DNA supercoiling factor (SCF)
entry list
alignment
DNA supercoiling factor (SCF) is capable of generating negative
supercoils into a relaxed DNA in conjunction with eukaryotic DNA
topoisomerase II. SCF has 322 residues and contains six EF-hands, five
of which are predicted to bind calcium. SCF requires ~10 _M Ca2+ for
activity. This is inferred to reflect an in vivo response to a calcium
signal [29]. Several domains of SCF and RTC are most closely related;
however, there is no apparent relation in their functions nor homology
in the domains at their N-termini.