signaling. EMBO J, 21:3274-3285. 2002.
  • Yamanashi K, Miyamae T, Sasaki Y, Maeda M, Hirano H, Misu Y, Goshima Y. Involvement of nitric oxide production via kynurenic acid-sensitive glutamate receptors in DOPA-induced depressor responses in the nucleus tractus solitarii of anesthetized rats. Neurosci Res, 43: 231-238. 2002.
    ドーパシグナルの下流にnNOSの活性化過程が存在することを証明しました。
  • Sasaki Y, Cheng C, Uchida Y, Nakajima O, Ohshima T, Yagi T, Taniguchi T, Nakayama T, Kishida R, Kudo Y,Ohno S, Nakamura F, Goshima Y.Fyn and Cdk5 MediateSemaphorin-3A Signaling, Which Is Involved in Regulation of Dendrite Orientation in Cerebral Cortex. Neuron, 35: 907-920. 2002.
    セマフォリンSema3Aの下流にFyn、CdK5活性化機構が存在することを証明しました。
  • Goshima Y, Ito T, Sasaki Y, Nakamura F. Semaphorins as signals for cell repulsion and invasion. J Clin Invest, 109: 993-998. 2002. (Review)
  • Misu Y, Goshima Y, Miyamae T. Is DOPA a neurotransmitter?
    Trends Pharmacol Sci, 23: 262-268. 2002. (Review)
  • Misu Y, Goshima Y, Furukawa N, Arai N, Miyamae T. DOPA is a causal factor for glutamate release and delayed neuron death by transient ischemia in striatum and hippocampal CA1 of conscious rats. Advance in behavioral biology, 53, Catecholamine Research from molecular insights to clinical medicine: 229- 232. 2002. (Review)
  • Goshima Y, Yamanashi K, Miyamae T, Sasaki Y, Maeda M, Hirano H, Misu Y. Involvement of ionotropic glutamate receptors and nitric oxide in DOPA- induced depressor responses in the nucleus tractus solitarii. Advance in behavioral biology, 53, Catecholamine Research from molecular insights to clinical medicine: 293-296. 2002. (Review)
  • Misu Y, Furukawa N, Arai N, Miyamae T, Goshima Y, Fujita K.DOPA causes glutamate release and delayed neuron death by brain ischemia in rats. Neurotoxicol Teratol, 24: 629-638. 2002. (Review)
  • 竹居光太郎
    レーザー分子不活性化法:Chromophore-assisted laser inactivation (CALI法). Medical Science Digest, 20(6): 6-7, 2002. (Review)

2001年

  • Sugaya Y, Sasaki Y, Goshima Y, Kitahama K, Kusakabe Y, Miyamae T, Kato T, Misu Y.
    Autoradiographic studies using L-14C- and 3H-DOPA reveal regional Na+-dependent uptake of the neurotransmitter candidate L-DOPA in the central nervous system.
    Neuroscience, 104: 1-14. 2001.
    脳内諸部位におけるドーパ取り込み部位を発見しました。
  • Kubo T, Yokoi T, Hagiwara Y, Fukumori R.Characteristics of protective effects of NMOA autagonist and calcium channel antagonist on ischemic calcium accumulation in rat hippocampal CA1 region. Brain Res Bull, 54: 413-419. 2001.
  • Furukawa N, Arai N, Goshima Y, Miyamae T, Ohshima E, Szuki F, Fujita K, Misu Y.
    Endogenously released DOPA is a causal factor for glutamate release and resultant delayed neuronal cell death by transient ischemia in rat striata. J Neurochem, 76: 1-11. 2001.
    ドーパは脳虚血時グルタミン遊離-神経細胞死の上流因子となっていることを証明しました。
  • Arai N, Furukawa N, Miyamae T, Goshima Y, Sasaki Y, Ohshima E, Suzuki F, Fujita K and Misu Y. DOPA cyclohexyl ester, a competitive DOPA antagonist, protects glutamate release and resultant delayed neuron death by transient ischemia in hippocampus CA1 of conscious rats. Neurosci Lett, 299: 213-216. 2001.
  • Aizawa H, Wakatuki S, Ishii A, Moriyama K, Sasaki Y, Ohashi K, Sekine-Aizawa Y, Sehara-Fujisawa A, Mizuno K, Goshima Y, Yahara I. Phosphorylation of cofilin by LIM-kinase is necessary for semaphorin3A-induced growth cone collapse.
    Nature Neurosci. 4,:367-373. 2001.
  • Akbar M, Ishihara K, Sasa M, Misu Y. Inhibition by L-3,4-dihydroxyphenylalanine of hippocampal CA1 neurons with facilitation of noradrenaline and γ-aminobutyric acid release.
    Eur J Pharmacol, 414: 197-203. 2001.
  • Kagoshima M, Ito T, Kitamura H, Goshima Y.Diverse gene expression and function of semaphorins in developing lung:positive and negativeregulatory roles of semaphorins in lung branching morphogenesis. Genes to Cells, 6: 559-571. 2001.
  • Yamanashi K, Miyamae T. Misu Y, Goshima Y. Tonic function of nicotinic receptors in stress-induced release of L-DOPA from the nucleus accumbens in freely moving rats.
    Eur. J. Pharmacol, 424: 199-202. 2001.
  • 佐々木幸生, 五嶋良郎.
    ガイダンス分子のシグナル伝達. 細胞工学, 20: 530-537. 2001.
  • 中村史雄, 五嶋良郎 神経回路形成とチロシンフォスファターゼ. 細胞工学,20: 873-881. 2001.
  • 三須良實, 五嶋良郎. L-DOPA 神経伝達物質説. 脳の科学, 23: 895-901. 2001.

2000年

  • Takemoto T, Sasaki Y, Hamajima N, Goshima Y, Nonaka M, Kimura H. Cloning and characterization of the Caenorhabditis elegans CeCRMP/DHP-1 and -2; common ancestors of the CRMP and dihydropyrimidinase? Gene, 261: 259-267. 2000.
    線虫CRMP相同分子を同定しました。
  • Ito T, Kagoshima M, Sasaki Y, Li C, Udaka N, Kitsukawa T, Fujisawa H, Taniguchi M, Yagi T, Kitamura H, Goshima Y. Repulsive axon guidance molecule Sema3A inhibits branching morphogenesis of fetal mouse lung. Mech Dev, 97: 35-45. 2000.
    セマフォリンの肺発達における役割を発見しました。
  • Furukawa N, Goshima Y, Miyamae T, Sugiyama Y, Shimizu M, Ohshima E, Suzuki F, Arai N, Fujita K, Misu Y.L-DOPA cyclohexyl ester is a novel potent and relatively stable competitive antagonist against L-DOPA among several L-DOPA ester compounds. Jpn J Pharmacol, 82: 40-47. 2000.
  • Ishii H, Sasaki Y, Goshima Y, Kanai Y, Endou H, Ayusawa D, Ono H, Miyamae T, Misu Y.
    Involvement of rBAT in Na+-dependent and ?independent transport of the neurotransmitter candidate L-DOPA in Xenopus laevis oocytes injected with rabbit samll intestinal epithelium polyA+ RNA. Biochim Biophys Acta, 1466: 61-70. 2000.
    Na+依存性のドーパ取り込み機構を証明しました。
  • Fournier AE, Nakamura F, Kawamoto S, Goshima Y, Kalb RG, Strittmatter SM.
    Semaphorin3A enhances endocytosis at site of receptor-F-actin colocalization during growth cone collapse. J Cell Biol, 149: 411-421. 2000.
  • Arimatsu N, Inagaki N, Chihara K, Menager C, Nakamura N, Amano M, Iwamatsu A, Goshima Y, Kaibuchi K. Phosphorylation of collapsin response mediator protein-2 by Rho-kinase: evidence for two separate signaling pathways for growth cone collapse.
    J Biol Chem, 275: 23973-23980. 2000.
  • Makatani M, Fujitani Y, Takimoto M, Oda K, Sasaki Y, Hori S, Inui T, Sakaki J, Okada T,Hoshiko K, Yamamura T. Effect of a novel bifunctional endothelin receptor antagonist, IRL 3630A, on guinea pig respiratory mechanics. Eur J Pharmacol, 406:139-147. 2000.
  • GrandPre T, Nakamura F, Vartanian T, Strittmatter SM. Identification of the Nogo inhibitor of axon regeneration as a Reticulon protein. Nature, 403:439-444. 2000.
  • Sawada H, Ibi M, Kihara T, Urushitani M, Honda K, Nakanishi M, Akaike A, Shimohama S.
    Mechanisms of antiapoptotic effects of estrogens in nigral dopaminergic neurons.
    FASEB J, 14: 1202-1214. 2000.
  • Sawada H, Ibi M, Kihara T, Urushitani M, Nakanishi M, Akaike A, Shimohama S.
    Neuroprotective mechanism of glial cell line-derived neurotrophic factor in mesencephalic neurons. J Neurochem, 74: 1175-1184. 2000.
  • Li C, Sasaki Y, Hori H, Ishikawa Y, Kawakami T, Goshima Y.Involvement of lavendustin A-sensitive tyrosine kinase(s) in Sema3A mediated axoplasmic transport in cultured mouse dorsal root ganglion neurons. Neurosci Res, Suppl, 24: S104. 2000.
  • Miyamae T, Yamanashi K, Sasaki Y, Misu Y, Goshima Y. Involvement of glutamate receptor and nitric oxide in DOPA-induced depressor responses in the nucleus tractus solitarii of anesthetized rats. Neurosci Res, Suppl. 24: S172. 2000.
  • Goshima Y, Sasaki Y, Nakayama T, Ito T, Kimura T. Functions of Semaphorins in axon guidance and neuronal regeneration. Jpn J Pharmacol, 82: 273-279. 2000.
  • Nakamura F, Kalb RG, Strittmatter SM. Molecular basis of semaphorin-mediated axon guidance. J Neurobiol, 44:219-229. 2000.
  • 中村史雄. 中枢神経系の軸索伸長抑制因子Nogo(NI-35/250)の同定. 実験医学, 18:1103-1105. 2000.
  • 鹿子島雅子,伊藤隆明,五嶋良郎. セマフォリンと肺分岐形成.
    THE LUNG perspectives, 18:352-358. 2000.
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